| 70499 | Birc5 | baculoviral IAP repeat-containing 5 | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); enzyme binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to ethanol; cellular response to stem cell factor stimulus; negative regulation of a poptotic process; PARTICIPATES IN histone modification pathway; colorectal cancer pathway; ASSOCIATED WITH acute necrotizing pancreatitis; acute pancreatitis; Brain Injuries; FOUND IN apical plasma membrane; centriole (ortholog); chromosome passenger complex (ortholog); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 1-naphthyl isothiocyanate | 10 | 103567369 | 103580069 | Rat | 936 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 732772 | Birc5 | baculoviral IAP repeat-containing 5 | This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The enco ded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene's expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate. [provided by RefSeq, Jul 2008] | 11 | 117740063 | 117746569 | Mouse | 965 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 737482 | BIRC5 | baculoviral IAP repeat containing 5 | This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The enco ded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011] | 17 | 78214253 | 78225635 | Human | 934 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 11938488 | BIRC5 | baculoviral IAP repeat containing 5 | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); enzyme binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to ethanol (ortholog); cellular response to stem cell factor stimulus (ortholog); ch romosome localization (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH acute megakaryocytic leukemia (ortholog); acute necrotizing pancreatitis (ortholog); acute pancreatitis (ortholog); FOUND IN apical plasma membrane (ortholog); centriole (ortholog); chromosome passenger complex (ortholog) | 17 | 72292332 | 72303493 | Bonobo | 171 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12244289 | BIRC5 | baculoviral IAP repeat containing 5 | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); enzyme binding (ortholog); identical protein binding (ortholog); INVOLVED IN cell division (ortholog); cellular response to ethanol (ortholog); cellular response to stem cell fact or stimulus (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH acute megakaryocytic leukemia (ortholog); acute necrotizing pancreatitis (ortholog); acute pancreatitis (ortholog); FOUND IN apical plasma membrane (ortholog); centriole (ortholog); chromosome passenger complex (ortholog); INTERACTS WITH masitinib | 9 | 2930308 | 2959307 | Dog | 187 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12461336 | Birc5 | baculoviral IAP repeat containing 5 | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); enzyme binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to ethanol (ortholog); cellular response to stem cell factor stimulus (ortholog); ch romosome localization (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH acute megakaryocytic leukemia (ortholog); acute necrotizing pancreatitis (ortholog); acute pancreatitis (ortholog); FOUND IN apical plasma membrane (ortholog); centriole (ortholog); chromosome passenger complex (ortholog) | NW_004936594 | 2812165 | 2820618 | Squirrel | 170 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625936211 | Birc5 | baculoviral IAP repeat containing 5 | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); enzyme binding (ortholog); identical protein binding (ortholog); INVOLVED IN cell division (ortholog); cellular response to ethanol (ortholog); cellular response to stem cell fact or stimulus (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH acute megakaryocytic leukemia (ortholog); acute necrotizing pancreatitis (ortholog); acute pancreatitis (ortholog); FOUND IN apical plasma membrane (ortholog); centriole (ortholog); chromosome passenger complex (ortholog) | | | | Black Rat | 168 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285218261 | birc5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14187995 | BIRC5 | baculoviral IAP repeat containing 5 | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); enzyme binding (ortholog); identical protein binding (ortholog); INVOLVED IN cell division (ortholog); cellular response to ethanol (ortholog); cellular response to stem cell fact or stimulus (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH acute megakaryocytic leukemia (ortholog); acute necrotizing pancreatitis (ortholog); acute pancreatitis (ortholog); FOUND IN apical plasma membrane (ortholog); centriole (ortholog); chromosome passenger complex (ortholog) | | | | Pig | 187 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 39131482 | BIRC5 | baculoviral IAP repeat containing 5 | | | | | Chinchilla | | symbol | gene, protein-coding |
| 18765498 | BIRC5 | baculoviral IAP repeat containing 5 | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); enzyme binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to ethanol (ortholog); cellular response to stem cell factor stimulus (ortholog); ch romosome localization (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH acute megakaryocytic leukemia (ortholog); acute necrotizing pancreatitis (ortholog); acute pancreatitis (ortholog); FOUND IN apical plasma membrane (ortholog); centriole (ortholog); chromosome passenger complex (ortholog) | | | | Green Monkey | 171 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18902353 | Birc5 | baculoviral IAP repeat containing 5 | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); enzyme binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to ethanol (ortholog); cellular response to stem cell factor stimulus (ortholog); ch romosome localization (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH acute megakaryocytic leukemia (ortholog); acute necrotizing pancreatitis (ortholog); acute pancreatitis (ortholog); FOUND IN apical plasma membrane (ortholog); centriole (ortholog); chromosome passenger complex (ortholog) | | | | Naked Mole-Rat | 171 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 286153393 | birc5.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 284763296 | birc5.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 155246360 | birc5l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155252731 | birc5l.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155253320 | birc5l.S | | | | | | African Clawed Frog | | symbol | gene, null |