| 2037 | Adcyap1 | adenylate cyclase activating polypeptide 1 | ENCODES a protein that exhibits neuropeptide hormone activity; pituitary adenylate cyclase activating polypeptide activity; pituitary adenylate cyclase-activating polypeptide receptor binding; INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-mo dulating G protein-coupled receptor signaling pathway; behavioral fear response; ASSOCIATED WITH acute necrotizing pancreatitis; Brain Injuries; cystitis; FOUND IN extracellular space; neuronal dense core vesicle lumen; terminal bouton; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; alendronic acid | 9 | 120550236 | 120569096 | Rat | 226 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 10084 | Adcyap1 | adenylate cyclase activating polypeptide 1 | This gene encodes a member of the glucagon superfamily of hormones that have important roles in growth and metabolism. The encoded protein undergoes proteolytic processing to generate mature peptides that function as hypophysiotropic hormones, neurotransmitters, neuromodulators and vasoregulators. M ice lacking the encoded protein exhibit a high rate of early mortality. The surviving adult animals lacking the encoded protein exhibit decreased anxiety, hyperactive behavior and impaired steroidogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015] | 17 | 93506448 | 93513967 | Mouse | 318 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 732730 | ADCYAP1 | adenylate cyclase activating polypeptide 1 | This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediat ors of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013] | 18 | 904411 | 912172 | Human | 214 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8718744 | Adcyap1 | adenylate cyclase activating polypeptide 1 | ENCODES a protein that exhibits neuropeptide hormone activity (ortholog); peptide hormone receptor binding (ortholog); pituitary adenylate cyclase activating polypeptide activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate c yclase-modulating G protein-coupled receptor signaling pathway (ortholog); behavioral fear response (ortholog); ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); alcohol dependence (ortholog); Brain Injuries (ortholog); FOUND IN extracellular space (ortholog); neuronal dense core vesicle lumen (ortholog); terminal bouton (ortholog) | NW_004955402 | 9091927 | 9099803 | Chinchilla | 94 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11690392 | ADCYAP1 | adenylate cyclase activating polypeptide 1 | ENCODES a protein that exhibits pituitary adenylate cyclase-activating polypeptide receptor binding (ortholog); INVOLVED IN behavioral fear response (ortholog); cAMP biosynthetic process (ortholog); cellular response to glucocorticoid stimulus (ortholog); ASSOCIATED WITH acute necrotizing pancreatit is (ortholog); alcohol dependence (ortholog); Brain Injuries (ortholog); FOUND IN extracellular space (ortholog); neuronal dense core vesicle lumen (ortholog); terminal bouton (ortholog) | 18 | 13414618 | 13421668 | Bonobo | 93 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12217549 | ADCYAP1 | adenylate cyclase activating polypeptide 1 | ENCODES a protein that exhibits pituitary adenylate cyclase-activating polypeptide receptor binding (ortholog); INVOLVED IN behavioral fear response (ortholog); cAMP biosynthetic process (ortholog); cellular response to glucocorticoid stimulus (ortholog); ASSOCIATED WITH acute necrotizing pancreatit is (ortholog); alcohol dependence (ortholog); Brain Injuries (ortholog); FOUND IN extracellular space (ortholog); neuronal dense core vesicle lumen (ortholog); terminal bouton (ortholog) | 7 | 67682421 | 67691035 | Dog | 93 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12658174 | Adcyap1 | adenylate cyclase activating polypeptide 1 | ENCODES a protein that exhibits pituitary adenylate cyclase-activating polypeptide receptor binding (ortholog); INVOLVED IN behavioral fear response (ortholog); cAMP biosynthetic process (ortholog); cellular response to glucocorticoid stimulus (ortholog); ASSOCIATED WITH acute necrotizing pancreatit is (ortholog); alcohol dependence (ortholog); Brain Injuries (ortholog); FOUND IN extracellular space (ortholog); neuronal dense core vesicle lumen (ortholog); terminal bouton (ortholog) | NW_004936672 | 3461387 | 3468053 | Squirrel | 93 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14028124 | ADCYAP1 | adenylate cyclase activating polypeptide 1 | ENCODES a protein that exhibits pituitary adenylate cyclase activating polypeptide activity; neuropeptide hormone activity (ortholog); peptide hormone receptor binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of protein localizatio n; adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); alcohol dependence (ortholog); Brain Injuries (ortholog); FOUND IN extracellular space (ortholog); neuronal dense core vesicle lumen (ortholog); terminal bouton (ortholog); INTERACTS WITH (S)-nicotine; 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one; bisphenol A | | | | Pig | 119 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18779317 | ADCYAP1 | adenylate cyclase activating polypeptide 1 | ENCODES a protein that exhibits pituitary adenylate cyclase-activating polypeptide receptor binding (ortholog); signaling receptor binding (ortholog); type 1 vasoactive intestinal polypeptide receptor binding (ortholog); INVOLVED IN adenylate cyclase-modulating G protein-coupled receptor signaling p athway (ortholog); behavioral fear response (ortholog); cAMP biosynthetic process (ortholog); ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); alcohol dependence (ortholog); Brain Injuries (ortholog); FOUND IN extracellular space (ortholog); neuronal dense core vesicle lumen (ortholog); terminal bouton (ortholog) | | | | Green Monkey | 87 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18925164 | Adcyap1 | adenylate cyclase activating polypeptide 1 | ENCODES a protein that exhibits pituitary adenylate cyclase-activating polypeptide receptor binding (ortholog); signaling receptor binding (ortholog); type 1 vasoactive intestinal polypeptide receptor binding (ortholog); INVOLVED IN adenylate cyclase-modulating G protein-coupled receptor signaling p athway (ortholog); behavioral fear response (ortholog); cAMP biosynthetic process (ortholog); ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); alcohol dependence (ortholog); Brain Injuries (ortholog); FOUND IN extracellular space (ortholog); neuronal dense core vesicle lumen (ortholog); terminal bouton (ortholog) | | | | Naked Mole-Rat | 90 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234657 | adcyap1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625992820 | Adcyap1 | adenylate cyclase activating polypeptide 1 | ENCODES a protein that exhibits neuropeptide hormone activity (ortholog); peptide hormone receptor binding (ortholog); pituitary adenylate cyclase activating polypeptide activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate c yclase-modulating G protein-coupled receptor signaling pathway (ortholog); behavioral fear response (ortholog); ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); alcohol dependence (ortholog); Brain Injuries (ortholog); FOUND IN extracellular space (ortholog); neuronal dense core vesicle lumen (ortholog); terminal bouton (ortholog) | | | | Black Rat | 94 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245079 | adcyap1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155234656 | adcyap1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16564033 | AP000894.2 | novel transcript, antisense to ADCYAP1 | | | | | Human | | name | gene, lncrna |
| 16564113 | AP000894.3 | novel transcript, antisense to ADCYAP1 | | | | | Human | | name | gene, lncrna |
| 2038 | Adcyap1r1 | ADCYAP receptor type I | ENCODES a protein that exhibits adenylate cyclase binding; small GTPase binding; pituitary adenylate cyclase-activating polypeptide receptor activity (ortholog); INVOLVED IN cAMP biosynthetic process; cAMP metabolic process; development of primary female sexual characteristics; ASSOCIATED WITH cysti tis; Reperfusion Injury; asthma (ortholog); FOUND IN bicellular tight junction; caveola; cell surface; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; acetamide | 4 | 85924171 | 85972973 | Rat | 141 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 10085 | Adcyap1r1 | adenylate cyclase activating polypeptide 1 receptor 1 | Predicted to enable several functions, including G protein-coupled receptor activity; enzyme binding activity; and neuropeptide binding activity. Predicted to be involved in several processes, including cAMP-mediated signaling; positive regulation of inositol phosphate biosynthetic process; and posi tive regulation of intracellular signal transduction. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in several cellular components, including bicellular tight junction; caveola; and cell surface. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; immune system; and nervous system. Orthologous to human ADCYAP1R1 (ADCYAP receptor type I). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 55428486 | 55478440 | Mouse | 169 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 736792 | ADCYAP1R1 | ADCYAP receptor type I | This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 an d is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010] | 7 | 31052308 | 31111474 | Human | 151 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9040653 | Adcyap1r1 | ADCYAP receptor type I | ENCODES a protein that exhibits adenylate cyclase binding (ortholog); pituitary adenylate cyclase-activating polypeptide receptor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cAMP biosynthetic process (ortholog); cAMP metabolic process (ortholog); ASSOCIATED WITH asthma (ortholog); cystitis (ortholog); Reperfusion Injury (ortholog); FOUND IN bicellular tight junction (ortholog); caveola (ortholog); cell surface (ortholog) | NW_004955410 | 32176683 | 32229187 | Chinchilla | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11794541 | ADCYAP1R1 | ADCYAP receptor type I | ENCODES a protein that exhibits adenylate cyclase binding (ortholog); small GTPase binding (ortholog); INVOLVED IN cAMP biosynthetic process (ortholog); cAMP metabolic process (ortholog); development of primary female sexual characteristics (ortholog); ASSOCIATED WITH asthma (ortholog); cystitis (or tholog); Reperfusion Injury (ortholog); FOUND IN bicellular tight junction (ortholog); caveola (ortholog); cell surface (ortholog) | 7 | 31597251 | 31724299 | Bonobo | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12270529 | ADCYAP1R1 | ADCYAP receptor type I | ENCODES a protein that exhibits adenylate cyclase binding (ortholog); small GTPase binding (ortholog); INVOLVED IN cAMP biosynthetic process (ortholog); cAMP metabolic process (ortholog); development of primary female sexual characteristics (ortholog); ASSOCIATED WITH asthma (ortholog); cystitis (or tholog); Reperfusion Injury (ortholog); FOUND IN bicellular tight junction (ortholog); caveola (ortholog); cell surface (ortholog) | 14 | 43707683 | 43761166 | Dog | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12447404 | Adcyap1r1 | ADCYAP receptor type I | ENCODES a protein that exhibits adenylate cyclase binding (ortholog); small GTPase binding (ortholog); INVOLVED IN cAMP biosynthetic process (ortholog); cAMP metabolic process (ortholog); development of primary female sexual characteristics (ortholog); ASSOCIATED WITH asthma (ortholog); cystitis (or tholog); Reperfusion Injury (ortholog); FOUND IN bicellular tight junction (ortholog); caveola (ortholog); cell surface (ortholog) | NW_004936478 | 7278081 | 7322970 | Squirrel | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13905267 | ADCYAP1R1 | ADCYAP receptor type I | ENCODES a protein that exhibits adenylate cyclase binding (ortholog); small GTPase binding (ortholog); INVOLVED IN cAMP biosynthetic process (ortholog); cAMP metabolic process (ortholog); development of primary female sexual characteristics (ortholog); ASSOCIATED WITH asthma (ortholog); cystitis (or tholog); Reperfusion Injury (ortholog); FOUND IN bicellular tight junction (ortholog); caveola (ortholog); cell surface (ortholog); INTERACTS WITH (S)-nicotine; carbon dioxide; dioxygen | | | | Pig | 49 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18491596 | ADCYAP1R1 | ADCYAP receptor type I | ENCODES a protein that exhibits adenylate cyclase binding (ortholog); small GTPase binding (ortholog); INVOLVED IN cAMP biosynthetic process (ortholog); cAMP metabolic process (ortholog); development of primary female sexual characteristics (ortholog); ASSOCIATED WITH asthma (ortholog); cystitis (or tholog); Reperfusion Injury (ortholog); FOUND IN bicellular tight junction (ortholog); caveola (ortholog); cell surface (ortholog) | | | | Green Monkey | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18899618 | Adcyap1r1 | ADCYAP receptor type I | ENCODES a protein that exhibits adenylate cyclase binding (ortholog); pituitary adenylate cyclase-activating polypeptide receptor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cAMP biosynthetic process (ortholog); cAMP metabolic process (ortholog); ASSOCIATED WITH asthma (ortholog); cystitis (ortholog); Reperfusion Injury (ortholog); FOUND IN bicellular tight junction (ortholog); caveola (ortholog); cell surface (ortholog) | | | | Naked Mole-Rat | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247223 | adcyap1r1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625890175 | Adcyap1r1 | ADCYAP receptor type I | ENCODES a protein that exhibits adenylate cyclase binding (ortholog); pituitary adenylate cyclase-activating polypeptide receptor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cAMP biosynthetic process (ortholog); cAMP metabolic process (ortholog); ASSOCIATED WITH asthma (ortholog); cystitis (ortholog); Reperfusion Injury (ortholog); FOUND IN bicellular tight junction (ortholog); caveola (ortholog); cell surface (ortholog) | | | | Black Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155259219 | adcyap1r1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155233973 | adcyap1r1.S | | | | | | African Clawed Frog | | symbol | gene, null |