RGD Reference Report - Plasma myeloperoxidase activity and apolipoprotein a-1 expression in chronic hepatitis B patients. - Rat Genome Database

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Plasma myeloperoxidase activity and apolipoprotein a-1 expression in chronic hepatitis B patients.

Authors: Mohamadkhani, A  Rastgar Jazii, F  Sayehmiri, K  Jafari-Nejad, S  Montaser-Kouhsari, L  Poustchi, H  Montazeri, G 
Citation: Mohamadkhani A, etal., Arch Iran Med. 2011 Jul;14(4):254-8.
RGD ID: 5508214
Pubmed: PMID:21726101   (View Abstract at PubMed)
DOI: DOI:0011144/AIM.006   (Journal Full-text)

BACKGROUND: Hepatitis B virus initiates a complicated cascade process leading to chronic hepatitis B, cirrhosis, and hepatocellular carcinoma. In inflammatory situations, myeloperoxidase is released in plasma and binds to apolipoprotein A-1 in high-density lipoproteins. This study aims to evaluate the level of plasma myeloperoxidase as well as the pattern of plasma proteins in patients with chronic hepatitis B. METHODS: Included in this study were 30 male subjects: 19 chronic hepatitis B patients, 6 HBV-related cirrhotic patients, and 5 healthy controls. Plasma myeloperoxidase was measured using enzyme-linked immunosorbent assay. Proteomic analysis of plasma proteins was performed by two-dimensional gel electrophoresis (2-DE) and mass spectrometry. One way ANOVA was used for data analysis. RESULTS: Mean plasma myeloperoxidase levels were higher in patients with liver cirrhosis (65.5+/-12.5; P=0.007) and chronic hepatitis B (53.7+/-10.6; P=0.18) when compared with healthy subjects (45+/-7.6). Moreover, a positive correlation was found between plasma myeloperoxidase levels and hepatic fibrosis stage (r=0.53, P=0.002; r=0.63, P=0.000). Proteomic analysis showed an altered plasma protein pattern in progressive hepatitis B and down-regulation of the major apolipoprotein A-1 along with the appearance of a variety of spots noted to be apolipoprotein A-1isoforms with different molecular masses. CONCLUSION: In this study, progressive liver injury due to HBV infection correlated with higher plasma myeloperoxidase and an altered plasma apolipoprotein A-1pattern.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Chronic Hepatitis B  IEP 5508214protein:decreased expressionRGD 
Chronic Hepatitis B  ISOAPOA1 (Homo sapiens)5508214; 5508214protein:decreased expressionRGD 

Objects Annotated

Genes (Rattus norvegicus)
Apoa1  (apolipoprotein A1)

Genes (Mus musculus)
Apoa1  (apolipoprotein A-I)

Genes (Homo sapiens)
APOA1  (apolipoprotein A1)


Additional Information