| 1343744 | BAG2 | BAG cochaperone 2 | BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008] | 6 | 57172326 | 57189833 | Human | 197 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1585173 | Bag2 | BAG cochaperone 2 | ENCODES a protein that exhibits adenyl-nucleotide exchange factor activity (ortholog); heat shock protein binding (ortholog); identical protein binding (ortholog); INVOLVED IN negative regulation of protein ubiquitination (ortholog); positive regulation of proteasomal protein catabolic process (orth olog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; ASSOCIATED WITH Carpenter syndrome 1 (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); dendritic microtubule (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol | 9 | 43465993 | 43476637 | Rat | 170 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1621366 | Bag2 | BCL2-associated athanogene 2 | Enables heat shock protein binding activity and tau protein binding activity. Involved in negative regulation of protein ubiquitination and positive regulation of proteasomal protein catabolic process. Located in axon and dendrite. Colocalizes with dendritic microtubule. Orthologous to human BAG2 tyle='font-weight:700;'>BAG2 (BAG cochaperone 2). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 33784565 | 33796831 | Mouse | 200 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8779766 | Bag2 | BAG cochaperone 2 | ENCODES a protein that exhibits adenyl-nucleotide exchange factor activity (ortholog); heat shock protein binding (ortholog); identical protein binding (ortholog); INVOLVED IN negative regulation of protein ubiquitination (ortholog); positive regulation of proteasomal protein catabolic process (orth olog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH Carpenter syndrome 1 (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); dendritic microtubule (ortholog) | NW_004955502 | 2984233 | 2994457 | Chinchilla | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11735213 | BAG2 | BAG cochaperone 2 | ENCODES a protein that exhibits adenyl-nucleotide exchange factor activity (inferred); heat shock protein binding (inferred); identical protein binding (inferred); INVOLVED IN positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH Carpenter syndr ome 1 (ortholog); FOUND IN axon (inferred); dendrite (inferred); dendritic microtubule (inferred) | 6 | 56730297 | 56743123 | Bonobo | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12099582 | BAG2 | BAG cochaperone 2 | ENCODES a protein that exhibits heat shock protein binding (ortholog); identical protein binding (ortholog); tau protein binding (ortholog); INVOLVED IN positive regulation of proteasomal protein catabolic process (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic p rocess (ortholog); positive regulation of protein processing (ortholog); ASSOCIATED WITH Carpenter syndrome 1 (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); dendritic microtubule (ortholog) | 12 | 24353549 | 24369190 | Dog | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12637427 | Bag2 | BAG cochaperone 2 | ENCODES a protein that exhibits adenyl-nucleotide exchange factor activity (inferred); heat shock protein binding (inferred); identical protein binding (inferred); INVOLVED IN positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH Carpenter syndr ome 1 (ortholog); FOUND IN axon (inferred); dendrite (inferred); dendritic microtubule (inferred) | NW_004936476 | 4131159 | 4142357 | Squirrel | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18725763 | BAG2 | BAG cochaperone 2 | ENCODES a protein that exhibits adenyl-nucleotide exchange factor activity (inferred); heat shock protein binding (inferred); identical protein binding (inferred); INVOLVED IN positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH Carpenter syndr ome 1 (ortholog); FOUND IN axon (inferred); dendrite (inferred); dendritic microtubule (inferred) | | | | Green Monkey | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155232131 | bag2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626005258 | Bag2 | BAG cochaperone 2 | ENCODES a protein that exhibits adenyl-nucleotide exchange factor activity (ortholog); heat shock protein binding (ortholog); identical protein binding (ortholog); INVOLVED IN negative regulation of protein ubiquitination (ortholog); positive regulation of proteasomal protein catabolic process (orth olog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH Carpenter syndrome 1 (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); dendritic microtubule (ortholog) | | | | Black Rat | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18899766 | Bag2 | BAG cochaperone 2 | ENCODES a protein that exhibits heat shock protein binding (ortholog); identical protein binding (ortholog); tau protein binding (ortholog); INVOLVED IN positive regulation of proteasomal protein catabolic process (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic p rocess (ortholog); positive regulation of protein processing (ortholog); ASSOCIATED WITH Carpenter syndrome 1 (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); dendritic microtubule (ortholog) | | | | Naked Mole-Rat | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13876712 | BAG2 | BAG cochaperone 2 | ENCODES a protein that exhibits adenyl-nucleotide exchange factor activity (inferred); heat shock protein binding (inferred); identical protein binding (inferred); INVOLVED IN positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH Carpenter syndr ome 1 (ortholog); FOUND IN axon (inferred); dendrite (inferred); dendritic microtubule (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236203 | bag2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155232132 | bag2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 13864640 | ARHGEF2 | Rho/Rac guanine nucleotide exchange factor 2 | ENCODES a protein that exhibits small GTPase binding; guanyl-nucleotide exchange factor activity (ortholog); microtubule binding (ortholog); INVOLVED IN positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of met alloendopeptidase activity; PARTICIPATES IN Reelin signaling pathway; ASSOCIATED WITH microcephaly (ortholog); myoepithelioma (ortholog); neurodevelopmental disorder with midbrain and hindbrain malformations (ortholog); FOUND IN cytoplasm (ortholog); cytoskeleton (ortholog); dendritic shaft (ortholog) | | | | Pig | 111 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 14280814 | AXL | AXL receptor tyrosine kinase | ENCODES a protein that exhibits myosin heavy chain binding (ortholog); phosphatidylinositol 3-kinase binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); apoptotic cell clearance (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN Gas6 - Axl signaling axis; ASSOCIATED WI TH amenorrhea (ortholog); Diabetic Nephropathies (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell surface (ortholog) | | | | Pig | 119 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1563268 | Brsk1 | BR serine/threonine kinase 1 | ENCODES a protein that exhibits protein serine/threonine kinase activity; gamma-tubulin binding (ortholog); magnesium ion binding (ortholog); INVOLVED IN neurotransmitter secretion; regulation of synaptic vesicle priming; associative learning (ortholog); FOUND IN cholinergic synapse; distal axon; po stsynaptic density; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; acetamide | 1 | 78162944 | 78193598 | Rat | 149 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1319476 | Calr3 | calreticulin 3 | Enables protein folding chaperone. Predicted to be involved in ERAD pathway and protein folding. Predicted to be located in endoplasmic reticulum lumen and nuclear envelope. Predicted to be active in endoplasmic reticulum membrane. Is expressed in cerebral cortex and telencephalon. Orthologous to hu man CALR3 (calreticulin 3). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 73178020 | 73197638 | Mouse | 79 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 14223907 | RAI14 | retinoic acid induced 14 | ENCODES a protein that exhibits actin binding (inferred); FOUND IN cytoskeleton (inferred); cytosol (inferred); nucleoplasm (inferred); INTERACTS WITH graphene oxide | | | | Pig | 13 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 13858149 | SFRP4 | secreted frizzled related protein 4 | ENCODES a protein that exhibits Wnt-protein binding (ortholog); INVOLVED IN decidualization (ortholog); female pregnancy (ortholog); mammary gland involution (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Desbuquois dysplasia (ortholog) ; Experimental Arthritis (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH ammonia | | | | Pig | 54 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 14148996 | SMAP2 | small ArfGAP2 | ENCODES a protein that exhibits GTPase activator activity (inferred); metal ion binding (inferred); zinc ion binding (inferred); FOUND IN cytosol (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 11 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1317192 | BAG3 | BAG cochaperone 3 | BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008] | 10 | 119651380 | 119677819 | Human | 735 | description | gene, protein-coding, REVIEWED [RefSeq] |