| 621138 | Dao | D-amino-acid oxidase | ENCODES a protein that exhibits D-amino-acid dehydrogenase activity (ortholog); D-amino-acid oxidase activity (ortholog); FAD binding (ortholog); INVOLVED IN D-alanine catabolic process (ortholog); D-amino acid catabolic process (ortholog); D-serine catabolic process (ortholog); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); autistic disorder (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN peroxisomal matrix; presynaptic active zone; cytoplasm (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine | 12 | 48252900 | 48275964 | Rat | 203 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 731443 | Dao | D-amino acid oxidase | Enables D-amino-acid dehydrogenase activity; D-amino-acid oxidase activity; and FAD binding activity. Involved in several processes, including D-alanine catabolic process; dopamine biosynthetic process; and neutrophil-mediated killing of gram-negative bacterium. Acts upstream of or within L-leucine metabolic process. Located in extracellular space and peroxisomal matrix. Is expressed in metanephros; renal cortex; ureter; and urinary system. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human DAO (D-amino acid oxidase). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 114137696 | 114163736 | Mouse | 209 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1350103 | DAO | D-amino acid oxidase | This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological functi on is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008] | 12 | 108880092 | 108901043 | Human | 238 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8718955 | Dao | D-amino acid oxidase | ENCODES a protein that exhibits D-amino-acid dehydrogenase activity (ortholog); D-amino-acid oxidase activity (ortholog); FAD binding (ortholog); INVOLVED IN D-alanine catabolic process (ortholog); D-amino acid catabolic process (ortholog); D-serine catabolic process (ortholog); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); autistic disorder (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); extracellular space (ortholog) | NW_004955455 | 10095597 | 10127244 | Chinchilla | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11782789 | DAO | D-amino acid oxidase | ENCODES a protein that exhibits D-amino-acid dehydrogenase activity (ortholog); identical protein binding (ortholog); INVOLVED IN D-serine metabolic process (ortholog); digestion (ortholog); killing by host of symbiont cells (ortholog); PARTICIPATES IN AGAT deficiency pathway; arginine and proline m etabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); autistic disorder (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN extracellular space (ortholog); mitochondrial outer membrane (ortholog) | 12 | 106453807 | 106475409 | Bonobo | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12225830 | DAO | D-amino acid oxidase | ENCODES a protein that exhibits D-amino-acid dehydrogenase activity (inferred); D-amino-acid oxidase activity (inferred); FAD binding (inferred); INVOLVED IN L-leucine metabolic process (ortholog); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate meth yltransferase deficiency pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); autistic disorder (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); extracellular region (inferred); INTERACTS WITH digoxin; Doramectin; ivermectin | 26 | 18032663 | 18057277 | Dog | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12702601 | Dao | D-amino acid oxidase | ENCODES a protein that exhibits D-amino-acid dehydrogenase activity (inferred); D-amino-acid oxidase activity (inferred); FAD binding (inferred); INVOLVED IN L-leucine metabolic process (ortholog); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate meth yltransferase deficiency pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); autistic disorder (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); extracellular region (inferred) | NW_004936769 | 744862 | 758086 | Squirrel | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18936466 | Dao | D-amino acid oxidase | ENCODES a protein that exhibits D-amino-acid dehydrogenase activity (ortholog); identical protein binding (ortholog); INVOLVED IN D-serine metabolic process (ortholog); digestion (ortholog); killing by host of symbiont cells (ortholog); PARTICIPATES IN AGAT deficiency pathway; arginine and proline m etabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); autistic disorder (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN extracellular space (ortholog); mitochondrial outer membrane (ortholog) | | | | Naked Mole-Rat | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245858 | dao | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625869148 | Dao | D-amino acid oxidase | ENCODES a protein that exhibits D-amino-acid dehydrogenase activity (ortholog); D-amino-acid oxidase activity (ortholog); FAD binding (ortholog); INVOLVED IN D-alanine catabolic process (ortholog); D-amino acid catabolic process (ortholog); D-serine catabolic process (ortholog); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); autistic disorder (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); extracellular space (ortholog) | | | | Black Rat | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14171512 | DAO | D-amino acid oxidase | ENCODES a protein that exhibits D-amino-acid oxidase activity; INVOLVED IN D-amino acid catabolic process; neutrophil-mediated killing of gram-negative bacterium; digestion (ortholog); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); autistic disorder (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN peroxisomal matrix; peroxisome (ortholog); presynaptic active zone (ortholog); INTERACTS WITH 5-methyl-pyrazole-3-carboxylic acid; chlorpromazine; copper(II) sulfate | | | | Pig | 73 | symbol , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18550678 | DAO | D-amino acid oxidase | ENCODES a protein that exhibits D-amino-acid dehydrogenase activity (inferred); D-amino-acid oxidase activity (inferred); FAD binding (inferred); INVOLVED IN L-leucine metabolic process (ortholog); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate meth yltransferase deficiency pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); autistic disorder (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); extracellular region (inferred) | | | | Green Monkey | 60 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 25826005 | dao | | | | | | Fly | | symbol | gene, null |
| 14375191 | dao-3 | | | | | | Roundworm | | symbol | gene, null |
| 14382873 | dao-5 | | | | | | Roundworm | | symbol | gene, null |
| 155235815 | dao.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 61296 | Aoc1 | amine oxidase, copper containing 1 | ENCODES a protein that exhibits diamine oxidase activity; putrescine oxidase activity; calcium ion binding (ortholog); INVOLVED IN putrescine metabolic process (ortholog); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; ASSOCIA TED WITH Experimental Diabetes Mellitus; autism spectrum disorder (ortholog); Cardiomegaly (ortholog); FOUND IN bicellular tight junction; extracellular exosome (ortholog); extracellular space (ortholog); INTERACTS WITH (R)-adrenaline; (S)-timolol (anhydrous); 1-naphthyl isothiocyanate | 4 | 79143126 | 79162705 | Rat | 195 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 732341 | AOC1 | amine oxidase copper containing 1 | This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013] | 7 | 150852120 | 150861504 | Human | 186 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 732342 | Aoc1 | amine oxidase, copper-containing 1 | Predicted to enable several functions, including heparin binding activity; metal ion binding activity; and oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. Predicted to be involved in putrescine metabolic process. Predicted to be located in bicellular tight junction and extracellular exosome. Predicted to be active in plasma membrane. Is expressed in mesonephros and urinary system. Orthologous to human AOC1 (amine oxidase copper containing 1). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 48872189 | 48886122 | Mouse | 197 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 13918368 | AOC1 | amine oxidase copper containing 1 | ENCODES a protein that exhibits diamine oxidase activity; primary methylamine oxidase activity; putrescine oxidase activity; INVOLVED IN putrescine metabolic process; PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; ASSOCIATED W ITH autism spectrum disorder (ortholog); Cardiomegaly (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN plasma membrane; bicellular tight junction (ortholog); extracellular space (ortholog); INTERACTS WITH cobalt dichloride; copper(II) chloride; glutathione | | | | Pig | 62 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1349838 | DAOA | D-amino acid oxidase activator | This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Mar 2011] | 13 | 105465867 | 105491034 | Human | 27 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 11668001 | DAOA | D-amino acid oxidase activator | INVOLVED IN D-amino acid metabolic process (ortholog); positive regulation of protein catabolic process (ortholog); ASSOCIATED WITH bipolar disorder (ortholog); schizophrenia (ortholog); FOUND IN Golgi apparatus (ortholog); mitochondrion (ortholog); perinuclear region of cytoplasm (ortholog) | 13 | 86607991 | 86631776 | Bonobo | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 40898463 | DAOA | D-amino acid oxidase activator | INVOLVED IN D-amino acid metabolic process (ortholog); positive regulation of protein catabolic process (ortholog); ASSOCIATED WITH bipolar disorder (ortholog); schizophrenia (ortholog); FOUND IN Golgi apparatus (ortholog); mitochondrion (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Green Monkey | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 4107151 | DAOA-AS1 | DAOA antisense RNA 1 | INTERACTS WITH aflatoxin B1; benzo[a]pyrene; benzo[e]pyrene | 13 | 105459055 | 105505681 | Human | 5 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 1344698 | AOC2 | amine oxidase copper containing 2 | Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved m otifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] | 17 | 42844580 | 42850707 | Human | 80 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |