| 2294 | Ccne1 | cyclin E1 | ENCODES a protein that exhibits protein kinase binding; protein-containing complex binding; cyclin-dependent protein serine/threonine kinase regulator activity (ortholog); INVOLVED IN animal organ regeneration; antral ovarian follicle growth; cellular response to nutrient; PARTICIPATES IN G1/S trans ition pathway; mTOR signaling pathway; cell cycle pathway, mitotic; ASSOCIATED WITH Colonic Neoplasms; Diabetic Nephropathies; Experimental Mammary Neoplasms; FOUND IN centrosome; cyclin E1-CDK2 complex (ortholog); cyclin-dependent protein kinase holoenzyme complex (ortholog); INTERACTS WITH (-)-citrinin; (Z)-3-butylidenephthalide; 1,3-dichloropropan-2-ol | 1 | 99918672 | 99927986 | Rat | 673 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 736488 | CCNE1 | cyclin E1 | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016] | 19 | 29811991 | 29824312 | Human | 677 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 736489 | Ccne1 | cyclin E1 | Enables cyclin-dependent protein serine/threonine kinase regulator activity; kinase activity; and protein kinase binding activity. Acts upstream of or within several processes, including DNA replication initiation; chromosome organization; and negative regulation of transcription by RNA polymerase I I. Located in nucleus. Part of cyclin E1-CDK2 complex. Is expressed in several structures, including brain; early conceptus; embryo ectoderm; eye; and spleen. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human CCNE1 (cyclin E1). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 37797409 | 37806915 | Mouse | 736 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8764969 | Ccne1 | cyclin E1 | ENCODES a protein that exhibits cyclin-dependent protein serine/threonine kinase regulator activity (ortholog); kinase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); antral ovarian follicle growth (ortholog); cellular response to nutrient (o rtholog); PARTICIPATES IN G1/S transition pathway; mTOR signaling pathway; ASSOCIATED WITH Bowen's Disease (ortholog); breast adenocarcinoma (ortholog); breast cancer (ortholog); FOUND IN centrosome (ortholog); cyclin E1-CDK2 complex (ortholog); cyclin-dependent protein kinase holoenzyme complex (ortholog) | NW_004955468 | 7803610 | 7814872 | Chinchilla | 103 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11939303 | CCNE1 | cyclin E1 | ENCODES a protein that exhibits protein kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); antral ovarian follicle growth (ortholog); cellular response to nutrient (ortholog); PARTICIPATES IN G1/S transition pathway; mTOR signa ling pathway; ASSOCIATED WITH Bowen's Disease (ortholog); breast adenocarcinoma (ortholog); breast cancer (ortholog); FOUND IN centrosome (ortholog) | 19 | 26739285 | 26751630 | Bonobo | 104 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12210477 | CCNE1 | cyclin E1 | ENCODES a protein that exhibits protein kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); antral ovarian follicle growth (ortholog); cellular response to nutrient (ortholog); PARTICIPATES IN G1/S transition pathway; mTOR signa ling pathway; ASSOCIATED WITH Bowen's Disease (ortholog); breast adenocarcinoma (ortholog); breast cancer (ortholog); FOUND IN centrosome (ortholog) | 1 | 121688622 | 121697533 | Dog | 111 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12688680 | Ccne1 | cyclin E1 | ENCODES a protein that exhibits protein kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); antral ovarian follicle growth (ortholog); cellular response to nutrient (ortholog); PARTICIPATES IN G1/S transition pathway; mTOR signa ling pathway; ASSOCIATED WITH Bowen's Disease (ortholog); breast adenocarcinoma (ortholog); breast cancer (ortholog); FOUND IN centrosome (ortholog) | NW_004936570 | 5536817 | 5547880 | Squirrel | 104 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626115388 | Ccne1 | cyclin E1 | ENCODES a protein that exhibits cyclin-dependent protein serine/threonine kinase regulator activity (ortholog); kinase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); antral ovarian follicle growth (ortholog); cellular response to nutrient (o rtholog); PARTICIPATES IN G1/S transition pathway; mTOR signaling pathway; ASSOCIATED WITH Bowen's Disease (ortholog); breast adenocarcinoma (ortholog); breast cancer (ortholog); FOUND IN centrosome (ortholog); cyclin E1-CDK2 complex (ortholog); cyclin-dependent protein kinase holoenzyme complex (ortholog) | | | | Black Rat | 103 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13981040 | CCNE1 | cyclin E1 | ENCODES a protein that exhibits protein kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); antral ovarian follicle growth (ortholog); cellular response to nutrient (ortholog); PARTICIPATES IN G1/S transition pathway; mTOR signa ling pathway; ASSOCIATED WITH Bowen's Disease (ortholog); breast adenocarcinoma (ortholog); breast cancer (ortholog); FOUND IN centrosome (ortholog); INTERACTS WITH bifenthrin; etoxazole; hydrogen peroxide | | | | Pig | 117 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155232423 | ccne1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18560622 | CCNE1 | cyclin E1 | ENCODES a protein that exhibits cyclin-dependent protein serine/threonine kinase regulator activity (ortholog); kinase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); antral ovarian follicle growth (ortholog); cellular response to nutrient (o rtholog); PARTICIPATES IN G1/S transition pathway; mTOR signaling pathway; ASSOCIATED WITH Bowen's Disease (ortholog); breast adenocarcinoma (ortholog); breast cancer (ortholog); FOUND IN centrosome (ortholog); cyclin E1-CDK2 complex (ortholog); cyclin-dependent protein kinase holoenzyme complex (ortholog) | | | | Green Monkey | 103 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18916555 | Ccne1 | cyclin E1 | ENCODES a protein that exhibits cyclin-dependent protein serine/threonine kinase regulator activity (ortholog); kinase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); antral ovarian follicle growth (ortholog); cellular response to nutrient (o rtholog); PARTICIPATES IN G1/S transition pathway; mTOR signaling pathway; ASSOCIATED WITH Bowen's Disease (ortholog); breast adenocarcinoma (ortholog); breast cancer (ortholog); FOUND IN centrosome (ortholog); cyclin E1-CDK2 complex (ortholog); cyclin-dependent protein kinase holoenzyme complex (ortholog) | | | | Naked Mole-Rat | 103 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866079 | CCNE1 | cyclin E1 | ENCODES a protein that exhibits cyclin-dependent protein serine/threonine kinase regulator activity (inferred); kinase activity (inferred); protein kinase binding (inferred); INVOLVED IN cell division (inferred); G1/S transition of mitotic cell cycle (inferred); positive regulation of mesenchymal st em cell proliferation (inferred); FOUND IN cyclin E1-CDK2 complex (inferred); cyclin-dependent protein kinase holoenzyme complex (inferred); nucleoplasm (inferred) | | | | Green Monkey | 10 | symbol | gene, protein-coding |
| 155232424 | ccne1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155243630 | ccne1.S | | | | | | African Clawed Frog | | symbol | gene, null |
