| 71082 | Bmpr2 | bone morphogenetic protein receptor type 2 | ENCODES a protein that exhibits growth factor binding; activin receptor activity, type II (ortholog); BMP binding (ortholog); INVOLVED IN retina development in camera-type eye; angiogenesis (ortholog); anterior/posterior pattern specification (ortholog); PARTICIPATES IN Bone morphogenetic proteins s ignaling pathway; cytokine mediated signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; ASSOCIATED WITH vascular smooth muscle hypertrophy; ASSOCIATED WITH Brain Injuries; Experimental Diabetes Mellitus; Femoral Fractures; FOUND IN apical plasma membrane; basal plasma membrane; caveola; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 9 | 68685942 | 68801353 | Rat | 350 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 735373 | BMPR2 | bone morphogenetic protein receptor type 2 | This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signa ls through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, May 2020] | 2 | 202376327 | 202567749 | Human | 1437 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 735374 | Bmpr2 | bone morphogenetic protein receptor type 2 | This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type II receptor that binds extracellular BMPs and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream t o activate SMAD transcriptional regulators. This signaling is important during embryonic development. Mutations in this gene can cause pulmonary hypertension. [provided by RefSeq, Mar 2013] | 1 | 59802721 | 59917240 | Mouse | 458 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8700292 | Bmpr2 | bone morphogenetic protein receptor type 2 | ENCODES a protein that exhibits activin receptor activity, type II (ortholog); BMP binding (ortholog); BMP receptor activity (ortholog); INVOLVED IN angiogenesis (ortholog); anterior/posterior pattern specification (ortholog); aortic valve development (ortholog); PARTICIPATES IN Bone morphogenetic p roteins signaling pathway; ASSOCIATED WITH asthma (ortholog); Brain Injuries (ortholog); Breast Neoplasms (ortholog); FOUND IN adherens junction (ortholog); apical plasma membrane (ortholog); axon (ortholog) | NW_004955457 | 12235780 | 12315680 | Chinchilla | 135 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11759533 | BMPR2 | bone morphogenetic protein receptor type 2 | ENCODES a protein that exhibits growth factor binding (ortholog); INVOLVED IN angiogenesis (ortholog); anterior/posterior pattern specification (ortholog); atrioventricular valve morphogenesis (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH asthma (ortholog ); Brain Injuries (ortholog); Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); caveola (ortholog) | 2B | 89631622 | 89823438 | Bonobo | 170 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12070199 | BMPR2 | bone morphogenetic protein receptor type 2 | ENCODES a protein that exhibits growth factor binding (ortholog); INVOLVED IN angiogenesis (ortholog); anterior/posterior pattern specification (ortholog); atrioventricular valve morphogenesis (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH asthma (ortholog ); Brain Injuries (ortholog); Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); caveola (ortholog) | 37 | 11342292 | 11540199 | Dog | 167 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12555351 | Bmpr2 | bone morphogenetic protein receptor type 2 | ENCODES a protein that exhibits growth factor binding (ortholog); INVOLVED IN angiogenesis (ortholog); anterior/posterior pattern specification (ortholog); atrioventricular valve morphogenesis (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH asthma (ortholog ); Brain Injuries (ortholog); Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); caveola (ortholog) | NW_004936726 | 1543263 | 1711422 | Squirrel | 169 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18900954 | Bmpr2 | bone morphogenetic protein receptor type 2 | ENCODES a protein that exhibits activin receptor activity, type II (ortholog); BMP binding (ortholog); BMP receptor activity (ortholog); INVOLVED IN angiogenesis (ortholog); anterior/posterior pattern specification (ortholog); aortic valve development (ortholog); PARTICIPATES IN Bone morphogenetic p roteins signaling pathway; ASSOCIATED WITH asthma (ortholog); Brain Injuries (ortholog); Breast Neoplasms (ortholog); FOUND IN adherens junction (ortholog); apical plasma membrane (ortholog); axon (ortholog) | | | | Naked Mole-Rat | 144 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14160134 | BMPR2 | bone morphogenetic protein receptor type 2 | ENCODES a protein that exhibits growth factor binding (ortholog); INVOLVED IN angiogenesis (ortholog); anterior/posterior pattern specification (ortholog); atrioventricular valve morphogenesis (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH asthma (ortholog ); Brain Injuries (ortholog); Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); caveola (ortholog) | | | | Pig | 172 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155236504 | bmpr2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18494972 | BMPR2 | bone morphogenetic protein receptor type 2 | ENCODES a protein that exhibits growth factor binding (ortholog); INVOLVED IN angiogenesis (ortholog); anterior/posterior pattern specification (ortholog); atrioventricular valve morphogenesis (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH asthma (ortholog ); Brain Injuries (ortholog); Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); caveola (ortholog) | | | | Green Monkey | 166 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625908413 | Bmpr2 | bone morphogenetic protein receptor type 2 | ENCODES a protein that exhibits activin receptor activity, type II (ortholog); BMP binding (ortholog); BMP receptor activity (ortholog); INVOLVED IN angiogenesis (ortholog); anterior/posterior pattern specification (ortholog); aortic valve development (ortholog); PARTICIPATES IN Bone morphogenetic p roteins signaling pathway; ASSOCIATED WITH asthma (ortholog); Brain Injuries (ortholog); Breast Neoplasms (ortholog); FOUND IN adherens junction (ortholog); apical plasma membrane (ortholog); axon (ortholog) | | | | Black Rat | 133 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236505 | bmpr2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155242242 | bmpr2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 38501087 | Bmpr2em1Ang | bone morphogenetic protein receptor type 2; ZFN induced mutant 1, Ang | ASSOCIATED WITH vascular smooth muscle hypertrophy; ASSOCIATED WITH Vascular Remodeling | | | | Rat | 2 | symbol , description | gene, allele |
| 14981587 | Bmpr2em1Sage | bone morphogenetic protein receptor type 2; ZFN induced mutant 1, Sage | ASSOCIATED WITH pulmonary hypertension | | | | Rat | 1 | symbol , description , old_gene_symbol | gene, allele |
| 14981589 | Bmpr2em2Sage | bone morphogenetic protein receptor type 2; ZFN induced mutant 2, Sage | ASSOCIATED WITH pulmonary hypertension | | | | Rat | 1 | symbol , description | gene, allele |
| 734372 | BMPR1A | bone morphogenetic protein receptor type 1A | The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008] | 10 | 86755763 | 86932844 | Human | 1027 | description | gene, protein-coding, REVIEWED [RefSeq] |