| 1344478 | HDAC8 | histone deacetylase 8 | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] | X | 72329516 | 72572843 | Human | 390 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1558090 | Hdac8 | histone deacetylase 8 | Predicted to enable several functions, including heat shock protein binding activity; histone deacetylase activity; and histone decrotonylase activity. Predicted to be involved in several processes, including cellular response to forskolin; cellular response to trichostatin A; and regulation of macr omolecule metabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of histone deacetylase complex. Is expressed in several structures, including 2-cell stage embryo; brain; embryo ectoderm; foregut; and retina. Used to study Cornelia de Lange syndrome 5. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8). [provided by Alliance of Genome Resources, Jul 2025] | X | 101328244 | 101549005 | Mouse | 194 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1562895 | Hdac8 | histone deacetylase 8 | ENCODES a protein that exhibits chromatin binding; deacetylase activity; transcription factor binding; INVOLVED IN cellular response to forskolin; cellular response to trichostatin A; negative regulation of gene expression; PARTICIPATES IN histone modification pathway; ASSOCIATED WITH amphetamine ab use; Cardiomegaly; hypertension; FOUND IN chromosome (inferred); cytoplasm (inferred); nucleus (inferred); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,4-dinitrotoluene; 2,6-dinitrotoluene | X | 71425240 | 71632865 | Rat | 156 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 9064500 | Hdac8 | histone deacetylase 8 | ENCODES a protein that exhibits chromatin binding (ortholog); deacetylase activity (ortholog); histone deacetylase activity (ortholog); INVOLVED IN cellular response to forskolin (ortholog); cellular response to trichostatin A (ortholog); mitotic sister chromatid cohesion (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH amphetamine abuse (ortholog); atrial heart septal defect (ortholog); Cardiomegaly (ortholog) | NW_004955475 | 11748502 | 12012884 | Chinchilla | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11695538 | HDAC8 | histone deacetylase 8 | ENCODES a protein that exhibits chromatin binding (ortholog); deacetylase activity (ortholog); transcription factor binding (ortholog); INVOLVED IN cellular response to forskolin (ortholog); cellular response to trichostatin A (ortholog); negative regulation of gene expression (ortholog); PARTICIPAT ES IN histone modification pathway; ASSOCIATED WITH amphetamine abuse (ortholog); atrial heart septal defect (ortholog); Cardiomegaly (ortholog); FOUND IN chromosome (inferred); cytoplasm (inferred); nucleus (inferred) | X | 61565790 | 61811588 | Bonobo | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12135951 | HDAC8 | histone deacetylase 8 | ENCODES a protein that exhibits chromatin binding (ortholog); deacetylase activity (ortholog); transcription factor binding (ortholog); INVOLVED IN cellular response to forskolin (ortholog); cellular response to trichostatin A (ortholog); negative regulation of gene expression (ortholog); PARTICIPAT ES IN histone modification pathway; ASSOCIATED WITH amphetamine abuse (ortholog); atrial heart septal defect (ortholog); Cardiomegaly (ortholog); FOUND IN chromosome (inferred); cytoplasm (inferred); nucleus (inferred) | X | 56357205 | 56574443 | Dog | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12719654 | Hdac8 | histone deacetylase 8 | ENCODES a protein that exhibits chromatin binding (ortholog); deacetylase activity (ortholog); transcription factor binding (ortholog); INVOLVED IN cellular response to forskolin (ortholog); cellular response to trichostatin A (ortholog); negative regulation of gene expression (ortholog); PARTICIPAT ES IN histone modification pathway; ASSOCIATED WITH amphetamine abuse (ortholog); atrial heart septal defect (ortholog); Cardiomegaly (ortholog); FOUND IN chromosome (inferred); cytoplasm (inferred); nucleus (inferred) | NW_004936762 | 1425337 | 1652058 | Squirrel | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625995699 | Hdac8 | histone deacetylase 8 | ENCODES a protein that exhibits chromatin binding (ortholog); deacetylase activity (ortholog); histone deacetylase activity (ortholog); INVOLVED IN cellular response to forskolin (ortholog); cellular response to trichostatin A (ortholog); mitotic sister chromatid cohesion (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH amphetamine abuse (ortholog); atrial heart septal defect (ortholog); Cardiomegaly (ortholog) | | | | Black Rat | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155242647 | hdac8 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18528671 | HDAC8 | histone deacetylase 8 | ENCODES a protein that exhibits chromatin binding (ortholog); deacetylase activity (ortholog); transcription factor binding (ortholog); INVOLVED IN cellular response to forskolin (ortholog); cellular response to trichostatin A (ortholog); negative regulation of gene expression (ortholog); PARTICIPAT ES IN histone modification pathway; ASSOCIATED WITH amphetamine abuse (ortholog); atrial heart septal defect (ortholog); Cardiomegaly (ortholog); FOUND IN chromosome (inferred); cytoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18904835 | Hdac8 | histone deacetylase 8 | ENCODES a protein that exhibits chromatin binding (ortholog); deacetylase activity (ortholog); histone decrotonylase activity (ortholog); INVOLVED IN cellular response to forskolin (ortholog); cellular response to trichostatin A (ortholog); mitotic sister chromatid cohesion (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH amphetamine abuse (ortholog); atrial heart septal defect (ortholog); Cardiomegaly (ortholog); FOUND IN chromosome (inferred); cytoplasm (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13872743 | HDAC8 | histone deacetylase 8 | ENCODES a protein that exhibits chromatin binding (ortholog); deacetylase activity (ortholog); transcription factor binding (ortholog); INVOLVED IN cellular response to forskolin (ortholog); cellular response to trichostatin A (ortholog); negative regulation of gene expression (ortholog); PARTICIPAT ES IN histone modification pathway; ASSOCIATED WITH amphetamine abuse (ortholog); atrial heart septal defect (ortholog); Cardiomegaly (ortholog); FOUND IN chromosome (inferred); cytoplasm (inferred); nucleus (inferred) | | | | Pig | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155251555 | hdac8.L | | | | | | African Clawed Frog | | symbol | gene, null |