| 620514 | Acads | acyl-CoA dehydrogenase short chain | ENCODES a protein that exhibits acyl-CoA dehydrogenase activity; FAD binding; flavin adenine dinucleotide binding; INVOLVED IN butyrate catabolic process; fatty acid beta-oxidation using acyl-CoA dehydrogenase; response to glucocorticoid; PARTICIPATES IN fatty acid beta degradation pathway; 3-hydrox y-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; ASSOCIATED WITH alcohol use disorder (ortholog); congestive heart failure (ortholog); genetic disease (ortholog); FOUND IN mitochondrial matrix; mitochondrial membrane; mitochondrion (ortholog); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 12 | 47154259 | 47163580 | Rat | 233 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732202 | ACADS | acyl-CoA dehydrogenase short chain | This gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with short-chain acyl-CoA dehydrogenase (SCAD) deficiency. Alternative splicing results in two variants which encode different isoforms. [provided by RefSeq, Oct 2014] | 12 | 120725826 | 120740008 | Human | 362 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 732203 | Acads | acyl-Coenzyme A dehydrogenase, short chain | This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four st eps, each member of the Acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum at C(four)-CoA. In mice, deficiency of this gene has been linked to cold sensitivity and increased high-density lipoprotein levels. [provided by RefSeq, Nov 2012] | 5 | 115248358 | 115257405 | Mouse | 261 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8699899 | Acads | acyl-CoA dehydrogenase short chain | ENCODES a protein that exhibits acyl-CoA dehydrogenase activity (ortholog); FAD binding (ortholog); flavin adenine dinucleotide binding (ortholog); INVOLVED IN butyrate catabolic process (ortholog); fatty acid beta-oxidation using acyl-CoA dehydrogenase (ortholog); response to glucocorticoid (orthol og); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; ASSOCIATED WITH alcohol use disorder (ortholog); congestive heart failure (ortholog); genetic disease (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrial membrane (ortholog); mitochondrion (ortholog) | NW_004955455 | 10928560 | 10942748 | Chinchilla | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11923393 | ACADS | acyl-CoA dehydrogenase short chain | ENCODES a protein that exhibits acyl-CoA dehydrogenase activity (ortholog); FAD binding (ortholog); flavin adenine dinucleotide binding (ortholog); INVOLVED IN butyrate catabolic process (ortholog); fatty acid beta-oxidation using acyl-CoA dehydrogenase (ortholog); response to glucocorticoid (orthol og); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; ASSOCIATED WITH alcohol use disorder (ortholog); congestive heart failure (ortholog); genetic disease (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrial membrane (ortholog) | 12 | 118309303 | 118323489 | Bonobo | 60 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12074954 | ACADS | acyl-CoA dehydrogenase short chain | ENCODES a protein that exhibits acyl-CoA dehydrogenase activity (ortholog); FAD binding (ortholog); flavin adenine dinucleotide binding (ortholog); INVOLVED IN butyrate catabolic process (ortholog); fatty acid beta-oxidation using acyl-CoA dehydrogenase (ortholog); response to glucocorticoid (orthol og); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; ASSOCIATED WITH alcohol use disorder (ortholog); congestive heart failure (ortholog); genetic disease (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrial membrane (ortholog) | 26 | 16572936 | 16584760 | Dog | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12552826 | Acads | acyl-CoA dehydrogenase short chain | ENCODES a protein that exhibits acyl-CoA dehydrogenase activity (ortholog); FAD binding (ortholog); flavin adenine dinucleotide binding (ortholog); INVOLVED IN butyrate catabolic process (ortholog); fatty acid beta-oxidation using acyl-CoA dehydrogenase (ortholog); response to glucocorticoid (orthol og); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; ASSOCIATED WITH alcohol use disorder (ortholog); congestive heart failure (ortholog); genetic disease (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrial membrane (ortholog) | NW_004936668 | 257214 | 272089 | Squirrel | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626096402 | Acads | acyl-CoA dehydrogenase short chain | ENCODES a protein that exhibits acyl-CoA dehydrogenase activity (ortholog); FAD binding (ortholog); flavin adenine dinucleotide binding (ortholog); INVOLVED IN butyrate catabolic process (ortholog); fatty acid beta-oxidation using acyl-CoA dehydrogenase (ortholog); response to glucocorticoid (orthol og); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; ASSOCIATED WITH alcohol use disorder (ortholog); congestive heart failure (ortholog); genetic disease (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrial membrane (ortholog); mitochondrion (ortholog) | | | | Black Rat | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18749853 | ACADS | acyl-CoA dehydrogenase short chain | ENCODES a protein that exhibits acyl-CoA dehydrogenase activity (ortholog); FAD binding (ortholog); flavin adenine dinucleotide binding (ortholog); INVOLVED IN butyrate catabolic process (ortholog); fatty acid beta-oxidation using acyl-CoA dehydrogenase (ortholog); response to glucocorticoid (orthol og); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; ASSOCIATED WITH alcohol use disorder (ortholog); congestive heart failure (ortholog); genetic disease (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrial membrane (ortholog) | | | | Green Monkey | 60 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254789 | acads | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13992934 | ACADS | acyl-CoA dehydrogenase short chain | ENCODES a protein that exhibits acyl-CoA dehydrogenase activity (ortholog); FAD binding (ortholog); flavin adenine dinucleotide binding (ortholog); INVOLVED IN butyrate catabolic process (ortholog); fatty acid beta-oxidation using acyl-CoA dehydrogenase (ortholog); response to glucocorticoid (orthol og); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; ASSOCIATED WITH alcohol use disorder (ortholog); congestive heart failure (ortholog); genetic disease (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrial membrane (ortholog) | | | | Pig | 63 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18927533 | Acads | acyl-CoA dehydrogenase short chain | ENCODES a protein that exhibits acyl-CoA dehydrogenase activity (ortholog); FAD binding (ortholog); flavin adenine dinucleotide binding (ortholog); INVOLVED IN butyrate catabolic process (ortholog); fatty acid beta-oxidation using acyl-CoA dehydrogenase (ortholog); response to glucocorticoid (orthol og); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; ASSOCIATED WITH alcohol use disorder (ortholog); congestive heart failure (ortholog); genetic disease (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrial membrane (ortholog) | | | | Naked Mole-Rat | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254790 | acads.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 2013 | Acadsb | acyl-CoA dehydrogenase, short/branched chain | ENCODES a protein that exhibits acyl-CoA dehydrogenase activity; electron transfer activity; short-chain fatty acyl-CoA dehydrogenase activity; INVOLVED IN acyl-CoA metabolic process; fatty acid metabolic process (ortholog); L-isoleucine catabolic process (ortholog); PARTICIPATES IN 3-hydroxy-3-meth ylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH 2-Methylbutyryl-CoA Dehydrogenase Deficiency (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN mitochondrion (ortholog); INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; 17beta-estradiol | 1 | 195619088 | 195660564 | Rat | 208 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 735869 | ACADSB | acyl-CoA dehydrogenase short/branched chain | Short/branched chain acyl-CoA dehydrogenase(ACADSB) is a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. Substrate specificity is the primary characteristic used to define members of this gene family. The ACADSB gene product has the greatest activity towards the short branched chain acyl-CoA derivative, (S)-2-methylbutyryl-CoA, but also reacts significantly with other 2-methyl branched chain substrates and with short straight chain acyl-CoAs. The cDNA encodes for a mitochondrial precursor protein which is cleaved upon mitochondrial import and predicted to yield a mature peptide of approximately 43.7-KDa. [provided by RefSeq, Jul 2008] | 10 | 123009006 | 123058290 | Human | 238 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 735870 | Acadsb | acyl-Coenzyme A dehydrogenase, short/branched chain | Predicted to enable electron transfer activity; identical protein binding activity; and short-chain 2-methyl fatty acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid metabolic process and isoleucine catabolic process. Predicted to act upstream of or within acyl-CoA metabolic pro cess. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ACADSB (acyl-CoA dehydrogenase short/branched chain). [provided by Alliance of Genome Resources, Apr 2025] | 7 | 131012330 | 131047940 | Mouse | 212 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8821648 | Acadsb | acyl-CoA dehydrogenase short/branched chain | ENCODES a protein that exhibits acyl-CoA dehydrogenase activity (ortholog); electron transfer activity (ortholog); identical protein binding (ortholog); INVOLVED IN acyl-CoA metabolic process (ortholog); fatty acid metabolic process (ortholog); L-isoleucine catabolic process (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH 2-Methylbutyryl-CoA Dehydrogenase Deficiency (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN mitochondrion (ortholog) | NW_004955477 | 1177704 | 1213347 | Chinchilla | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12039770 | ACADSB | acyl-CoA dehydrogenase short/branched chain | ENCODES a protein that exhibits acyl-CoA dehydrogenase activity (ortholog); electron transfer activity (ortholog); INVOLVED IN acyl-CoA metabolic process (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA ca rboxylase 1 deficiency pathway; ASSOCIATED WITH 2-Methylbutyryl-CoA Dehydrogenase Deficiency (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN mitochondrial matrix (inferred); mitochondrion (inferred) | 10 | 119565913 | 119612092 | Bonobo | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12238622 | ACADSB | acyl-CoA dehydrogenase short/branched chain | ENCODES a protein that exhibits acyl-CoA dehydrogenase activity (ortholog); electron transfer activity (ortholog); INVOLVED IN acyl-CoA metabolic process (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA ca rboxylase 1 deficiency pathway; ASSOCIATED WITH 2-Methylbutyryl-CoA Dehydrogenase Deficiency (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN mitochondrial matrix (inferred); mitochondrion (inferred) | 28 | 32563697 | 32604006 | Dog | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12595786 | Acadsb | acyl-CoA dehydrogenase short/branched chain | ENCODES a protein that exhibits acyl-CoA dehydrogenase activity (ortholog); electron transfer activity (ortholog); INVOLVED IN acyl-CoA metabolic process (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA ca rboxylase 1 deficiency pathway; ASSOCIATED WITH 2-Methylbutyryl-CoA Dehydrogenase Deficiency (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN mitochondrial matrix (inferred); mitochondrion (inferred) | NW_004936486 | 11668099 | 11707946 | Squirrel | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18935992 | Acadsb | acyl-CoA dehydrogenase short/branched chain | ENCODES a protein that exhibits acyl-CoA dehydrogenase activity (ortholog); electron transfer activity (ortholog); identical protein binding (ortholog); INVOLVED IN acyl-CoA metabolic process (ortholog); L-isoleucine catabolic process (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH 2-Methylbutyryl-CoA Dehydrogenase Deficiency (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN mitochondrial matrix (inferred); mitochondrion (inferred) | | | | Naked Mole-Rat | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18486931 | ACADSB | acyl-CoA dehydrogenase short/branched chain | ENCODES a protein that exhibits acyl-CoA dehydrogenase activity (ortholog); electron transfer activity (ortholog); INVOLVED IN acyl-CoA metabolic process (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA ca rboxylase 1 deficiency pathway; ASSOCIATED WITH 2-Methylbutyryl-CoA Dehydrogenase Deficiency (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN mitochondrial matrix (inferred); mitochondrion (inferred) | | | | Green Monkey | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625866775 | Acadsb | acyl-CoA dehydrogenase short/branched chain | ENCODES a protein that exhibits acyl-CoA dehydrogenase activity (ortholog); electron transfer activity (ortholog); identical protein binding (ortholog); INVOLVED IN acyl-CoA metabolic process (ortholog); fatty acid metabolic process (ortholog); L-isoleucine catabolic process (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH 2-Methylbutyryl-CoA Dehydrogenase Deficiency (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN mitochondrion (ortholog) | | | | Black Rat | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155248033 | acadsb | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14131472 | ACADSB | acyl-CoA dehydrogenase short/branched chain | ENCODES a protein that exhibits acyl-CoA dehydrogenase activity (ortholog); electron transfer activity (ortholog); INVOLVED IN acyl-CoA metabolic process (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA ca rboxylase 1 deficiency pathway; ASSOCIATED WITH 2-Methylbutyryl-CoA Dehydrogenase Deficiency (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN mitochondrial matrix (inferred); mitochondrion (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155255758 | acadsb.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1346668 | ACAD10 | acyl-CoA dehydrogenase family member 10 | This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central regio n, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Nov 2008] | 12 | 111686053 | 111757099 | Human | 82 | description | gene, protein-coding, REVIEWED [RefSeq] |
