| 621392 | Ccn2 | cellular communication network factor 2 | ENCODES a protein that exhibits fibronectin binding; growth factor activity; heparin binding (ortholog); INVOLVED IN calcium ion transmembrane import into cytosol; cellular response to fatty acid; cellular response to glucose stimulus; PARTICIPATES IN transforming growth factor-beta Smad dependent s ignaling pathway; ASSOCIATED WITH aortic valve insufficiency; bone disease; Carotid Artery Injuries; FOUND IN cell cortex; extracellular space; perinuclear region of cytoplasm; INTERACTS WITH (R)-carnitine; (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane | 1 | 22621498 | 22624614 | Rat | 763 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 731013 | CCN2 | cellular communication network factor 2 | The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009] | 6 | 131948176 | 131951372 | Human | 846 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 731014 | Ccn2 | cellular communication network factor 2 | Enables heparin binding activity and integrin binding activity. Acts upstream of or within several processes, including cartilage development; cell surface receptor signaling pathway; and chondrocyte proliferation. Located in extracellular matrix and extracellular region. Is expressed in several str uctures, including alimentary system; cardiovascular system; central nervous system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Li-Shao-Li type. Orthologous to human CCN2 (cellular communication network factor 2). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 24471340 | 24474581 | Mouse | 866 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 9019253 | Ccn2 | cellular communication network factor 2 | ENCODES a protein that exhibits fibronectin binding (ortholog); growth factor activity (ortholog); heparin binding (ortholog); INVOLVED IN angiogenesis (ortholog); calcium ion transmembrane import into cytosol (ortholog); cartilage condensation (ortholog); PARTICIPATES IN transforming growth factor- beta Smad dependent signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Aggressive Fibromatosis (ortholog); aortic valve insufficiency (ortholog); FOUND IN cell cortex (ortholog); extracellular matrix (ortholog); extracellular region (ortholog) | NW_004955436 | 12523602 | 12526986 | Chinchilla | 124 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12046063 | CCN2 | cellular communication network factor 2 | ENCODES a protein that exhibits fibronectin binding (ortholog); growth factor activity (ortholog); INVOLVED IN angiogenesis (ortholog); calcium ion transmembrane import into cytosol (ortholog); cartilage condensation (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signalin g pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Aggressive Fibromatosis (ortholog); aortic valve insufficiency (ortholog); FOUND IN cell cortex (ortholog); extracellular space (ortholog); perinuclear region of cytoplasm (ortholog) | 6 | 129729572 | 129733113 | Bonobo | 139 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12141372 | CCN2 | cellular communication network factor 2 | ENCODES a protein that exhibits fibronectin binding (ortholog); growth factor activity (ortholog); INVOLVED IN angiogenesis (ortholog); calcium ion transmembrane import into cytosol (ortholog); cartilage condensation (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signalin g pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Aggressive Fibromatosis (ortholog); aortic valve insufficiency (ortholog); FOUND IN cell cortex (ortholog); extracellular space (ortholog); perinuclear region of cytoplasm (ortholog) | 1 | 25508082 | 25511058 | Dog | 138 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12636841 | Ccn2 | cellular communication network factor 2 | ENCODES a protein that exhibits fibronectin binding (ortholog); growth factor activity (ortholog); INVOLVED IN angiogenesis (ortholog); calcium ion transmembrane import into cytosol (ortholog); cartilage condensation (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signalin g pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Aggressive Fibromatosis (ortholog); aortic valve insufficiency (ortholog); FOUND IN cell cortex (ortholog); extracellular space (ortholog); perinuclear region of cytoplasm (ortholog) | NW_004936560 | 42561 | 45748 | Squirrel | 139 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 14020178 | CCN2 | cellular communication network factor 2 | ENCODES a protein that exhibits fibronectin binding (ortholog); growth factor activity (ortholog); INVOLVED IN angiogenesis (ortholog); calcium ion transmembrane import into cytosol (ortholog); cartilage condensation (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signalin g pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Aggressive Fibromatosis (ortholog); aortic valve insufficiency (ortholog); FOUND IN cell cortex (ortholog); extracellular space (ortholog); perinuclear region of cytoplasm (ortholog); INTERACTS WITH bis(2-chloroethyl) sulfide | | | | Pig | 142 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18900027 | Ccn2 | cellular communication network factor 2 | ENCODES a protein that exhibits fibronectin binding (ortholog); growth factor activity (ortholog); INVOLVED IN angiogenesis (ortholog); calcium ion transmembrane import into cytosol (ortholog); cartilage condensation (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signalin g pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Aggressive Fibromatosis (ortholog); aortic valve insufficiency (ortholog); FOUND IN cell cortex (ortholog); extracellular space (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Naked Mole-Rat | 133 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18468626 | CCN2 | cellular communication network factor 2 | ENCODES a protein that exhibits fibronectin binding (ortholog); growth factor activity (ortholog); INVOLVED IN angiogenesis (ortholog); calcium ion transmembrane import into cytosol (ortholog); cartilage condensation (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signalin g pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Aggressive Fibromatosis (ortholog); aortic valve insufficiency (ortholog); FOUND IN cell cortex (ortholog); extracellular space (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Green Monkey | 139 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 621867 | Ccn5 | cellular communication network factor 5 | ENCODES a protein that exhibits integrin binding; INVOLVED IN negative regulation of cell population proliferation; regulation of cell growth (ortholog); FOUND IN cell surface; nucleus; podosome; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate | 3 | 172910670 | 172922064 | Rat | 174 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 737121 | Ccn5 | cellular communication network factor 5 | Predicted to enable growth factor activity; heparin binding activity; and integrin binding activity. Acts upstream of or within regulation of cell growth. Located in extracellular space; nucleus; and plasma membrane. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; long bone epiphyseal plate; and respiratory system. Orthologous to human CCN5 (cellular communication network factor 5). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 163662724 | 163675066 | Mouse | 177 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1351496 | CCN5 | cellular communication network factor 5 | This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse d evelopmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008] | 20 | 44714861 | 44727811 | Human | 168 | description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 285728954 | ctgfl | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 69487 | CCN4 | cellular communication network factor 4 | This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse d evelopmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011] | 8 | 133191039 | 133231690 | Human | 155 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1345324 | CCN6 | cellular communication network factor 6 | This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse d evelopmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 6 | 112052813 | 112069686 | Human | 187 | description | gene, protein-coding, REVIEWED [RefSeq] |
