BMPR2 (bone morphogenetic protein receptor type 2) - Rat Genome Database

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Gene: BMPR2 (bone morphogenetic protein receptor type 2) Sus scrofa
Analyze
Symbol: BMPR2
Name: bone morphogenetic protein receptor type 2
RGD ID: 14160134
Description: ENCODES a protein that exhibits growth factor binding (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); artery development (ortholog); atrioventricular valve morphogenesis (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH asthma (ortholog); Brain Injuries (ortholog); Breast Neoplasms (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); caveola (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15105,970,427 - 106,135,730 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115105,971,577 - 106,132,496 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215117,426,776 - 117,589,050 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (IEA,ISO)
aortic valve development  (IEA)
artery development  (ISO)
atrial septum morphogenesis  (IEA)
atrioventricular valve morphogenesis  (ISO)
blood vessel development  (IBA)
blood vessel remodeling  (IEA)
BMP signaling pathway  (IBA,IEA,ISO)
brain development  (ISO)
cardiac muscle tissue development  (ISO)
cellular response to BMP stimulus  (ISO)
cellular response to growth factor stimulus  (IBA)
cellular response to starvation  (IEA)
chondrocyte development  (IEA)
endocardial cushion development  (IEA)
endochondral bone morphogenesis  (ISS)
endothelial cell apoptotic process  (IEA)
endothelial cell proliferation  (IEA)
limb development  (IEA,ISO)
lung alveolus development  (IEA)
lymphangiogenesis  (IEA)
lymphatic endothelial cell differentiation  (IEA)
maternal placenta development  (IEA,ISO)
mesoderm formation  (IEA,ISO)
mitral valve morphogenesis  (IEA)
negative regulation of cell growth  (IEA)
negative regulation of cell proliferation involved in heart valve morphogenesis  (IEA)
negative regulation of chondrocyte proliferation  (IEA)
negative regulation of DNA biosynthetic process  (IEA)
negative regulation of muscle cell differentiation  (IEA)
negative regulation of smooth muscle cell proliferation  (IEA)
negative regulation of systemic arterial blood pressure  (IEA)
negative regulation of vasoconstriction  (IEA)
osteoblast differentiation  (IEA)
outflow tract morphogenesis  (ISO)
outflow tract septum morphogenesis  (IEA,ISO)
pharyngeal arch artery morphogenesis  (IEA,ISO)
positive regulation of axon extension involved in axon guidance  (IEA)
positive regulation of BMP signaling pathway  (IEA)
positive regulation of bone mineralization  (IEA)
positive regulation of cartilage development  (ISS)
positive regulation of endothelial cell migration  (IEA)
positive regulation of endothelial cell proliferation  (IEA)
positive regulation of epithelial cell migration  (ISO)
positive regulation of ossification  (ISO)
positive regulation of osteoblast differentiation  (IEA)
positive regulation of pathway-restricted SMAD protein phosphorylation  (IEA)
positive regulation of protein serine/threonine kinase activity  (IEA)
positive regulation of SMAD protein signal transduction  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
protein phosphorylation  (IBA,IEA)
proteoglycan biosynthetic process  (ISS)
pulmonary valve development  (IEA)
regulation of cell population proliferation  (ISO)
regulation of lung blood pressure  (IEA)
retina development in camera-type eye  (ISO)
retina vasculature development in camera-type eye  (IEA)
semi-lunar valve development  (ISO)
transmembrane receptor protein serine/threonine kinase signaling pathway  (IEA)
tricuspid valve morphogenesis  (IEA)
venous blood vessel development  (IEA)
ventricular septum morphogenesis  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16024566   PMID:19359354  


Genomics

Comparative Map Data
BMPR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15105,970,427 - 106,135,730 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115105,971,577 - 106,132,496 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215117,426,776 - 117,589,050 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BMPR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2202,376,327 - 202,567,751 (+)EnsemblGRCh38hg38GRCh38
GRCh382202,376,310 - 202,567,751 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372203,241,050 - 203,432,472 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362202,949,916 - 203,140,719 (+)NCBINCBI36hg18NCBI36
Build 342203,067,104 - 203,257,979NCBI
Celera2196,992,827 - 197,184,404 (+)NCBI
Cytogenetic Map2q33.1-q33.2NCBI
HuRef2195,088,272 - 195,279,312 (+)NCBIHuRef
CHM1_12203,247,530 - 203,439,226 (+)NCBICHM1_1
Bmpr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39159,802,721 - 59,917,240 (+)NCBIGRCm39mm39
GRCm39 Ensembl159,802,559 - 59,918,173 (+)Ensembl
GRCm38159,764,279 - 59,878,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl159,763,400 - 59,879,014 (+)EnsemblGRCm38mm10GRCm38
MGSCv37159,821,481 - 59,927,703 (+)NCBIGRCm37mm9NCBIm37
MGSCv36159,709,183 - 59,815,405 (+)NCBImm8
Celera160,279,442 - 60,385,822 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map130.44NCBI
Bmpr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2961,192,718 - 61,307,280 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl961,190,566 - 61,301,809 (+)Ensembl
Rnor_6.0966,568,074 - 66,683,019 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl966,568,074 - 66,676,494 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0966,371,542 - 66,486,121 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4958,327,587 - 58,436,057 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1958,524,438 - 58,554,549 (+)NCBI
Celera958,627,253 - 58,735,336 (+)NCBICelera
Cytogenetic Map9q31NCBI
Bmpr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545712,235,780 - 12,316,727 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545712,235,780 - 12,315,680 (-)NCBIChiLan1.0ChiLan1.0
BMPR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B207,780,568 - 207,968,900 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B207,780,741 - 207,961,072 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B89,631,622 - 89,823,438 (+)NCBIMhudiblu_PPA_v0panPan3
BMPR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13711,342,292 - 11,540,199 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3711,342,384 - 11,533,024 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3712,225,170 - 12,423,716 (+)NCBI
ROS_Cfam_1.03711,278,198 - 11,476,750 (+)NCBI
UMICH_Zoey_3.13711,228,404 - 11,433,107 (+)NCBI
UNSW_CanFamBas_1.03711,207,452 - 11,404,742 (+)NCBI
UU_Cfam_GSD_1.03711,200,863 - 11,398,681 (+)NCBI
Bmpr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303159,573,093 - 159,741,130 (+)NCBI
SpeTri2.0NW_0049367261,543,263 - 1,711,422 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMPR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11088,103,442 - 88,302,578 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1088,106,072 - 88,303,734 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040111,076,327 - 111,285,567 (-)NCBIVero_WHO_p1.0
Bmpr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476513,849,689 - 13,950,839 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000034069   ⟹   ENSSSCP00000028426
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15105,970,488 - 106,135,730 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000076560   ⟹   ENSSSCP00000063228
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15105,970,427 - 106,132,251 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000078952   ⟹   ENSSSCP00000074024
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15105,970,488 - 106,135,730 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000079406   ⟹   ENSSSCP00000070805
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15105,970,630 - 106,133,703 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000087335   ⟹   ENSSSCP00000064108
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15105,970,488 - 106,135,730 (+)Ensembl
RefSeq Acc Id: NM_001204900   ⟹   NP_001191829
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115105,971,577 - 106,132,496 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001191829 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACD70395 (Get FASTA)   NCBI Sequence Viewer  
  ADX68945 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001191829   ⟸   NM_001204900
- Peptide Label: precursor
- UniProtKB: F1SI16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000074024   ⟸   ENSSSCT00000078952
RefSeq Acc Id: ENSSSCP00000028426   ⟸   ENSSSCT00000034069
RefSeq Acc Id: ENSSSCP00000070805   ⟸   ENSSSCT00000079406
RefSeq Acc Id: ENSSSCP00000063228   ⟸   ENSSSCT00000076560
RefSeq Acc Id: ENSSSCP00000064108   ⟸   ENSSSCT00000087335
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000016113 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070022547 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000028426 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000063228 UniProtKB/TrEMBL
  ENSSSCP00000064108 UniProtKB/TrEMBL
  ENSSSCP00000070805 UniProtKB/TrEMBL
  ENSSSCP00000074024 UniProtKB/TrEMBL
  ENSSSCP00070037785 UniProtKB/TrEMBL
  ENSSSCP00070037791 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000034069 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000076560 UniProtKB/TrEMBL
  ENSSSCT00000078952 UniProtKB/TrEMBL
  ENSSSCT00000079406 UniProtKB/TrEMBL
  ENSSSCT00000087335 UniProtKB/TrEMBL
  ENSSSCT00070044837 UniProtKB/TrEMBL
  ENSSSCT00070044845 UniProtKB/TrEMBL
InterPro Activin_recp UniProtKB/TrEMBL
  BMPR2 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  TGFB_receptor UniProtKB/TrEMBL
  Transform_growth_fac-b_typ-2 UniProtKB/TrEMBL
KEGG Report ssc:100127483 UniProtKB/TrEMBL
NCBI Gene BMPR2 ENTREZGENE
PANTHER PTHR23255 UniProtKB/TrEMBL
  PTHR23255:SF97 UniProtKB/TrEMBL
Pfam Activin_recp UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PIRSF TGFRII UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A4X1V4U3_PIG UniProtKB/TrEMBL
  A0A4X1V8C6_PIG UniProtKB/TrEMBL
  A0A5G2QG49_PIG UniProtKB/TrEMBL
  A0A5G2QH51_PIG UniProtKB/TrEMBL
  A0A5G2R0W5_PIG UniProtKB/TrEMBL
  A0A5G2R9P4_PIG UniProtKB/TrEMBL
  B3GEL9_PIG UniProtKB/TrEMBL
  F1SI16 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1CK16 UniProtKB/TrEMBL
  K7GKP9 UniProtKB/TrEMBL
VGNC ID VGNC:95494 ENTREZGENE