GPR37L1 (G protein-coupled receptor 37 like 1) - Rat Genome Database

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Gene: GPR37L1 (G protein-coupled receptor 37 like 1) Homo sapiens
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Symbol: GPR37L1
Name: G protein-coupled receptor 37 like 1
RGD ID: 1606828
HGNC Page HGNC:14923
Description: Enables G protein-coupled peptide receptor activity; peptide binding activity; and prosaposin receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and positive regulation of MAPK cascade. Located in plasma membrane. Part of receptor complex.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: endothelin B receptor-like protein 2; endothelin type b receptor-like protein 2; ET(B)R-LP-2; ETBR-LP-2; ETBRLP2; G-protein coupled receptor 37 like 1; G-protein coupled receptor 37-like 1; prosaposin receptor GPR37L1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381202,122,917 - 202,133,592 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1202,122,886 - 202,133,592 (+)EnsemblGRCh38hg38GRCh38
GRCh371202,092,045 - 202,102,720 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361200,358,652 - 200,365,257 (+)NCBINCBI36Build 36hg18NCBI36
Celera1175,215,891 - 175,222,492 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1173,257,557 - 173,264,172 (+)NCBIHuRef
CHM1_11203,514,323 - 203,520,925 (+)NCBICHM1_1
T2T-CHM13v2.01201,376,262 - 201,391,163 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell projection  (IEA)
ciliary membrane  (IEA)
membrane  (IEA,NAS)
plasma membrane  (IBA,IDA,IEA,TAS)
receptor complex  (IBA,IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8125298   PMID:9539149   PMID:12477932   PMID:15489334   PMID:20237496   PMID:20360844   PMID:20517885   PMID:21873635   PMID:23382219   PMID:23690594   PMID:24749734   PMID:27072655  
PMID:28688853   PMID:30021884   PMID:30423289   PMID:32296183   PMID:32357304   PMID:33203955   PMID:33649602   PMID:34100078   PMID:34533400   PMID:35914814   PMID:36430934   PMID:36949045  
PMID:38530364   PMID:38569927  


Genomics

Comparative Map Data
GPR37L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381202,122,917 - 202,133,592 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1202,122,886 - 202,133,592 (+)EnsemblGRCh38hg38GRCh38
GRCh371202,092,045 - 202,102,720 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361200,358,652 - 200,365,257 (+)NCBINCBI36Build 36hg18NCBI36
Celera1175,215,891 - 175,222,492 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1173,257,557 - 173,264,172 (+)NCBIHuRef
CHM1_11203,514,323 - 203,520,925 (+)NCBICHM1_1
T2T-CHM13v2.01201,376,262 - 201,391,163 (+)NCBIT2T-CHM13v2.0
Gpr37l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,087,988 - 135,095,419 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,087,972 - 135,095,419 (-)EnsemblGRCm39 Ensembl
GRCm381135,160,250 - 135,167,681 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,160,234 - 135,167,681 (-)EnsemblGRCm38mm10GRCm38
MGSCv371137,056,827 - 137,064,258 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361136,976,661 - 136,983,835 (-)NCBIMGSCv36mm8
Celera1137,787,013 - 137,794,466 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.25NCBI
Gpr37l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81349,150,355 - 49,157,204 (-)NCBIGRCr8
mRatBN7.21346,598,574 - 46,605,421 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1346,598,578 - 46,605,421 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1349,205,278 - 49,212,462 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01350,493,346 - 50,500,533 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01347,759,407 - 47,766,588 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01351,985,698 - 51,992,547 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1351,985,684 - 51,992,693 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01357,037,408 - 57,044,257 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41348,121,001 - 48,127,850 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11348,135,043 - 48,141,951 (-)NCBI
Celera1346,923,830 - 46,930,679 (-)NCBICelera
Cytogenetic Map13q13NCBI
Gpr37l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540638,214,423 - 38,223,281 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540638,214,490 - 38,223,281 (+)NCBIChiLan1.0ChiLan1.0
GPR37L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2147,252,311 - 47,258,956 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1147,216,988 - 47,223,643 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01177,720,832 - 177,731,551 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11182,022,600 - 182,028,623 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1182,022,600 - 182,028,623 (+)Ensemblpanpan1.1panPan2
GPR37L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.17882,672 - 887,679 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl7883,279 - 887,811 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha7934,690 - 939,694 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.07890,517 - 895,524 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl7888,710 - 895,660 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.17878,740 - 883,744 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.07986,968 - 991,972 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.071,010,981 - 1,015,985 (-)NCBIUU_Cfam_GSD_1.0
Gpr37l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934473,173,650 - 73,179,749 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365672,407,339 - 2,414,437 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365672,408,326 - 2,414,411 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR37L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1024,307,058 - 24,315,103 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11024,306,731 - 24,315,093 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21028,707,707 - 28,712,746 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPR37L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12527,276,393 - 27,283,231 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2527,277,360 - 27,283,350 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605528,054,557 - 28,063,314 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr37l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248078,605,488 - 8,611,669 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248078,605,488 - 8,611,760 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GPR37L1
37 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q31.1-42.11(chr1:187143981-224299417)x3 copy number gain See cases [RCV000051857] Chr1:187143981..224299417 [GRCh38]
Chr1:187113113..224487119 [GRCh37]
Chr1:185379736..222553742 [NCBI36]
Chr1:1q31.1-42.11		 pathogenic
NM_004767.3(GPR37L1):c.71G>A (p.Gly24Glu) single nucleotide variant Malignant melanoma [RCV000064457] Chr1:202123034 [GRCh38]
Chr1:202092162 [GRCh37]
Chr1:200358785 [NCBI36]
Chr1:1q32.1		 not provided
GRCh38/hg38 1q32.1(chr1:200144603-203112078)x1 copy number loss See cases [RCV000133625] Chr1:200144603..203112078 [GRCh38]
Chr1:200113731..203081206 [GRCh37]
Chr1:198380354..201347829 [NCBI36]
Chr1:1q32.1		 pathogenic
GRCh37/hg19 1q31.3-42.13(chr1:197811907-228997888)x3 copy number gain See cases [RCV000240137] Chr1:197811907..228997888 [GRCh37]
Chr1:1q31.3-42.13		 pathogenic
GRCh37/hg19 1q31.3-44(chr1:195483439-249213000)x3 copy number gain See cases [RCV000449172] Chr1:195483439..249213000 [GRCh37]
Chr1:1q31.3-44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NM_004767.5(GPR37L1):c.1047G>T (p.Lys349Asn) single nucleotide variant not provided [RCV000625728] Chr1:202128157 [GRCh38]
Chr1:202097285 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.1418C>T (p.Pro473Leu) single nucleotide variant not specified [RCV004318322] Chr1:202128528 [GRCh38]
Chr1:202097656 [GRCh37]
Chr1:1q32.1		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NC_000001.11:g.202057882_202124606dup duplication Primary amenorrhea [RCV000754398] Chr1:202057882..202124606 [GRCh38]
Chr1:202027010..202093734 [GRCh37]
Chr1:1q32.1		 likely benign
GRCh37/hg19 1q25.3-41(chr1:185644663-221698833)x3 copy number gain not provided [RCV000749265] Chr1:185644663..221698833 [GRCh37]
Chr1:1q25.3-41		 pathogenic
NM_004767.5(GPR37L1):c.1039G>T (p.Ala347Ser) single nucleotide variant not specified [RCV004293430] Chr1:202128149 [GRCh38]
Chr1:202097277 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.1205A>G (p.Gln402Arg) single nucleotide variant not specified [RCV004313184] Chr1:202128315 [GRCh38]
Chr1:202097443 [GRCh37]
Chr1:1q32.1		 uncertain significance
GRCh37/hg19 1q25.3-44(chr1:182388773-249111240)x3 copy number gain not provided [RCV000845852] Chr1:182388773..249111240 [GRCh37]
Chr1:1q25.3-44		 pathogenic
NM_004767.5(GPR37L1):c.614C>T (p.Ala205Val) single nucleotide variant not specified [RCV004287742] Chr1:202123577 [GRCh38]
Chr1:202092705 [GRCh37]
Chr1:1q32.1		 uncertain significance
GRCh37/hg19 1q31.3-32.2(chr1:194356425-210988710)x3 copy number gain not provided [RCV001249273] Chr1:194356425..210988710 [GRCh37]
Chr1:1q31.3-32.2		 not provided
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44		 uncertain significance
NC_000001.10:g.(?_200522516)_(206945780_?)dup duplication Epilepsy, familial adult myoclonic, 5 [RCV003116306] Chr1:200522516..206945780 [GRCh37]
Chr1:1q32.1		 uncertain significance
NC_000001.10:g.(?_200522516)_(208391267_?)dup duplication Hypokalemic periodic paralysis, type 1 [RCV003119239]|not provided [RCV003119240] Chr1:200522516..208391267 [GRCh37]
Chr1:1q32.1-32.2		 uncertain significance|no classifications from unflagged records
GRCh37/hg19 1q31.3-44(chr1:197867914-249224684)x3 copy number gain See cases [RCV002287837] Chr1:197867914..249224684 [GRCh37]
Chr1:1q31.3-44		 pathogenic
NM_004767.5(GPR37L1):c.325G>A (p.Ala109Thr) single nucleotide variant not specified [RCV004084009] Chr1:202123288 [GRCh38]
Chr1:202092416 [GRCh37]
Chr1:1q32.1		 likely benign
GRCh37/hg19 1q25.3-32.3(chr1:181453460-213107248)x3 copy number gain not provided [RCV002475637] Chr1:181453460..213107248 [GRCh37]
Chr1:1q25.3-32.3		 pathogenic
NM_004767.5(GPR37L1):c.1347T>A (p.Asn449Lys) single nucleotide variant not specified [RCV004208567] Chr1:202128457 [GRCh38]
Chr1:202097585 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.1081G>A (p.Val361Met) single nucleotide variant not specified [RCV004182352] Chr1:202128191 [GRCh38]
Chr1:202097319 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.1328C>T (p.Ser443Leu) single nucleotide variant not specified [RCV004178430] Chr1:202128438 [GRCh38]
Chr1:202097566 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.1240G>T (p.Val414Leu) single nucleotide variant not specified [RCV004196263] Chr1:202128350 [GRCh38]
Chr1:202097478 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.1327T>C (p.Ser443Pro) single nucleotide variant not specified [RCV004218147] Chr1:202128437 [GRCh38]
Chr1:202097565 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.976G>A (p.Val326Ile) single nucleotide variant not specified [RCV004143806] Chr1:202128086 [GRCh38]
Chr1:202097214 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.365C>G (p.Pro122Arg) single nucleotide variant not specified [RCV004136202] Chr1:202123328 [GRCh38]
Chr1:202092456 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.1339G>A (p.Ala447Thr) single nucleotide variant not specified [RCV004206353] Chr1:202128449 [GRCh38]
Chr1:202097577 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.886G>A (p.Glu296Lys) single nucleotide variant not specified [RCV004235039] Chr1:202127996 [GRCh38]
Chr1:202097124 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.444C>A (p.Asn148Lys) single nucleotide variant not specified [RCV004191196] Chr1:202123407 [GRCh38]
Chr1:202092535 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.1178C>T (p.Thr393Ile) single nucleotide variant not specified [RCV004221469] Chr1:202128288 [GRCh38]
Chr1:202097416 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.879C>A (p.Ser293Arg) single nucleotide variant not specified [RCV004075258] Chr1:202127989 [GRCh38]
Chr1:202097117 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.1169C>T (p.Thr390Ile) single nucleotide variant not specified [RCV004266672] Chr1:202128279 [GRCh38]
Chr1:202097407 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.63G>C (p.Arg21Ser) single nucleotide variant not specified [RCV004257447] Chr1:202123026 [GRCh38]
Chr1:202092154 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.205C>T (p.Arg69Trp) single nucleotide variant not specified [RCV004275692] Chr1:202123168 [GRCh38]
Chr1:202092296 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.166G>A (p.Val56Met) single nucleotide variant not specified [RCV004252562] Chr1:202123129 [GRCh38]
Chr1:202092257 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.932G>T (p.Trp311Leu) single nucleotide variant not specified [RCV004316963] Chr1:202128042 [GRCh38]
Chr1:202097170 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.745C>G (p.Leu249Val) single nucleotide variant not specified [RCV004338022] Chr1:202127855 [GRCh38]
Chr1:202096983 [GRCh37]
Chr1:1q32.1		 uncertain significance
GRCh37/hg19 1q32.1(chr1:199373229-204335027)x3 copy number gain not specified [RCV003986684] Chr1:199373229..204335027 [GRCh37]
Chr1:1q32.1		 likely pathogenic
GRCh37/hg19 1q31.3-32.1(chr1:197216705-203683110)x1 copy number loss not specified [RCV003986384] Chr1:197216705..203683110 [GRCh37]
Chr1:1q31.3-32.1		 likely pathogenic
NM_004767.5(GPR37L1):c.1420C>T (p.Leu474Phe) single nucleotide variant not specified [RCV004391093] Chr1:202128530 [GRCh38]
Chr1:202097658 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.748G>A (p.Ala250Thr) single nucleotide variant not specified [RCV004391097] Chr1:202127858 [GRCh38]
Chr1:202096986 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.1141G>A (p.Val381Met) single nucleotide variant not specified [RCV004391089] Chr1:202128251 [GRCh38]
Chr1:202097379 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.1129G>A (p.Val377Ile) single nucleotide variant not specified [RCV004391088] Chr1:202128239 [GRCh38]
Chr1:202097367 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.1352C>T (p.Ser451Leu) single nucleotide variant not specified [RCV004391092] Chr1:202128462 [GRCh38]
Chr1:202097590 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.1346A>G (p.Asn449Ser) single nucleotide variant not specified [RCV004391091] Chr1:202128456 [GRCh38]
Chr1:202097584 [GRCh37]
Chr1:1q32.1		 likely benign
NM_004767.5(GPR37L1):c.165C>T (p.Gly55=) single nucleotide variant not specified [RCV004391094] Chr1:202123128 [GRCh38]
Chr1:202092256 [GRCh37]
Chr1:1q32.1		 likely benign
NM_004767.5(GPR37L1):c.583C>G (p.Gln195Glu) single nucleotide variant not specified [RCV004391096] Chr1:202123546 [GRCh38]
Chr1:202092674 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.1162G>A (p.Glu388Lys) single nucleotide variant not specified [RCV004391090] Chr1:202128272 [GRCh38]
Chr1:202097400 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.181C>T (p.Pro61Ser) single nucleotide variant not specified [RCV004391095] Chr1:202123144 [GRCh38]
Chr1:202092272 [GRCh37]
Chr1:1q32.1		 uncertain significance
NC_000001.10:g.(?_190829412)_(216061974_?)del deletion not provided [RCV004579260] Chr1:190829412..216061974 [GRCh37]
Chr1:1q31.2-41		 pathogenic
NM_004767.5(GPR37L1):c.202C>T (p.Pro68Ser) single nucleotide variant not specified [RCV004632501] Chr1:202123165 [GRCh38]
Chr1:202092293 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.829G>A (p.Ala277Thr) single nucleotide variant not specified [RCV004632502] Chr1:202127939 [GRCh38]
Chr1:202097067 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.977T>G (p.Val326Gly) single nucleotide variant not specified [RCV004632504] Chr1:202128087 [GRCh38]
Chr1:202097215 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_004767.5(GPR37L1):c.601G>A (p.Val201Ile) single nucleotide variant not specified [RCV004623995] Chr1:202123564 [GRCh38]
Chr1:202092692 [GRCh37]
Chr1:1q32.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2824
Count of miRNA genes:979
Interacting mature miRNAs:1171
Transcripts:ENST00000367282
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406988487GWAS637463_Hdiverticular disease QTL GWAS637463 (human)0.000007diverticular disease1202124558202124559Human
406959931GWAS608907_Htyrosine-protein phosphatase non-receptor type 7 measurement QTL GWAS608907 (human)9e-13tyrosine-protein phosphatase non-receptor type 7 measurement1202128181202128182Human

Markers in Region
RH103692  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371202,098,461 - 202,098,593UniSTSGRCh37
Build 361200,365,084 - 200,365,216RGDNCBI36
Celera1175,222,319 - 175,222,451RGD
Cytogenetic Map1q32.1UniSTS
HuRef1173,263,999 - 173,264,131UniSTS
GeneMap99-GB4 RH Map1666.51UniSTS
GPR37L1_8922  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371202,097,174 - 202,098,036UniSTSGRCh37
Build 361200,363,797 - 200,364,659RGDNCBI36
Celera1175,221,033 - 175,221,895RGD
HuRef1173,262,713 - 173,263,575UniSTS
SHGC-146622  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1q32.1UniSTS
HuRef1173,256,479 - 173,256,761UniSTS
TNG Radiation Hybrid Map143751.0UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1174 2426 2752 2200 4934 1646 2257 4 550 1601 392 2219 6743 6040 48 3726 786 1718 1595 173 1

Sequence


Ensembl Acc Id: ENST00000367282   ⟹   ENSP00000356251
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,122,917 - 202,133,592 (+)Ensembl
Ensembl Acc Id: ENST00000682422
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,126,559 - 202,128,963 (+)Ensembl
Ensembl Acc Id: ENST00000682545   ⟹   ENSP00000508402
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,122,915 - 202,128,556 (+)Ensembl
Ensembl Acc Id: ENST00000682887   ⟹   ENSP00000506946
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,122,964 - 202,128,880 (+)Ensembl
Ensembl Acc Id: ENST00000683302   ⟹   ENSP00000507885
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,122,886 - 202,128,598 (+)Ensembl
Ensembl Acc Id: ENST00000683457
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,127,027 - 202,128,168 (+)Ensembl
Ensembl Acc Id: ENST00000683557   ⟹   ENSP00000508029
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,122,889 - 202,129,018 (+)Ensembl
RefSeq Acc Id: NM_004767   ⟹   NP_004758
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,122,917 - 202,133,592 (+)NCBI
GRCh371202,092,029 - 202,098,634 (+)RGD
Build 361200,358,652 - 200,365,257 (+)NCBI Archive
Celera1175,215,891 - 175,222,492 (+)RGD
HuRef1173,257,557 - 173,264,172 (+)ENTREZGENE
CHM1_11203,514,323 - 203,520,925 (+)NCBI
T2T-CHM13v2.01201,380,483 - 201,391,163 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054339633   ⟹   XP_054195608
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01201,376,262 - 201,391,163 (+)NCBI
RefSeq Acc Id: NP_004758   ⟸   NM_004767
- Peptide Label: precursor
- UniProtKB: Q86VP7 (UniProtKB/Swiss-Prot),   Q5SXP7 (UniProtKB/Swiss-Prot),   O60883 (UniProtKB/Swiss-Prot),   B2R7M9 (UniProtKB/Swiss-Prot),   A0A804HKD8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000356251   ⟸   ENST00000367282
Ensembl Acc Id: ENSP00000508029   ⟸   ENST00000683557
Ensembl Acc Id: ENSP00000507885   ⟸   ENST00000683302
Ensembl Acc Id: ENSP00000506946   ⟸   ENST00000682887
Ensembl Acc Id: ENSP00000508402   ⟸   ENST00000682545
RefSeq Acc Id: XP_054195608   ⟸   XM_054339633
- Peptide Label: isoform X1
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O60883-F1-model_v2 AlphaFold O60883 1-481 view protein structure

Promoters
RGD ID:6858570
Promoter ID:EPDNEW_H2450
Type:initiation region
Name:GPR37L1_3
Description:G protein-coupled receptor 37 like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2449  EPDNEW_H2451  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,118,796 - 202,118,856EPDNEW
RGD ID:6858572
Promoter ID:EPDNEW_H2451
Type:initiation region
Name:GPR37L1_1
Description:G protein-coupled receptor 37 like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2449  EPDNEW_H2450  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,122,917 - 202,122,977EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:14923 AgrOrtholog
COSMIC GPR37L1 COSMIC
Ensembl Genes ENSG00000170075 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000367282 ENTREZGENE
  ENST00000367282.6 UniProtKB/Swiss-Prot
  ENST00000682545.1 UniProtKB/TrEMBL
  ENST00000682887.1 UniProtKB/TrEMBL
  ENST00000683302.1 UniProtKB/TrEMBL
  ENST00000683557.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000170075 GTEx
HGNC ID HGNC:14923 ENTREZGENE
Human Proteome Map GPR37L1 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPR37_orph UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:9283 UniProtKB/Swiss-Prot
NCBI Gene GPR37L1 ENTREZGENE
OMIM 617630 OMIM
PANTHER G-PROTEIN COUPLED RECEPTOR 37-LIKE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46216 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28883 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPR37ORPHANR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A804HI82_HUMAN UniProtKB/TrEMBL
  A0A804HKD8 ENTREZGENE, UniProtKB/TrEMBL
  A0A804HKQ6_HUMAN UniProtKB/TrEMBL
  A0A804HLL0_HUMAN UniProtKB/TrEMBL
  B2R7M9 ENTREZGENE
  G37L1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q5SXP7 ENTREZGENE
  Q86VP7 ENTREZGENE
UniProt Secondary B2R7M9 UniProtKB/Swiss-Prot
  Q5SXP7 UniProtKB/Swiss-Prot
  Q86VP7 UniProtKB/Swiss-Prot