Slc34a3 (solute carrier family 34 member 3) - Rat Genome Database

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Gene: Slc34a3 (solute carrier family 34 member 3) Rattus norvegicus
Analyze
Symbol: Slc34a3
Name: solute carrier family 34 member 3
RGD ID: 708551
Description: Enables sodium:phosphate symporter activity. Involved in response to magnesium ion; response to nutrient levels; and sodium-dependent phosphate transport. Located in apical plasma membrane and brush border membrane. Human ortholog(s) of this gene implicated in hereditary hypophosphatemic rickets with hypercalciuria. Orthologous to human SLC34A3 (solute carrier family 34 member 3); PARTICIPATES IN phosphate transport pathway; INTERACTS WITH 3-chloropropane-1,2-diol; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC246234; na(+)-dependent phosphate cotransporter 2C; na(+)/Pi cotransporter 2C; Na+/Pi-cotransporter type IIc; naPi-2c; sodium-dependent phosphate transport protein 2C; sodium-phosphate transport protein 2C; sodium/phosphate cotransporter 2C; solute carrier family 34 (sodium phosphate), member 3; solute carrier family 34 (type II sodium/phosphate contransporter), member 3; solute carrier family 34 (type II sodium/phosphate cotransporter), member 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,044,294 - 8,050,034 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,044,296 - 8,049,970 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,149,001 - 11,154,548 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0319,735,230 - 19,740,777 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0317,925,073 - 17,930,620 (-)NCBIRnor_WKY
Rnor_6.032,448,391 - 2,454,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,448,381 - 2,453,933 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,429,674 - 2,435,318 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,393,502 - 3,399,042 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,393,501 - 3,399,042 (-)NCBI
Celera32,870,932 - 2,876,472 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
apical plasma membrane  (IBA,IDA,IEA,ISO)
brush border  (IBA,ISO)
brush border membrane  (IDA,IEA,ISO)
vesicle  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differential Regulation of the Renal Sodium/Phosphate Co-Transporters NaPi-IIa, NaPi-IIc and PiT-2 in Dietary Potassium Deficiency. Breusegem SY, etal., Am J Physiol Renal Physiol. 2009 Jun 3.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Phosphate handling: new genes, new molecules. Prie D, etal., Horm Res Paediatr. 2011;76 Suppl 1:71-5. doi: 10.1159/000329175. Epub 2011 Jul 21.
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Parathyroid hormone-dependent endocytosis of renal type IIc Na-Pi cotransporter. Segawa H, etal., Am J Physiol Renal Physiol. 2007 Jan;292(1):F395-403. Epub 2006 Sep 19.
11. Growth-related renal type II Na/Pi cotransporter. Segawa H, etal., J Biol Chem 2002 May 31;277(22):19665-72. Epub 2002 Mar 5.
12. Effect of hydrolysis-resistant FGF23-R179Q on dietary phosphate regulation of the renal type-II Na/Pi transporter. Segawa H, etal., Pflugers Arch. 2003 Aug;446(5):585-92. Epub 2003 Jul 8.
13. Magnesium stimulates renal phosphate reabsorption. Thumfart J, etal., Am J Physiol Renal Physiol. 2008 Oct;295(4):F1126-33. Epub 2008 Aug 13.
14. Role of rat sodium/phosphate cotransporters in the cell membrane transport of arsenate. Villa-Bellosta R and Sorribas V, Toxicol Appl Pharmacol. 2008 Oct 1;232(1):125-34. Epub 2008 Jun 10.
Additional References at PubMed
PMID:12690469   PMID:16358214   PMID:19841935   PMID:20526720   PMID:23816829  


Genomics

Comparative Map Data
Slc34a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,044,294 - 8,050,034 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,044,296 - 8,049,970 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,149,001 - 11,154,548 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0319,735,230 - 19,740,777 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0317,925,073 - 17,930,620 (-)NCBIRnor_WKY
Rnor_6.032,448,391 - 2,454,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,448,381 - 2,453,933 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,429,674 - 2,435,318 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,393,502 - 3,399,042 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,393,501 - 3,399,042 (-)NCBI
Celera32,870,932 - 2,876,472 (-)NCBICelera
Cytogenetic Map3p13NCBI
SLC34A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,229,730 - 137,236,555 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9137,230,757 - 137,236,555 (+)EnsemblGRCh38hg38GRCh38
GRCh379140,125,209 - 140,131,007 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,245,206 - 139,250,827 (+)NCBINCBI36Build 36hg18NCBI36
Build 349137,401,221 - 137,406,843NCBI
Cytogenetic Map9q34.3NCBI
HuRef9109,584,535 - 109,590,318 (+)NCBIHuRef
CHM1_19140,273,943 - 140,279,740 (+)NCBICHM1_1
T2T-CHM13v2.09149,468,426 - 149,474,224 (+)NCBIT2T-CHM13v2.0
Slc34a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,118,909 - 25,124,282 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,118,910 - 25,124,376 (-)EnsemblGRCm39 Ensembl
GRCm38225,228,897 - 25,234,270 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,228,898 - 25,234,364 (-)EnsemblGRCm38mm10GRCm38
MGSCv37225,084,417 - 25,089,727 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,050,908 - 25,056,212 (-)NCBIMGSCv36mm8
Celera224,956,687 - 24,961,997 (-)NCBICelera
Cytogenetic Map2A3NCBI
Slc34a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,228,598 - 5,234,128 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,228,575 - 5,233,501 (+)NCBIChiLan1.0ChiLan1.0
SLC34A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan192,164,281 - 2,170,390 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09108,290,905 - 108,296,186 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19137,259,237 - 137,264,948 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,259,243 - 137,264,947 (+)Ensemblpanpan1.1panPan2
SLC34A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,437,893 - 48,444,103 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,438,007 - 48,440,736 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,624,212 - 47,630,451 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,299,065 - 49,305,304 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,299,179 - 49,303,795 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,075,466 - 48,081,705 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,374,286 - 48,380,522 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,421,436 - 48,427,675 (-)NCBIUU_Cfam_GSD_1.0
Slc34a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,614,803 - 202,619,560 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669755,528 - 760,522 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936669755,091 - 760,365 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC34A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21314,141,884 - 314,142,446 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC34A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112952,486 - 958,602 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12952,278 - 957,308 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660584,348,543 - 4,353,451 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc34a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760720,472 - 725,551 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624760720,539 - 725,940 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc34a3
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:121
Count of miRNA genes:102
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000014060
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat

Markers in Region
RH128751  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,044,339 - 8,044,524 (+)MAPPERmRatBN7.2
Rnor_6.032,448,437 - 2,448,621NCBIRnor6.0
Rnor_5.032,429,720 - 2,429,904UniSTSRnor5.0
RGSC_v3.433,393,546 - 3,393,730UniSTSRGSC3.4
Celera32,870,976 - 2,871,160UniSTS
Cytogenetic Map3p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23
Low 4 4 4 1 8 6 11
Below cutoff 9 19 14 4 14 8 9 12 15 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_139338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB077042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000014060   ⟹   ENSRNOP00000014060
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,044,296 - 8,049,837 (-)Ensembl
Rnor_6.0 Ensembl32,448,393 - 2,453,933 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079773   ⟹   ENSRNOP00000074364
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,044,296 - 8,049,970 (-)Ensembl
Rnor_6.0 Ensembl32,448,381 - 2,453,415 (-)Ensembl
RefSeq Acc Id: NM_139338   ⟹   NP_647554
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,044,296 - 8,049,837 (-)NCBI
Rnor_6.032,448,393 - 2,453,933 (-)NCBI
Rnor_5.032,429,674 - 2,435,318 (-)NCBI
RGSC_v3.433,393,502 - 3,399,042 (-)RGD
Celera32,870,932 - 2,876,472 (-)RGD
Sequence:
RefSeq Acc Id: XM_039104250   ⟹   XP_038960178
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,044,294 - 8,050,034 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_647554   ⟸   NM_139338
- UniProtKB: G3V7E1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074364   ⟸   ENSRNOT00000079773
RefSeq Acc Id: ENSRNOP00000014060   ⟸   ENSRNOT00000014060
RefSeq Acc Id: XP_038960178   ⟸   XM_039104250
- Peptide Label: isoform X1
- UniProtKB: G3V7E1 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K4R8-F1-model_v2 AlphaFold Q8K4R8 1-601 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708551 AgrOrtholog
BioCyc Gene G2FUF-50473 BioCyc
Ensembl Genes ENSRNOG00000010451 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000014060 ENTREZGENE
  ENSRNOP00000014060.3 UniProtKB/TrEMBL
  ENSRNOP00000074364.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014060 ENTREZGENE
  ENSRNOT00000014060.7 UniProtKB/TrEMBL
  ENSRNOT00000079773.2 UniProtKB/TrEMBL
InterPro Na/Pi_transpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:246234 UniProtKB/Swiss-Prot
NCBI Gene 246234 ENTREZGENE
PANTHER PTHR10010 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10010:SF35 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Na_Pi_cotrans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc34a3 PhenoGen
TIGRFAMs 2a58 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K7V6_RAT UniProtKB/TrEMBL
  G3V7E1 ENTREZGENE, UniProtKB/TrEMBL
  NPT2C_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc34a3  solute carrier family 34 member 3  Slc34a3  solute carrier family 34 (type II sodium/phosphate cotransporter), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-11-26 Slc34a3  solute carrier family 34 (type II sodium/phosphate cotransporter), member 3  Slc34a3  solute carrier family 34 (type II sodium/phosphate contransporter), member 3  Name changed 629549 APPROVED
2013-08-02 Slc34a3  solute carrier family 34 (type II sodium/phosphate contransporter), member 3  Slc34a3  solute carrier family 34 (sodium phosphate), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc34a3  solute carrier family 34 (sodium phosphate), member 3  LOC246234  Na+/Pi-cotransporter type IIc  Symbol and Name updated 1299863 APPROVED