| 2326 | Cebpa | CCAAT/enhancer binding protein alpha | ENCODES a protein that exhibits DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding; INVOLVED IN acute-phase response; animal organ regeneration; cell differentiation; PARTICIPATES IN forkhead class A signaling pathway; acut e myeloid leukemia pathway; ASSOCIATED WITH abnormal lipid level; ASSOCIATED WITH Acute-Phase Reaction; alcohol-associated liver disease; transient cerebral ischemia; FOUND IN CHOP-C/EBP complex; nuclear matrix; nucleolus; INTERACTS WITH (+)-pilocarpine; (-)-cotinine; (S)-nicotine | 1 | 96896584 | 96899256 | Rat | 722 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 10325 | Cebpa | CCAAT/enhancer binding protein alpha | This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of t his protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. The use of alternative in-frame non-AUG (CUG) and AUG start codons results in several protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the CUG and the first AUG start codons. [provided by RefSeq, Sep 2014] | 7 | 34818718 | 34821353 | Mouse | 902 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 69121 | CEBPA | CCAAT enhancer binding protein alpha | This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of t his protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013] | 19 | 33299934 | 33302534 | Human | 1690 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8951649 | Cebpa | CCAAT enhancer binding protein alpha | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN acute-phase response (ortholog); animal organ regeneration (ortholog); brown fat cell differentiation (ortholog); PARTICIPATES IN forkhead class A signaling pathway; AS SOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); Acute-Phase Reaction (ortholog); FOUND IN C/EBP complex (ortholog); CHOP-C/EBP complex (ortholog); nuclear matrix (ortholog) | NW_004955468 | 3046544 | 3049217 | Chinchilla | 193 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11739234 | CEBPA | CCAAT enhancer binding protein alpha | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN acute-phase response (ortholog); animal organ regeneration (ortholog); brown fat cell differentiation (ortholog); PARTICIPATES IN forkhead class A signaling pathway; AS SOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); Acute-Phase Reaction (ortholog); FOUND IN C/EBP complex (ortholog); CHOP-C/EBP complex (ortholog); nuclear matrix (ortholog) | 19 | 30223567 | 30226204 | Bonobo | 193 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12179653 | CEBPA | CCAAT enhancer binding protein alpha | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN acute-phase response (ortholog); animal organ regeneration (ortholog); brown fat cell differentiation (ortholog); PARTICIPATES IN forkhead class A signaling pathway; AS SOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); Acute-Phase Reaction (ortholog); FOUND IN C/EBP complex (ortholog); CHOP-C/EBP complex (ortholog); nuclear matrix (ortholog) | 1 | 118846252 | 118851045 | Dog | 193 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12532631 | Cebpa | CCAAT enhancer binding protein alpha | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN acute-phase response (ortholog); animal organ regeneration (ortholog); brown fat cell differentiation (ortholog); PARTICIPATES IN forkhead class A signaling pathway; AS SOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); Acute-Phase Reaction (ortholog); FOUND IN C/EBP complex (ortholog); CHOP-C/EBP complex (ortholog); nuclear matrix (ortholog) | NW_004936570 | 2513561 | 2516213 | Squirrel | 193 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625936701 | Cebpa | CCAAT enhancer binding protein alpha | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN acute-phase response (ortholog); animal organ regeneration (ortholog); brown fat cell differentiation (ortholog); PARTICIPATES IN forkhead class A signaling pathway; AS SOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); Acute-Phase Reaction (ortholog); FOUND IN C/EBP complex (ortholog); CHOP-C/EBP complex (ortholog); nuclear matrix (ortholog) | | | | Black Rat | 190 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155246895 | cebpa | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18502792 | CEBPA | CCAAT enhancer binding protein alpha | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor binding (ortholog); histone deacetylase binding (ortholog); INVOLVED IN acute-phase response (ortholog); animal organ regeneration (ortholog); brown fat cell differentiation (ortholog); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); Acute-Phase Reaction (ortholog); FOUND IN nuclear matrix (ortholog); nucleolus (ortholog); nucleus (ortholog) | | | | Green Monkey | 172 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18932894 | Cebpa | CCAAT enhancer binding protein alpha | ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN acute-phase response (ortholog); animal organ regeneration (ortholog); brown fat cell differentiation (ortholog); PARTICIPATES IN forkhead class A signaling pathway; AS SOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); Acute-Phase Reaction (ortholog); FOUND IN C/EBP complex (ortholog); CHOP-C/EBP complex (ortholog); nuclear matrix (ortholog) | | | | Naked Mole-Rat | 187 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20867445 | CEBPA | CCAAT enhancer binding protein alpha | | | | | Green Monkey | | symbol | gene, protein-coding |
| 14220489 | CEBPA | CCAAT enhancer binding protein alpha | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor binding (ortholog); histone deacetylase binding (ortholog); INVOLVED IN acute-phase response (ortholog); animal organ regeneration (ortholog); brown fat cell differentiation (ortholog); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); Acute-Phase Reaction (ortholog); FOUND IN nuclear matrix (ortholog); nucleolus (ortholog); nucleus (ortholog); INTERACTS WITH dexamethasone; glycerol 2-phosphate; L-ascorbic acid | | | | Pig | 157 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249227 | cebpa.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155246894 | cebpa.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2303684 | CEBPA-DT | CEBPA divergent transcript | ASSOCIATED WITH Colorectal Neoplasms; INTERACTS WITH aflatoxin B1; aristolochic acid A; arsane | 19 | 33302821 | 33305057 | Human | 18 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 1312756 | Cebpz | CCAAT/enhancer binding protein zeta | Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of CCAAT-binding activity factor complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary sy stem; bone; brain; genitourinary system; and hemolymphoid system gland. Orthologous to human CEBPZ (CCAAT enhancer binding protein zeta). [provided by Alliance of Genome Resources, Apr 2025] | 17 | 79226432 | 79244499 | Mouse | 81 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 732913 | Prkch | protein kinase C, eta | Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC f amily members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in the human gene are associated with susceptibility to cerebral infarction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015] | 12 | 73631570 | 73824959 | Mouse | 250 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 735345 | PRKCH | protein kinase C eta | Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC f amily members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. [provided by RefSeq, Sep 2015] | 14 | 61187468 | 61550976 | Human | 219 | description | gene, protein-coding, REVIEWED [RefSeq] |