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Strain: SS.MNS-(D2Chm366-D2Rat52),LEW-(D18Rat61-D18Rat45),LEW-(D10Chm128-D10Chm121)/Ayd

Symbol: SS.MNS-(D2Chm366-D2Rat52),LEW-(D18Rat61-D18Rat45),LEW-(D10Chm128-D10Chm121)/Ayd
Strain: SS.MNS-(D2Chm366-D2Rat52),LEW-(D18Rat61-D18Rat45),LEW-(D10Chm128-D10Chm121)
Substrain: Ayd
RGD ID: 8657351
Citation ID: RRID:RGD_8657351
Ontology ID: RS:0003778
Also Known As: CC(i); C10S.L15/ C2S.M24/C18S.L2; CC(ii); SS.MNS-(D2Chm366-D2Rat52),LEW-(D18Rat61-D18Rat45),LEW-(D10Chm128-D10Chm121)/Ayd; congenic combination (ii); C2S.M24/C10S.L15/C18S.L2
Type: congenic
Available Source: Not Available
Origination: Research Centre, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, Canada
Description: A triple congenic strain derived from the progenitor strain SS.MNS-(D2Chm366-D2Rat52)/Ayd, SS.LEW-(D18Rat61-D18Rat45)/Ayd and SS.LEW-(D10Chm128-D10Chm121)/Ayd
Last Known Status: Unknown

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype


References - curated
# Reference Title Reference Citation
1. Unique quantitative trait loci in synergy permanently improve diastolic dysfunction. Chauvet C, etal., Can J Cardiol. 2013 Oct;29(10):1302-9. doi: 10.1016/j.cjca.2013.03.012. Epub 2013 Jun 14.
2. Combining distinctive and novel loci doubles BP reduction, reverses diastolic dysfunction and mitigates LV hypertrophy. Crespo K, etal., J Hypertens. 2013 May;31(5):927-35. doi: 10.1097/HJH.0b013e32835edc7e.
3. Genetics of diastolic heart failure. Deng AY J Hypertens. 2013 Dec;31(12):2329-36. doi: 10.1097/HJH.0b013e328365662c.
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics SS.MNS-(D2Chm366-D2Rat52)/Ayd (C2S.M24) contains Bp366, SS.LEW-(D18Rat61-D18Rat45)/Ayd (C18S.L2) contains Bp319, and SS.LEW-(D10Chm128-D10Chm121)/Ayd (C10S.L15) contains Bp312 8657131
strain_characteristics isovolumetric relaxation time was normalized 8657131
strain_characteristics this region impacts the reversal of diastolic dysfunction 8657131