BMPR2 (bone morphogenetic protein receptor type 2) - Rat Genome Database

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Gene: BMPR2 (bone morphogenetic protein receptor type 2) Canis lupus familiaris
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Symbol: BMPR2
Name: bone morphogenetic protein receptor type 2
RGD ID: 12070199
Description: ENCODES a protein that exhibits BMP binding (ortholog); BMP receptor activity (ortholog); cadherin binding (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); aortic valve development (ortholog); artery development (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH asthma (ortholog); Brain Injuries (ortholog); Breast Neoplasms (ortholog); FOUND IN adherens junction (ortholog); apical plasma membrane (ortholog); basal plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: bone morphogenetic protein receptor type-2; LOW QUALITY PROTEIN: bone morphogenetic protein receptor type-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13711,342,292 - 11,540,199 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3711,342,384 - 11,533,024 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3712,225,170 - 12,423,716 (+)NCBI
ROS_Cfam_1.03711,278,198 - 11,476,750 (+)NCBI
UMICH_Zoey_3.13711,228,404 - 11,433,107 (+)NCBI
UNSW_CanFamBas_1.03711,207,452 - 11,404,742 (+)NCBI
UU_Cfam_GSD_1.03711,200,863 - 11,398,681 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (ISO)
aortic valve development  (ISO)
artery development  (ISO)
atrial septum morphogenesis  (ISO)
atrioventricular valve morphogenesis  (ISO)
blood vessel remodeling  (ISO)
BMP signaling pathway  (ISO)
brain development  (ISO)
cardiac muscle tissue development  (ISO)
cellular response to BMP stimulus  (ISO)
cellular response to starvation  (ISO)
chondrocyte development  (ISO)
endocardial cushion development  (ISO)
endothelial cell apoptotic process  (ISO)
endothelial cell proliferation  (ISO)
limb development  (ISO)
lung alveolus development  (ISO)
lymphangiogenesis  (ISO)
lymphatic endothelial cell differentiation  (ISO)
maternal placenta development  (ISO)
mesoderm formation  (ISO)
mitral valve morphogenesis  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell proliferation involved in heart valve morphogenesis  (ISO)
negative regulation of chondrocyte proliferation  (ISO)
negative regulation of DNA biosynthetic process  (ISO)
negative regulation of muscle cell differentiation  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of systemic arterial blood pressure  (ISO)
negative regulation of vasoconstriction  (ISO)
osteoblast differentiation  (ISO)
outflow tract morphogenesis  (ISO)
outflow tract septum morphogenesis  (ISO)
pharyngeal arch artery morphogenesis  (ISO)
positive regulation of axon extension involved in axon guidance  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of ossification  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
pulmonary valve development  (ISO)
regulation of cell population proliferation  (ISO)
regulation of lung blood pressure  (ISO)
retina development in camera-type eye  (ISO)
retina vasculature development in camera-type eye  (ISO)
semi-lunar valve development  (ISO)
transmembrane receptor protein serine/threonine kinase signaling pathway  (ISO)
tricuspid valve morphogenesis  (ISO)
venous blood vessel development  (ISO)
ventricular septum morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
BMPR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13711,342,292 - 11,540,199 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3711,342,384 - 11,533,024 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3712,225,170 - 12,423,716 (+)NCBI
ROS_Cfam_1.03711,278,198 - 11,476,750 (+)NCBI
UMICH_Zoey_3.13711,228,404 - 11,433,107 (+)NCBI
UNSW_CanFamBas_1.03711,207,452 - 11,404,742 (+)NCBI
UU_Cfam_GSD_1.03711,200,863 - 11,398,681 (+)NCBI
BMPR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2202,376,327 - 202,567,751 (+)EnsemblGRCh38hg38GRCh38
GRCh382202,376,310 - 202,567,751 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372203,241,050 - 203,432,472 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362202,949,916 - 203,140,719 (+)NCBINCBI36hg18NCBI36
Build 342203,067,104 - 203,257,979NCBI
Celera2196,992,827 - 197,184,404 (+)NCBI
Cytogenetic Map2q33.1-q33.2NCBI
HuRef2195,088,272 - 195,279,312 (+)NCBIHuRef
CHM1_12203,247,530 - 203,439,226 (+)NCBICHM1_1
Bmpr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39159,802,721 - 59,917,240 (+)NCBIGRCm39mm39
GRCm39 Ensembl159,802,559 - 59,918,173 (+)Ensembl
GRCm38159,764,279 - 59,878,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl159,763,400 - 59,879,014 (+)EnsemblGRCm38mm10GRCm38
MGSCv37159,821,481 - 59,927,703 (+)NCBIGRCm37mm9NCBIm37
MGSCv36159,709,183 - 59,815,405 (+)NCBImm8
Celera160,279,442 - 60,385,822 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map130.44NCBI
Bmpr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2961,192,718 - 61,307,280 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl961,190,566 - 61,301,809 (+)Ensembl
Rnor_6.0966,568,074 - 66,683,019 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl966,568,074 - 66,676,494 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0966,371,542 - 66,486,121 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4958,327,587 - 58,436,057 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1958,524,438 - 58,554,549 (+)NCBI
Celera958,627,253 - 58,735,336 (+)NCBICelera
Cytogenetic Map9q31NCBI
Bmpr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545712,235,780 - 12,316,727 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545712,235,780 - 12,315,680 (-)NCBIChiLan1.0ChiLan1.0
BMPR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B207,780,568 - 207,968,900 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B207,780,741 - 207,961,072 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B89,631,622 - 89,823,438 (+)NCBIMhudiblu_PPA_v0panPan3
Bmpr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303159,573,093 - 159,741,130 (+)NCBI
SpeTri2.0NW_0049367261,543,263 - 1,711,422 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMPR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15105,970,427 - 106,135,730 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115105,971,577 - 106,132,496 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215117,426,776 - 117,589,050 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BMPR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11088,103,442 - 88,302,578 (+)NCBI
ChlSab1.1 Ensembl1088,106,072 - 88,303,734 (+)Ensembl
Vero_WHO_p1.0NW_023666040111,076,327 - 111,285,567 (-)NCBI
Bmpr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476513,849,689 - 13,950,839 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 2 12 10 6
Low 4 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000036570   ⟹   ENSCAFP00000031969
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3711,342,384 - 11,533,024 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000066641   ⟹   ENSCAFP00000043645
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3711,342,384 - 11,532,689 (+)Ensembl
RefSeq Acc Id: XM_022415218   ⟹   XP_022270926
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13711,342,292 - 11,540,199 (+)NCBI
Dog10K_Boxer_Tasha3712,225,170 - 12,423,716 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038447635   ⟹   XP_038303563
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03711,278,198 - 11,476,750 (+)NCBI
RefSeq Acc Id: XM_038521689   ⟹   XP_038377617
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13711,228,404 - 11,433,107 (+)NCBI
RefSeq Acc Id: XM_038585397   ⟹   XP_038441325
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03711,200,863 - 11,398,681 (+)NCBI
RefSeq Acc Id: XM_038649801   ⟹   XP_038505729
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03711,207,452 - 11,404,742 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_022270926   ⟸   XM_022415218
- Sequence:
RefSeq Acc Id: ENSCAFP00000043645   ⟸   ENSCAFT00000066641
RefSeq Acc Id: ENSCAFP00000031969   ⟸   ENSCAFT00000036570
RefSeq Acc Id: XP_038377617   ⟸   XM_038521689
RefSeq Acc Id: XP_038505729   ⟸   XM_038649801
RefSeq Acc Id: XP_038303563   ⟸   XM_038447635
RefSeq Acc Id: XP_038441325   ⟸   XM_038585397

Promoters
RGD ID:13689123
Promoter ID:EPDNEW_C7190
Type:initiation region
Name:BMPR2_1
Description:bone morphogenetic protein receptor type 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13711,342,472 - 11,342,532EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000023687 Ensembl, ENTREZGENE
NCBI Gene BMPR2 ENTREZGENE
VGNC ID VGNC:38486 ENTREZGENE