RGD Reference Report - A loss of genome buffering capacity of Dahl salt-sensitive model to modulate blood pressure as a cause of hypertension. - Rat Genome Database

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A loss of genome buffering capacity of Dahl salt-sensitive model to modulate blood pressure as a cause of hypertension.

Authors: Charron, S  Lambert, R  Eliopoulos, V  Duong, C  Menard, A  Roy, J  Deng, AY 
Citation: Charron S, etal., Hum Mol Genet. 2005 Dec 15;14(24):3877-84. Epub 2005 Nov 8.
RGD ID: 1578386
Pubmed: PMID:16278234   (View Abstract at PubMed)
DOI: DOI:10.1093/hmg/ddi412   (Journal Full-text)

Essential hypertension is a complex trait influenced by multiple genes known as quantitative trait loci (QTLs) for blood pressure (BP). It is not clear, however, what roles these QTLs play in maintaining normotension. Insights gained toward the maintenance of normotension will shed light on how hypertension can result from a deficiency or malfunctioning of this maintenance. Currently, congenic strains were systematically constructed using Dahl salt-sensitive (DSS) and Lewis (LEW) rats not only to define QTLs (i.e. in DSS background), but also to ascertain effects of the same QTLs in preserving normotension (i.e. in LEW background), a first such study. Results showed that although LEW alleles for two QTLs on Chromosome (Chr) 18 lowered BP on the DSS background, their BP-increasing DSS alleles failed to influence BP in the LEW background. To further prove that the LEW background is resistant and the DSS background is susceptible to the effects of QTLs, BP-increasing alleles of a QTL on Chr 2 were introgressed into the DSS background, and its BP-decreasing alleles into the LEW background. Indeed, there was no BP-decreasing effect on the LEW background while demonstrating a BP-increasing effect on the DSS background. Thus, a genetic regulation of BP QTLs in the LEW genome inhibits BP changes by nullifying the effects of BP-altering QTLs. In comparison, the DSS genome must have lost the buffering capacity for stabilizing BP. The current work presents good evidence that a lack of regulation for functions of BP QTLs is a potential underlying cause of hypertension.




Objects Annotated

QTLs
Bp318  (Blood pressure QTL 318)

Objects referenced in this article
Marker D18Chm68 D18Chm68 Rattus norvegicus
Marker D18Chm42 D18Chm42 Rattus norvegicus
Marker D18Chm88 D18Chm88 Rattus norvegicus
Marker D18Chm67 D18Chm67 Rattus norvegicus
Marker D18Chm54 D18Chm54 Rattus norvegicus
Marker D18Chm16 D18Chm16 Rattus norvegicus
Marker D18Chm25 D18Chm25 Rattus norvegicus
Marker D18Chm71 D18Chm71 Rattus norvegicus
Marker D18Chm53 D18Chm53 Rattus norvegicus
Marker D18Chm94 D18Chm94 Rattus norvegicus
Marker D18Chm64 D18Chm64 Rattus norvegicus
Marker D18Chm89 D18Chm89 Rattus norvegicus
Marker D18Chm83 D18Chm83 Rattus norvegicus
Marker D18Chm50 D18Chm50 Rattus norvegicus
Marker D18Chm19 D18Chm19 Rattus norvegicus
Marker D18Chm6 D18Chm6 Rattus norvegicus
Marker D18Chm98 D18Chm98 Rattus norvegicus
Marker D18Chm37 D18Chm37 Rattus norvegicus
Marker D18Chm22 D18Chm22 Rattus norvegicus
Marker D18Chm69 D18Chm69 Rattus norvegicus
Marker D18Chm63 D18Chm63 Rattus norvegicus
Marker D18Chm60 D18Chm60 Rattus norvegicus
Marker D18Chm1 D18Chm1 Rattus norvegicus
Marker D18Chm2 D18Chm2 Rattus norvegicus
Marker D18Chm48 D18Chm48 Rattus norvegicus
Marker D18Chm47 D18Chm47 Rattus norvegicus
Marker D18Chm82 D18Chm82 Rattus norvegicus
Marker D18Chm58 D18Chm58 Rattus norvegicus
Marker D18Chm57 D18Chm57 Rattus norvegicus
Marker D18Chm31 D18Chm31 Rattus norvegicus
Marker D18Chm92 D18Chm92 Rattus norvegicus
Marker D18Chm70 D18Chm70 Rattus norvegicus
Marker D18Chm95 D18Chm95 Rattus norvegicus
Marker D18Chm87 D18Chm87 Rattus norvegicus
Marker D18Chm91 D18Chm91 Rattus norvegicus
Marker D18Chm84 D18Chm84 Rattus norvegicus
Marker D18Chm78 D18Chm78 Rattus norvegicus
Marker D18Chm26 D18Chm26 Rattus norvegicus
Marker D18Chm12 D18Chm12 Rattus norvegicus
Marker D18Chm38 D18Chm38 Rattus norvegicus
Marker D18Chm9 D18Chm9 Rattus norvegicus
Marker D18Chm35 D18Chm35 Rattus norvegicus
Marker D18Chm77 D18Chm77 Rattus norvegicus
Marker D18Chm100 D18Chm100 Rattus norvegicus
Marker D18Chm86 D18Chm86 Rattus norvegicus
Marker D18Chm72 D18Chm72 Rattus norvegicus
Marker D18Chm28 D18Chm28 Rattus norvegicus
Marker D18Chm8 D18Chm8 Rattus norvegicus
Marker D18Chm14 D18Chm14 Rattus norvegicus
Marker D18Chm96 D18Chm96 Rattus norvegicus
Marker D18Chm61 D18Chm61 Rattus norvegicus
Marker D18Chm66 D18Chm66 Rattus norvegicus
Marker D18Chm90 D18Chm90 Rattus norvegicus
Marker D18Chm21 D18Chm21 Rattus norvegicus
Marker D18Chm80 D18Chm80 Rattus norvegicus
Marker D18Chm27 D18Chm27 Rattus norvegicus
Marker D18Chm30 D18Chm30 Rattus norvegicus
Marker D18Chm79 D18Chm79 Rattus norvegicus
Marker D18Chm52 D18Chm52 Rattus norvegicus
Marker D18Chm44 D18Chm44 Rattus norvegicus
Marker D18Chm65 D18Chm65 Rattus norvegicus
Marker D18Chm5 D18Chm5 Rattus norvegicus
Marker D18Chm56 D18Chm56 Rattus norvegicus
Marker D18Chm41 D18Chm41 Rattus norvegicus
Marker D18Chm101 D18Chm101 Rattus norvegicus
Marker D18Chm46 D18Chm46 Rattus norvegicus
Marker D18Chm11 D18Chm11 Rattus norvegicus
Marker D18Chm76 D18Chm76 Rattus norvegicus
Marker D18Chm74 D18Chm74 Rattus norvegicus
Marker D18Chm15 D18Chm15 Rattus norvegicus
Marker D18Chm81 D18Chm81 Rattus norvegicus
Marker D18Chm34 D18Chm34 Rattus norvegicus
Marker D18Chm43 D18Chm43 Rattus norvegicus
Marker D18Chm13 D18Chm13 Rattus norvegicus
Marker D18Chm55 D18Chm55 Rattus norvegicus
Marker D18Chm73 D18Chm73 Rattus norvegicus
Marker D18Chm39 D18Chm39 Rattus norvegicus
Marker D18Chm23 D18Chm23 Rattus norvegicus
Marker D18Chm85 D18Chm85 Rattus norvegicus
Marker D18Chm62 D18Chm62 Rattus norvegicus
Marker D18Chm24 D18Chm24 Rattus norvegicus
Marker D18Chm29 D18Chm29 Rattus norvegicus
Marker D18Chm17 D18Chm17 Rattus norvegicus
Marker D18Chm97 D18Chm97 Rattus norvegicus
Marker D18Chm32 D18Chm32 Rattus norvegicus
Marker D18Chm7 D18Chm7 Rattus norvegicus
Marker D18Chm36 D18Chm36 Rattus norvegicus
Marker D18Chm3 D18Chm3 Rattus norvegicus
Marker D18Chm20 D18Chm20 Rattus norvegicus
Marker D18Chm33 D18Chm33 Rattus norvegicus
Marker D18Chm49 D18Chm49 Rattus norvegicus
Marker D18Chm10 D18Chm10 Rattus norvegicus
Marker D18Chm4 D18Chm4 Rattus norvegicus
Marker D18Chm93 D18Chm93 Rattus norvegicus
Marker D18Chm99 D18Chm99 Rattus norvegicus
Marker D18Chm45 D18Chm45 Rattus norvegicus
Marker D18Chm40 D18Chm40 Rattus norvegicus
Marker D18Chm18 D18Chm18 Rattus norvegicus
Marker D18Chm75 D18Chm75 Rattus norvegicus
Marker D18Chm51 D18Chm51 Rattus norvegicus
Marker D18Chm59 D18Chm59 Rattus norvegicus
QTL Bp317 Blood pressure QTL 317 Rattus norvegicus
QTL Bp319 Blood pressure QTL 319 Rattus norvegicus
Strain LEW.SS-(D18Chm31-D18Mit8)/Ayd null Rattus norvegicus
Strain LEW.SS-(D2Uia5-D2Rat143)/Ayd null Rattus norvegicus
Strain SS.LEW-(D18Chm31-D18Rat55)/Ayd null Rattus norvegicus
Strain SS.LEW-(D18Chm41-D18Rat45)/Ayd null Rattus norvegicus
Strain SS.LEW-(D18Chm41-D18Rat92)/Ayd null Rattus norvegicus
Strain SS.LEW-(D18Chm56-D18Rat55)/Ayd null Rattus norvegicus
Strain SS.LEW-(D18Chm91-D18Rat67)/Ayd null Rattus norvegicus
Strain SS.LEW-(D18Rat29-D18Rat55)/Ayd null Rattus norvegicus
Strain SS.LEW-(D18Rat61-D18Rat45)/Ayd null Rattus norvegicus
Strain SS.LEW-(D18Rat67-D18Rat55)/Ayd null Rattus norvegicus

Additional Information