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Strain Registration

Strain: SS.LEW-(D18Rat61-D18Rat45)/Ayd

Symbol: SS.LEW-(D18Rat61-D18Rat45)/Ayd
Strain: SS.LEW-(D18Rat61-D18Rat45)
Substrain: Ayd
RGD ID: 2301386
Citation ID: RRID:RGD_2301386
Ontology ID: RS:0001659
Also Known As: C18S.L2;DSS X LEW-(D18Rat61-D18Rat45)/Lt;SS.LEW-(D18Rat61-D18Rat45)/Ayd; SS.LEW-(D18Rat55-D18Rat1)/Ayd; SS.LEW-(D18Rat55-D18Rat1)/Ayd; SS.LEW-(D18Rat61-D18Rat45)/Ayd
Type: congenic
Available Source: Not Available
Origination: Research Centre-CHUM, Montreal, Quebec, Canada
Description: SS/Jr and LEW/Crlc were backcrossed for 5 generations, then BC5 rat was mated with LEW/Crlc to produce the desired congenic strain
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81861,075,796 - 76,330,704RGD_MAPPER_PIPELINE
mRatBN7.21858,805,687 - 74,055,742RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01860,971,508 - 77,212,332RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01860,167,906 - 76,318,715RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41861,571,526 - 77,511,190RGD_MAPPER_PIPELINERGSC3.4





Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SS.LEW-(D18Rat61-D18Rat45)/AydRatdecreased systemic arterial blood pressure  IAGP 8657072as compared to parental SS/JrRGD 
SS.LEW-(D18Rat61-D18Rat45)/AydRatdecreased systemic arterial systolic blood pressure  IAGP 8657131compared to SS/JrHsdRGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
SS.LEW-(D18Rat61-D18Rat45)/AydRatSS.LEW-(D18Rat61-D18Rat45)/Ayd  IEA 7241799 RGD 


#
Reference Title
Reference Citation
1. A loss of genome buffering capacity of Dahl salt-sensitive model to modulate blood pressure as a cause of hypertension. Charron S, etal., Hum Mol Genet. 2005 Dec 15;14(24):3877-84. Epub 2005 Nov 8.
2. alpha-Kinase 2 is a novel candidate gene for inherited hypertension in Dahl rats. Chauvet C, etal., J Hypertens. 2011 Jul;29(7):1320-6. doi: 10.1097/HJH.0b013e32834705e4.
3. Combining distinctive and novel loci doubles BP reduction, reverses diastolic dysfunction and mitigates LV hypertrophy. Crespo K, etal., J Hypertens. 2013 May;31(5):927-35. doi: 10.1097/HJH.0b013e32835edc7e.
4. Distinct quantitative trait loci for kidney, cardiac, and aortic mass dissociated from and associated with blood pressure in Dahl congenic rats. Duong C, etal., Mamm Genome. 2006 Dec;17(12):1147-61. Epub 2006 Dec 1.
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines



Flank 1 / 1 (D18Rat61)
Rat AssemblyChrPosition (strand)Source
GRCr81861,075,796 - 61,076,043 (+)Marker Load Pipeline
mRatBN7.21858,805,687 - 58,805,936 (+)MAPPER
Rnor_6.01860,971,508 - 60,971,754NCBI
Rnor_5.01860,167,906 - 60,168,152UniSTS
RGSC_v3.41861,571,526 - 61,571,773RGD
RGSC_v3.41861,571,527 - 61,571,773UniSTS
RGSC_v3.11861,644,728 - 61,644,974RGD
Celera1856,934,591 - 56,934,837UniSTS
RH 3.4 Map18595.5RGD
RH 3.4 Map18595.5UniSTS
RH 2.0 Map18321.4RGD
SHRSP x BN Map1833.1899RGD
FHH x ACI Map1843.03RGD
Cytogenetic Map18q12.1UniSTS

Flank 2 / 1 (D18Rat45)
Rat AssemblyChrPosition (strand)Source
GRCr81876,330,583 - 76,330,704 (+)Marker Load Pipeline
mRatBN7.21874,055,619 - 74,055,742 (+)MAPPER
Rnor_6.01877,212,212 - 77,212,332NCBI
Rnor_5.01876,318,595 - 76,318,715UniSTS
RGSC_v3.41877,510,828 - 77,511,190RGD
RGSC_v3.41877,510,855 - 77,510,975UniSTS
RGSC_v3.11877,584,128 - 77,584,248RGD
Celera1872,713,123 - 72,713,243UniSTS
RH 3.4 Map18794.7RGD
RH 3.4 Map18794.7UniSTS
RH 2.0 Map18106.0RGD
SHRSP x BN Map1847.8399RGD
FHH x ACI Map1858.5499RGD
Cytogenetic Map18q12.3UniSTS
1 to 7 of 7 rows
Symbol
Name
Trait
Am18 Aortic mass QTL 18 aorta mass   (VT:0002845)    
Bp319 Blood pressure QTL 319 arterial blood pressure trait   (VT:2000000)    
Bw187 Body weight QTL 187 body mass   (VT:0001259)    
Cm122 Cardiac mass QTL 122 heart mass   (VT:0007028)    
Cm123 Cardiac mass QTL 123 heart left ventricle mass   (VT:0007031)    
Cm124 Cardiac mass QTL 124 heart right ventricle mass   (VT:0007033)    
Kidm71 Kidney mass QTL 71 kidney mass   (VT:0002707)    
1 to 7 of 7 rows