GPR37L1 (G protein-coupled receptor 37 like 1) - Rat Genome Database

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Gene: GPR37L1 (G protein-coupled receptor 37 like 1) Homo sapiens
Analyze
Symbol: GPR37L1
Name: G protein-coupled receptor 37 like 1
RGD ID: 1606828
HGNC Page HGNC:14923
Description: Enables G protein-coupled peptide receptor activity; peptide binding activity; and prosaposin receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and positive regulation of MAPK cascade. Located in plasma membrane. Part of receptor complex.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: endothelin B receptor-like protein 2; endothelin type b receptor-like protein 2; ET(B)R-LP-2; ETBR-LP-2; ETBRLP2; G-protein coupled receptor 37 like 1; G-protein coupled receptor 37-like 1; prosaposin receptor GPR37L1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381202,122,917 - 202,133,592 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1202,122,886 - 202,133,592 (+)EnsemblGRCh38hg38GRCh38
GRCh371202,092,045 - 202,102,720 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361200,358,652 - 200,365,257 (+)NCBINCBI36Build 36hg18NCBI36
Celera1175,215,891 - 175,222,492 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1173,257,557 - 173,264,172 (+)NCBIHuRef
CHM1_11203,514,323 - 203,520,925 (+)NCBICHM1_1
T2T-CHM13v2.01201,376,262 - 201,391,163 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GPR37L1Humanamenorrhea  IAGPRGD:143524808554872ClinVar Annotator: match by term: Primary amenorrheaClinVarPMID:21681106
GPR37L1Humanfamilial adult myoclonic epilepsy 5  IAGPRGD:1564453658554872ClinVar Annotator: match by term: Epilepsy, familial adult myoclonic, 5ClinVarPMID:28492532
GPR37L1Humangastrointestinal stromal tumor  IAGPRGD:1267343158554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
GPR37L1HumanHypokalemic Periodic Paralysis, Type 1  IAGPRGD:1564476988554872ClinVar Annotator: match by term: Hypokalemic periodic paralysis, type 1ClinVarPMID:28492532
GPR37L1Humanparathyroid carcinoma  IAGPRGD:1267343158554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532

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Object Symbol
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Original Reference(s)
GPR37L1Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:7313186480464Tetrachlorodibenzodioxin affects the expression of GPR37L1 mRNACTDPMID:21570461
GPR37L1Human6-propyl-2-thiouracil decreases expressionISORGD:6288356480464Propylthiouracil results in decreased expression of GPR37L1 mRNACTDPMID:24780913|PMID:25825206
GPR37L1Humanacrylamide affects methylationISORGD:7313186480464Acrylamide affects the methylation of GPR37L1 geneCTDPMID:35032568
GPR37L1HumanAflatoxin B2 alpha decreases methylationEXP 6480464aflatoxin B2 results in decreased methylation of GPR37L1 3' UTRCTDPMID:30157460
GPR37L1Humanamitrole decreases expressionISORGD:6288356480464Amitrole results in decreased expression of GPR37L1 mRNACTDPMID:38685447
GPR37L1Humanammonium chloride affects expressionISORGD:6288356480464Ammonium Chloride affects the expression of GPR37L1 mRNACTDPMID:16483693
GPR37L1HumanAzoxymethane multiple interactionsISORGD:7313186480464[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of GPR37L1 more ...CTDPMID:29950665
GPR37L1Humanbenzo[a]pyrene decreases expressionISORGD:7313186480464Benzo(a)pyrene results in decreased expression of GPR37L1 mRNACTDPMID:22228805
GPR37L1Humanbenzo[a]pyrene affects methylationEXP 6480464Benzo(a)pyrene affects the methylation of GPR37L1 exon; Benzo(a)pyrene affects the methylation of GPR37L1 promoterCTDPMID:27901495|PMID:30157460
GPR37L1Humanbisphenol A decreases expressionISORGD:6288356480464bisphenol A results in decreased expression of GPR37L1 mRNACTDPMID:25181051|PMID:30816183|PMID:32528016
GPR37L1Humanbisphenol A decreases expressionISORGD:7313186480464bisphenol A results in decreased expression of GPR37L1 mRNACTDPMID:32156529
GPR37L1Humanbutanal increases expressionEXP 6480464butyraldehyde results in increased expression of GPR37L1 mRNACTDPMID:26079696
GPR37L1Humancalcitriol increases expressionEXP 6480464Calcitriol results in increased expression of GPR37L1 mRNACTDPMID:21592394
GPR37L1Humancalcitriol multiple interactionsEXP 6480464[Testosterone co-treated with Calcitriol] results in increased expression of GPR37L1 mRNACTDPMID:21592394
GPR37L1Humandextran sulfate multiple interactionsISORGD:7313186480464[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of GPR37L1 more ...CTDPMID:29950665
GPR37L1Humanethanol increases expressionISORGD:7313186480464Ethanol results in increased expression of GPR37L1 mRNACTDPMID:30319688
GPR37L1Humanfolic acid decreases expressionEXP 6480464Folic Acid results in decreased expression of GPR37L1 proteinCTDPMID:21867686
GPR37L1Humanfuran increases expressionISORGD:6288356480464furan results in increased expression of GPR37L1 mRNACTDPMID:27387713
GPR37L1Humangentamycin decreases expressionISORGD:6288356480464Gentamicins results in decreased expression of GPR37L1 mRNACTDPMID:33387578
GPR37L1Humanketamine increases expressionISORGD:6288356480464Ketamine results in increased expression of GPR37L1 mRNACTDPMID:20080153

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Biological Process
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Source
Original Reference(s)
GPR37L1Humanadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway involved_inIBAPANTHER:PTN002517510|UniProtKB:O15354|UniProtKB:O60883150520179 GO_CentralGO_REF:0000033
GPR37L1Humanadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway involved_inIDA 150520179 PMID:23690594ParkinsonsUK-UCLPMID:23690594
GPR37L1HumanBergmann glial cell differentiation acts_upstream_ofIEAUniProtKB:Q99JG2|ensembl:ENSMUSP00000027682150520179 EnsemblGO_REF:0000107
GPR37L1Humancellular response to reactive oxygen species involved_inIEAUniProtKB:Q99JG2|ensembl:ENSMUSP00000027682150520179 EnsemblGO_REF:0000107
GPR37L1Humancellular response to reactive oxygen species involved_inISSUniProtKB:Q99JG2150520179 PMID:23690594ParkinsonsUK-UCLPMID:23690594
GPR37L1HumanG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276|InterPro:IPR003909150520179 InterProGO_REF:0000002
GPR37L1HumanG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-0297150520179 UniProtGO_REF:0000043
GPR37L1Humannegative regulation of astrocyte differentiation acts_upstream_of_or_withinIEAUniProtKB:Q99JG2|ensembl:ENSMUSP00000027682150520179 EnsemblGO_REF:0000107
GPR37L1Humannegative regulation of neuron differentiation acts_upstream_of_or_withinIEAUniProtKB:Q99JG2|ensembl:ENSMUSP00000027682150520179 EnsemblGO_REF:0000107
GPR37L1Humannegative regulation of smoothened signaling pathway acts_upstream_of_or_withinIEAUniProtKB:Q99JG2|ensembl:ENSMUSP00000027682150520179 EnsemblGO_REF:0000107
GPR37L1Humannegative regulation of systemic arterial blood pressure involved_inISSUniProtKB:Q99JG2150520179 UniProtGO_REF:0000024
GPR37L1Humannegative regulation of systemic arterial blood pressure involved_inIEAUniProtKB:Q99JG2|ensembl:ENSMUSP00000027682150520179 EnsemblGO_REF:0000107
GPR37L1Humanpositive regulation of cerebellar granule cell precursor proliferation acts_upstream_of_or_withinIEAUniProtKB:Q99JG2|ensembl:ENSMUSP00000027682150520179 EnsemblGO_REF:0000107
GPR37L1Humanpositive regulation of MAPK cascade involved_inIEAUniProtKB:Q99JG2|ensembl:ENSMUSP00000027682150520179 EnsemblGO_REF:0000107
GPR37L1Humanpositive regulation of MAPK cascade involved_inIBAMGI:1313297|MGI:1928503|PANTHER:PTN002517510|UniProtKB:O15354|UniProtKB:O60883150520179 GO_CentralGO_REF:0000033
GPR37L1Humanpositive regulation of MAPK cascade involved_inIDA 150520179 PMID:23690594ParkinsonsUK-UCLPMID:23690594
GPR37L1Humansignal transduction involved_inIEAUniProtKB-KW:KW-0807150520179 UniProtGO_REF:0000043
GPR37L1Humansmoothened signaling pathway acts_upstream_ofIEAUniProtKB:Q99JG2|ensembl:ENSMUSP00000027682150520179 EnsemblGO_REF:0000107
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Cellular Component
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Object Symbol
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Reference
Notes
Source
Original Reference(s)
GPR37L1Humancell projection located_inIEAUniProtKB-KW:KW-0966150520179 UniProtGO_REF:0000043
GPR37L1Humancell projection located_inIEAUniProtKB-SubCell:SL-0280150520179 UniProtGO_REF:0000044
GPR37L1Humanciliary membrane located_inIEAUniProtKB-SubCell:SL-0305150520179 UniProtGO_REF:0000044
GPR37L1Humanmembrane located_inIEAInterPro:IPR000276|InterPro:IPR003909|InterPro:IPR017452150520179 InterProGO_REF:0000002
GPR37L1Humanmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
GPR37L1Humanmembrane located_inNAS 150520179 PMID:9539149UniProtPMID:9539149
GPR37L1Humanplasma membrane located_inIDA 150520179 PMID:28688853UniProtPMID:28688853
GPR37L1Humanplasma membrane is_active_inIBAMGI:1928503|PANTHER:PTN002517510|UniProtKB:O15354|UniProtKB:O60883150520179 GO_CentralGO_REF:0000033
GPR37L1Humanplasma membrane located_inIEAUniProtKB-SubCell:SL-0039150520179 UniProtGO_REF:0000044
GPR37L1Humanplasma membrane located_inTAS 150520179 ReactomeReactome:R-HSA-380073|Reactome:R-HSA-5336184|Reactome:R-HSA-749454|Reactome:R-HSA-749456
GPR37L1Humanplasma membrane located_inIEAUniProtKB:Q99JG2|ensembl:ENSMUSP00000027682150520179 EnsemblGO_REF:0000107
GPR37L1Humanplasma membrane located_inIEAUniProtKB-KW:KW-1003150520179 UniProtGO_REF:0000043
GPR37L1Humanreceptor complex part_ofIDA 150520179 PMID:23382219MGIPMID:23382219
GPR37L1Humanreceptor complex part_ofIBAPANTHER:PTN002517510|UniProtKB:O15354|UniProtKB:O60883150520179 GO_CentralGO_REF:0000033
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Molecular Function
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Object Symbol
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Reference
Notes
Source
Original Reference(s)
GPR37L1HumanG protein-coupled peptide receptor activity enablesIBAPANTHER:PTN002517510|UniProtKB:O15354|UniProtKB:O60883150520179 GO_CentralGO_REF:0000033
GPR37L1HumanG protein-coupled peptide receptor activity enablesIDA 150520179 PMID:23690594ParkinsonsUK-UCLPMID:23690594
GPR37L1HumanG protein-coupled receptor activity enablesIEAInterPro:IPR000276150520179 InterProGO_REF:0000002
GPR37L1HumanG protein-coupled receptor activity enablesIDA 150520179 PMID:27072655UniProtPMID:27072655
GPR37L1HumanG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-0297150520179 UniProtGO_REF:0000043
GPR37L1Humanpeptide binding enablesIPIUniProtKB:Q61207150520179 PMID:23690594ParkinsonsUK-UCLPMID:23690594
GPR37L1Humanprosaposin receptor activity enablesIDA 150520179 PMID:23690594ParkinsonsUK-UCLPMID:23690594
GPR37L1Humanprosaposin receptor activity NOT|enablesIDA 150520179 PMID:27072655, PMID:28688853UniProtPMID:27072655|PMID:28688853
GPR37L1Humanprotein binding enablesIPIUniProtKB:A0A087WZY1|UniProtKB:O14798|UniProtKB:O15529|UniProtKB:O15552|UniProtKB:O60242|UniProtKB:O75841|UniProtKB:O95471|UniProtKB:O95859|UniProtKB:P15529-3|UniProtKB:P24593|UniProtKB:P26678|UniProtKB:P27105|UniProtKB:P29972|UniProtKB:P48230|UniProtKB:Q14108|UniProtKB:Q14162|UniProtKB:Q14802-3|UniProtKB:Q3SXY8|UniProtKB:Q4KMG9|UniProtKB:Q5BJF2|UniProtKB:Q5JX71|UniProtKB:Q6UVW9|UniProtKB:Q8IWU4|UniProtKB:Q8N2M4|UniProtKB:Q8N5K1|UniProtKB:Q8N5M9|UniProtKB:Q8N661|UniProtKB:Q8NBI2|UniProtKB:Q8NHS1|UniProtKB:Q8TAF8|UniProtKB:Q8TBG9|UniProtKB:Q8TDT2|UniProtKB:Q8TED1|UniProtKB:Q8WY91|UniProtKB:Q969K7|UniProtKB:Q96BA8|UniProtKB:Q96HE8|UniProtKB:Q96IW7|UniProtKB:Q96PS8|UniProtKB:Q9BQ51|UniProtKB:Q9BU79|UniProtKB:Q9BVK8|UniProtKB:Q9C0I4|UniProtKB:Q9GZR5|UniProtKB:Q9H1C4|UniProtKB:Q9H9V4|UniProtKB:Q9NS64|UniProtKB:Q9NWD8|UniProtKB:Q9UKR5|UniProtKB:Q9Y5U4|UniProtKB:Q9Y6X1150520179 PMID:32296183IntActPMID:32296183
GPR37L1Humanprotein binding enablesIPIUniProtKB:Q9EP80150520179 PMID:24749734ParkinsonsUK-UCLPMID:24749734
GPR37L1Humanprotein binding enablesIPIUniProtKB:P42785150520179 PMID:20517885IntActPMID:20517885
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Object Symbol
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Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
GPR37L1HumanGastrointestinal stroma tumor  IAGPRGD:1267343158554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
GPR37L1HumanParathyroid carcinoma  IAGPRGD:1267343158554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
GPR37L1HumanPrimary amenorrhea  IAGPRGD:143524808554872ClinVar Annotator: match by term: Primary amenorrheaClinVarPMID:21681106

#
Reference Title
Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:8125298   PMID:9539149   PMID:12477932   PMID:15489334   PMID:20237496   PMID:20360844   PMID:20517885   PMID:21873635   PMID:23382219   PMID:23690594   PMID:24749734   PMID:27072655  
PMID:28688853   PMID:30021884   PMID:30423289   PMID:32296183   PMID:32357304   PMID:33203955   PMID:33649602   PMID:34100078   PMID:34533400   PMID:35914814   PMID:36430934   PMID:36949045  
PMID:38530364   PMID:38569927  



GPR37L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381202,122,917 - 202,133,592 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1202,122,886 - 202,133,592 (+)EnsemblGRCh38hg38GRCh38
GRCh371202,092,045 - 202,102,720 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361200,358,652 - 200,365,257 (+)NCBINCBI36Build 36hg18NCBI36
Celera1175,215,891 - 175,222,492 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1173,257,557 - 173,264,172 (+)NCBIHuRef
CHM1_11203,514,323 - 203,520,925 (+)NCBICHM1_1
T2T-CHM13v2.01201,376,262 - 201,391,163 (+)NCBIT2T-CHM13v2.0
Gpr37l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,087,988 - 135,095,419 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,087,972 - 135,095,419 (-)EnsemblGRCm39 Ensembl
GRCm381135,160,250 - 135,167,681 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,160,234 - 135,167,681 (-)EnsemblGRCm38mm10GRCm38
MGSCv371137,056,827 - 137,064,258 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361136,976,661 - 136,983,835 (-)NCBIMGSCv36mm8
Celera1137,787,013 - 137,794,466 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.25NCBI
Gpr37l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81349,150,355 - 49,157,204 (-)NCBIGRCr8
mRatBN7.21346,598,574 - 46,605,421 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1346,598,578 - 46,605,421 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1349,205,278 - 49,212,462 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01350,493,346 - 50,500,533 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01347,759,407 - 47,766,588 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01351,985,698 - 51,992,547 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1351,985,684 - 51,992,693 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01357,037,408 - 57,044,257 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41348,121,001 - 48,127,850 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11348,135,043 - 48,141,951 (-)NCBI
Celera1346,923,830 - 46,930,679 (-)NCBICelera
Cytogenetic Map13q13NCBI
Gpr37l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540638,214,423 - 38,223,281 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540638,214,490 - 38,223,281 (+)NCBIChiLan1.0ChiLan1.0
GPR37L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2147,252,311 - 47,258,956 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1147,216,988 - 47,223,643 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01177,720,832 - 177,731,551 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11182,022,600 - 182,028,623 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1182,022,600 - 182,028,623 (+)Ensemblpanpan1.1panPan2
GPR37L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.17882,672 - 887,679 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl7883,279 - 887,811 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha7934,690 - 939,694 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.07890,517 - 895,524 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl7888,710 - 895,660 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.17878,740 - 883,744 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.07986,968 - 991,972 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.071,010,981 - 1,015,985 (-)NCBIUU_Cfam_GSD_1.0
Gpr37l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934473,173,650 - 73,179,749 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365672,407,339 - 2,414,437 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365672,408,326 - 2,414,411 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR37L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1024,307,058 - 24,315,103 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11024,306,731 - 24,315,093 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21028,707,707 - 28,712,746 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPR37L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12527,276,393 - 27,283,231 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2527,277,360 - 27,283,350 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605528,054,557 - 28,063,314 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr37l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248078,605,488 - 8,611,669 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248078,605,488 - 8,611,760 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in GPR37L1
49 total Variants

1 to 10 of 1654 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
NM_001184880.2(PCDH19):c.1700C>T (p.Pro567Leu) single nucleotide variant Developmental and epileptic encephalopathy, 9 [RCV000763636]|not provided [RCV000521156] ChrX:100406898 [GRCh38]
ChrX:99661896 [GRCh37]
ChrX:Xq22.1		 pathogenic|likely pathogenic|conflicting interpretations of pathogenicity
NM_001184880.2(PCDH19):c.209_210del (p.His70fs) microsatellite not provided [RCV000517089] ChrX:100408388..100408389 [GRCh38]
ChrX:99663386..99663387 [GRCh37]
ChrX:Xq22.1		 pathogenic
NM_001184880.2(PCDH19):c.2994T>C (p.Thr998=) single nucleotide variant Developmental and epileptic encephalopathy, 9 [RCV001419244]|Inborn genetic diseases [RCV002438374] ChrX:100296730 [GRCh38]
ChrX:99551728 [GRCh37]
ChrX:Xq22.1		 likely benign
NM_001184880.2(PCDH19):c.1079A>C (p.Glu360Ala) single nucleotide variant not provided [RCV000520491] ChrX:100407519 [GRCh38]
ChrX:99662517 [GRCh37]
ChrX:Xq22.1		 uncertain significance
NM_001184880.2(PCDH19):c.701A>G (p.Asn234Ser) single nucleotide variant not provided [RCV000523297] ChrX:100407897 [GRCh38]
ChrX:99662895 [GRCh37]
ChrX:Xq22.1		 likely pathogenic
NM_001184880.2(PCDH19):c.2453del (p.Gln818fs) deletion Developmental and epileptic encephalopathy, 9 [RCV000555563] ChrX:100402687 [GRCh38]
ChrX:99657685 [GRCh37]
ChrX:Xq22.1		 pathogenic
NM_001184880.2(PCDH19):c.2798A>G (p.Asp933Gly) single nucleotide variant Developmental and epileptic encephalopathy, 9 [RCV001857916]|not specified [RCV000516258] ChrX:100341953 [GRCh38]
ChrX:99596951 [GRCh37]
ChrX:Xq22.1		 uncertain significance
NM_001184880.2(PCDH19):c.1555C>T (p.Arg519Ter) single nucleotide variant Developmental and epileptic encephalopathy, 9 [RCV000641125] ChrX:100407043 [GRCh38]
ChrX:99662041 [GRCh37]
ChrX:Xq22.1		 pathogenic
NM_001184880.2(PCDH19):c.2191G>A (p.Gly731Arg) single nucleotide variant Developmental and epileptic encephalopathy, 9 [RCV000641128] ChrX:100403621 [GRCh38]
ChrX:99658619 [GRCh37]
ChrX:Xq22.1		 uncertain significance
NM_001184880.2(PCDH19):c.2391C>G (p.Asp797Glu) single nucleotide variant Developmental and epileptic encephalopathy, 9 [RCV000641129] ChrX:100402749 [GRCh38]
ChrX:99657747 [GRCh37]
ChrX:Xq22.1		 uncertain significance
1 to 10 of 1654 rows

Predicted Target Of
Summary Value
Count of predictions:2824
Count of miRNA genes:979
Interacting mature miRNAs:1171
Transcripts:ENST00000367282
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597177088GWAS1273162_Htyrosine-protein phosphatase non-receptor type 7 measurement QTL GWAS1273162 (human)9e-13tyrosine-protein phosphatase non-receptor type 7 measurement1202128181202128182Human
597100888GWAS1196962_Hdiverticular disease QTL GWAS1196962 (human)0.000007diverticular disease1202124558202124559Human

RH103692  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371202,098,461 - 202,098,593UniSTSGRCh37
Build 361200,365,084 - 200,365,216RGDNCBI36
Celera1175,222,319 - 175,222,451RGD
Cytogenetic Map1q32.1UniSTS
HuRef1173,263,999 - 173,264,131UniSTS
GeneMap99-GB4 RH Map1666.51UniSTS
GPR37L1_8922  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371202,097,174 - 202,098,036UniSTSGRCh37
Build 361200,363,797 - 200,364,659RGDNCBI36
Celera1175,221,033 - 175,221,895RGD
HuRef1173,262,713 - 173,263,575UniSTS
SHGC-146622  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1q32.1UniSTS
HuRef1173,256,479 - 173,256,761UniSTS
TNG Radiation Hybrid Map143751.0UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1174 2426 2752 2200 4934 1646 2257 4 550 1601 392 2219 6743 6040 48 3726 786 1718 1595 173 1



Ensembl Acc Id: ENST00000367282   ⟹   ENSP00000356251
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,122,917 - 202,133,592 (+)Ensembl
Ensembl Acc Id: ENST00000682422
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,126,559 - 202,128,963 (+)Ensembl
Ensembl Acc Id: ENST00000682545   ⟹   ENSP00000508402
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,122,915 - 202,128,556 (+)Ensembl
Ensembl Acc Id: ENST00000682887   ⟹   ENSP00000506946
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,122,964 - 202,128,880 (+)Ensembl
Ensembl Acc Id: ENST00000683302   ⟹   ENSP00000507885
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,122,886 - 202,128,598 (+)Ensembl
Ensembl Acc Id: ENST00000683457
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,127,027 - 202,128,168 (+)Ensembl
Ensembl Acc Id: ENST00000683557   ⟹   ENSP00000508029
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1202,122,889 - 202,129,018 (+)Ensembl
RefSeq Acc Id: NM_004767   ⟹   NP_004758
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,122,917 - 202,133,592 (+)NCBI
GRCh371202,092,029 - 202,098,634 (+)RGD
Build 361200,358,652 - 200,365,257 (+)NCBI Archive
Celera1175,215,891 - 175,222,492 (+)RGD
HuRef1173,257,557 - 173,264,172 (+)ENTREZGENE
CHM1_11203,514,323 - 203,520,925 (+)NCBI
T2T-CHM13v2.01201,380,483 - 201,391,163 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054339633   ⟹   XP_054195608
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01201,376,262 - 201,391,163 (+)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_004758 (Get FASTA)   NCBI Sequence Viewer  
  XP_054195608 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH50334 (Get FASTA)   NCBI Sequence Viewer  
  BAD96359 (Get FASTA)   NCBI Sequence Viewer  
  BAG35876 (Get FASTA)   NCBI Sequence Viewer  
  BAG58475 (Get FASTA)   NCBI Sequence Viewer  
  CAA76153 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000356251
  ENSP00000356251.4
GenBank Protein O60883 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_004758   ⟸   NM_004767
- Peptide Label: precursor
- UniProtKB: Q86VP7 (UniProtKB/Swiss-Prot),   Q5SXP7 (UniProtKB/Swiss-Prot),   O60883 (UniProtKB/Swiss-Prot),   B2R7M9 (UniProtKB/Swiss-Prot),   A0A804HKD8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000356251   ⟸   ENST00000367282
Ensembl Acc Id: ENSP00000508029   ⟸   ENST00000683557
Ensembl Acc Id: ENSP00000507885   ⟸   ENST00000683302
Ensembl Acc Id: ENSP00000506946   ⟸   ENST00000682887
G-protein coupled receptors family 1 profile

Name Modeler Protein Id AA Range Protein Structure
AF-O60883-F1-model_v2 AlphaFold O60883 1-481 view protein structure

RGD ID:6858570
Promoter ID:EPDNEW_H2450
Type:initiation region
Name:GPR37L1_3
Description:G protein-coupled receptor 37 like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2449  EPDNEW_H2451  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,118,796 - 202,118,856EPDNEW
RGD ID:6858572
Promoter ID:EPDNEW_H2451
Type:initiation region
Name:GPR37L1_1
Description:G protein-coupled receptor 37 like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2449  EPDNEW_H2450  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,122,917 - 202,122,977EPDNEW


1 to 33 of 33 rows
Database
Acc Id
Source(s)
COSMIC GPR37L1 COSMIC
Ensembl Genes ENSG00000170075 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000367282 ENTREZGENE
  ENST00000367282.6 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
GTEx ENSG00000170075 GTEx
HGNC ID HGNC:14923 ENTREZGENE
Human Proteome Map GPR37L1 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  GPR37_orph UniProtKB/Swiss-Prot
KEGG Report hsa:9283 UniProtKB/Swiss-Prot
NCBI Gene GPR37L1 ENTREZGENE
OMIM 617630 OMIM
PANTHER G-PROTEIN COUPLED RECEPTOR 37-LIKE 1 UniProtKB/Swiss-Prot
  PTHR46216 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB PA28883 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  GPR37ORPHANR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A0A804HI82_HUMAN UniProtKB/TrEMBL
  A0A804HKD8 ENTREZGENE, UniProtKB/TrEMBL
  A0A804HKQ6_HUMAN UniProtKB/TrEMBL
  A0A804HLL0_HUMAN UniProtKB/TrEMBL
  B2R7M9 ENTREZGENE
  G37L1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q5SXP7 ENTREZGENE
  Q86VP7 ENTREZGENE
UniProt Secondary B2R7M9 UniProtKB/Swiss-Prot
  Q5SXP7 UniProtKB/Swiss-Prot
  Q86VP7 UniProtKB/Swiss-Prot
1 to 33 of 33 rows