| 1311155 | Il33 | interleukin 33 | ENCODES a protein that exhibits cytokine activity (ortholog); interleukin-33 receptor binding (ortholog); INVOLVED IN cellular response to mechanical stimulus; positive regulation of oligodendrocyte differentiation; antibacterial innate immune response (ortholog); PARTICIPATES IN influenza A pathway ; ASSOCIATED WITH acute myocardial infarction; Cardiomegaly; colon cancer; FOUND IN cytoplasm (ortholog); extracellular space (ortholog); nucleoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol | 1 | 237115478 | 237149897 | Rat | 422 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1322461 | IL33 | interleukin 33 | The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been fo und for this gene. [provided by RefSeq, Sep 2015] | 9 | 6215149 | 6257983 | Human | 433 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1322462 | Il33 | interleukin 33 | Enables cytokine activity and interleukin-33 receptor binding activity. Involved in several processes, including antibacterial innate immune response; regulation of gene expression; and regulation of inflammatory response. Acts upstream of or within several processes, including negative regulation o f macrophage proliferation; positive regulation of cellular defense response; and positive regulation of macromolecule metabolic process. Located in nucleus. Is active in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in candidiasis; inflammatory bowel disease; and peptic ulcer disease. Orthologous to human IL33 (interleukin 33). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 29902513 | 29938118 | Mouse | 481 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8800431 | Il33 | interleukin 33 | ENCODES a protein that exhibits cytokine activity (ortholog); interleukin-33 receptor binding (ortholog); INVOLVED IN antibacterial innate immune response (ortholog); cellular response to mechanical stimulus (ortholog); defense response to virus (ortholog); ASSOCIATED WITH acute myocardial infarctio n (ortholog); Alzheimer's disease (ortholog); angiostrongyliasis (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); nucleoplasm (ortholog) | NW_004955434 | 10145449 | 10187595 | Chinchilla | 152 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12041432 | IL33 | interleukin 33 | ENCODES a protein that exhibits cytokine activity (inferred); interleukin-33 receptor binding (inferred); INVOLVED IN cellular response to mechanical stimulus (ortholog); defense response to virus (ortholog); extrinsic apoptotic signaling pathway (ortholog); ASSOCIATED WITH acute myocardial infarcti on (ortholog); Alzheimer's disease (ortholog); angiostrongyliasis (ortholog); FOUND IN chromosome (inferred); cytoplasm (inferred); cytoplasmic vesicle (inferred) | 9 | 6027014 | 6069540 | Bonobo | 160 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12333507 | IL33 | interleukin 33 | ENCODES a protein that exhibits interleukin-33 receptor binding (ortholog); INVOLVED IN antibacterial innate immune response (ortholog); cellular response to mechanical stimulus (ortholog); defense response to virus (ortholog); ASSOCIATED WITH acute myocardial infarction (ortholog); Alzheimer's dise ase (ortholog); angiostrongyliasis (ortholog); FOUND IN chromosome (inferred); cytoplasm (inferred); cytoplasmic vesicle (inferred) | 11 | 27219878 | 27256723 | Dog | 159 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12551321 | Il33 | interleukin 33 | ENCODES a protein that exhibits cytokine activity (inferred); interleukin-33 receptor binding (inferred); INVOLVED IN cellular response to mechanical stimulus (ortholog); defense response to virus (ortholog); extrinsic apoptotic signaling pathway (ortholog); ASSOCIATED WITH acute myocardial infarcti on (ortholog); Alzheimer's disease (ortholog); angiostrongyliasis (ortholog); FOUND IN chromosome (inferred); cytoplasm (inferred); cytoplasmic vesicle (inferred) | NW_004936539 | 763755 | 791461 | Squirrel | 159 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626049303 | Il33 | interleukin 33 | ENCODES a protein that exhibits cytokine activity (ortholog); interleukin-33 receptor binding (ortholog); INVOLVED IN antibacterial innate immune response (ortholog); cellular response to mechanical stimulus (ortholog); defense response to virus (ortholog); ASSOCIATED WITH acute myocardial infarctio n (ortholog); Alzheimer's disease (ortholog); angiostrongyliasis (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 151 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18907367 | Il33 | interleukin 33 | ENCODES a protein that exhibits interleukin-33 receptor binding (ortholog); INVOLVED IN antibacterial innate immune response (ortholog); cellular response to mechanical stimulus (ortholog); defense response to virus (ortholog); ASSOCIATED WITH acute myocardial infarction (ortholog); Alzheimer's dise ase (ortholog); angiostrongyliasis (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 161 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14276548 | IL33 | interleukin 33 | ENCODES a protein that exhibits interleukin-33 receptor binding (ortholog); INVOLVED IN antibacterial innate immune response (ortholog); cellular response to mechanical stimulus (ortholog); defense response to virus (ortholog); ASSOCIATED WITH acute myocardial infarction (ortholog); Alzheimer's dise ase (ortholog); angiostrongyliasis (ortholog); FOUND IN chromosome (inferred); cytoplasm (inferred); cytoplasmic vesicle (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 161 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18619227 | IL33 | interleukin 33 | ENCODES a protein that exhibits cytokine activity (inferred); interleukin-33 receptor binding (inferred); INVOLVED IN cellular response to mechanical stimulus (ortholog); defense response to virus (ortholog); extrinsic apoptotic signaling pathway (ortholog); ASSOCIATED WITH acute myocardial infarcti on (ortholog); Alzheimer's disease (ortholog); angiostrongyliasis (ortholog); FOUND IN chromosome (inferred); cytoplasm (inferred); cytoplasmic vesicle (inferred) | | | | Green Monkey | 159 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 2894 | Il1rl1 | interleukin 1 receptor-like 1 | ENCODES a protein that exhibits interleukin-33 binding (ortholog); interleukin-33 receptor activity (ortholog); INVOLVED IN cellular response to endothelin; cellular response to mechanical stimulus; negative regulation of cell population proliferation; ASSOCIATED WITH acute myocardial infarction; ba cterial pneumonia; Intervertebral Disc Displacement; FOUND IN cell surface; external side of plasma membrane; extracellular space; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine | 9 | 50157326 | 50222888 | Rat | 328 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 736158 | IL1RL1 | interleukin 1 receptor like 1 | The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), in terleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] | 2 | 102311563 | 102352356 | Human | 324 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |