| 68402 | Dpp6 | dipeptidyl peptidase like 6 | ENCODES a protein that exhibits dipeptidyl-peptidase activity (ortholog); potassium channel regulator activity (ortholog); INVOLVED IN positive regulation of potassium ion transport; positive regulation of protein localization to plasma membrane; neuronal action potential (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 33 (ortholog); cardiac arrest (ortholog); FOUND IN cell surface; neuronal cell body; voltage-gated potassium channel complex; INTERACTS WITH alpha-Zearalanol; atrazine; bis(2-ethylhexyl) phthalate | 4 | 8323220 | 9242694 | Rat | 144 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 68590 | DPP6 | dipeptidyl peptidase like 6 | This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. Ho wever, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] | 7 | 153748133 | 154894285 | Human | 163 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 68591 | Dpp6 | dipeptidylpeptidase 6 | Enables potassium channel regulator activity. Involved in protein localization to plasma membrane; regulation of postsynaptic membrane potential; and regulation of potassium ion transmembrane transport. Acts upstream of or within neuronal action potential and positive regulation of potassium ion tra nsmembrane transport. Located in plasma membrane. Part of voltage-gated potassium channel complex. Is active in synapse. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; intervertebral disc; and nose. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; autosomal dominant intellectual developmental disorder 33; and spinal muscular atrophy. Orthologous to human DPP6 (dipeptidyl peptidase like 6). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 27022355 | 27932498 | Mouse | 144 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9037012 | Dpp6 | dipeptidyl peptidase like 6 | ENCODES a protein that exhibits dipeptidyl-peptidase activity (ortholog); potassium channel regulator activity (ortholog); INVOLVED IN neuronal action potential (ortholog); positive regulation of potassium ion transmembrane transport (ortholog); positive regulation of potassium ion transport (orthol og); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 33 (ortholog); FOUND IN cell surface (ortholog); membrane (ortholog); neuronal cell body (ortholog) | NW_004955491 | 7325720 | 8167949 | Chinchilla | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11930933 | DPP6 | dipeptidyl peptidase like 6 | ENCODES a protein that exhibits dipeptidyl-peptidase activity (ortholog); INVOLVED IN neuronal action potential (ortholog); positive regulation of potassium ion transmembrane transport (ortholog); positive regulation of potassium ion transport (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosi s (ortholog); autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 33 (ortholog); FOUND IN cell surface (ortholog); neuronal cell body (ortholog); synapse (ortholog) | 7 | 145356340 | 146492773 | Bonobo | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12402234 | DPP6 | dipeptidyl peptidase like 6 | ENCODES a protein that exhibits dipeptidyl-peptidase activity (ortholog); INVOLVED IN neuronal action potential (ortholog); positive regulation of potassium ion transmembrane transport (ortholog); positive regulation of potassium ion transport (ortholog); ASSOCIATED WITH autism spectrum disorder (or tholog); autosomal dominant intellectual developmental disorder 33 (ortholog); cardiac arrest (ortholog); FOUND IN cell surface (ortholog); neuronal cell body (ortholog); synapse (ortholog) | 16 | 17357461 | 18043547 | Dog | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12581180 | Dpp6 | dipeptidyl peptidase like 6 | ENCODES a protein that exhibits dipeptidyl-peptidase activity (ortholog); INVOLVED IN neuronal action potential (ortholog); positive regulation of potassium ion transmembrane transport (ortholog); positive regulation of potassium ion transport (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosi s (ortholog); autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 33 (ortholog); FOUND IN cell surface (ortholog); neuronal cell body (ortholog); synapse (ortholog) | NW_004936527 | 8574455 | 9423445 | Squirrel | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14230784 | DPP6 | dipeptidyl peptidase like 6 | ENCODES a protein that exhibits dipeptidyl-peptidase activity (ortholog); INVOLVED IN neuronal action potential (ortholog); positive regulation of potassium ion transmembrane transport (ortholog); positive regulation of potassium ion transport (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosi s (ortholog); autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 33 (ortholog); FOUND IN cell surface (ortholog); neuronal cell body (ortholog); synapse (ortholog) | | | | Pig | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18596362 | DPP6 | dipeptidyl peptidase like 6 | ENCODES a protein that exhibits dipeptidyl-peptidase activity (ortholog); INVOLVED IN neuronal action potential (ortholog); positive regulation of potassium ion transmembrane transport (ortholog); positive regulation of potassium ion transport (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosi s (ortholog); autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 33 (ortholog); FOUND IN cell surface (ortholog); neuronal cell body (ortholog); synapse (ortholog) | | | | Green Monkey | 50 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18927639 | Dpp6 | dipeptidyl peptidase like 6 | ENCODES a protein that exhibits dipeptidyl-peptidase activity (ortholog); INVOLVED IN neuronal action potential (ortholog); positive regulation of potassium ion transmembrane transport (ortholog); positive regulation of potassium ion transport (ortholog); ASSOCIATED WITH autism spectrum disorder (or tholog); autosomal dominant intellectual developmental disorder 33 (ortholog); cardiac arrest (ortholog); FOUND IN cell surface (ortholog); membrane (ortholog); neuronal cell body (ortholog) | | | | Naked Mole-Rat | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249341 | dpp6 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626023726 | Dpp6 | dipeptidyl peptidase like 6 | ENCODES a protein that exhibits dipeptidyl-peptidase activity (ortholog); potassium channel regulator activity (ortholog); INVOLVED IN neuronal action potential (ortholog); positive regulation of potassium ion transmembrane transport (ortholog); positive regulation of potassium ion transport (orthol og); ASSOCIATED WITH autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 33 (ortholog); cardiac arrest (ortholog); FOUND IN cell surface (ortholog); membrane (ortholog); neuronal cell body (ortholog) | | | | Black Rat | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405856765 | dpp6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859176 | dpp6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860719 | dpp6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863083 | dpp6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626185295 | dpp6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856443 | dpp6.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858415 | dpp6.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859097 | dpp6.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863716 | dpp6.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626171150 | dpp6.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626181488 | dpp6.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 597621581 | DPP6-AS1 | DPP6 antisense RNA 1 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna |
| 16571576 | AC024730.1 | novel transcript, antisense to DPP6 | | | | | Human | | name | gene, lncrna |
| 16567911 | AC092666.2 | dipeptidyl-peptidase 6 (DPP6) pseudogene | | | | | Human | | name | gene, unprocessed_pseudogene |
