FGA (fibrinogen alpha chain) - Rat Genome Database

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Gene: FGA (fibrinogen alpha chain) Canis lupus familiaris
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Symbol: FGA
Name: fibrinogen alpha chain
RGD ID: 12120302
Description: ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN acute-phase response (ortholog); blood coagulation (ortholog); blood coagulation, fibrin clot formation (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Liver Failure (ortholog); Acute Lung Injury (ortholog); FOUND IN blood microparticle (ortholog); cell surface (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: carboxy-terminal region; fibrinogen A-alpha-chain
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11552,238,305 - 52,247,017 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1552,236,198 - 52,246,975 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1552,584,628 - 52,591,483 (-)NCBI
ROS_Cfam_1.01552,924,743 - 52,933,990 (-)NCBI
UMICH_Zoey_3.11552,179,682 - 52,188,900 (-)NCBI
UNSW_CanFamBas_1.01552,283,995 - 52,293,478 (-)NCBI
UU_Cfam_GSD_1.01552,601,176 - 52,608,068 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (ISO)
adaptive immune response  (IEA)
blood coagulation  (IEA,ISO)
blood coagulation, common pathway  (IEA)
blood coagulation, fibrin clot formation  (ISO)
cell-matrix adhesion  (IEA)
cellular protein-containing complex assembly  (ISO)
cellular response to granulocyte colony-stimulating factor  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to organic cyclic compound  (ISO)
envenomation resulting in modulation of blood coagulation in other organism  (ISO)
fibrinolysis  (IEA)
induction of bacterial agglutination  (IEA)
innate immune response  (IEA)
liver regeneration  (ISO)
negative regulation of endothelial cell apoptotic process  (IEA)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA)
plasminogen activation  (IEA)
platelet activation  (IEA)
platelet aggregation  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of exocytosis  (IEA)
positive regulation of heterotypic cell-cell adhesion  (IEA)
positive regulation of peptide hormone secretion  (IEA)
positive regulation of protein secretion  (IEA)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of vasoconstriction  (IEA)
protein polymerization  (IEA)
protein-containing complex assembly  (ISO)
response to calcium ion  (IEA)
response to cycloheximide  (ISO)
response to estradiol  (ISO)
response to genistein  (ISO)
response to growth hormone  (ISO)
response to insulin  (ISO)
response to morphine  (ISO)
response to thyroid hormone  (ISO)
response to toxic substance  (ISO)
response to X-ray  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:8497848  


Genomics

Comparative Map Data
FGA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11552,238,305 - 52,247,017 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1552,236,198 - 52,246,975 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1552,584,628 - 52,591,483 (-)NCBI
ROS_Cfam_1.01552,924,743 - 52,933,990 (-)NCBI
UMICH_Zoey_3.11552,179,682 - 52,188,900 (-)NCBI
UNSW_CanFamBas_1.01552,283,995 - 52,293,478 (-)NCBI
UU_Cfam_GSD_1.01552,601,176 - 52,608,068 (-)NCBI
FGA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4154,583,128 - 154,590,745 (-)EnsemblGRCh38hg38GRCh38
GRCh384154,583,126 - 154,590,742 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374155,504,278 - 155,511,894 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364155,723,730 - 155,731,347 (-)NCBINCBI36hg18NCBI36
Build 344155,864,033 - 155,869,470NCBI
Celera4152,835,246 - 152,842,862 (-)NCBI
Cytogenetic Map4q31.3NCBI
HuRef4151,244,861 - 151,252,473 (-)NCBIHuRef
CHM1_14155,482,201 - 155,489,817 (-)NCBICHM1_1
Fga
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39382,933,460 - 82,940,934 (+)NCBIGRCm39mm39
GRCm39 Ensembl382,933,383 - 82,940,934 (+)Ensembl
GRCm38383,026,153 - 83,033,627 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,026,076 - 83,033,627 (+)EnsemblGRCm38mm10GRCm38
MGSCv37382,830,075 - 82,837,549 (+)NCBIGRCm37mm9NCBIm37
MGSCv36383,112,081 - 83,118,197 (+)NCBImm8
Celera383,030,275 - 83,037,743 (+)NCBICelera
Cytogenetic Map3E3NCBI
cM Map336.96NCBI
Fga
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22168,365,364 - 168,381,533 (+)NCBI
Rnor_6.0 Ensembl2182,006,242 - 182,013,763 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02181,997,562 - 182,013,726 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02201,412,182 - 201,428,346 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42174,737,640 - 174,753,598 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12174,694,725 - 174,703,904 (+)NCBI
Celera2162,392,064 - 162,408,023 (+)NCBICelera
Cytogenetic Map2q34NCBI
Fga
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554718,806,650 - 8,816,791 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554718,806,964 - 8,814,671 (+)NCBIChiLan1.0ChiLan1.0
FGA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14158,767,782 - 158,775,414 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v04146,949,680 - 146,957,291 (-)NCBIMhudiblu_PPA_v0panPan3
Fga
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530138,217,093 - 38,224,715 (+)NCBI
SpeTri2.0NW_0049365761,322,406 - 1,329,743 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl874,574,882 - 74,584,202 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1874,574,870 - 74,584,202 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2878,935,842 - 78,938,718 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17101,127,554 - 101,134,881 (-)NCBI
ChlSab1.1 Ensembl7101,125,791 - 101,134,405 (-)Ensembl
Vero_WHO_p1.0NW_02366603780,782,883 - 80,789,839 (-)NCBI
Fga
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248585,848,817 - 5,856,448 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 6 6 6
Medium
Low 1 8 1 1
Below cutoff 5 5 16 5 6 5 12 9 5

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_038496680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038559074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038623009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038688683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_532697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D43756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK410299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK410300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK410301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK410302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK410303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK410304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK410305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK410306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK410307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK410308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK410309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK410310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK410311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000013402   ⟹   ENSCAFP00000012402
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1552,238,735 - 52,246,975 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000043702   ⟹   ENSCAFP00000036232
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1552,236,198 - 52,246,975 (-)Ensembl
RefSeq Acc Id: XM_038496680   ⟹   XP_038352608
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11552,179,682 - 52,188,900 (-)NCBI
RefSeq Acc Id: XM_038559074   ⟹   XP_038415002
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01552,601,176 - 52,608,068 (-)NCBI
RefSeq Acc Id: XM_038623009   ⟹   XP_038478937
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01552,283,995 - 52,293,478 (-)NCBI
RefSeq Acc Id: XM_038688683   ⟹   XP_038544611
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01552,924,743 - 52,933,990 (-)NCBI
RefSeq Acc Id: XM_532697   ⟹   XP_532697
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11552,238,305 - 52,247,017 (-)NCBI
Dog10K_Boxer_Tasha1552,584,628 - 52,591,483 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_532697   ⟸   XM_532697
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCAFP00000036232   ⟸   ENSCAFT00000043702
RefSeq Acc Id: ENSCAFP00000012402   ⟸   ENSCAFT00000013402
RefSeq Acc Id: XP_038352608   ⟸   XM_038496680
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038478937   ⟸   XM_038623009
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038544611   ⟸   XM_038688683
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038415002   ⟸   XM_038559074
- Peptide Label: isoform X2
Promoters
RGD ID:13686005
Promoter ID:EPDNEW_C4073
Type:multiple initiation site
Name:FGA_1
Description:fibrinogen alpha chain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11552,246,978 - 52,247,038EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000023178 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000012402 UniProtKB/TrEMBL
  ENSCAFP00000036232 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000013402 UniProtKB/TrEMBL
  ENSCAFT00000043702 UniProtKB/TrEMBL
InterPro Fibrinogen-like_C UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_dom UniProtKB/TrEMBL
  Fibrinogen_a/b/g_coil_dom UniProtKB/TrEMBL
  Fibrinogen_aC UniProtKB/TrEMBL
  Fibrinogen_alpha UniProtKB/TrEMBL
  Fibrinogen_CS UniProtKB/TrEMBL
NCBI Gene FGA ENTREZGENE
PANTHER PTHR47221 UniProtKB/TrEMBL
Pfam Fib_alpha UniProtKB/TrEMBL
  Fibrinogen_aC UniProtKB/TrEMBL
  Fibrinogen_C UniProtKB/TrEMBL
PROSITE FIBRINOGEN_C_1 UniProtKB/TrEMBL
  FIBRINOGEN_C_2 UniProtKB/TrEMBL
SMART FBG UniProtKB/TrEMBL
  Fib_alpha UniProtKB/TrEMBL
Superfamily-SCOP SSF56496 UniProtKB/TrEMBL
UniProt A0A4P8VTF3_CANLF UniProtKB/TrEMBL
  A0A4P8VTK6_CANLF UniProtKB/TrEMBL
  A0A4P8VV79_CANLF UniProtKB/TrEMBL
  A0A4V1FUJ2_CANLF UniProtKB/TrEMBL
  F1PBL4_CANLF UniProtKB/TrEMBL
  FIBA_CANLF UniProtKB/Swiss-Prot
  J9NRV7_CANLF UniProtKB/TrEMBL
  P68213 ENTREZGENE
UniProt Secondary P02673 UniProtKB/Swiss-Prot
  P14464 UniProtKB/Swiss-Prot
VGNC ID VGNC:54205 ENTREZGENE