DAO (D-amino acid oxidase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: DAO (D-amino acid oxidase) Canis lupus familiaris
Analyze
Symbol: DAO
Name: D-amino acid oxidase
RGD ID: 12225830
Description: ENCODES a protein that exhibits D-amino-acid dehydrogenase activity (ortholog); INVOLVED IN digestion (ortholog); killing by host of symbiont cells (ortholog); L-leucine metabolic process (ortholog); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); autistic disorder (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN extracellular space (ortholog); presynaptic active zone (ortholog); INTERACTS WITH digoxin; Doramectin; ivermectin
Type: protein-coding
RefSeq Status: MODEL
Previously known as: D-amino-acid oxidase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12618,032,663 - 18,057,277 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2618,033,392 - 18,057,238 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2617,744,673 - 17,773,938 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02618,371,860 - 18,401,188 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2618,376,518 - 18,395,445 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12617,954,290 - 17,983,467 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02618,362,722 - 18,391,870 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02618,381,507 - 18,410,821 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
digoxin  (EXP)
Doramectin  (EXP)
ivermectin  (EXP)
milbemycin  (EXP)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DAO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12618,032,663 - 18,057,277 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2618,033,392 - 18,057,238 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2617,744,673 - 17,773,938 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02618,371,860 - 18,401,188 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2618,376,518 - 18,395,445 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12617,954,290 - 17,983,467 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02618,362,722 - 18,391,870 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02618,381,507 - 18,410,821 (-)NCBIUU_Cfam_GSD_1.0
DAO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812108,880,092 - 108,901,043 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12108,858,932 - 108,901,043 (+)EnsemblGRCh38hg38GRCh38
GRCh3712109,273,868 - 109,294,819 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612107,797,986 - 107,818,839 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412107,776,332 - 107,797,162NCBI
Celera12108,942,740 - 108,963,590 (+)NCBICelera
Cytogenetic Map12q24.11NCBI
HuRef12106,338,463 - 106,359,320 (+)NCBIHuRef
CHM1_112109,241,476 - 109,262,347 (+)NCBICHM1_1
T2T-CHM13v2.012108,854,786 - 108,875,798 (+)NCBIT2T-CHM13v2.0
Dao
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395114,137,696 - 114,163,736 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5114,141,764 - 114,163,743 (+)EnsemblGRCm39 Ensembl
GRCm385113,999,635 - 114,025,675 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5114,003,703 - 114,025,682 (+)EnsemblGRCm38mm10GRCm38
MGSCv375114,453,835 - 114,475,469 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365114,270,835 - 114,285,905 (+)NCBIMGSCv36mm8
Celera5111,106,565 - 111,127,023 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.93NCBI
Dao
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81248,252,900 - 48,275,964 (-)NCBIGRCr8
mRatBN7.21242,592,342 - 42,613,046 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,592,343 - 42,612,741 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1243,758,494 - 43,778,668 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01244,372,084 - 44,392,254 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,432,603 - 43,452,773 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,353,691 - 48,373,647 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,354,196 - 48,365,784 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01250,135,334 - 50,157,417 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,627,593 - 43,648,332 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11243,490,980 - 43,511,720 (-)NCBI
Celera1244,196,549 - 44,215,768 (-)NCBICelera
Cytogenetic Map12q16NCBI
Dao
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545510,095,300 - 10,127,666 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545510,095,597 - 10,127,244 (+)NCBIChiLan1.0ChiLan1.0
DAO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210116,932,153 - 116,965,615 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112116,928,929 - 116,962,014 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012106,453,807 - 106,475,409 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112109,849,995 - 109,870,065 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12109,849,995 - 109,870,065 (+)Ensemblpanpan1.1panPan2
Dao
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118144,717,426 - 144,736,206 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936769744,864 - 758,452 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936769744,862 - 758,086 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1441,931,541 - 41,950,633 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11441,931,549 - 41,950,628 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21444,473,515 - 44,492,595 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap14q2.1-q2.3NCBI
DAO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111104,080,915 - 104,104,017 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11104,081,672 - 104,106,222 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037140,993,522 - 141,016,334 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dao
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474712,105,133 - 12,116,604 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474712,094,658 - 12,117,000 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DAO
391 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 6 6 5 6
Low 4 5 16 1 6 12 7 10 6
Below cutoff 6 1

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022410543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038437010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038437011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038459433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038511879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038511880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038575418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038575419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038639600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038639601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_543443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCAFT00000017842   ⟹   ENSCAFP00000016517
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2618,038,360 - 18,051,544 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000017850   ⟹   ENSCAFP00000016525
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2618,033,608 - 18,057,238 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000070975   ⟹   ENSCAFP00000051895
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2618,033,527 - 18,051,544 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000080355   ⟹   ENSCAFP00000055234
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2618,038,360 - 18,051,544 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000080542   ⟹   ENSCAFP00000066131
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2618,033,392 - 18,051,544 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845045360   ⟹   ENSCAFP00845035578
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2618,376,518 - 18,395,445 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845045449   ⟹   ENSCAFP00845035650
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2618,377,007 - 18,395,445 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845045571   ⟹   ENSCAFP00845035746
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2618,382,297 - 18,395,445 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845045676   ⟹   ENSCAFP00845035841
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2618,382,297 - 18,395,445 (-)Ensembl
RefSeq Acc Id: XM_038437010   ⟹   XP_038292938
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02618,381,406 - 18,401,188 (-)NCBI
RefSeq Acc Id: XM_038437011   ⟹   XP_038292939
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02618,371,860 - 18,401,188 (-)NCBI
RefSeq Acc Id: XM_038459433   ⟹   XP_038315361
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2617,744,673 - 17,773,938 (+)NCBI
RefSeq Acc Id: XM_038511879   ⟹   XP_038367807
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12617,954,290 - 17,973,968 (+)NCBI
RefSeq Acc Id: XM_038511880   ⟹   XP_038367808
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12617,954,290 - 17,983,467 (+)NCBI
RefSeq Acc Id: XM_038575418   ⟹   XP_038431346
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02618,391,051 - 18,410,821 (-)NCBI
RefSeq Acc Id: XM_038575419   ⟹   XP_038431347
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02618,381,507 - 18,410,821 (-)NCBI
RefSeq Acc Id: XM_038639600   ⟹   XP_038495528
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02618,372,241 - 18,391,870 (-)NCBI
RefSeq Acc Id: XM_038639601   ⟹   XP_038495529
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02618,362,722 - 18,391,870 (-)NCBI
RefSeq Acc Id: XM_543443   ⟹   XP_543443
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12618,037,463 - 18,057,261 (-)NCBI
Dog10K_Boxer_Tasha2617,744,673 - 17,764,420 (+)NCBI
Sequence:
RefSeq Acc Id: XP_543443   ⟸   XM_543443
- Peptide Label: isoform X1
- UniProtKB: A0A8C0THP9 (UniProtKB/TrEMBL),   A0A8P0NDF3 (UniProtKB/TrEMBL),   A0A8C0PSD3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000051895   ⟸   ENSCAFT00000070975
RefSeq Acc Id: ENSCAFP00000055234   ⟸   ENSCAFT00000080355
RefSeq Acc Id: ENSCAFP00000016517   ⟸   ENSCAFT00000017842
RefSeq Acc Id: ENSCAFP00000016525   ⟸   ENSCAFT00000017850
RefSeq Acc Id: ENSCAFP00000066131   ⟸   ENSCAFT00000080542
RefSeq Acc Id: XP_038367808   ⟸   XM_038511880
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038367807   ⟸   XM_038511879
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038495529   ⟸   XM_038639601
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038495528   ⟸   XM_038639600
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038292939   ⟸   XM_038437011
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PSD3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038292938   ⟸   XM_038437010
- Peptide Label: isoform X1
- UniProtKB: A0A8C0THP9 (UniProtKB/TrEMBL),   A0A8P0NDF3 (UniProtKB/TrEMBL),   A0A8C0PSD3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038315361   ⟸   XM_038459433
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PSD3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038431347   ⟸   XM_038575419
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PSD3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038431346   ⟸   XM_038575418
- Peptide Label: isoform X1
- UniProtKB: A0A8C0PSD3 (UniProtKB/TrEMBL),   A0A8C0THP9 (UniProtKB/TrEMBL),   A0A8P0NDF3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845035746   ⟸   ENSCAFT00845045571
RefSeq Acc Id: ENSCAFP00845035578   ⟸   ENSCAFT00845045360
RefSeq Acc Id: ENSCAFP00845035841   ⟸   ENSCAFT00845045676
RefSeq Acc Id: ENSCAFP00845035650   ⟸   ENSCAFT00845045449
Promoters
RGD ID:13687949
Promoter ID:EPDNEW_C6016
Type:initiation region
Name:DAO_1
Description:D-amino acid oxidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12618,057,203 - 18,057,263EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011224 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030026183 UniProtKB/TrEMBL
  ENSCAFG00040022184 UniProtKB/TrEMBL
  ENSCAFG00845025695 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000017842.6 UniProtKB/TrEMBL
  ENSCAFT00000080355.2 UniProtKB/TrEMBL
  ENSCAFT00030048465.1 UniProtKB/TrEMBL
  ENSCAFT00030048468.1 UniProtKB/TrEMBL
  ENSCAFT00040041208.1 UniProtKB/TrEMBL
  ENSCAFT00040041252.1 UniProtKB/TrEMBL
  ENSCAFT00845045360.1 UniProtKB/TrEMBL
  ENSCAFT00845045449.1 UniProtKB/TrEMBL
  ENSCAFT00845045571 ENTREZGENE
  ENSCAFT00845045571.1 UniProtKB/TrEMBL
  ENSCAFT00845045676.1 UniProtKB/TrEMBL
Gene3D-CATH D-Amino Acid Oxidase, subunit A, domain 2 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro D-amino_acid_oxidase_CS UniProtKB/TrEMBL
  DAO UniProtKB/TrEMBL
  FAD-dep_OxRdtase UniProtKB/TrEMBL
NCBI Gene DAO ENTREZGENE
PANTHER D-AMINO-ACID OXIDASE UniProtKB/TrEMBL
  PTHR11530 UniProtKB/TrEMBL
Pfam DAO UniProtKB/TrEMBL
PIRSF D-aa_oxidase UniProtKB/TrEMBL
PROSITE DAO UniProtKB/TrEMBL
Superfamily-SCOP FAD-linked reductases, C-terminal domain UniProtKB/TrEMBL
  Nucleotide-binding domain UniProtKB/TrEMBL
UniProt A0A8C0PIY9_CANLF UniProtKB/TrEMBL
  A0A8C0PSD3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0THP9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PRS5_CANLF UniProtKB/TrEMBL
  A0A8I3PRZ0_CANLF UniProtKB/TrEMBL
  A0A8I3PS36_CANLF UniProtKB/TrEMBL
  A0A8I3PWE9_CANLF UniProtKB/TrEMBL
  A0A8P0NDF3 ENTREZGENE
UniProt Secondary A0A8P0NDF3 UniProtKB/TrEMBL
VGNC ID VGNC:39768 ENTREZGENE