Moxd2 (monooxygenase, DBH-like 2) - Rat Genome Database

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Gene: Moxd2 (monooxygenase, DBH-like 2) Mus musculus
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Symbol: Moxd2
Name: monooxygenase, DBH-like 2
RGD ID: 1558176
MGI Page MGI
Description: Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Predicted to be involved in dopamine catabolic process; norepinephrine biosynthetic process; and octopamine biosynthetic process. Predicted to be located in membrane. Predicted to be active in extracellular space and secretory granule membrane. Orthologous to human MOXD2P (monooxygenase DBH like 2, pseudogene).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DBH-like monooxygenase protein 2; Dbhl; Dbhl1; dopamine beta-hydroxylase-like 1; dopamine-beta-hydroxylase; dopamine-beta-hydroxylase-like protein
RGD Orthologs
Human
Rat
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39640,855,728 - 40,864,428 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl640,855,728 - 40,864,428 (-)EnsemblGRCm39 Ensembl
GRCm38640,878,794 - 40,887,494 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl640,878,794 - 40,887,494 (-)EnsemblGRCm38mm10GRCm38
MGSCv37640,828,793 - 40,837,493 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36640,808,401 - 40,817,101 (-)NCBIMGSCv36mm8
Celera640,865,046 - 40,873,746 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map618.92NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
hypertension  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11160223   PMID:21267068   PMID:21677750   PMID:21873635  


Genomics

Comparative Map Data
Moxd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39640,855,728 - 40,864,428 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl640,855,728 - 40,864,428 (-)EnsemblGRCm39 Ensembl
GRCm38640,878,794 - 40,887,494 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl640,878,794 - 40,887,494 (-)EnsemblGRCm38mm10GRCm38
MGSCv37640,828,793 - 40,837,493 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36640,808,401 - 40,817,101 (-)NCBIMGSCv36mm8
Celera640,865,046 - 40,873,746 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map618.92NCBI
MOXD2P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387142,240,737 - 142,247,067 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7142,240,740 - 142,247,067 (-)EnsemblGRCh38hg38GRCh38
GRCh377141,940,556 - 141,946,886 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367141,587,033 - 141,593,382 (+)NCBINCBI36Build 36hg18NCBI36
Celera7136,718,050 - 136,724,380 (-)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7136,235,297 - 136,241,627 (-)NCBIHuRef
CHM1_17141,874,709 - 141,881,039 (-)NCBICHM1_1
T2T-CHM13v2.07143,555,786 - 143,562,117 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27141,278,759 - 141,285,091 (-)NCBI
Moxd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8470,691,373 - 70,699,868 (-)NCBIGRCr8
mRatBN7.2469,724,693 - 69,733,188 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl469,724,239 - 69,733,299 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx474,648,079 - 74,656,571 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0470,569,220 - 70,577,712 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0468,982,774 - 68,991,265 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0469,117,477 - 69,125,972 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl469,117,477 - 69,125,972 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04133,906,617 - 133,915,610 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4468,505,742 - 68,514,237 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera464,715,240 - 64,723,735 (-)NCBICelera
Cytogenetic Map4q23NCBI
MOXD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1167,019,646 - 7,042,005 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha167,878,452 - 7,900,885 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0166,940,707 - 6,963,133 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl166,941,194 - 6,963,034 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1166,894,193 - 6,904,823 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0166,735,320 - 6,745,957 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0166,804,208 - 6,826,638 (+)NCBIUU_Cfam_GSD_1.0
MOXD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1187,742,254 - 7,751,098 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2188,009,635 - 8,019,554 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:77
Interacting mature miRNAs:80
Transcripts:ENSMUST00000031937
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
11252142Mom12_mModifier of Min 12 (mouse)63387226167872400Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63387226167872400Mouse
1300767Aliq4_macute lung injury QTL 4 (mouse)Not determined63627333270273435Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
14746995Manh60_mmandible shape 60 (mouse)63720266271202662Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
4141094Hrtr1_mheart rate 1 (mouse)Not determined3674146370741463Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2829099362291115Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3282758578215957Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63267698066676980Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3170349965703611Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
1357539Bsbob3_mBSB obesity 3 (mouse)Not determined63644845670448576Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000031937   ⟹   ENSMUSP00000031937
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl640,855,728 - 40,864,428 (-)Ensembl
GRCm38.p6 Ensembl640,878,794 - 40,887,494 (-)Ensembl
RefSeq Acc Id: NM_139296   ⟹   NP_647457
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39640,855,728 - 40,864,428 (-)NCBI
GRCm38640,878,794 - 40,887,494 (-)ENTREZGENE
MGSCv37640,828,793 - 40,837,493 (-)RGD
Celera640,865,046 - 40,873,746 (-)RGD
cM Map6 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_647457 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB69054 (Get FASTA)   NCBI Sequence Viewer  
  BAB62024 (Get FASTA)   NCBI Sequence Viewer  
  EDL13566 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000031937
  ENSMUSP00000031937.4
GenBank Protein Q7TT41 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_647457   ⟸   NM_139296
- Peptide Label: precursor
- UniProtKB: Q91XT2 (UniProtKB/Swiss-Prot),   Q7TT41 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000031937   ⟸   ENSMUST00000031937
Protein Domains
DOMON

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TT41-F1-model_v2 AlphaFold Q7TT41 1-619 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2388042 AgrOrtholog
Ensembl Genes ENSMUSG00000029885 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000031937 ENTREZGENE
  ENSMUST00000031937.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.230 UniProtKB/Swiss-Prot
  2.60.120.310 UniProtKB/Swiss-Prot
InterPro Cu2_ascorb_mOase-like_C UniProtKB/Swiss-Prot
  Cu2_ascorb_mOase_N UniProtKB/Swiss-Prot
  Cu2_ascorb_mOase_N_sf UniProtKB/Swiss-Prot
  Cu2_monoox_C UniProtKB/Swiss-Prot
  DBH-like UniProtKB/Swiss-Prot
  DOH_DOMON UniProtKB/Swiss-Prot
  DOMON_domain UniProtKB/Swiss-Prot
  PHM/PNGase_F_dom_sf UniProtKB/Swiss-Prot
  Tbh/DBH UniProtKB/Swiss-Prot
KEGG Report mmu:194357 UniProtKB/Swiss-Prot
MGD MGI:2388042 ENTREZGENE
NCBI Gene 194357 ENTREZGENE
PANTHER PTHR10157 UniProtKB/Swiss-Prot
  PTHR10157:SF31 UniProtKB/Swiss-Prot
Pfam Cu2_monoox_C UniProtKB/Swiss-Prot
  Cu2_monooxygen UniProtKB/Swiss-Prot
  DOMON UniProtKB/Swiss-Prot
PhenoGen Moxd2 PhenoGen
PRINTS DBMONOXGNASE UniProtKB/Swiss-Prot
PROSITE DOMON UniProtKB/Swiss-Prot
SMART DoH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49742 UniProtKB/Swiss-Prot
UniProt MOXD2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q91XT2 ENTREZGENE
UniProt Secondary Q91XT2 UniProtKB/Swiss-Prot