Gpr37l1 (G protein-coupled receptor 37-like 1) - Rat Genome Database

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Gene: Gpr37l1 (G protein-coupled receptor 37-like 1) Mus musculus
Analyze
Symbol: Gpr37l1
Name: G protein-coupled receptor 37-like 1
RGD ID: 731318
MGI Page MGI
Description: Predicted to enable G protein-coupled peptide receptor activity and peptide binding activity. Involved in cellular response to reactive oxygen species; negative regulation of systemic arterial blood pressure; and positive regulation of MAPK cascade. Acts upstream of or within negative regulation of cell differentiation; negative regulation of smoothened signaling pathway; and positive regulation of cerebellar granule cell precursor proliferation. Located in plasma membrane. Is expressed in brain; dentate gyrus subgranular zone; spinal cord; spinal cord gray matter; and spinal cord white matter. Orthologous to human GPR37L1 (G protein-coupled receptor 37 like 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW047233; CAG-1; CAG-18; D0Kis; D0Kist8; endothelin B receptor-like protein 2; endothelin B receptor-like protein-2; ETBR-LP-2; G protein-coupled receptor 37-lke 1; G-protein coupled receptor 37-like 1; orphan Gpr37-like protein 1; prosaposin receptor GPR37L1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,087,988 - 135,095,419 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,087,972 - 135,095,419 (-)EnsemblGRCm39 Ensembl
GRCm381135,160,250 - 135,167,681 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,160,234 - 135,167,681 (-)EnsemblGRCm38mm10GRCm38
MGSCv371137,056,827 - 137,064,258 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361136,976,661 - 136,983,835 (-)NCBIMGSCv36mm8
Celera1137,787,013 - 137,794,466 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell projection  (IEA)
membrane  (IEA)
plasma membrane  (IBA,IDA,ISO)
receptor complex  (IBA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:9367917   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12679517   PMID:14610273   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17114649  
PMID:18287559   PMID:20100464   PMID:21677750   PMID:21873635   PMID:23382219   PMID:23690594   PMID:24062445   PMID:24154525   PMID:24952961   PMID:25609427   PMID:26935062   PMID:27072655  
PMID:27881777   PMID:28642167   PMID:28688853   PMID:28795439   PMID:29625592   PMID:30452905   PMID:30566002   PMID:33350496   PMID:33633567   PMID:34100078   PMID:34248495   PMID:34533400  
PMID:34601807   PMID:35457105   PMID:35681509   PMID:36727569   PMID:37029775   PMID:37075680   PMID:38187761  


Genomics

Comparative Map Data
Gpr37l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,087,988 - 135,095,419 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,087,972 - 135,095,419 (-)EnsemblGRCm39 Ensembl
GRCm381135,160,250 - 135,167,681 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,160,234 - 135,167,681 (-)EnsemblGRCm38mm10GRCm38
MGSCv371137,056,827 - 137,064,258 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361136,976,661 - 136,983,835 (-)NCBIMGSCv36mm8
Celera1137,787,013 - 137,794,466 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.25NCBI
GPR37L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381202,122,917 - 202,133,592 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1202,122,886 - 202,133,592 (+)EnsemblGRCh38hg38GRCh38
GRCh371202,092,045 - 202,102,720 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361200,358,652 - 200,365,257 (+)NCBINCBI36Build 36hg18NCBI36
Celera1175,215,891 - 175,222,492 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1173,257,557 - 173,264,172 (+)NCBIHuRef
CHM1_11203,514,323 - 203,520,925 (+)NCBICHM1_1
T2T-CHM13v2.01201,376,262 - 201,391,163 (+)NCBIT2T-CHM13v2.0
Gpr37l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81349,150,355 - 49,157,204 (-)NCBIGRCr8
mRatBN7.21346,598,574 - 46,605,421 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1346,598,578 - 46,605,421 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1349,205,278 - 49,212,462 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01350,493,346 - 50,500,533 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01347,759,407 - 47,766,588 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01351,985,698 - 51,992,547 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1351,985,684 - 51,992,693 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01357,037,408 - 57,044,257 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41348,121,001 - 48,127,850 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11348,135,043 - 48,141,951 (-)NCBI
Celera1346,923,830 - 46,930,679 (-)NCBICelera
Cytogenetic Map13q13NCBI
Gpr37l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540638,214,423 - 38,223,281 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540638,214,490 - 38,223,281 (+)NCBIChiLan1.0ChiLan1.0
GPR37L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2147,252,311 - 47,258,956 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1147,216,988 - 47,223,643 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01177,720,832 - 177,731,551 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11182,022,600 - 182,028,623 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1182,022,600 - 182,028,623 (+)Ensemblpanpan1.1panPan2
GPR37L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.17882,672 - 887,679 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl7883,279 - 887,811 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha7934,690 - 939,694 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.07890,517 - 895,524 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl7888,710 - 895,660 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.17878,740 - 883,744 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.07986,968 - 991,972 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.071,010,981 - 1,015,985 (-)NCBIUU_Cfam_GSD_1.0
Gpr37l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934473,173,650 - 73,179,749 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365672,407,339 - 2,414,437 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365672,408,326 - 2,414,411 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR37L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1024,307,058 - 24,315,103 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11024,306,731 - 24,315,093 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21028,707,707 - 28,712,746 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPR37L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12527,276,393 - 27,283,231 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2527,277,360 - 27,283,350 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605528,054,557 - 28,063,314 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr37l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248078,605,488 - 8,611,669 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248078,605,488 - 8,611,760 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr37l1
290 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:313
Count of miRNA genes:224
Interacting mature miRNAs:265
Transcripts:ENSMUST00000027682
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182643189135615379Mouse
27095913Scvln2_msacral vertebrae length 2, 5 week (mouse)194127725148775742Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195527725162027569Mouse
1301193Lxw3_mlupus BXSB x NZW 3 (mouse)Not determined1102968534136968667Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
12790994Aaaq1_maortic arch angle QTL 1 (mouse)1109495943143495943Mouse
1301979Melm1_mmelanoma modifier 1 (mouse)Not determined1109638262143638479Mouse
1357600Obq17_mobesity QTL 17 (mouse)Not determined1110553179144553298Mouse
10401248Bglu12_mblood glucose level 12 (mouse)Not determined1110553179144553298Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112008822168186402Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
1301249Sbw1_msplenomegaly-NZB x NZW 1 (mouse)Not determined1112131005146131085Mouse
10045640Jckm4_mjuvenile cystic kidney modifier 4 (mouse)Not determined1116290836150290937Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
1302161Exq2_mexploratory and excitability QTL 2 (mouse)Not determined1118099720152099816Mouse
27226714Metcl1_mmetatarsal-calcaneal length 1, 5 week (mouse)1121727729139727738Mouse
27226740Metcl13_mmetatarsal-calcaneal length 13, 16 week (mouse)1121727729153775746Mouse
27226743Metcl7_mmetatarsal-calcaneal length 7, 10 week (mouse)1121727729153875746Mouse
27226767Tibl10_mtibia length 10, 10 week (mouse)1121727729164827569Mouse
27226799Feml5_mfemur length 5, 5 week (mouse)1122027729164827569Mouse
12880408V125Dq3_mvitamin D active form serum level QTL 3 (mouse)1122927738156927738Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
1301608Emo3_memotionality 3 (mouse)Not determined1129130858163130993Mouse
1302128Ity3_mimmunity to S. typhimurium 3 (mouse)Not determined11131156308165139464Mouse
13524520Bodwtq1_mbody wweight QTL 1 (mouse)1131191160135621161Mouse
13513913Heal51_mwound healing/ regeneration 51 (mouse)1131780648135499606Mouse
14746980Manh50_mmandible shape 50 (mouse)1134131564168131564Mouse
13504831Bacszq1_mbaculum size QTL 1 (mouse)1134331161148128608Mouse

Markers in Region
AW047233  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381135,160,435 - 135,160,524UniSTSGRCm38
MGSCv371137,057,012 - 137,057,101UniSTSGRCm37
Celera1137,787,198 - 137,787,287UniSTS
Cytogenetic Map1E4UniSTS
Whitehead/MRC_RH11918.41UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000027682   ⟹   ENSMUSP00000027682
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1135,087,972 - 135,095,419 (-)Ensembl
GRCm38.p6 Ensembl1135,160,234 - 135,167,681 (-)Ensembl
RefSeq Acc Id: NM_134438   ⟹   NP_602320
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391135,087,988 - 135,095,419 (-)NCBI
GRCm381135,160,250 - 135,167,681 (-)ENTREZGENE
MGSCv371137,056,827 - 137,064,258 (-)RGD
Celera1137,787,013 - 137,794,466 (-)RGD
cM Map1 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_602320   ⟸   NM_134438
- Peptide Label: precursor
- UniProtKB: Q80UB9 (UniProtKB/Swiss-Prot),   O88313 (UniProtKB/Swiss-Prot),   Q99JG1 (UniProtKB/Swiss-Prot),   Q99JG2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000027682   ⟸   ENSMUST00000027682
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99JG2-F1-model_v2 AlphaFold Q99JG2 1-481 view protein structure

Promoters
RGD ID:6875050
Promoter ID:EPDNEW_M976
Type:initiation region
Name:Gpr37l1_1
Description:Mus musculus G protein-coupled receptor 37-like 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381135,167,546 - 135,167,606EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1928503 AgrOrtholog
Ensembl Genes ENSMUSG00000026424 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000027682 ENTREZGENE
  ENSMUST00000027682.9 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPR37_orph UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:171469 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1928503 ENTREZGENE
NCBI Gene 171469 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR 37-LIKE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46216 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gpr37l1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPR37ORPHANR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A1L151_MOUSE UniProtKB/TrEMBL
  G37L1_MOUSE UniProtKB/Swiss-Prot
  O88313 ENTREZGENE
  Q80UB9 ENTREZGENE
  Q99JG1 ENTREZGENE
  Q99JG2 ENTREZGENE
UniProt Secondary O88313 UniProtKB/Swiss-Prot
  Q4G0C9 UniProtKB/TrEMBL
  Q80UB9 UniProtKB/Swiss-Prot
  Q99JG1 UniProtKB/Swiss-Prot