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Gene: H2-Aa (histocompatibility 2, class II antigen A, alpha) Mus musculus
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Symbol: H2-Aa
Name: histocompatibility 2, class II antigen A, alpha
Description: Exhibits peptide antigen binding activity. Involved in antigen processing and presentation of exogenous peptide antigen via MHC class II; positive regulation of T cell differentiation; and response to interferon-gamma. Localizes to MHC class II protein complex; external side of plasma membrane; and lysosome. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); bone inflammation disease (multiple); glucose metabolism disease (multiple); hematologic cancer (multiple); and liver disease (multiple). Is expressed in central nervous system; retina; and thymus primordium. Orthologous to several human genes including HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1); PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; asthma pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A alpha; Aalpha; H-2 class II histocompatibility antigen, A-B alpha chain; H-2 class II histocompatibility antigen, A-D alpha chain; H-2 class II histocompatibility antigen, A-F alpha chain; H-2 class II histocompatibility antigen, A-K alpha chain; H-2 class II histocompatibility antigen, A-Q alpha chain; H-2 class II histocompatibility antigen, A-R alpha chain; H-2 class II histocompatibility antigen, A-S alpha chain; H-2 class II histocompatibility antigen, A-U alpha chain; H-2 class II histocompatibility antigen, I-E alpha chain; H-2Aa; H2Aa; HLA class II histocompatibility antigen, DQ alpha 1 chain; I-Aalpha; Ia-1; Ia1; IAalpha; major histocompatibility protein class II alpha chain; MHC class II antigen; MHC class II antigen A alpha isoform-004; MHC class II antigen alpha chain; MHC-II I-A(d) alpha
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1734,282,744 - 34,287,823 (-)EnsemblGRCm38mm10GRCm38
GRCm381734,282,744 - 34,287,823 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371734,419,696 - 34,424,716 (-)NCBIGRCm37mm9NCBIm37
MGSCv361733,891,091 - 33,896,110 (-)NCBImm8
Celera1737,044,263 - 37,049,282 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on H2-Aa
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1619269
Created: 2007-05-01
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.