| 2489 | Dbh | dopamine beta-hydroxylase | ENCODES a protein that exhibits copper ion binding; dopamine beta-monooxygenase activity; INVOLVED IN bone development; cellular response to manganese ion; cellular response to nicotine; PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosy nthetic pathway; ASSOCIATED WITH Anorexia; brain ischemia; Contusions; FOUND IN apical part of cell; axon; dendrite; INTERACTS WITH 2,4-D; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil | 3 | 30886313 | 30903313 | Rat | 258 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 10460 | Dbh | dopamine beta hydroxylase | Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Involved in catecholamine metabolic process; locomotory behavior; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including behavioral response to ethanol; h omoiothermy; and learning or memory. Located in secretory granule lumen and secretory granule membrane. Is expressed in several structures, including adrenal gland; alimentary system; and nervous system. Used to study dopamine beta-hydroxylase deficiency. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 27055519 | 27073216 | Mouse | 337 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 736659 | DBH | dopamine beta-hydroxylase | The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which func tions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. [provided by RefSeq, Aug 2017] | 9 | 133636363 | 133659329 | Human | 311 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9038569 | Dbh | dopamine beta-hydroxylase | ENCODES a protein that exhibits copper ion binding (ortholog); dopamine beta-monooxygenase activity (ortholog); INVOLVED IN associative learning (ortholog); behavioral response to ethanol (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid deca rboxylase deficiency pathway; catecholamine biosynthetic pathway; ASSOCIATED WITH Anorexia (ortholog); attention deficit hyperactivity disorder (ortholog); brain ischemia (ortholog); FOUND IN apical part of cell (ortholog); axon (ortholog); dendrite (ortholog) | NW_004955513 | 2918085 | 2932481 | Chinchilla | 92 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11833519 | DBH | dopamine beta-hydroxylase | ENCODES a protein that exhibits copper ion binding (ortholog); dopamine beta-monooxygenase activity (ortholog); INVOLVED IN associative learning (ortholog); behavioral response to ethanol (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid deca rboxylase deficiency pathway; catecholamine biosynthetic pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Anorexia (ortholog); attention deficit hyperactivity disorder (ortholog); FOUND IN apical part of cell (ortholog); axon (ortholog); dendrite (ortholog) | 9 | 104761504 | 104784445 | Bonobo | 111 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12363704 | DBH | dopamine beta-hydroxylase | ENCODES a protein that exhibits copper ion binding (ortholog); dopamine beta-monooxygenase activity (ortholog); INVOLVED IN associative learning (ortholog); behavioral response to ethanol (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid deca rboxylase deficiency pathway; catecholamine biosynthetic pathway; ASSOCIATED WITH Anorexia (ortholog); attention deficit hyperactivity disorder (ortholog); brain ischemia (ortholog); FOUND IN apical part of cell (ortholog); axon (ortholog); dendrite (ortholog) | 9 | 50004806 | 50024130 | Dog | 122 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12554623 | Dbh | dopamine beta-hydroxylase | ENCODES a protein that exhibits copper ion binding (ortholog); dopamine beta-monooxygenase activity (ortholog); INVOLVED IN associative learning (ortholog); behavioral response to ethanol (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid deca rboxylase deficiency pathway; catecholamine biosynthetic pathway; ASSOCIATED WITH Anorexia (ortholog); attention deficit hyperactivity disorder (ortholog); brain ischemia (ortholog); FOUND IN apical part of cell (ortholog); axon (ortholog); dendrite (ortholog) | NW_004936669 | 3302014 | 3326233 | Squirrel | 111 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14229673 | DBH | dopamine beta-hydroxylase | ENCODES a protein that exhibits copper ion binding (ortholog); dopamine beta-monooxygenase activity (ortholog); INVOLVED IN associative learning (ortholog); behavioral response to ethanol (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid deca rboxylase deficiency pathway; catecholamine biosynthetic pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Anorexia (ortholog); attention deficit hyperactivity disorder (ortholog); FOUND IN apical part of cell (ortholog); axon (ortholog); dendrite (ortholog); INTERACTS WITH bisphenol A; deoxynivalenol | | | | Pig | 113 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18678850 | DBH | dopamine beta-hydroxylase | ENCODES a protein that exhibits copper ion binding (ortholog); dopamine beta-monooxygenase activity (ortholog); INVOLVED IN associative learning (ortholog); behavioral response to ethanol (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid deca rboxylase deficiency pathway; catecholamine biosynthetic pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Anorexia (ortholog); attention deficit hyperactivity disorder (ortholog); FOUND IN apical part of cell (ortholog); axon (ortholog); dendrite (ortholog) | | | | Green Monkey | 111 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18904204 | Dbh | dopamine beta-hydroxylase | ENCODES a protein that exhibits copper ion binding (ortholog); dopamine beta-monooxygenase activity (ortholog); INVOLVED IN associative learning (ortholog); behavioral response to ethanol (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid deca rboxylase deficiency pathway; catecholamine biosynthetic pathway; ASSOCIATED WITH Anorexia (ortholog); attention deficit hyperactivity disorder (ortholog); brain ischemia (ortholog); FOUND IN apical part of cell (ortholog); axon (ortholog); dendrite (ortholog) | | | | Naked Mole-Rat | 106 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155231689 | dbh | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625910629 | Dbh | dopamine beta-hydroxylase | ENCODES a protein that exhibits copper ion binding (ortholog); dopamine beta-monooxygenase activity (ortholog); INVOLVED IN associative learning (ortholog); behavioral response to ethanol (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid deca rboxylase deficiency pathway; catecholamine biosynthetic pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Anorexia (ortholog); attention deficit hyperactivity disorder (ortholog); FOUND IN apical part of cell (ortholog); axon (ortholog); dendrite (ortholog) | | | | Black Rat | 92 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155231690 | dbh.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155232276 | dbh.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2301570 | DBH-AS1 | DBH antisense RNA 1 | INTERACTS WITH aflatoxin B1; benzo[a]pyrene; beta-lapachone | 9 | 133654587 | 133657408 | Human | 15 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 9666926 | Gm13398 | predicted gene 13398 | | 2 | 26926691 | 26930870 | Mouse | | old_gene_symbol | gene, ncrna, MODEL [RefSeq] |
| 1320700 | MOXD1 | monooxygenase DBH like 1 | Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Predicted to be involved in dopamine catabolic process; norepinephrine biosynthetic process; and octopamine biosynthetic process. Part of endoplasmic reticulum membrane. [provided by Alliance of Genome Resource s, Jul 2025] | 6 | 132296055 | 132401475 | Human | 111 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 8845489 | Moxd1 | monooxygenase DBH like 1 | ASSOCIATED WITH silicosis (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) | NW_004955436 | 12818375 | 12872229 | Chinchilla | 4 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11906363 | MOXD1 | monooxygenase DBH like 1 | ENCODES a protein that exhibits catalytic activity (inferred); copper ion binding (inferred); dopamine beta-monooxygenase activity (inferred); INVOLVED IN dopamine catabolic process (inferred); norepinephrine biosynthetic process (inferred); octopamine biosynthetic process (inferred); ASSOCIATED WIT H silicosis (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); extracellular space (inferred); secretory granule membrane (inferred) | 6 | 130073802 | 130177753 | Bonobo | 20 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12345115 | MOXD1 | monooxygenase DBH like 1 | ENCODES a protein that exhibits catalytic activity (inferred); copper ion binding (inferred); dopamine beta-monooxygenase activity (inferred); ASSOCIATED WITH silicosis (ortholog); FOUND IN endoplasmic reticulum membrane (inferred) | 1 | 25018452 | 25114028 | Dog | 20 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12721074 | Moxd1 | monooxygenase DBH like 1 | ENCODES a protein that exhibits catalytic activity (inferred); copper ion binding (inferred); dopamine beta-monooxygenase activity (inferred); INVOLVED IN dopamine catabolic process (inferred); norepinephrine biosynthetic process (inferred); octopamine biosynthetic process (inferred); ASSOCIATED WIT H silicosis (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); extracellular space (inferred); secretory granule membrane (inferred) | NW_004936560 | 334294 | 413559 | Squirrel | 20 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14138789 | MOXD1 | monooxygenase DBH like 1 | ENCODES a protein that exhibits catalytic activity (inferred); copper ion binding (inferred); dopamine beta-monooxygenase activity (inferred); ASSOCIATED WITH silicosis (ortholog); FOUND IN endoplasmic reticulum membrane (inferred) | | | | Pig | 20 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18718567 | MOXD1 | monooxygenase DBH like 1 | ENCODES a protein that exhibits catalytic activity (inferred); copper ion binding (inferred); dopamine beta-monooxygenase activity (inferred); INVOLVED IN dopamine catabolic process (inferred); norepinephrine biosynthetic process (inferred); octopamine biosynthetic process (inferred); ASSOCIATED WIT H silicosis (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); extracellular space (inferred); secretory granule membrane (inferred) | | | | Green Monkey | 20 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18935307 | Moxd1 | monooxygenase DBH like 1 | ENCODES a protein that exhibits catalytic activity (inferred); copper ion binding (inferred); dopamine beta-monooxygenase activity (inferred); INVOLVED IN dopamine catabolic process (inferred); norepinephrine biosynthetic process (inferred); octopamine biosynthetic process (inferred); ASSOCIATED WIT H silicosis (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) | | | | Naked Mole-Rat | 20 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 20867292 | MOXD1 | monooxygenase DBH like 1 | | | | | Green Monkey | | name | gene, protein-coding |
| 625935197 | Moxd1 | monooxygenase DBH like 1 | ASSOCIATED WITH silicosis (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog) | | | | Black Rat | 4 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12068592 | MOXD2 | monooxygenase DBH like 2 | ENCODES a protein that exhibits catalytic activity (inferred); copper ion binding (inferred); dopamine beta-monooxygenase activity (inferred); ASSOCIATED WITH hypertension (ortholog) | 16 | 7019646 | 7042005 | Dog | 16 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14268242 | MOXD2 | monooxygenase DBH like 2 | ENCODES a protein that exhibits catalytic activity (inferred); copper ion binding (inferred); dopamine beta-monooxygenase activity (inferred); ASSOCIATED WITH hypertension (ortholog) | | | | Pig | 16 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1310033 | Moxd1 | monooxygenase, DBH-like 1 | ENCODES a protein that exhibits catalytic activity (inferred); copper ion binding (inferred); dopamine beta-monooxygenase activity (inferred); ASSOCIATED WITH silicosis (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 1 | 22894543 | 22984599 | Rat | 106 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1320701 | Moxd1 | monooxygenase, DBH-like 1 | Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Predicted to be involved in dopamine catabolic process; norepinephrine biosynthetic process; and octopamine biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be activ e in extracellular space and secretory granule membrane. Is expressed in several structures, including brain; exocrine gland; genitourinary system; respiratory system; and sensory organ. Orthologous to human MOXD1 (monooxygenase DBH like 1). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 24099415 | 24178681 | Mouse | 115 | old_gene_name , name , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1558176 | Moxd2 | monooxygenase, DBH-like 2 | Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Predicted to be involved in dopamine catabolic process; norepinephrine biosynthetic process; and octopamine biosynthetic process. Predicted to be located in membrane. Predicted to be active in extracellular spa ce and secretory granule membrane. Orthologous to human MOXD2P (monooxygenase DBH like 2, pseudogene). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 40855728 | 40864428 | Mouse | 24 | old_gene_name , name , description , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1564286 | Moxd2 | monooxygenase, DBH-like 2 | ENCODES a protein that exhibits catalytic activity (inferred); copper ion binding (inferred); dopamine beta-monooxygenase activity (inferred); ASSOCIATED WITH hypertension (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; alachlor; bisphenol A | 4 | 70691373 | 70699868 | Rat | 23 | name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 626076652 | LOC116902695 | DBH-like monooxygenase protein 2 | | | | | Black Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 16563051 | AC002101.1 | novel transcript, antisense to DBH | | | | | Human | | name | gene, lncrna |
| 1641965 | MOXD2P | monooxygenase DBH like 2, pseudogene | Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Predicted to be involved in dopamine catabolic process; norepinephrine biosynthetic process; and octopamine biosynthetic process. Predicted to be active in extracellular space and secretory granule membrane. [p rovided by Alliance of Genome Resources, Jul 2025] | 7 | 142240737 | 142247067 | Human | 23 | old_gene_name , name | gene, pseudo, VALIDATED [RefSeq] |
| 11907777 | LOC100991710 | putative DBH-like monooxygenase protein 2 | | 7 | 134166566 | 134174624 | Bonobo | | name | gene, protein-coding, MODEL [RefSeq] |
| 18928796 | LOC101701601 | putative DBH-like monooxygenase protein 2 | ENCODES a protein that exhibits catalytic activity (inferred); copper ion binding (inferred); dopamine beta-monooxygenase activity (inferred); INVOLVED IN dopamine catabolic process (inferred); norepinephrine biosynthetic process (inferred); octopamine biosynthetic process (inferred); FOUND IN extra cellular space (inferred); secretory granule membrane (inferred) | | | | Naked Mole-Rat | 15 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18923439 | LOC101711916 | putative DBH-like monooxygenase protein 2 | ENCODES a protein that exhibits catalytic activity (inferred); copper ion binding (inferred); dopamine beta-monooxygenase activity (inferred); INVOLVED IN dopamine catabolic process (inferred); norepinephrine biosynthetic process (inferred); octopamine biosynthetic process (inferred); FOUND IN extra cellular space (inferred); secretory granule membrane (inferred) | | | | Naked Mole-Rat | 15 | name | gene, protein-coding, MODEL [RefSeq] |
| 12585356 | LOC101967457 | putative DBH-like monooxygenase protein 2 | ENCODES a protein that exhibits catalytic activity (inferred); copper ion binding (inferred); dopamine beta-monooxygenase activity (inferred); INVOLVED IN dopamine catabolic process (inferred); norepinephrine biosynthetic process (inferred); octopamine biosynthetic process (inferred); FOUND IN extra cellular space (inferred); secretory granule membrane (inferred) | NW_004936971 | 172262 | 179921 | Squirrel | 15 | name | gene, protein-coding, MODEL [RefSeq] |
| 8953690 | LOC102012212 | putative DBH-like monooxygenase protein 2 | | NW_004955494 | 1292620 | 1301008 | Chinchilla | | name | gene, protein-coding, MODEL [RefSeq] |
| 18444248 | LOC103227050 | putative DBH-like monooxygenase protein 2 | | | | | Green Monkey | | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14128982 | LOC110257568 | putative DBH-like monooxygenase protein 2 | | | | | Pig | | name | gene, protein-coding, MODEL [RefSeq] |
| 7180882 | Dbhos | dopamine beta hydroxylase, opposite strand | INTERACTS WITH bisphenol A | 2 | 27034910 | 27052715 | Mouse | 4 | symbol , PhenoGen | gene, ncrna, VALIDATED [RefSeq] |