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Gene: CD53 (CD53 molecule) Pan paniscus

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Symbol:

CD53

Name:

CD53 molecule

RGD ID:

11782461

Description:

ENCODES a protein that exhibits identical protein binding (inferred); protein-membrane adaptor activity (inferred); INVOLVED IN cell-cell adhesion (ortholog); regulation of myoblast differentiation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Gastro-Enteropancreatic Neuroendocrine Tumor (ortholog); FOUND IN cell surface (ortholog); synapse (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

leukocyte surface antigen CD53

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CD53 (CD53 molecule)	NCBI	Ortholog
Mus musculus (house mouse):	Cd53 (CD53 antigen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cd53 (Cd53 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cd53 (CD53 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CD53 (CD53 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cd53 (CD53 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CD53 (CD53 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CD53 (CD53 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cd53 (CD53 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Cd53 (CD53 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	116,142,917 - 116,172,063 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	115,291,592 - 115,320,348 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	113,517,715 - 113,546,466 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	126,799,910 - 126,828,671 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	126,799,910 - 126,826,714 (-)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

Gastro-Enteropancreatic Neuroendocrine Tumor (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell-cell adhesion (ISO)

positive regulation of myoblast fusion (IEA)

receptor clustering (IEA)

regulation of myoblast differentiation (ISO)

Cellular Component

anchoring junction (IEA)

cell surface (ISO)

cell-cell junction (IEA)

immunological synapse (IEA)

membrane (IEA)

plasma membrane (IEA)

synapse (ISO)

Molecular Function

identical protein binding (IEA)

protein-membrane adaptor activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

CD53
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	116,142,917 - 116,172,063 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	115,291,592 - 115,320,348 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	113,517,715 - 113,546,466 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	126,799,910 - 126,828,671 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	126,799,910 - 126,826,714 (-)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

CD53
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	110,871,210 - 110,899,922 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	110,871,170 - 110,899,936 (+)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	1	111,413,832 - 111,442,544 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	111,215,344 - 111,244,081 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	111,127,814 - 111,234,716	NCBI
Celera	1	109,660,823 - 109,689,572 (+)	NCBI		Celera
Cytogenetic Map	1	p13.3	NCBI
HuRef	1	109,285,008 - 109,313,782 (+)	NCBI		HuRef
CHM1_1	1	111,528,958 - 111,557,705 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	110,885,966 - 110,914,720 (+)	NCBI		T2T-CHM13v2.0

Cd53
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	106,666,177 - 106,697,465 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	106,666,177 - 106,697,530 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	106,758,861 - 106,790,149 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	106,759,921 - 106,790,149 (-)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	3	106,561,779 - 106,593,067 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	106,887,989 - 106,918,107 (-)	NCBI		MGSCv36	mm8
Celera	3	109,088,034 - 109,119,379 (-)	NCBI		Celera
Cytogenetic Map	3	F2.3	NCBI
cM Map	3	46.53	NCBI

Cd53
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	197,040,369 - 197,087,925 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	197,040,369 - 197,218,593 (-)	Ensembl				GRCr8
mRatBN7.2	2	194,352,139 - 194,399,668 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	194,352,139 - 194,399,657 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	201,985,357 - 202,031,562 (-)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	199,865,663 - 199,913,115 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	194,682,627 - 194,730,079 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	2	196,665,336 - 196,717,899 (-)	NCBI
Lyon_Normotensive	2	196,904,513 - 196,957,076 (-)	NCBI
Lyon_Hypertensive	2	196,511,320 - 196,563,914 (-)	NCBI
F344_StmMcwi	2	196,623,040 - 196,675,636 (-)	NCBI
Rnor_6.0	2	209,489,279 - 209,537,098 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	209,489,279 - 209,537,087 (-)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	2	228,956,378 - 229,004,197 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	202,186,125 - 202,234,570 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	187,021,863 - 187,068,114 (-)	NCBI		Celera
RGSC_v3.1	2	202,148,878 - 202,197,324 (-)	NCBI
RH 3.4 Map	2	1352.8	RGD
Cytogenetic Map	2	q34	NCBI

Cd53
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955435	14,388,726 - 14,413,249 (+)	Ensembl		ChiLan1.0 Ensembl
ChiLan1.0	NW_004955435	14,388,925 - 14,410,543 (+)	NCBI	ChiLan1.0	ChiLan1.0

CD53
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	41,070,132 - 41,089,329 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	41,070,788 - 41,089,221 (-)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	43,847,669 - 43,866,859 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	41,401,987 - 41,421,177 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	41,401,991 - 41,421,159 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	41,122,453 - 41,141,639 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	41,092,762 - 41,111,952 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	41,528,153 - 41,547,338 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cd53
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	11	103,974,709 - 103,997,100 (+)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024405058	17,828,648 - 17,850,910 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936704	2,262,945 - 2,285,631 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936704	2,263,248 - 2,285,625 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CD53
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	109,306,555 - 109,335,802 (-)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	4	109,306,552 - 109,335,876 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	119,674,096 - 119,703,422 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CD53
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	20	25,662,425 - 25,691,302 (-)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666038	35,778,039 - 35,806,921 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	20	22,653,361 - 22,687,172 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	22,652,819 - 22,685,287 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

Cd53
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624772	6,630,152 - 6,660,871 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2
HetGla_female_1.0 Ensembl	NW_004624772	6,630,123 - 6,661,599 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl	19	16,263,040 - 16,497,345 (-)	Ensembl

Cd53
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	51,318,031 - 51,461,652 (+)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003810667	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000053454 ⟹ ENSPPAP00000030591

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	126,799,910 - 126,826,714 (-)	Ensembl

RefSeq Acc Id:

XM_003810667 ⟹ XP_003810715

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	116,142,917 - 116,172,063 (-)	NCBI
NHGRI_mPanPan1	1	115,291,592 - 115,320,348 (-)	NCBI
Mhudiblu_PPA_v0	1	113,517,715 - 113,546,466 (+)	NCBI
PanPan1.1	1	126,799,910 - 126,828,671 (-)	NCBI

Sequence:

show sequence

GGCTCTCCTCCCTTCTTCCTGAGGACAGACTGAAGAAACATCCAAGCTGGTCTTGAAGGAGAGT
GGGATCCTGTAACACAGCCCCGGATATCTGTGTTACCAGCCTTGTCTCGGCCACCTCAAGGATA
ATCACTAAATTCTGTCTAAAGGACTGAGGAACGGTGCCTGGAAAAGGGCAAGAATATCACGGCA
TGGGCATGAGTAGCTTGAAACTGCTGAAGTATGTCCTGTTTTTCTTCAACTTGCTCTTTTGGAT
CTGTGGCTGCTGCATTTTGGGCTTTGGGATCTACCTGCTGATCCACAACAATTTCGGAGTGCTC
TTCCATAACCTCCCCTCCCTCACGCTGGGCAATGTGTTTGTCATCGTGGGCTCTATTATCATGG
TAGTTGCCTTCCTGGGCTGCATGGGCTCTATCAAGGAAAACAAGTGTCTGCTTATGTCGTTCTT
CATCCTGCTGCTGATTATCCTCCTTGCTGAGGTGACCTTGGCCATCCTGCTCTTTGTATATGAA
CAGAAGCTGAATGAGTATGTGGCTAAGGGTCTGACCGACAGCATCCACCGTTATCACTCAGACA
ATAGCACCAAGGCAGCGTGGGACTCCATCCAGTCATTTCTGCAGTGTTGTGGTATAAATGGCAC
GAGTGATTGGACCAGTGGCCCACCAGCATCTTGCCCCTCAGATCGAAAAGTGGAGGGTTGCTAT
GCGAAAGCAAGACTGTGGTTTCATTCCAATTTCCTGTATATCGGAATCATCACCATCTGTGTAT
GTGTGATTGAGGTGTTGGGGATGTCCTTTGCACTGACCCTGAACTGCCAGATTGACAAAACCAG
CCAGACCATAGGGCTATGATCTGCAGTGGTCCTGTGGTGAAGAGACTTGTTTCATCTATGGAAA
TGCAAAACCATTTATAGCATGAAGCCCTACATGATCACTGCGGGATGATCCTCCTCCCATCCTT
TCCCTTTTTAGGTCCCTGTCTTATACAACCAGAGAAGTGGGTGTTGGCCAGGCATATCCCATCT
CAGGCAGCAAGACAATCTTTCACTCACTGATGGCAGCAGCCATGTCTCTCAAAGTGGTGAAACT
AATATCTGAGCATCTTTTAGACAAGAGAGGCAAAGAGAAACTGGATCTAATGGCCCAACATCAA
AGGGTGAACCCAGGATATGAATTTTTGCATCTTCCCATTGTCGAATTAGTCTCCAGCCTCTAAA
TAATGCCCAGTCTTCTCCCCAAAGTCAAGCAAGAGACTAGTTGAAGGGAGTTCTGGGGCCAGGC
TCACTGGACCATTGTCACACCCCTCTGTTTCTCTTTGACTAAGAGCCCTGGCTACAGGAATTAC
ACAGTTCTCTTTCTCCAAAGGGCAAGATCTCATTTCAATTTCTTTATTAGAGGGCCTTATTGAT
GTGTTCTAAGTCTTTCCAGAAAAAAACTATCCAGTGATTTATATCCTGACTTCAACCAGTCACT
TAGCTGATAATCACAGTAAGAAGACTTCTGGTATTCTCTCTCTATCAGATAAGATTTTGTTAAT
GTACTATTTTACTCTTCAATAAATAAAACAGTTTATTATCTCAATCACAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003810715	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000030591.1
	ENSPPAP00050017990

RefSeq Acc Id:

XP_003810715 ⟸ XM_003810667

- UniProtKB:

A0A2R9BVP1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGMSSLKLLKYVLFFFNLLFWICGCCILGFGIYLLIHNNFGVLFHNLPSLTLGNVFVIVGSIIM
VVAFLGCMGSIKENKCLLMSFFILLLIILLAEVTLAILLFVYEQKLNEYVAKGLTDSIHRYHSD
NSTKAAWDSIQSFLQCCGINGTSDWTSGPPASCPSDRKVEGCYAKARLWFHSNFLYIGIITICV
CVIEVLGMSFALTLNCQIDKTSQTIGL

hide sequence

Ensembl Acc Id:

ENSPPAP00000030591 ⟸ ENSPPAT00000053454

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000038281	Ensembl, UniProtKB/TrEMBL
	ENSPPAG00050013565	ENTREZGENE
Ensembl Transcript	ENSPPAT00000053454.1	UniProtKB/TrEMBL
	ENSPPAT00050028528	ENTREZGENE
Gene3D-CATH	1.10.1450.10	UniProtKB/TrEMBL
InterPro	Tetraspanin/Peripherin	UniProtKB/TrEMBL
	Tetraspanin_animals	UniProtKB/TrEMBL
	Tetraspanin_CS	UniProtKB/TrEMBL
	Tetraspanin_EC2_sf	UniProtKB/TrEMBL
KEGG Report	pps:100973946	UniProtKB/TrEMBL
NCBI Gene	CD53	ENTREZGENE
PANTHER	LEUKOCYTE SURFACE ANTIGEN CD53	UniProtKB/TrEMBL
	PTHR19282	UniProtKB/TrEMBL
Pfam	Tetraspanin	UniProtKB/TrEMBL
PIRSF	Tetraspanin	UniProtKB/TrEMBL
PRINTS	TMFOUR	UniProtKB/TrEMBL
PROSITE	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
	TM4_1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48652	UniProtKB/TrEMBL
UniProt	A0A2R9BVP1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD