RGD Reference Report - NGF and BDNF long-term variations in the thyroid, testis and adrenal glands of a mouse model of fetal alcohol spectrum disorders. - Rat Genome Database

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NGF and BDNF long-term variations in the thyroid, testis and adrenal glands of a mouse model of fetal alcohol spectrum disorders.

Authors: Ceccanti, Mauro  De Nicolò, Sara  Mancinelli, Rosanna  Chaldakov, George  Carito, Valentina  Ceccanti, Marco  Laviola, Giovanni  Tirassa, Paola  Fiore, Marco 
Citation: Ceccanti M, etal., Ann Ist Super Sanita. 2013;49(4):383-90. doi: 10.4415/ANN_13_04_11.
RGD ID: 401976286
Pubmed: PMID:24334784   (View Abstract at PubMed)
DOI: DOI:10.4415/ANN_13_04_11   (Journal Full-text)


OBJECTIVES: Fetal Alcohol Spectrum Disorders (FASD) due to prenatal ethanol consumption may induce long-lasting changes to the newborns affecting also the endocrine system and the nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) signaling. Thus the aim of this study was to investigate in the thyroid, testis and adrenal glands of a FASD mouse model the long-lasting effects of ethanol exposure during pregnancy and lactation on NGF and BDNF and their main receptors, TrkA and TrkB, including their phosphorylated patterns.
METHODS: We used aged male CD-1 mice early exposed to ethanol solution or red wine at same ethanol concentration (11% vol).
RESULTS: We found elevations in NGF and BDNF in the thyroid of aged mice exposed to ethanol solution only but not in the red wine group. In the testis NGF resulted to be increased only in the ethanol solution group. In the adrenal glands data showed an elevation in NGF in both the ethanol solution group and red wine. No changes in TrkA, TrkB, phospho-TrkA and phospho-TrkB were revealed in all tissues examined.
CONCLUSIONS: Early administration of ethanol may induce long-lasting changes in the mouse thyroid, testis and adrenal glands at NGF and BDNF levels.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BDNFHumanPrenatal Exposure Delayed Effects  ISOBdnf (Mus musculus)associated with alcohol use disorder and protein:increased expression:thyroid glandRGD 
BdnfRatPrenatal Exposure Delayed Effects  ISOBdnf (Mus musculus)associated with alcohol use disorder and protein:increased expression:thyroid glandRGD 
BdnfMousePrenatal Exposure Delayed Effects  IEP associated with alcohol use disorder and protein:increased expression:thyroid glandRGD 
NGFHumanPrenatal Exposure Delayed Effects  ISONgf (Rattus norvegicus)associated with alcohol use disorder more ...RGD 
NgfMousePrenatal Exposure Delayed Effects  ISONgf (Rattus norvegicus)associated with alcohol use disorder more ...RGD 
NgfRatPrenatal Exposure Delayed Effects  IEP associated with alcohol use disorder more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bdnf  (brain-derived neurotrophic factor)
Ngf  (nerve growth factor)

Genes (Mus musculus)
Bdnf  (brain derived neurotrophic factor)
Ngf  (nerve growth factor)

Genes (Homo sapiens)
BDNF  (brain derived neurotrophic factor)
NGF  (nerve growth factor)


Additional Information