BAG2 (BAG cochaperone 2) - Rat Genome Database

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Gene: BAG2 (BAG cochaperone 2) Canis lupus familiaris
Analyze
Symbol: BAG2
Name: BAG cochaperone 2
RGD ID: 12099582
Description: ENCODES a protein that exhibits heat shock protein binding (ortholog); tau protein binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN positive regulation of proteasomal protein catabolic process (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); protein metabolic process (ortholog); ASSOCIATED WITH Carpenter syndrome (ortholog); Carpenter Syndrome 1 (ortholog); genetic disease (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); dendritic microtubule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: BAG family molecular chaperone regulator 2; BCL2 associated athanogene 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11224,353,549 - 24,369,190 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1224,353,663 - 24,368,350 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1224,283,590 - 24,299,229 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01224,893,036 - 24,908,696 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1224,893,052 - 24,908,693 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11224,390,264 - 24,405,914 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01224,491,610 - 24,506,382 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01224,623,002 - 24,638,655 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
BAG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11224,353,549 - 24,369,190 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1224,353,663 - 24,368,350 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1224,283,590 - 24,299,229 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01224,893,036 - 24,908,696 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1224,893,052 - 24,908,693 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11224,390,264 - 24,405,914 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01224,491,610 - 24,506,382 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01224,623,002 - 24,638,655 (+)NCBIUU_Cfam_GSD_1.0
BAG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38657,172,326 - 57,189,833 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl657,172,326 - 57,189,833 (+)EnsemblGRCh38hg38GRCh38
GRCh37657,037,124 - 57,054,631 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36657,145,293 - 57,157,694 (+)NCBINCBI36Build 36hg18NCBI36
Build 34657,145,292 - 57,157,692NCBI
Celera658,700,203 - 58,713,112 (+)NCBICelera
Cytogenetic Map6p12.1NCBI
HuRef656,871,161 - 56,884,070 (+)NCBIHuRef
CHM1_1657,037,430 - 57,050,339 (+)NCBICHM1_1
T2T-CHM13v2.0657,011,351 - 57,028,858 (+)NCBIT2T-CHM13v2.0
Bag2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39133,784,565 - 33,796,831 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl133,784,565 - 33,796,876 (-)EnsemblGRCm39 Ensembl
GRCm38133,745,484 - 33,757,750 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl133,745,484 - 33,757,795 (-)EnsemblGRCm38mm10GRCm38
MGSCv37133,802,329 - 33,814,595 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36133,690,030 - 33,702,309 (-)NCBIMGSCv36mm8
Celera133,520,517 - 33,532,756 (-)NCBICelera
Cytogenetic Map1BNCBI
cM Map112.81NCBI
Bag2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8943,465,993 - 43,476,637 (-)NCBIGRCr8
mRatBN7.2935,970,033 - 35,980,677 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl935,970,033 - 35,980,721 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx944,466,951 - 44,477,595 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0949,598,137 - 49,608,781 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0947,880,055 - 47,890,699 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0938,456,487 - 38,467,120 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl938,456,468 - 38,467,118 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0938,145,393 - 38,147,904 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4932,491,167 - 32,493,678 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera933,762,835 - 33,773,286 (-)NCBICelera
Cytogenetic Map9q21NCBI
Bag2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555022,984,233 - 2,994,457 (-)NCBIChiLan1.0ChiLan1.0
BAG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2571,642,366 - 71,656,326 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1667,523,808 - 67,536,531 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0656,730,297 - 56,743,123 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1658,360,889 - 58,373,733 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl658,360,889 - 58,373,733 (+)Ensemblpanpan1.1panPan2
Bag2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494659,817,850 - 59,829,590 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364764,129,013 - 4,142,357 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364764,131,159 - 4,142,357 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl728,659,753 - 28,680,491 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1728,668,587 - 28,680,497 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2733,129,078 - 33,140,950 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BAG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11714,420,196 - 14,432,910 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1714,420,947 - 14,433,354 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605820,509,961 - 20,527,469 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bag2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475318,983,449 - 18,986,078 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BAG2
169 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3
Low 2 5 22 6 6 6 6 6 12 8 10 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000048878   ⟹   ENSCAFP00000040404
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1224,353,663 - 24,368,350 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845024651   ⟹   ENSCAFP00845019396
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1224,893,052 - 24,908,693 (+)Ensembl
RefSeq Acc Id: XM_038492132   ⟹   XP_038348060
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11224,390,264 - 24,405,914 (+)NCBI
RefSeq Acc Id: XM_038554415   ⟹   XP_038410343
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01224,623,002 - 24,638,655 (+)NCBI
RefSeq Acc Id: XM_038618281   ⟹   XP_038474209
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01224,491,610 - 24,506,382 (+)NCBI
RefSeq Acc Id: XM_038683849   ⟹   XP_038539777
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01224,893,036 - 24,908,696 (+)NCBI
RefSeq Acc Id: XM_848025   ⟹   XP_853118
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11224,353,549 - 24,369,190 (+)NCBI
Dog10K_Boxer_Tasha1224,283,590 - 24,299,229 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_853118   ⟸   XM_848025
- UniProtKB: A0A8C0MH46 (UniProtKB/TrEMBL),   A0A8C0KRN4 (UniProtKB/TrEMBL),   A0A8I3P0Z8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000040404   ⟸   ENSCAFT00000048878
RefSeq Acc Id: XP_038348060   ⟸   XM_038492132
RefSeq Acc Id: XP_038474209   ⟸   XM_038618281
RefSeq Acc Id: XP_038539777   ⟸   XM_038683849
- UniProtKB: A0A8C0MH46 (UniProtKB/TrEMBL),   A0A8C0KRN4 (UniProtKB/TrEMBL),   A0A8I3P0Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038410343   ⟸   XM_038554415
- UniProtKB: A0A8C0KRN4 (UniProtKB/TrEMBL),   A0A8C0MH46 (UniProtKB/TrEMBL),   A0A8I3P0Z8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845019396   ⟸   ENSCAFT00845024651
Protein Domains
BAG

Promoters
RGD ID:13685475
Promoter ID:EPDNEW_C3543
Type:initiation region
Name:BAG2_1
Description:BCL2 associated athanogene 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11224,353,605 - 24,353,665EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000028759 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030005265 UniProtKB/TrEMBL
  ENSCAFG00040018805 UniProtKB/TrEMBL
  ENSCAFG00845013818 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000048878.3 UniProtKB/TrEMBL
  ENSCAFT00030009644.1 UniProtKB/TrEMBL
  ENSCAFT00040034799.1 UniProtKB/TrEMBL
  ENSCAFT00845024651 ENTREZGENE
  ENSCAFT00845024651.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.890 UniProtKB/TrEMBL
InterPro BAG2 UniProtKB/TrEMBL
  BAG_domain UniProtKB/TrEMBL
KEGG Report cfa:610506 UniProtKB/TrEMBL
NCBI Gene BAG2 ENTREZGENE
PANTHER BAG FAMILY MOLECULAR CHAPERONE REGULATOR 2 UniProtKB/TrEMBL
  PTHR12334 UniProtKB/TrEMBL
PROSITE BAG UniProtKB/TrEMBL
SMART BAG UniProtKB/TrEMBL
UniProt A0A8C0KRN4 ENTREZGENE
  A0A8C0MH46 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P0Z8 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:38364 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-10-08 BAG2  BAG cochaperone 2  BAG2  BCL2 associated athanogene 2  Symbol and/or name change 5135510 APPROVED