| 1310783 | Cnot6 | CCR4-NOT transcription complex, subunit 6 | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); RNA exonuclease activity (ortholog); transcription coactivator activity (ortholog); INVOLVED IN miRNA-mediated gene silencing by mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, no-go decay (ortholog); nuclear-transcribed mRNA poly(A) tail shortening (ortholog); PARTICIPATES IN microRNA pathway; RNA degradation pathway; FOUND IN CCR4-NOT complex (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol | 10 | 34479892 | 34532166 | Rat | 92 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1347023 | CNOT6 | CCR4-NOT transcription complex subunit 6 | This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation , and transcriptional regulation. [provided by RefSeq, Dec 2014] | 5 | 180494379 | 180578358 | Human | 92 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1551782 | Cnot6 | CCR4-NOT transcription complex, subunit 6 | Predicted to enable poly(A)-specific ribonuclease activity and transcription coactivator activity. Predicted to be involved in negative regulation of gene expression; positive regulation of cell population proliferation; and positive regulation of cytoplasmic mRNA processing body assembly. Predicted to be located in cytosol. Predicted to be part of CCR4-NOT complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human CNOT6 (CCR4-NOT transcription complex subunit 6). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 49562324 | 49604227 | Mouse | 103 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8999234 | Cnot6 | CCR4-NOT transcription complex subunit 6 | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); RNA exonuclease activity (ortholog); transcription coactivator activity (ortholog); INVOLVED IN miRNA-mediated gene silencing by mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, no-go decay (ortholog); nuclear-transcribed mRNA poly(A) tail shortening (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (ortholog) | NW_004955408 | 170399 | 239492 | Chinchilla | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11949517 | CNOT6 | CCR4-NOT transcription complex subunit 6 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); catalytic activity (inferred); exonuclease activity (inferred); INVOLVED IN DNA-templated transcription (inferred); miRNA-mediated gene silencing by mRNA destabilization (inferred); nuclear-transcribed mRNA catabolic process, no-go decay (inferred); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | 5 | 175695802 | 175780534 | Bonobo | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12157674 | CNOT6 | CCR4-NOT transcription complex subunit 6 | ENCODES a protein that exhibits catalytic activity (inferred); exonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN DNA-templated transcription (inferred); miRNA-mediated gene silencing by mRNA destabilization (inferred); nuclear-transcribed mRNA catabolic process, no-go decay (inferred); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | 11 | 1209732 | 1277435 | Dog | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12694482 | Cnot6 | CCR4-NOT transcription complex subunit 6 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); catalytic activity (inferred); exonuclease activity (inferred); INVOLVED IN DNA-templated transcription (inferred); miRNA-mediated gene silencing by mRNA destabilization (inferred); nuclear-transcribed mRNA catabolic process, no-go decay (inferred); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | NW_004936739 | 308117 | 384600 | Squirrel | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18929113 | Cnot6 | CCR4-NOT transcription complex subunit 6 | ENCODES a protein that exhibits RNA exonuclease activity (ortholog); transcription coactivator activity (ortholog); INVOLVED IN miRNA-mediated gene silencing by mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, no-go decay (ortholog); nuclear-transcribed mRNA poly(A) tail shortening (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (ortholog) | | | | Naked Mole-Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14039251 | CNOT6 | CCR4-NOT transcription complex subunit 6 | ENCODES a protein that exhibits catalytic activity (inferred); exonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN DNA-templated transcription (inferred); miRNA-mediated gene silencing by mRNA destabilization (inferred); nuclear-transcribed mRNA catabolic process, no-go decay (inferred); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Pig | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18405567 | CNOT6 | CCR4-NOT transcription complex subunit 6 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); catalytic activity (inferred); exonuclease activity (inferred); INVOLVED IN DNA-templated transcription (inferred); miRNA-mediated gene silencing by mRNA destabilization (inferred); nuclear-transcribed mRNA catabolic process, no-go decay (inferred); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626024019 | Cnot6 | CCR4-NOT transcription complex subunit 6 | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); RNA exonuclease activity (ortholog); transcription coactivator activity (ortholog); INVOLVED IN miRNA-mediated gene silencing by mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, no-go decay (ortholog); nuclear-transcribed mRNA poly(A) tail shortening (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (ortholog) | | | | Black Rat | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1309128 | Cnot6l | CCR4-NOT transcription complex, subunit 6-like | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); INVOLVED IN mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (ortholog); positive regulation of cell population proliferation (ortholog); PARTICIPATES IN micro RNA pathway; RNA degradation pathway; FOUND IN CCR4-NOT complex (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 14 | 13714475 | 13806481 | Rat | 115 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1319296 | CNOT6L | CCR4-NOT transcription complex subunit 6 like | Predicted to enable 3'-5'-RNA exonuclease activity. Involved in positive regulation of cell population proliferation and positive regulation of cytoplasmic mRNA processing body assembly. Located in cytosol and nucleus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 77713387 | 77820269 | Human | 122 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1551166 | Cnot6l | CCR4-NOT transcription complex, subunit 6-like | Enables poly(A)-specific ribonuclease activity. Acts upstream of or within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay and positive regulation of cell population proliferation. Located in cytoplasm. Is expressed in several structures, including brain; genitourinary syst em; gut; hemolymphoid system gland; and musculature. Orthologous to human CNOT6L (CCR4-NOT transcription complex subunit 6 like). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 96218192 | 96312044 | Mouse | 137 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8793346 | Cnot6l | CCR4-NOT transcription complex subunit 6 like | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); INVOLVED IN mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (ortholog); positive regulation of cell population proliferation (ortholog); PARTICIPATES IN micro RNA pathway; FOUND IN CCR4-NOT complex (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955433 | 2206462 | 2290773 | Chinchilla | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11743640 | CNOT6L | CCR4-NOT transcription complex subunit 6 like | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); catalytic activity (inferred); exonuclease activity (inferred); INVOLVED IN mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (ortholog); positive regulation of cell po pulation proliferation (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (ortholog); cytosol (ortholog) | 4 | 46374255 | 46482552 | Bonobo | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12426935 | CNOT6L | CCR4-NOT transcription complex subunit 6 like | ENCODES a protein that exhibits catalytic activity (inferred); exonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (ortholog); positive regulation of cell population pro liferation (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | 32 | 2192800 | 2305526 | Dog | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12496940 | Cnot6l | CCR4-NOT transcription complex subunit 6 like | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); catalytic activity (inferred); exonuclease activity (inferred); INVOLVED IN mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (ortholog); positive regulation of cell po pulation proliferation (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | NW_004936676 | 1401428 | 1474167 | Squirrel | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625934660 | Cnot6l | CCR4-NOT transcription complex subunit 6 like | ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); INVOLVED IN mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (ortholog); positive regulation of cell population proliferation (ortholog); PARTICIPATES IN micro RNA pathway; FOUND IN CCR4-NOT complex (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18577679 | CNOT6L | CCR4-NOT transcription complex subunit 6 like | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); catalytic activity (inferred); exonuclease activity (inferred); INVOLVED IN mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (ortholog); positive regulation of cell po pulation proliferation (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237105 | cnot6l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13844228 | CNOT6L | CCR4-NOT transcription complex subunit 6 like | ENCODES a protein that exhibits catalytic activity (inferred); exonuclease activity (inferred); hydrolase activity (inferred); INVOLVED IN mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (ortholog); positive regulation of cell population pro liferation (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Pig | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18919538 | Cnot6l | CCR4-NOT transcription complex subunit 6 like | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (inferred); catalytic activity (inferred); exonuclease activity (inferred); INVOLVED IN mRNA destabilization (ortholog); nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (ortholog); positive regulation of cell po pulation proliferation (ortholog); PARTICIPATES IN microRNA pathway; FOUND IN CCR4-NOT complex (ortholog) | | | | Naked Mole-Rat | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11359066 | Cnot6l2 | CCR4-NOT transcription complex, subunit 6 like 2 | INTERACTS WITH glyphosate | 10 | 34520768 | 34531728 | Rat | 1 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 155237104 | cnot6l.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155239402 | cnot6l.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2303314 | CNOT6LP1 | CNOT6L pseudogene 1 | INTERACTS WITH sodium arsenite | 15 | 56003305 | 56007179 | Human | 1 | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 629021571 | CNOT6L-DT | CNOT6L divergent transcript | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna |