| 2310 | Cd53 | Cd53 molecule | ENCODES a protein that exhibits identical protein binding (ortholog); protein-membrane adaptor activity (ortholog); INVOLVED IN cell-cell adhesion (ortholog); positive regulation of myoblast fusion (ortholog); receptor clustering (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); G astro-Enteropancreatic Neuroendocrine Tumor (ortholog); FOUND IN cell surface; cell-cell junction (ortholog); immunological synapse (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol | 2 | 197040369 | 197087925 | Rat | 137 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, VALIDATED [RefSeq] |
| 10313 | Cd53 | CD53 antigen | Predicted to enable identical protein binding activity and protein-membrane adaptor activity. Involved in positive regulation of myoblast fusion. Located in cell-cell junction and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymph oid system; and liver and biliary system. Orthologous to human CD53 (CD53 molecule). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 106666177 | 106697465 | Mouse | 140 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 737207 | CD53 | CD53 molecule | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] | 1 | 110871210 | 110899922 | Human | 141 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8920655 | Cd53 | CD53 molecule | ENCODES a protein that exhibits identical protein binding (ortholog); protein-membrane adaptor activity (ortholog); INVOLVED IN cell-cell adhesion (ortholog); positive regulation of myoblast fusion (ortholog); receptor clustering (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); G astro-Enteropancreatic Neuroendocrine Tumor (ortholog); FOUND IN cell surface (ortholog); cell-cell junction (ortholog); immunological synapse (ortholog) | NW_004955435 | 14388925 | 14410543 | Chinchilla | 15 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11782461 | CD53 | CD53 molecule | ENCODES a protein that exhibits identical protein binding (inferred); protein-membrane adaptor activity (inferred); INVOLVED IN cell-cell adhesion (ortholog); regulation of myoblast differentiation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Gastro-Enteropancreatic Neuroendo crine Tumor (ortholog); FOUND IN cell surface (ortholog) | 1 | 113517715 | 113546466 | Bonobo | 21 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12204707 | CD53 | CD53 molecule | ENCODES a protein that exhibits identical protein binding (inferred); protein-membrane adaptor activity (inferred); INVOLVED IN cell-cell adhesion (ortholog); regulation of myoblast differentiation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Gastro-Enteropancreatic Neuroendo crine Tumor (ortholog); FOUND IN cell surface (ortholog) | 6 | 41070132 | 41089329 | Dog | 21 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12640942 | Cd53 | CD53 molecule | ENCODES a protein that exhibits identical protein binding (inferred); protein-membrane adaptor activity (inferred); INVOLVED IN cell-cell adhesion (ortholog); regulation of myoblast differentiation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Gastro-Enteropancreatic Neuroendo crine Tumor (ortholog); FOUND IN cell surface (ortholog) | NW_004936704 | 2263248 | 2285625 | Squirrel | 21 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13843617 | CD53 | CD53 molecule | ENCODES a protein that exhibits identical protein binding (inferred); protein-membrane adaptor activity (inferred); INVOLVED IN cell-cell adhesion (ortholog); regulation of myoblast differentiation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Gastro-Enteropancreatic Neuroendo crine Tumor (ortholog); FOUND IN cell surface (ortholog) | | | | Pig | 21 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18748596 | CD53 | CD53 molecule | ENCODES a protein that exhibits identical protein binding (inferred); protein-membrane adaptor activity (inferred); INVOLVED IN cell-cell adhesion (ortholog); regulation of myoblast differentiation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Gastro-Enteropancreatic Neuroendo crine Tumor (ortholog); FOUND IN cell surface (ortholog) | | | | Green Monkey | 21 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18923737 | Cd53 | CD53 molecule | ENCODES a protein that exhibits identical protein binding (ortholog); protein-membrane adaptor activity (ortholog); INVOLVED IN cell-cell adhesion (ortholog); positive regulation of myoblast fusion (ortholog); receptor clustering (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); G astro-Enteropancreatic Neuroendocrine Tumor (ortholog); FOUND IN cell surface (ortholog); cell-cell junction (ortholog); immunological synapse (ortholog) | | | | Naked Mole-Rat | 20 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155251005 | cd53 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626088062 | Cd53 | CD53 molecule | ENCODES a protein that exhibits identical protein binding (ortholog); protein-membrane adaptor activity (ortholog); INVOLVED IN cell-cell adhesion (ortholog); positive regulation of myoblast fusion (ortholog); receptor clustering (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); G astro-Enteropancreatic Neuroendocrine Tumor (ortholog); FOUND IN cell surface (ortholog); cell-cell junction (ortholog); immunological synapse (ortholog) | | | | Black Rat | 15 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155248057 | cd53.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155247742 | cd53.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16558608 | AC083829.1 | CD53 molecule (CD53) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 38619338 | LOC100129137 | CD53 molecule pseudogene | | 4 | 88527562 | 88528167 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 13559530 | LOC112439594 | leukocyte surface antigen CD53-like | | 4 | 80813363 | 80814544 | Bonobo | | name | gene, pseudo, MODEL [RefSeq] |
| 598132590 | LOC140712004 | leukocyte surface antigen CD53 pseudogene | | | | | Green Monkey | | name | gene, pseudo, MODEL [RefSeq] |
| 1616644 | Ankhd1 | ankyrin repeat and KH domain containing 1 | Predicted to be involved in innate immune response. Predicted to be active in cytoplasm. Is expressed in blastocyst; brain; olfactory epithelium; and spinal cord. Orthologous to several human genes including ANKHD1 (ankyrin repeat and KH domain containing 1). [provided by Alliance of Genome Resource s, Jul 2025] | 18 | 36693656 | 36791961 | Mouse | 96 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1622270 | Ankle2 | ankyrin repeat and LEM domain containing 2 | Predicted to enable protein kinase inhibitor activity and protein phosphatase 2A binding activity. Predicted to be involved in several processes, including mitotic nuclear membrane reassembly; negative regulation of apoptotic process; and negative regulation of phosphorylation. Predicted to be locat ed in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 16. Orthologous to human ANKLE2 (ankyrin repeat and LEM domain containing 2). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 110378847 | 110404517 | Mouse | 100 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1321713 | Arhgef3 | Rho guanine nucleotide exchange factor 3 | Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of Rho protein signal transduction. Predicted to be located in cytoplasm. Is expressed in several structures, including bone marrow; enteric nervous system; forelimb bud; liver; and testis . Orthologous to human ARHGEF3 (Rho guanine nucleotide exchange factor 3). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 26836418 | 27125873 | Mouse | 135 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1557631 | Cep192 | centrosomal protein 192 | Predicted to enable phosphatase binding activity. Acts upstream of or within response to bacterium. Located in cytoplasm and pericentriolar material. Is expressed in cerebral cortex ventricular layer and meninges. Orthologous to human CEP192 (centrosomal protein 192). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 67933124 | 68018241 | Mouse | 97 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1323329 | Cep295 | centrosomal protein 295 | Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including centriole replication; positive regulation of protein acetylation; and regulation of centrosome duplication. Predicted to be located in cytoplasm; mitotic spindle microtubule; and plasma membra ne. Predicted to be active in centriole; centrosome; and cytosol. Orthologous to human CEP295 (centrosomal protein 295). [provided by Alliance of Genome Resources, Apr 2025] | 9 | 15228210 | 15269145 | Mouse | 89 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1620465 | Fubp3 | far upstream element (FUSE) binding protein 3 | Predicted to enable mRNA binding activity and single-stranded DNA binding activity. Predicted to be involved in DNA-templated transcription; intracellular mRNA localization; and positive regulation of macromolecule biosynthetic process. Predicted to be located in several cellular components, includi ng dendritic shaft; neuronal cell body; and ribosome. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human FUBP3 (far upstream element binding protein 3). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 31462655 | 31507538 | Mouse | 90 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 2308491 | Gm2381 | predicted gene 2381 | Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in testis and urinary system. [provided by Alliance of Genome R esources, Jul 2025] | 7 | 42466251 | 42516658 | Mouse | 7 | GenBank Nucleotide | gene, pseudo, VALIDATED [RefSeq] |
| 1320252 | Hapstr1 | HUWE1 associated protein modifying stress responses | Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of signal transduction by p53 class mediator and regulation of cellular response to stress. Predicted to be located in cytoplasm and nucleus. Is expressed in retina; retina inner nuclear la yer; and retina outer nuclear layer. Orthologous to human HAPSTR1 (HUWE1 associated protein modifying stress responses). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 8647964 | 8676788 | Mouse | 87 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1614393 | Mga | MAX gene associated | Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within cellular response to leukem ia inhibitory factor. Part of transcription regulator complex. Is expressed in several structures, including genitourinary system; gut; heart; nervous system; and sensory organ. Orthologous to human MGA (MAX dimerization protein MGA). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 119702974 | 119800610 | Mouse | 123 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1557486 | Osbpl3 | oxysterol binding protein-like 3 | Predicted to enable cholesterol binding activity. Predicted to be involved in lipid transport. Predicted to be located in endoplasmic reticulum membrane and filopodium tip. Predicted to be active in several cellular components, including cytosol; nuclear membrane; and perinuclear endoplasmic reticul um. Is expressed in several structures, including central nervous system; genitourinary system; immune system; olfactory epithelium; and respiratory system. Orthologous to human OSBPL3 (oxysterol binding protein like 3). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 50270307 | 50433334 | Mouse | 156 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1615673 | Plekha7 | pleckstrin homology domain containing, family A member 7 | Predicted to enable delta-catenin binding activity. Involved in cell-cell adhesion mediated by cadherin and pore complex assembly. Located in cell-cell junction. Part of pore complex. Is expressed in several structures, including brain ventricular layer; foregut; heart; nasal cavity epithelium; and tooth. Orthologous to human PLEKHA7 (pleckstrin homology domain containing A7). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 115722722 | 115907617 | Mouse | 118 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1622859 | Sbf2 | SET binding factor 2 | Enables several functions, including identical protein binding activity; phosphatase binding activity; and phosphatase regulator activity. Predicted to be involved in autophagy. Located in vacuolar membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and sciatic nerve. Used to study Charcot-Marie-Tooth disease type 4B2. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4B2. Orthologous to human SBF2 (SET binding factor 2). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 109907218 | 110215150 | Mouse | 125 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1318652 | Tasor | transcription activation suppressor | Predicted to enable chromatin binding activity. Involved in anterior/posterior axis specification, embryo and mesodermal to mesenchymal transition involved in gastrulation. Predicted to be active in heterochromatin and nucleoplasm. Is expressed in brain; egg cylinder; and embryo ectoderm. Orthologou s to human TASOR (transcription activation suppressor). [provided by Alliance of Genome Resources, Apr 2025] | 14 | 27150759 | 27205512 | Mouse | 138 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1620723 | Tmem181a | transmembrane protein 181A | Predicted to enable toxic substance binding activity. Is expressed in several structures, including cardiovascular system; central nervous system; gut; reproductive system; and trachea. Orthologous to human TMEM181 (transmembrane protein 181). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 6307001 | 6358589 | Mouse | 57 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1317578 | Trp53bp1 | transformation related protein 53 binding protein 1 | Enables damaged DNA binding activity; methylated histone binding activity; and telomeric DNA binding activity. Involved in double-strand break repair via nonhomologous end joining; negative regulation of double-strand break repair via homologous recombination; and positive regulation of isotype swit ching. Acts upstream of or within DNA repair. Located in chromosome and nuclear body. Part of DNA repair complex. Is expressed in several structures, including ileum; liver; lung; nervous system; and sensory organ. Orthologous to human TP53BP1 (tumor protein p53 binding protein 1). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 121025316 | 121126830 | Mouse | 264 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1552774 | Zfp473 | zinc finger protein 473 | Predicted to enable DNA-binding transcription factor binding activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage and negative regulation of transcription initiation by RNA polymerase II. Predicted to be located in Cajal body. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; genitourinary system; and pancreas epithelium. Orthologous to human ZNF473 (zinc finger protein 473). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 44380904 | 44398041 | Mouse | 99 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1625165 | Zfp600 | zinc finger protein 600 | Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in epiblast; primitive endoderm; and trophectoderm. Orthologous to several human genes including ZNF234 (zinc finger protein 234); ZNF254 (zinc finger protein 254); and ZNF43 2 (zinc finger protein 432). [provided by Alliance of Genome Resources, Apr 2025] | 4 | 146093397 | 146135326 | Mouse | 21 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1617802 | Zfp977 | zinc finger protein 977 | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Orthologous to human ZNF670 (zinc finger protein 670). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 42228821 | 42241969 | Mouse | 11 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1642218 | Zfp980 | zinc finger protein 980 | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be active in nucleus. Is expressed in e piblast; primitive endoderm; and trophectoderm. [provided by Alliance of Genome Resources, Jul 2025] | 4 | 145397267 | 145431007 | Mouse | 12 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1617965 | Zscan10 | zinc finger and SCAN domain containing 10 | Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; gut; limb mesenchyme; and nervous sys tem. Orthologous to human ZSCAN10 (zinc finger and SCAN domain containing 10). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 23819800 | 23829993 | Mouse | 103 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1314069 | TSPAN4 | tetraspanin 4 | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] | 11 | 842852 | 867111 | Human | 137 | description | gene, protein-coding, REVIEWED [RefSeq] |