| 71016 | Cyp8b1 | cytochrome P450 family 8 subfamily B member 1 | ENCODES a protein that exhibits sterol 12-alpha-hydroxylase activity; INVOLVED IN response to cholesterol; response to nutrient levels; bile acid biosynthetic process (ortholog); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis de fect pathway; ASSOCIATED WITH extrahepatic cholestasis; Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); INTERACTS WITH (+)-schisandrin B; 1,3,7,9-tetramethyluric acid; 1-(3-(trifluoromethyl)phenyl)piperazine | 8 | 130455622 | 130457592 | Rat | 290 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732213 | Cyp8b1 | cytochrome P450, family 8, subfamily b, polypeptide 1 | Predicted to enable sterol 12-alpha-hydroxylase activity. Involved in bile acid biosynthetic process and positive regulation of intestinal cholesterol absorption. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including liver; lung; skeletal muscle; sp leen; and testis. Orthologous to human CYP8B1 (cytochrome P450 family 8 subfamily B member 1). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 121743422 | 121745371 | Mouse | 303 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 736649 | CYP8B1 | cytochrome P450 family 8 subfamily B member 1 | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conve rsion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless. [provided by RefSeq, Jul 2008] | 3 | 42872192 | 42875879 | Human | 302 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 11703542 | CYP8B1 | cytochrome P450 family 8 subfamily B member 1 | ENCODES a protein that exhibits sterol 12-alpha-hydroxylase activity (ortholog); INVOLVED IN positive regulation of intestinal cholesterol absorption (ortholog); response to cholesterol (ortholog); response to nutrient levels (ortholog); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendino us xanthomatosis pathway; congenital bile acid synthesis defect pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); extrahepatic cholestasis (ortholog); FOUND IN endoplasmic reticulum membrane (inferred) | 3 | 42775679 | 42779440 | Bonobo | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12062795 | CYP8B1 | cytochrome P450 family 8 subfamily B member 1 | ENCODES a protein that exhibits sterol 12-alpha-hydroxylase activity (ortholog); INVOLVED IN positive regulation of intestinal cholesterol absorption (ortholog); response to cholesterol (ortholog); response to nutrient levels (ortholog); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendino us xanthomatosis pathway; congenital bile acid synthesis defect pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); extrahepatic cholestasis (ortholog); FOUND IN endoplasmic reticulum membrane (inferred) | 23 | 11965685 | 11968994 | Dog | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13905714 | CYP8B1 | cytochrome P450 family 8 subfamily B member 1 | ENCODES a protein that exhibits sterol 12-alpha-hydroxylase activity; INVOLVED IN bile acid biosynthetic process; positive regulation of intestinal cholesterol absorption (ortholog); response to cholesterol (ortholog); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pa thway; congenital bile acid synthesis defect pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); extrahepatic cholestasis (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); INTERACTS WITH cadmium atom | | | | Pig | 35 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18366798 | CYP8B1 | cytochrome P450 family 8 subfamily B member 1 | ENCODES a protein that exhibits sterol 12-alpha-hydroxylase activity (ortholog); INVOLVED IN positive regulation of intestinal cholesterol absorption (ortholog); response to cholesterol (ortholog); response to nutrient levels (ortholog); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendino us xanthomatosis pathway; congenital bile acid synthesis defect pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); extrahepatic cholestasis (ortholog); FOUND IN endoplasmic reticulum membrane (inferred) | | | | Green Monkey | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243530 | cyp8b1.1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 285665693 | cyp8b1.2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596934939 | cyp8b1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596935784 | cyp8b1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596933613 | cyp8b1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596935512 | cyp8b1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155249058 | cyp8b1.1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155243529 | cyp8b1.1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 285666438 | cyp8b1.2.L | | | | | | African Clawed Frog | | symbol | gene, null |
