| 2830 | Hrh1 | histamine receptor H 1 | ENCODES a protein that exhibits histamine binding; histamine receptor activity (ortholog); INVOLVED IN chemical synaptic transmission; negative regulation of steroid biosynthetic process; positive regulation of nitric oxide biosynthetic process; PARTICIPATES IN calcium/calcium-mediated signaling pat hway; ASSOCIATED WITH allergic rhinitis (ortholog); atherosclerosis (ortholog); Extravasation of Diagnostic and Therapeutic Materials (ortholog); FOUND IN plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-pyridylethylamine; 6-propyl-2-thiouracil | 4 | 149120511 | 149204267 | Rat | 214 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 10731 | Hrh1 | histamine receptor H1 | Predicted to enable calcium ion transmembrane transporter activity; histamine binding activity; and histamine receptor activity. Acts upstream of or within memory; regulation of synaptic plasticity; and visual learning. Predicted to be located in cytosol. Predicted to be active in dendrite and plasm a membrane. Is expressed in brain; stomach; and uterus. Orthologous to human HRH1 (histamine receptor H1). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 114374897 | 114459432 | Mouse | 267 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 736085 | HRH1 | histamine receptor H1 | Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor s uperfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015] | 3 | 11137238 | 11263557 | Human | 218 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8874762 | Hrh1 | histamine receptor H1 | ENCODES a protein that exhibits histamine binding (ortholog); histamine receptor activity (ortholog); INVOLVED IN cellular response to histamine (ortholog); chemical synaptic transmission (ortholog); G protein-coupled receptor signaling pathway (ortholog); ASSOCIATED WITH allergic rhinitis (ortholog ); atherosclerosis (ortholog); Extravasation of Diagnostic and Therapeutic Materials (ortholog); FOUND IN plasma membrane (ortholog) | NW_004955429 | 14022332 | 14069931 | Chinchilla | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11730629 | HRH1 | histamine receptor H1 | ENCODES a protein that exhibits histamine binding (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); memory (ortholog); negative regulation of steroid biosynthetic process (ortholog); ASSOCIATED WITH allergic rhinitis (ortholog); atherosclerosis (ortholog); Extravasation of Diagnosti c and Therapeutic Materials (ortholog); FOUND IN dendrite (inferred); membrane (inferred); plasma membrane (inferred) | 3 | 11074451 | 11199871 | Bonobo | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12348470 | HRH1 | histamine receptor H1 | ENCODES a protein that exhibits histamine binding (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); memory (ortholog); negative regulation of steroid biosynthetic process (ortholog); ASSOCIATED WITH allergic rhinitis (ortholog); atherosclerosis (ortholog); Extravasation of Diagnosti c and Therapeutic Materials (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); synapse (inferred) | 20 | 7160903 | 7236147 | Dog | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12638488 | Hrh1 | histamine receptor H1 | ENCODES a protein that exhibits histamine binding (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); memory (ortholog); negative regulation of steroid biosynthetic process (ortholog); ASSOCIATED WITH allergic rhinitis (ortholog); atherosclerosis (ortholog); Extravasation of Diagnosti c and Therapeutic Materials (ortholog); FOUND IN dendrite (inferred); membrane (inferred); plasma membrane (inferred) | NW_004936602 | 2182053 | 2185297 | Squirrel | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14030381 | HRH1 | histamine receptor H1 | ENCODES a protein that exhibits histamine binding (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); memory (ortholog); negative regulation of steroid biosynthetic process (ortholog); ASSOCIATED WITH allergic rhinitis (ortholog); atherosclerosis (ortholog); Extravasation of Diagnosti c and Therapeutic Materials (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); synapse (inferred); INTERACTS WITH deoxynivalenol; graphene oxide | | | | Pig | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625917311 | Hrh1 | histamine receptor H1 | ENCODES a protein that exhibits histamine binding (ortholog); histamine receptor activity (ortholog); INVOLVED IN cellular response to histamine (ortholog); chemical synaptic transmission (ortholog); G protein-coupled receptor signaling pathway (ortholog); ASSOCIATED WITH allergic rhinitis (ortholog ); atherosclerosis (ortholog); Extravasation of Diagnostic and Therapeutic Materials (ortholog); FOUND IN plasma membrane (ortholog) | | | | Black Rat | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18474441 | HRH1 | histamine receptor H1 | ENCODES a protein that exhibits histamine binding (ortholog); INVOLVED IN chemical synaptic transmission (ortholog); memory (ortholog); negative regulation of steroid biosynthetic process (ortholog); ASSOCIATED WITH allergic rhinitis (ortholog); atherosclerosis (ortholog); Extravasation of Diagnosti c and Therapeutic Materials (ortholog); FOUND IN dendrite (inferred); membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155242170 | hrh1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18917715 | Hrh1 | histamine receptor H1 | ENCODES a protein that exhibits histamine binding (ortholog); INVOLVED IN cellular response to histamine (ortholog); chemical synaptic transmission (ortholog); memory (ortholog); ASSOCIATED WITH allergic rhinitis (ortholog); atherosclerosis (ortholog); Extravasation of Diagnostic and Therapeutic Mat erials (ortholog); FOUND IN plasma membrane (ortholog) | | | | Naked Mole-Rat | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155242169 | hrh1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155240225 | hrh1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1605422 | DHX34 | DExH-box helicase 34 | DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splic eosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. It is mapped to the glioma 19q tumor suppressor region and is a tumor suppressor candidate gene. [provided by RefSeq, Jul 2008] | 19 | 47349315 | 47382704 | Human | 87 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1321795 | DHX8 | DEAH-box helicase 8 | This gene is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may be required for the replication of human immunodeficiency virus type 1 (HIV-1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] | 17 | 43483975 | 43544799 | Human | 97 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 38664915 | LOC102723663 | uncharacterized LOC102723663 | | 3 | 11193435 | 11225918 | Human | | old_gene_name | gene, ncrna, MODEL [RefSeq] |
