| 619848 | Gpr37 | G protein-coupled receptor 37 | ENCODES a protein that exhibits G protein-coupled peptide receptor activity (ortholog); heat shock protein binding (ortholog); Hsp70 protein binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); cellular response to reactive oxygen spec ies (ortholog); dendrite development (ortholog); PARTICIPATES IN Parkinson's disease pathway; ASSOCIATED WITH Lewy body dementia (ortholog); malignant mesothelioma (ortholog); Parkinson's disease (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; alpha-Zearalanol | 4 | 55104355 | 55126420 | Rat | 151 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 735262 | GPR37 | G protein-coupled receptor 37 | This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. Th is gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012] | 7 | 124743885 | 124765792 | Human | 141 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 735263 | Gpr37 | G protein-coupled receptor 37 | Enables PDZ domain binding activity. Involved in cellular response to reactive oxygen species; dendrite development; and positive regulation of MAPK cascade. Acts upstream of or within dopamine biosynthetic process; locomotion involved in locomotory behavior; and positive regulation of dopamine meta bolic process. Is active in cell surface and synapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Orthologous to human GPR37 (G protein-coupled receptor 37). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 25668522 | 25689979 | Mouse | 163 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8713505 | Gpr37 | G protein-coupled receptor 37 | ENCODES a protein that exhibits G protein-coupled peptide receptor activity (ortholog); heat shock protein binding (ortholog); Hsp70 protein binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); cellular response to reactive oxygen spec ies (ortholog); dendrite development (ortholog); ASSOCIATED WITH Lewy body dementia (ortholog); malignant mesothelioma (ortholog); Parkinson's disease (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog) | NW_004955479 | 6061424 | 6080129 | Chinchilla | 36 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11734511 | GPR37 | G protein-coupled receptor 37 | ENCODES a protein that exhibits G protein-coupled peptide receptor activity (inferred); G protein-coupled receptor activity (inferred); heat shock protein binding (inferred); INVOLVED IN dopamine biosynthetic process (ortholog); locomotion involved in locomotory behavior (ortholog); positive regulat ion of dopamine metabolic process (ortholog); ASSOCIATED WITH Lewy body dementia (ortholog); malignant mesothelioma (ortholog); Parkinson's disease (ortholog); FOUND IN cell projection (inferred); cell surface (inferred); cytoplasm (inferred) | 7 | 116727912 | 116751647 | Bonobo | 52 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12206007 | GPR37 | G protein-coupled receptor 37 | ENCODES a protein that exhibits G protein-coupled peptide receptor activity (inferred); G protein-coupled receptor activity (inferred); heat shock protein binding (inferred); INVOLVED IN dopamine biosynthetic process (ortholog); locomotion involved in locomotory behavior (ortholog); positive regulat ion of dopamine metabolic process (ortholog); ASSOCIATED WITH Lewy body dementia (ortholog); malignant mesothelioma (ortholog); Parkinson's disease (ortholog); FOUND IN cell projection (inferred); cell surface (inferred); cytoplasm (inferred) | 14 | 11113584 | 11137639 | Dog | 48 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12452549 | Gpr37 | G protein-coupled receptor 37 | ENCODES a protein that exhibits G protein-coupled peptide receptor activity (inferred); G protein-coupled receptor activity (inferred); heat shock protein binding (inferred); INVOLVED IN dopamine biosynthetic process (ortholog); locomotion involved in locomotory behavior (ortholog); positive regulat ion of dopamine metabolic process (ortholog); ASSOCIATED WITH Lewy body dementia (ortholog); malignant mesothelioma (ortholog); Parkinson's disease (ortholog); FOUND IN cell projection (inferred); cell surface (inferred); cytoplasm (inferred) | NW_004936605 | 978174 | 997093 | Squirrel | 49 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14140529 | GPR37 | G protein-coupled receptor 37 | ENCODES a protein that exhibits G protein-coupled peptide receptor activity (inferred); G protein-coupled receptor activity (inferred); heat shock protein binding (inferred); INVOLVED IN dopamine biosynthetic process (ortholog); locomotion involved in locomotory behavior (ortholog); positive regulat ion of dopamine metabolic process (ortholog); ASSOCIATED WITH Lewy body dementia (ortholog); malignant mesothelioma (ortholog); Parkinson's disease (ortholog); FOUND IN cell projection (inferred); cell surface (inferred); cytoplasm (inferred) | | | | Pig | 48 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18609265 | GPR37 | G protein-coupled receptor 37 | ENCODES a protein that exhibits G protein-coupled peptide receptor activity (inferred); G protein-coupled receptor activity (inferred); heat shock protein binding (inferred); INVOLVED IN dopamine biosynthetic process (ortholog); locomotion involved in locomotory behavior (ortholog); positive regulat ion of dopamine metabolic process (ortholog); ASSOCIATED WITH Lewy body dementia (ortholog); malignant mesothelioma (ortholog); Parkinson's disease (ortholog); FOUND IN cell projection (inferred); cell surface (inferred); cytoplasm (inferred) | | | | Green Monkey | 52 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18899827 | Gpr37 | G protein-coupled receptor 37 | ENCODES a protein that exhibits heat shock protein binding (ortholog); Hsp70 protein binding (ortholog); neuropeptide binding (ortholog); INVOLVED IN dopamine biosynthetic process (ortholog); locomotion involved in locomotory behavior (ortholog); neuropeptide signaling pathway (ortholog); ASSOCIATED WITH Lewy body dementia (ortholog); malignant mesothelioma (ortholog); Parkinson's disease (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog) | | | | Naked Mole-Rat | 46 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155230913 | gpr37 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625971325 | Gpr37 | G protein-coupled receptor 37 | ENCODES a protein that exhibits G protein-coupled peptide receptor activity (ortholog); heat shock protein binding (ortholog); Hsp70 protein binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); cellular response to reactive oxygen spec ies (ortholog); dendrite development (ortholog); ASSOCIATED WITH Lewy body dementia (ortholog); malignant mesothelioma (ortholog); Parkinson's disease (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog) | | | | Black Rat | 36 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155230914 | gpr37.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155248907 | gpr37.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 731318 | Gpr37l1 | G protein-coupled receptor 37-like 1 | Predicted to enable G protein-coupled peptide receptor activity; peptide binding activity; and prosaposin receptor activity. Involved in cellular response to reactive oxygen species; negative regulation of systemic arterial blood pressure; and positive regulation of MAPK cascade. Acts upstream of or within negative regulation of cell differentiation; negative regulation of smoothened signaling pathway; and positive regulation of cerebellar granule cell precursor proliferation. Located in plasma membrane. Is expressed in brain; dentate gyrus subgranular zone; spinal cord; spinal cord gray matter; and spinal cord white matter. Orthologous to human GPR37L1 (G protein-coupled receptor 37 like 1). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 135087988 | 135095419 | Mouse | 113 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 628835 | Gpr37l1 | G protein-coupled receptor 37-like 1 | ENCODES a protein that exhibits G protein-coupled peptide receptor activity (ortholog); G protein-coupled receptor activity (ortholog); peptide binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); cellular response to reactive oxygen s pecies (ortholog); negative regulation of astrocyte differentiation (ortholog); ASSOCIATED WITH albuminuria; salt-sensitive hypertension; ASSOCIATED WITH amenorrhea (ortholog); FOUND IN plasma membrane (ortholog); receptor complex (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; ammonium chloride | 13 | 49150355 | 49157204 | Rat | 102 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1606828 | GPR37L1 | G protein-coupled receptor 37 like 1 | Enables G protein-coupled peptide receptor activity; peptide binding activity; and prosaposin receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and positive regulation of MAPK cascade. Located in plasma membrane. Part of receptor complex. [provi ded by Alliance of Genome Resources, Jul 2025] | 1 | 202122917 | 202133592 | Human | 93 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 8729266 | Gpr37l1 | G protein-coupled receptor 37 like 1 | ENCODES a protein that exhibits G protein-coupled peptide receptor activity (ortholog); G protein-coupled receptor activity (ortholog); peptide binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); cellular response to reactive oxygen s pecies (ortholog); negative regulation of astrocyte differentiation (ortholog); ASSOCIATED WITH amenorrhea (ortholog); FOUND IN plasma membrane (ortholog); receptor complex (ortholog) | NW_004955406 | 38214490 | 38223281 | Chinchilla | 22 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11938268 | GPR37L1 | G protein-coupled receptor 37 like 1 | ENCODES a protein that exhibits prosaposin receptor activity (ortholog); INVOLVED IN negative regulation of astrocyte differentiation (ortholog); negative regulation of neuron differentiation (ortholog); negative regulation of smoothened signaling pathway (ortholog); ASSOCIATED WITH amenorrhea (orth olog); FOUND IN cell projection (inferred); membrane (inferred); plasma membrane (inferred) | 1 | 177720832 | 177731551 | Bonobo | 38 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12241487 | GPR37L1 | G protein-coupled receptor 37 like 1 | ENCODES a protein that exhibits prosaposin receptor activity (ortholog); INVOLVED IN negative regulation of astrocyte differentiation (ortholog); negative regulation of neuron differentiation (ortholog); negative regulation of smoothened signaling pathway (ortholog); ASSOCIATED WITH amenorrhea (orth olog); FOUND IN cell projection (inferred); membrane (inferred); plasma membrane (inferred) | 7 | 882672 | 887679 | Dog | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12676989 | Gpr37l1 | G protein-coupled receptor 37 like 1 | ENCODES a protein that exhibits prosaposin receptor activity (ortholog); INVOLVED IN negative regulation of astrocyte differentiation (ortholog); negative regulation of neuron differentiation (ortholog); negative regulation of smoothened signaling pathway (ortholog); ASSOCIATED WITH amenorrhea (orth olog); FOUND IN cell projection (inferred); membrane (inferred); plasma membrane (inferred) | NW_004936567 | 2408326 | 2414411 | Squirrel | 35 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14167375 | GPR37L1 | G protein-coupled receptor 37 like 1 | ENCODES a protein that exhibits prosaposin receptor activity (ortholog); INVOLVED IN negative regulation of astrocyte differentiation (ortholog); negative regulation of neuron differentiation (ortholog); negative regulation of smoothened signaling pathway (ortholog); ASSOCIATED WITH amenorrhea (orth olog); FOUND IN cell projection (inferred); membrane (inferred); plasma membrane (inferred) | | | | Pig | 34 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18583099 | GPR37L1 | G protein-coupled receptor 37 like 1 | ENCODES a protein that exhibits prosaposin receptor activity (ortholog); INVOLVED IN negative regulation of astrocyte differentiation (ortholog); negative regulation of neuron differentiation (ortholog); negative regulation of smoothened signaling pathway (ortholog); ASSOCIATED WITH amenorrhea (orth olog); FOUND IN cell projection (inferred); membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 38 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18911241 | Gpr37l1 | G protein-coupled receptor 37 like 1 | ENCODES a protein that exhibits peptide binding (ortholog); prosaposin receptor activity (ortholog); INVOLVED IN negative regulation of astrocyte differentiation (ortholog); negative regulation of neuron differentiation (ortholog); negative regulation of smoothened signaling pathway (ortholog); ASSO CIATED WITH amenorrhea (ortholog); FOUND IN cell projection (inferred); membrane (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 28 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155240589 | gpr37l1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625960350 | Gpr37l1 | G protein-coupled receptor 37 like 1 | ENCODES a protein that exhibits G protein-coupled peptide receptor activity (ortholog); G protein-coupled receptor activity (ortholog); peptide binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); cellular response to reactive oxygen s pecies (ortholog); negative regulation of astrocyte differentiation (ortholog); ASSOCIATED WITH amenorrhea (ortholog); FOUND IN plasma membrane (ortholog); receptor complex (ortholog) | | | | Black Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405858082 | gpr37l1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860000 | gpr37l1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860877 | gpr37l1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865523 | gpr37l1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626469685 | gpr37l1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155235840 | gpr37l1.S | | | | | | African Clawed Frog | | symbol | gene, null |