RGD Reference Report - The CD40/CD40 ligand system in the skin of patients with subacute cutaneous lupus erythematosus. - Rat Genome Database

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The CD40/CD40 ligand system in the skin of patients with subacute cutaneous lupus erythematosus.

Authors: Caproni, M  Torchia, D  Antiga, E  Giomi, B  Mercuri, M  Volpi, W  Fabbri, P 
Citation: Caproni M, etal., J Rheumatol. 2007 Dec;34(12):2412-6. Epub 2007 Nov 15.
RGD ID: 8547765
Pubmed: PMID:18050371   (View Abstract at PubMed)

OBJECTIVE: To investigate whether CD40 and CD40 ligand (CD40L) is expressed in the skin of patients with subacute cutaneous lupus erythematosus (SCLE). METHODS: Six female patients with SCLE were studied. Skin biopsies were obtained from lesional and healthy sunprotected skin. Frozen sections were stained immunohistochemically using monoclonal antibodies to CD4, CD40, and CD40L. As controls we used 5 patients with discoid LE (DLE), 5 with dermatomyositis (DM), 3 with lichen planus (LP), and 2 with erythema multiforme (EM), as well as the normal-appearing skin of 5 healthy volunteers. RESULTS: The CD40 was intensely expressed in all SCLE, DLE, and DM lesions, and only focally in healthy sunprotected skin specimens. The number of CD40+ cells in SCLE dermis was lower than in DLE, similar to that in DM, LP and EM, and higher than in SCLE sunprotected skin. CD40L+ cells infiltrated the SCLE, DLE, DM, LP, and EM lesional dermis, and were more numerous in SCLE lesional skin than in SCLE healthy sunprotected skin. CONCLUSION: We showed that the CD40/CD40L system may represent an important pathway of induction of SCLE lesions. The expression of such costimulatory system in healthy sunprotected skin also may signify that its abnormal activation is constitutive in SCLE, as previously observed in systemic LE.

RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CD40Humancutaneous lupus erythematosus  IEP  RGD 
CD40LGHumancutaneous lupus erythematosus  IEP  RGD 
Cd40Ratcutaneous lupus erythematosus  ISOCD40 (Homo sapiens) RGD 
Cd40Mousecutaneous lupus erythematosus  ISOCD40 (Homo sapiens) RGD 
Cd40lgRatcutaneous lupus erythematosus  ISOCD40LG (Homo sapiens) RGD 
Cd40lgMousecutaneous lupus erythematosus  ISOCD40LG (Homo sapiens) RGD 
CD40Humandermatomyositis  IEP  RGD 
CD40LGHumandermatomyositis  IEP  RGD 
Cd40Mousedermatomyositis  ISOCD40 (Homo sapiens) RGD 
Cd40Ratdermatomyositis  ISOCD40 (Homo sapiens) RGD 
Cd40lgRatdermatomyositis  ISOCD40LG (Homo sapiens) RGD 
Cd40lgMousedermatomyositis  ISOCD40LG (Homo sapiens) RGD 
CD40HumanDiscoid Lupus Erythematosus  IEP  RGD 
CD40LGHumanDiscoid Lupus Erythematosus  IEP  RGD 
Cd40MouseDiscoid Lupus Erythematosus  ISOCD40 (Homo sapiens) RGD 
Cd40RatDiscoid Lupus Erythematosus  ISOCD40 (Homo sapiens) RGD 
Cd40lgRatDiscoid Lupus Erythematosus  ISOCD40LG (Homo sapiens) RGD 
Cd40lgMouseDiscoid Lupus Erythematosus  ISOCD40LG (Homo sapiens) RGD 
CD40Humanerythema multiforme  IEP  RGD 
CD40LGHumanerythema multiforme  IEP  RGD 
Cd40Mouseerythema multiforme  ISOCD40 (Homo sapiens) RGD 
Cd40Raterythema multiforme  ISOCD40 (Homo sapiens) RGD 
Cd40lgRaterythema multiforme  ISOCD40LG (Homo sapiens) RGD 
Cd40lgMouseerythema multiforme  ISOCD40LG (Homo sapiens) RGD 
CD40Humanlichen planus  IEP  RGD 
CD40LGHumanlichen planus  IEP  RGD 
Cd40Mouselichen planus  ISOCD40 (Homo sapiens) RGD 
Cd40Ratlichen planus  ISOCD40 (Homo sapiens) RGD 
Cd40lgRatlichen planus  ISOCD40LG (Homo sapiens) RGD 
Cd40lgMouselichen planus  ISOCD40LG (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd40  (CD40 molecule)
Cd40lg  (CD40 ligand)

Genes (Mus musculus)
Cd40  (CD40 antigen)
Cd40lg  (CD40 ligand)

Genes (Homo sapiens)
CD40  (CD40 molecule)
CD40LG  (CD40 ligand)

Additional Information