RGD Reference Report - Phosphate handling: new genes, new molecules. - Rat Genome Database

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Phosphate handling: new genes, new molecules.

Authors: Prie, D  Torres, PU  Friedlander, G 
Citation: Prie D, etal., Horm Res Paediatr. 2011;76 Suppl 1:71-5. doi: 10.1159/000329175. Epub 2011 Jul 21.
RGD ID: 7207819
Pubmed: PMID:21778753   (View Abstract at PubMed)
DOI: DOI:10.1159/000329175   (Journal Full-text)

BACKGROUND: Inappropriate renal phosphate transport may alter serum phosphate concentration and bone mineralization, and it may also increase the risk of renal lithiasis or soft-tissue calcifications. Molecular identification of renal phosphate transporters and regulatory proteins has improved our knowledge of the mechanisms that control phosphate balance. This summary reviews recent findings regarding the consequences of mutations affecting several human genes encoding for phosphate transporters or regulatory proteins. Further, it describes the role played by the fibroblast growth factor 23-Klotho axis in phosphate homeostasis and its involvement in the pathophysiology of phosphate disturbances in chronic kidney diseases. CONCLUSIONS: This progress may allow development of new drugs that interfere with phosphate transporters, hormonal receptors or associated proteins to improve treatment and to help prevent secondary hyperparathyroidism.



Molecular Pathway Annotations    Click to see Annotation Detail View
Objects Annotated

Genes (Rattus norvegicus)
Slc20a1  (solute carrier family 20 member 1)
Slc20a2  (solute carrier family 20 member 2)
Slc34a1  (solute carrier family 34 member 1)
Slc34a2  (solute carrier family 34 member 2)
Slc34a3  (solute carrier family 34 member 3)

Genes (Mus musculus)
Slc20a1  (solute carrier family 20, member 1)
Slc20a2  (solute carrier family 20, member 2)
Slc34a1  (solute carrier family 34 (sodium phosphate), member 1)
Slc34a2  (solute carrier family 34 (sodium phosphate), member 2)
Slc34a3  (solute carrier family 34 (sodium phosphate), member 3)

Genes (Homo sapiens)
SLC20A1  (solute carrier family 20 member 1)
SLC20A2  (solute carrier family 20 member 2)
SLC34A1  (solute carrier family 34 member 1)
SLC34A2  (solute carrier family 34 member 2)
SLC34A3  (solute carrier family 34 member 3)


Additional Information