| 2752 | Gss | glutathione synthetase | ENCODES a protein that exhibits ATP binding; glutathione binding; glutathione synthase activity; INVOLVED IN glutathione biosynthetic process; response to amino acid; response to nutrient levels; PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; glutathio ne metabolic pathway; ASSOCIATED WITH Acute Experimental Pancreatitis; Alzheimer's disease (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN nucleoplasm (ortholog); INTERACTS WITH (R)-lipoic acid; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate | 3 | 164508005 | 164538343 | Rat | 323 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 10694 | Gss | glutathione synthetase | Enables glutathione synthase activity. Acts upstream of or within response to cadmium ion. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; integumental system; metanephros; nervous system; and sensory organ. Human ortholog(s) of this gene implicate d in Alzheimer's disease; congenital nonspherocytic hemolytic anemia 6; glutathione synthetase deficiency; and glutatione synthetase deficiency with 5-oxoprolinuria. Orthologous to human GSS (glutathione synthetase). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 155405101 | 155434730 | Mouse | 323 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 735330 | GSS | glutathione synthetase | Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthes is, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008] | 20 | 34928432 | 34956027 | Human | 680 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8707374 | Gss | glutathione synthetase | ENCODES a protein that exhibits ATP binding (ortholog); glutathione binding (ortholog); glutathione synthase activity (ortholog); INVOLVED IN glutathione biosynthetic process (ortholog); response to amino acid (ortholog); response to cadmium ion (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; glutathione metabolic pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Alzheimer's disease (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN nucleoplasm (ortholog) | NW_004955422 | 26427581 | 26483380 | Chinchilla | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11988282 | GSS | glutathione synthetase | ENCODES a protein that exhibits ATP binding (ortholog); glutathione binding (ortholog); glutathione synthase activity (ortholog); INVOLVED IN glutathione biosynthetic process (ortholog); response to amino acid (ortholog); response to cadmium ion (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; glutathione metabolic pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Alzheimer's disease (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred) | 20 | 31256734 | 31284356 | Bonobo | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12245225 | GSS | glutathione synthetase | ENCODES a protein that exhibits ATP binding (ortholog); glutathione binding (ortholog); glutathione synthase activity (ortholog); INVOLVED IN glutathione biosynthetic process (ortholog); response to amino acid (ortholog); response to cadmium ion (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; glutathione metabolic pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Alzheimer's disease (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN nucleoplasm (inferred); INTERACTS WITH bisphenol A | 24 | 23973807 | 24000281 | Dog | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12511311 | Gss | glutathione synthetase | ENCODES a protein that exhibits ATP binding (ortholog); glutathione binding (ortholog); glutathione synthase activity (ortholog); INVOLVED IN glutathione biosynthetic process (ortholog); response to amino acid (ortholog); response to cadmium ion (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; glutathione metabolic pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Alzheimer's disease (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred) | NW_004936561 | 5765637 | 5793951 | Squirrel | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155259159 | gss | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18646253 | GSS | glutathione synthetase | ENCODES a protein that exhibits ATP binding (ortholog); glutathione binding (ortholog); glutathione synthase activity (ortholog); INVOLVED IN glutathione biosynthetic process (ortholog); response to amino acid (ortholog); response to cadmium ion (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; glutathione metabolic pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Alzheimer's disease (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cytosol (inferred); nucleoplasm (inferred) | | | | Green Monkey | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18927321 | Gss | glutathione synthetase | ENCODES a protein that exhibits ATP binding (ortholog); glutathione binding (ortholog); glutathione synthase activity (ortholog); INVOLVED IN glutathione biosynthetic process (ortholog); response to amino acid (ortholog); response to cadmium ion (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; glutathione metabolic pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Alzheimer's disease (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Naked Mole-Rat | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14049682 | GSS | glutathione synthetase | ENCODES a protein that exhibits ATP binding (ortholog); glutathione binding (ortholog); glutathione synthase activity (ortholog); INVOLVED IN glutathione biosynthetic process (ortholog); response to amino acid (ortholog); response to cadmium ion (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; glutathione metabolic pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Alzheimer's disease (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN nucleoplasm (inferred); INTERACTS WITH deoxynivalenol; ethanol; folic acid | | | | Pig | 66 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 626034934 | Gss | glutathione synthetase | ENCODES a protein that exhibits ATP binding (ortholog); glutathione binding (ortholog); glutathione synthase activity (ortholog); INVOLVED IN glutathione biosynthetic process (ortholog); response to amino acid (ortholog); response to cadmium ion (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; glutathione metabolic pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Alzheimer's disease (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Black Rat | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14377016 | gss-1 | | | | | | Roundworm | | symbol | gene, null |
| 155240916 | gss.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 737306 | PRNP | prion protein (Kanno blood group) | The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upst ream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] | 20 | 4686456 | 4701588 | Human | 777 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 12327359 | LOC492037 | X chromosome GSS clone AHTX40 | | | | | Dog | | name | gene, protein-coding |
| 12153861 | ALDH1A1 | aldehyde dehydrogenase 1 family member A1 | ENCODES a protein that exhibits 3-chloroallyl aldehyde dehydrogenase activity (ortholog); aldehyde dehydrogenase (NAD+) activity (ortholog); aminobutyraldehyde dehydrogenase (NAD+) activity (ortholog); INVOLVED IN 9-cis-retinoic acid biosynthetic process (ortholog); 9-cis-retinoic acid metabolic pro cess (ortholog); embryonic eye morphogenesis (ortholog); PARTICIPATES IN cyclophosphamide pharmacodynamics pathway; cyclophosphamide pharmacokinetics pathway; ifosfamide pharmacodynamics pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); Creutzfeldt-Jakob disease (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN axon (ortholog); synapse (ortholog) | 1 | 84940411 | 84994789 | Dog | 71 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 12176140 | CEACAM16 | CEA cell adhesion molecule 16, tectorial membrane component | ENCODES a protein that exhibits identical protein binding (inferred); INVOLVED IN sensory perception of sound (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 4A (ortholog); autosomal dominant nonsyndromic deafness 4B (ortholog); autosomal recessive nonsyndromic deafness 113 (ort holog); FOUND IN extracellular region (inferred); extracellular space (inferred); stereocilium tip (inferred) | 1 | 110652362 | 110661173 | Dog | 14 | old_gene_name | gene, protein-coding, INFERRED [RefSeq] |
| 14377014 | Gss1 | | | | | | Fly | | symbol | gene, null |
| 14377015 | Gss2 | | | | | | Fly | | symbol | gene, null |
| 1617658 | Gssos1 | glutathione synthase, opposite strand 1 | INTERACTS WITH 2,4-D; aldehydo-D-glucose; D-glucose | | | | Mouse | 9 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding |
| 13822715 | Gssos2 | glutathione synthase, opposite strand 2 | INTERACTS WITH aldehydo-D-glucose; cadmium atom; cadmium dichloride | 2 | 155409406 | 155436446 | Mouse | 6 | symbol , PhenoGen | gene, ncrna, MODEL [RefSeq] |
| 12397982 | GGT7 | gamma-glutamyltransferase 7 | ENCODES a protein that exhibits acyltransferase activity (inferred); ATP binding (inferred); glutathione binding (inferred); INVOLVED IN glutathione biosynthetic process (inferred); glutathione catabolic process (inferred); glutathione metabolic process (inferred); FOUND IN plasma membrane (ortholog ) | 24 | 23900842 | 23924555 | Dog | 36 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 732221 | GSR | glutathione-disulfide reductase | This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010] | 8 | 30678066 | 30727846 | Human | 1412 | description | gene, protein-coding, REVIEWED [RefSeq] |
