RGD Reference Report - Associations of MHC class II alleles in Norwegian primary Sjogren's syndrome patients: implications for development of autoantibodies to the Ro52 autoantigen. - Rat Genome Database

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Associations of MHC class II alleles in Norwegian primary Sjogren's syndrome patients: implications for development of autoantibodies to the Ro52 autoantigen.

Authors: Nakken, B  Jonsson, R  Brokstad, KA  Omholt, K  Nerland, AH  Haga, HJ  Halse, AK 
Citation: Nakken B, etal., Scand J Immunol. 2001 Oct;54(4):428-33.
RGD ID: 5147809
Pubmed: PMID:11555411   (View Abstract at PubMed)

Sjogren's syndrome (SS) is a chronic autoimmune disease characterized by dryness of the eyes and mouth. Currently, the highly polymorphic major histocompatibility complex (MHC) genes are the best documented genetic risk factor for the development of autoimmune disease. We examined the MHC class II alleles DRB1, DRB3, DRB4, DRB5, DQA1 and DQB1 in a group of Norwegian pSS patients and compared with a group of healthy controls. Because a number of studies have shown that some of the MHC class II alleles are not associated with the disease as a whole, but rather to the development of autoantibodies, anti-Ro52 autoantibodies in serum were measured and compared to MHC class II allele status. A clear association with pSS was detected for the DRB1*0301 and DRB3*0101 alleles, but these alleles were more closely associated with the presence of anti-Ro52 autoantibodies than with pSS itself. Moreover, the DQA1*0501 and DQB1*0201 alleles were only associated with the presence of anti-Ro52 autoantibodies. This study shows that the production of anti-Ro52 autoantibodies in pSS is associated with the DRB1*0301, DRB3*0101, DQA1*0501 and DQB1*0201 alleles which are in strong linkage disequilibrium.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
H2-AaMouseSjogren's syndrome susceptibilityISOHLA-DQA1 (Homo sapiens)DNA:polymorphism:cds:HLA-DQA1*0101 (human)RGD 
H2-Eb1MouseSjogren's syndrome susceptibilityISOHLA-DRB1 (Homo sapiens)DNA:polymorphism:cds:HLA-DRB1*0301 (human)RGD 
HLA-DQA1HumanSjogren's syndrome susceptibilityIAGP DNA:polymorphism:cds:HLA-DQA1*0101 (human)RGD 
HLA-DRB1HumanSjogren's syndrome susceptibilityIAGP DNA:polymorphism:cds:HLA-DRB1*0301 (human)RGD 
RT1-BaRatSjogren's syndrome susceptibilityISOHLA-DQA1 (Homo sapiens)DNA:polymorphism:cds:HLA-DQA1*0101 (human)RGD 
RT1-Db1RatSjogren's syndrome susceptibilityISOHLA-DRB1 (Homo sapiens)DNA:polymorphism:cds:HLA-DRB1*0301 (human)RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
HLA-DQA1HumanAnti-La/SS-B antibody positivity susceptibilityIAGP DNA:polymorphisms:cds:HLA-DQA1*0101 and HLA-DQA1*0501RGD 
HLA-DRB1HumanAnti-La/SS-B antibody positivity susceptibilityIAGP DNA:polymorphism:cds:HLA-DRB1*0301RGD 

Genes (Rattus norvegicus)
RT1-Ba  (RT1 class II, locus Ba) RT1-Db1  (RT1 class II, locus Db1)

Genes (Mus musculus)
H2-Aa  (histocompatibility 2, class II antigen A, alpha) H2-Eb1  (histocompatibility 2, class II antigen E beta)

Genes (Homo sapiens)
HLA-DQA1  (major histocompatibility complex, class II, DQ alpha 1) HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)