RGD Reference Report - Urine NGAL and KIM-1 in children and adolescents with hyperuricemia. - Rat Genome Database

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Urine NGAL and KIM-1 in children and adolescents with hyperuricemia.

Authors: Tomczak, J  Wasilewska, A  Milewski, R 
Citation: Tomczak J, etal., Pediatr Nephrol. 2013 May 15.
RGD ID: 7244371
Pubmed: PMID:23673972   (View Abstract at PubMed)
PMCID: PMC3722436   (View Article at PubMed Central)
DOI: DOI:10.1007/s00467-013-2491-y   (Journal Full-text)

BACKGROUND: The aim of this study was to test the hypothesis that urine levels of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) are enhanced in pediatric patients with hyperuricemia. METHODS: The study included 88 children and adolescents (60 males, 28 females) with a median age of 16 (range 11-18.5) years who had been referred to our department to rule out or confirm hypertension. The subjects were divided into two groups: the hyperuricemic (HU) group comprising 59 subjects with hyperuricemia (defined as serum uric acid >4.8 and >5.5 mg/dl in girls and boys, respectively) and the reference group comprising 29 patients with normouricemia. Urine NGAL and KIM-1 levels were evaluated using a commercially available kit. RESULTS: Concentrations of the examined biomarkers [urine NGAL, NGAL/creatinine (cr.) ratio, urine KIM-1, KIM-1/cr. ratio] were increased in the HU group compared with the reference group (p < 0.01). There were positive correlations between the serum uric acid and urine NGAL/cr. ratio (R = 0.67, p < 0.001) and the urine KIM-1/cr. ratio (R = 0.36, p < 0.001). In the multiple regression models, serum uric acid, systolic blood pressure and cholesterol accounted for more than 49 % of the variation in the NGAL/cr. ratio (R = 0.702, p < 0.001). In the second model, serum uric acid, gender, age and systolic blood pressure accounted for more than 36 % of the variation in the KIM-1/cr. ratio (R = 0.604, p < 0.001). CONCLUSION: We demonstrated that male, obese, hypertensive adolescents with hyperuricemia have higher urine NGAL and KIM-1 levels relative to a reference group with normouricemia.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HAVCR1Humanhyperuricemia  IEP  RGD 
Havcr1Rathyperuricemia  ISOHAVCR1 (Homo sapiens) RGD 
Havcr1Mousehyperuricemia  ISOHAVCR1 (Homo sapiens) RGD 
LCN2Humanhyperuricemia  IEP  RGD 
Lcn2Rathyperuricemia  ISOLCN2 (Homo sapiens) RGD 
Lcn2Mousehyperuricemia  ISOLCN2 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Havcr1  (hepatitis A virus cellular receptor 1)
Lcn2  (lipocalin 2)

Genes (Mus musculus)
Havcr1  (hepatitis A virus cellular receptor 1)
Lcn2  (lipocalin 2)

Genes (Homo sapiens)
HAVCR1  (hepatitis A virus cellular receptor 1)
LCN2  (lipocalin 2)


Additional Information