| 620448 | Fhit | fragile histidine triad diadenosine triphosphatase | ENCODES a protein that exhibits bis(5'-adenosyl)-triphosphatase activity; nickel cation binding; adenosine 5'-monophosphoramidase activity (ortholog); INVOLVED IN diadenosine triphosphate catabolic process; DNA replication (ortholog); intrinsic apoptotic signaling pathway by p53 class mediator (orth olog); PARTICIPATES IN lung non-small cell carcinoma pathway; lung small cell carcinoma pathway; purine metabolic pathway; ASSOCIATED WITH hepatocellular carcinoma; amenorrhea (ortholog); amphetamine abuse (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 1-nitropropane; 2,4-diaminotoluene; 2,6-diaminotoluene | 15 | 16365401 | 17872901 | Rat | 228 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 732571 | Fhit | fragile histidine triad gene | This gene encodes a member of the HIT family of proteins that are characterized by the presence of a histidine triad sequence. The encoded protein is a diadenosine triphosphate hydrolase enzyme that cleaves the P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. This locus is very f ragile and has been found to be altered in different types of cancers. Mice lacking the encoded protein display increased susceptibility to spontaneous and induced tumors. Ectopic expression of the encoded protein in such knockout mice inhibits tumor development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] | 14 | 11307718 | 12919681 | Mouse | 237 | symbol , old_gene_name , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 1344220 | FHIT | fragile histidine triad diadenosine triphosphatase | The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts f rom this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017] | 3 | 59747277 | 61251452 | Human | 214 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8940002 | Fhit | fragile histidine triad diadenosine triphosphatase | ENCODES a protein that exhibits adenosine 5'-monophosphoramidase activity (ortholog); adenylylsulfatase activity (ortholog); adenylylsulfate-ammonia adenylyltransferase activity (ortholog); INVOLVED IN diadenosine triphosphate catabolic process (ortholog); DNA replication (ortholog); intrinsic apopt otic signaling pathway by p53 class mediator (ortholog); ASSOCIATED WITH amenorrhea (ortholog); amphetamine abuse (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); mitochondrion (ortholog) | NW_004955430 | 221518 | 508094 | Chinchilla | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11668325 | FHIT | fragile histidine triad diadenosine triphosphatase | ENCODES a protein that exhibits adenosine 5'-monophosphoramidase activity (ortholog); adenylylsulfatase activity (ortholog); adenylylsulfate-ammonia adenylyltransferase activity (ortholog); INVOLVED IN diadenosine triphosphate catabolic process (ortholog); DNA replication (ortholog); intrinsic apopt otic signaling pathway by p53 class mediator (ortholog); ASSOCIATED WITH amenorrhea (ortholog); amphetamine abuse (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); mitochondrion (ortholog) | 3 | 59670777 | 61177974 | Bonobo | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12127929 | FHIT | fragile histidine triad diadenosine triphosphatase | ENCODES a protein that exhibits bis(5'-adenosyl)-triphosphatase activity (ortholog); nickel cation binding (ortholog); INVOLVED IN diadenosine triphosphate catabolic process (ortholog); DNA replication (ortholog); ASSOCIATED WITH amenorrhea (ortholog); amphetamine abuse (ortholog); autistic disorder (ortholog); FOUND IN mitochondrion (ortholog) | 20 | 29735380 | 31113859 | Dog | 79 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12705889 | Fhit | fragile histidine triad diadenosine triphosphatase | ENCODES a protein that exhibits bis(5'-adenosyl)-triphosphatase activity (ortholog); nickel cation binding (ortholog); INVOLVED IN diadenosine triphosphate catabolic process (ortholog); DNA replication (ortholog); ASSOCIATED WITH amenorrhea (ortholog); amphetamine abuse (ortholog); autistic disorder (ortholog); FOUND IN mitochondrion (ortholog) | NW_004936473 | 397140 | 1424805 | Squirrel | 83 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18580494 | FHIT | fragile histidine triad diadenosine triphosphatase | ENCODES a protein that exhibits adenosine 5'-monophosphoramidase activity (ortholog); adenylylsulfatase activity (ortholog); adenylylsulfate-ammonia adenylyltransferase activity (ortholog); INVOLVED IN diadenosine triphosphate catabolic process (ortholog); DNA replication (ortholog); intrinsic apopt otic signaling pathway by p53 class mediator (ortholog); ASSOCIATED WITH amenorrhea (ortholog); amphetamine abuse (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); mitochondrion (ortholog) | | | | Green Monkey | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626160104 | Fhit | fragile histidine triad diadenosine triphosphatase | ENCODES a protein that exhibits adenosine 5'-monophosphoramidase activity (ortholog); adenylylsulfatase activity (ortholog); adenylylsulfate-ammonia adenylyltransferase activity (ortholog); INVOLVED IN diadenosine triphosphate catabolic process (ortholog); DNA replication (ortholog); intrinsic apopt otic signaling pathway by p53 class mediator (ortholog); ASSOCIATED WITH amenorrhea (ortholog); amphetamine abuse (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); mitochondrion (ortholog) | | | | Black Rat | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155257279 | fhit | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14273956 | FHIT | fragile histidine triad diadenosine triphosphatase | ENCODES a protein that exhibits bis(5'-adenosyl)-triphosphatase activity (ortholog); nickel cation binding (ortholog); INVOLVED IN diadenosine triphosphate catabolic process (ortholog); DNA replication (ortholog); ASSOCIATED WITH amenorrhea (ortholog); amphetamine abuse (ortholog); autistic disorder (ortholog); FOUND IN mitochondrion (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 84 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18908222 | Fhit | fragile histidine triad diadenosine triphosphatase | ENCODES a protein that exhibits bis(5'-adenosyl)-triphosphatase activity (ortholog); identical protein binding (ortholog); nickel cation binding (ortholog); INVOLVED IN diadenosine triphosphate catabolic process (ortholog); DNA replication (ortholog); ASSOCIATED WITH amenorrhea (ortholog); amphetami ne abuse (ortholog); autistic disorder (ortholog); FOUND IN cytosol (ortholog); mitochondrion (ortholog) | | | | Naked Mole-Rat | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155258033 | fhit.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155258129 | fhit.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16572726 | AC093418.1 | novel transcript, antisense to FHIT | | | | | Human | | name | gene, lncrna |
| 10001604 | Fhitos | fragile histidine triad gene, opposite strand | | 14 | 11690772 | 11731220 | Mouse | 3 | symbol , PhenoGen | gene, ncrna, VALIDATED [RefSeq] |
