| 2826 | Hprt1 | hypoxanthine phosphoribosyltransferase 1 | ENCODES a protein that exhibits hypoxanthine phosphoribosyltransferase activity; guanine phosphoribosyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to insulin stimulus; hypoxanthine metabolic process; spermatogenesis; PARTICIPATES IN adenine ph oshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Experimental Diabetes Mellitus; hepatocellular carcinoma; Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone | X | 137655744 | 137687718 | Rat | 388 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 731296 | HPRT1 | hypoxanthine phosphoribosyltransferase 1 | The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.[provided by RefSeq, Jun 2009] | X | 134460165 | 134500668 | Human | 515 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1549982 | Hprt1 | hypoxanthine phosphoribosyltransferase 1 | The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. [provided by RefSeq, Sep 2015] | X | 52076955 | 52110537 | Mouse | 740 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8755766 | Hprt1 | hypoxanthine phosphoribosyltransferase 1 | ENCODES a protein that exhibits guanine phosphoribosyltransferase activity (ortholog); hypoxanthine phosphoribosyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN adenine metabolic process (ortholog); AMP salvage (ortholog); cellular response to insulin stimulus (or tholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Experimental Diabetes Mellitus (ortholog); familial hypocalciuric hypercalcemia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog) | NW_004955473 | 462940 | 510006 | Chinchilla | 88 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11949750 | HPRT1 | hypoxanthine phosphoribosyltransferase 1 | ENCODES a protein that exhibits hypoxanthine phosphoribosyltransferase activity (ortholog); INVOLVED IN adenine metabolic process (ortholog); cellular response to insulin stimulus (ortholog); central nervous system neuron development (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase defic iency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Experimental Diabetes Mellitus (ortholog); familial hypocalciuric hypercalcemia (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | X | 123609248 | 123650102 | Bonobo | 97 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12132189 | HPRT1 | hypoxanthine phosphoribosyltransferase 1 | ENCODES a protein that exhibits guanine phosphoribosyltransferase activity (ortholog); hypoxanthine phosphoribosyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN adenine metabolic process (ortholog); AMP salvage (ortholog); cellular response to insulin stimulus (or tholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Experimental Diabetes Mellitus (ortholog); familial hypocalciuric hypercalcemia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog) | X | 105115732 | 105153702 | Dog | 94 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12628574 | Hprt1 | hypoxanthine phosphoribosyltransferase 1 | ENCODES a protein that exhibits hypoxanthine phosphoribosyltransferase activity (ortholog); INVOLVED IN adenine metabolic process (ortholog); cellular response to insulin stimulus (ortholog); central nervous system neuron development (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase defic iency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Experimental Diabetes Mellitus (ortholog); familial hypocalciuric hypercalcemia (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | NW_004936691 | 650753 | 694362 | Squirrel | 97 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866390 | HPRT1 | hypoxanthine phosphoribosyltransferase 1 | ENCODES a protein that exhibits glycosyltransferase activity (inferred); guanine phosphoribosyltransferase activity (inferred); hypoxanthine phosphoribosyltransferase activity (inferred); INVOLVED IN AMP salvage (inferred); GMP catabolic process (inferred); GMP salvage (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 30 | symbol | gene, protein-coding |
| 625971701 | Hprt1 | hypoxanthine phosphoribosyltransferase 1 | ENCODES a protein that exhibits guanine phosphoribosyltransferase activity (ortholog); hypoxanthine phosphoribosyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN adenine metabolic process (ortholog); AMP salvage (ortholog); cellular response to insulin stimulus (or tholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Experimental Diabetes Mellitus (ortholog); familial hypocalciuric hypercalcemia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 88 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18485130 | HPRT1 | hypoxanthine phosphoribosyltransferase 1 | ENCODES a protein that exhibits guanine phosphoribosyltransferase activity (ortholog); hypoxanthine phosphoribosyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN adenine metabolic process (ortholog); AMP salvage (ortholog); cellular response to insulin stimulus (or tholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Experimental Diabetes Mellitus (ortholog); familial hypocalciuric hypercalcemia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog) | | | | Green Monkey | 88 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14146862 | HPRT1 | hypoxanthine phosphoribosyltransferase 1 | ENCODES a protein that exhibits guanine phosphoribosyltransferase activity (ortholog); hypoxanthine phosphoribosyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN adenine metabolic process (ortholog); cellular response to insulin stimulus (ortholog); central nervous system neuron development (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Experimental Diabetes Mellitus (ortholog); familial hypocalciuric hypercalcemia (ortholog); FOUND IN cytoplasm (ortholog) | | | | Pig | 116 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18915136 | Hprt1 | hypoxanthine phosphoribosyltransferase 1 | ENCODES a protein that exhibits guanine phosphoribosyltransferase activity (ortholog); hypoxanthine phosphoribosyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN adenine metabolic process (ortholog); AMP salvage (ortholog); cellular response to insulin stimulus (or tholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Experimental Diabetes Mellitus (ortholog); familial hypocalciuric hypercalcemia (ortholog); FOUND IN cytosol (ortholog) | | | | Naked Mole-Rat | 89 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155238737 | hprt1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155235872 | hprt1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860752 | hprt1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860434 | hprt1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626469666 | hprt1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626469682 | hprt1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858083 | hprt1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864475 | hprt1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 6491257 | Hprt1-ps1 | hypoxanthine phosphoribosyltransferase 1, pseudogene 1 | | 16 | 40849238 | 40849881 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 40999085 | Hprt1-ps3 | hypoxanthine phosphoribosyltransferase 1, pseudogene 3 | | Y | 3493682 | 3494332 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1596190 | Hprt1-ps4 | hypoxanthine phosphoribosyltransferase 1, pseudogene 4 | | X | 2945539 | 2946267 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1319125 | EIF3B | eukaryotic translation initiation factor 3 subunit B | Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in several processes, including IRES-dependent viral translational initiation; translational initiation; and viral translational termination-reinitiation. Located in cytoplasmic stress granule. Part of euka ryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Jul 2025] | 7 | 2354086 | 2380745 | Human | 181 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1584006 | Eif3b-ps1 | eukaryotic translation initiation factor 3, subunit B, pseudogene 1 | | 6 | 43584821 | 43587086 | Rat | | old_gene_name | gene, pseudo, MODEL [RefSeq] |
| 9854675 | HPRT1P1 | hypoxanthine phosphoribosyltransferase 1 pseudogene 1 | | 4 | 15864738 | 15865197 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1351283 | HPRT1P2 | hypoxanthine phosphoribosyltransferase 1 pseudogene 2 | | 5 | 30248374 | 30249481 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1342808 | HPRT1P3 | hypoxanthine phosphoribosyltransferase 1 pseudogene 3 | | 11 | 93998643 | 93999232 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
