| 2603 | Fga | fibrinogen alpha chain | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); signaling receptor binding (ortholog); structural molecule activity (ortholog); INVOLVED IN acute-phase response; cellular response to granulocyte colony-stimulating factor; cellular response to interleukin-6; PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure; Acute Liver Failure; Acute Lung Injury; FOUND IN blood microparticle; extracellular space; cell cortex (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol | 2 | 170672169 | 170679572 | Rat | 360 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 10576 | Fga | fibrinogen alpha chain | This gene encodes a subunit of the coagulation factor fibrinogen, which is a component of the blood clot. The encoded protein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mice lacking the encoded protein display bleeding in the peritoneal cavity, skin and s oft tissues around joints immediately after birth, and are predisposed to spontaneous fatal abdominal hemorrhage as they grow. Pregnant mice lacking the encoded protein succumb to uterine bleeding during gestation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015] | 3 | 82933460 | 82940934 | Mouse | 392 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 737209 | FGA | fibrinogen alpha chain | This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disord ers, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. [provided by RefSeq, Jan 2016] | 4 | 154583126 | 154590742 | Human | 523 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8855293 | Fga | fibrinogen alpha chain | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); signaling receptor binding (ortholog); structural molecule activity (ortholog); INVOLVED IN acute-phase response (ortholog); blood coagulation (ortholog); blood coagulation, common pathway (ortholog); PARTICIPATES IN acenocou marol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); Acute Lung Injury (ortholog); FOUND IN blood microparticle (ortholog); cell cortex (ortholog); cell surface (ortholog) | NW_004955471 | 8806964 | 8814671 | Chinchilla | 127 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11716980 | FGA | fibrinogen alpha chain | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); signaling receptor binding (ortholog); structural molecule activity (ortholog); INVOLVED IN acute-phase response (ortholog); blood coagulation (ortholog); blood coagulation, common pathway (ortholog); PARTICIPATES IN acenocou marol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); Acute Lung Injury (ortholog); FOUND IN blood microparticle (ortholog); cell cortex (ortholog); cell surface (ortholog) | 4 | 146949680 | 146957291 | Bonobo | 127 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12120302 | FGA | fibrinogen alpha chain | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); signaling receptor binding (ortholog); structural molecule activity (ortholog); INVOLVED IN acute-phase response (ortholog); blood coagulation (ortholog); blood coagulation, fibrin clot formation (ortholog); PARTICIPATES IN a cenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); Acute Lung Injury (ortholog); FOUND IN blood microparticle (ortholog); cell surface (ortholog); endoplasmic reticulum (ortholog) | 15 | 52238305 | 52247017 | Dog | 141 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12655505 | Fga | fibrinogen alpha chain | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); signaling receptor binding (ortholog); structural molecule activity (ortholog); INVOLVED IN acute-phase response (ortholog); blood coagulation (ortholog); blood coagulation, fibrin clot formation (ortholog); PARTICIPATES IN a cenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); Acute Lung Injury (ortholog); FOUND IN blood microparticle (ortholog); cell surface (ortholog); endoplasmic reticulum (ortholog) | NW_004936576 | 1322406 | 1329743 | Squirrel | 142 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625898946 | Fga | fibrinogen alpha chain | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); signaling receptor binding (ortholog); structural molecule activity (ortholog); INVOLVED IN acute-phase response (ortholog); blood coagulation (ortholog); blood coagulation, common pathway (ortholog); PARTICIPATES IN acenocou marol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); Acute Lung Injury (ortholog); FOUND IN blood microparticle (ortholog); cell cortex (ortholog); cell surface (ortholog) | | | | Black Rat | 124 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237445 | fga | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14161339 | FGA | fibrinogen alpha chain | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); signaling receptor binding (ortholog); structural molecule activity (ortholog); INVOLVED IN acute-phase response (ortholog); blood coagulation (ortholog); blood coagulation, fibrin clot formation (ortholog); PARTICIPATES IN a cenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); Acute Lung Injury (ortholog); FOUND IN blood microparticle (ortholog); cell surface (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH ammonia | | | | Pig | 139 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18565649 | FGA | fibrinogen alpha chain | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); signaling receptor binding (ortholog); structural molecule activity (ortholog); INVOLVED IN acute-phase response (ortholog); blood coagulation (ortholog); cell-matrix adhesion (ortholog); PARTICIPATES IN acenocoumarol pharmac odynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); Acute Lung Injury (ortholog); FOUND IN blood microparticle (ortholog); cell surface (ortholog); endoplasmic reticulum (ortholog) | | | | Green Monkey | 144 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18922151 | Fga | fibrinogen alpha chain | ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); signaling receptor binding (ortholog); structural molecule activity (ortholog); INVOLVED IN acute-phase response (ortholog); blood coagulation (ortholog); blood coagulation, fibrin clot formation (ortholog); PARTICIPATES IN a cenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); Acute Lung Injury (ortholog); FOUND IN blood microparticle (ortholog); cell cortex (ortholog); cell surface (ortholog) | | | | Naked Mole-Rat | 142 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237444 | fga.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155251945 | fga.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1312648 | PFAS | phosphoribosylformylglycinamidine synthase | Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of I MP biosynthesis. [provided by RefSeq, Jul 2008] | 17 | 8247608 | 8270486 | Human | 163 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1614154 | Pfas | phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) | Predicted to enable phosphoribosylformylglycinamidine synthase activity. Acts upstream of or within anterior head development. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; cranium; integumental system; and liver. Orthol ogous to human PFAS (phosphoribosylformylglycinamidine synthase). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 68876527 | 68899286 | Mouse | 194 | old_gene_name , name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1304926 | Pfas | phosphoribosylformylglycinamidine synthase | ENCODES a protein that exhibits phosphoribosylformylglycinamidine synthase activity (ortholog); INVOLVED IN glutamine metabolic process; response to xenobiotic stimulus; 'de novo' AMP biosynthetic process (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine mono phosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Experimental Diabetes Mellitus; hepatocellular carcinoma; colon adenocarcinoma (ortholog); FOUND IN cytoplasm (inferred); INTERACTS WITH 6-propyl-2-thiouracil; amphetamine; bisphenol A | 10 | 54189157 | 54210685 | Rat | 158 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 12245753 | PFAS | phosphoribosylformylglycinamidine synthase | ENCODES a protein that exhibits ATP binding (inferred); ligase activity (inferred); metal ion binding (inferred); INVOLVED IN 'de novo' AMP biosynthetic process (ortholog); 'de novo' IMP biosynthetic process (ortholog); 'de novo' XMP biosynthetic process (ortholog); PARTICIPATES IN adenine phoshorib osyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH colon adenocarcinoma (ortholog); Experimental Diabetes Mellitus (ortholog); hepatocellular carcinoma (ortholog); FOUND IN cytoplasm (inferred) | 5 | 33055144 | 33076823 | Dog | 46 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |