RGD Reference Report - Idiopathic Pulmonary Arterial Hypertension: Network-Based Integration of Multi-Omics Data Reveals New Molecular Signatures and Candidate Drugs. - Rat Genome Database

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Idiopathic Pulmonary Arterial Hypertension: Network-Based Integration of Multi-Omics Data Reveals New Molecular Signatures and Candidate Drugs.

Authors: Kasavi, Ceyda 
Citation: Kasavi C, OMICS. 2023 Jul;27(7):315-326. doi: 10.1089/omi.2023.0066. Epub 2023 Jul 6.
RGD ID: 401940160
Pubmed: PMID:37410515   (View Abstract at PubMed)
DOI: DOI:10.1089/omi.2023.0066   (Journal Full-text)

Idiopathic pulmonary arterial hypertension (IPAH) is a progressive disease that affects the pulmonary arteries, resulting in increased pulmonary vascular resistance and right ventricular dysfunction, which can ultimately lead to heart failure and death. The molecular substrates of IPAH are poorly understood while diagnostics and therapeutics innovation remain as unmet needs for this debilitating disease. In this study, a network-based methodology was used to uncover the salient molecular mechanisms of IPAH to inform drug and diagnostic discovery, and personalized medicine. Expression profiling datasets associated with IPAH were obtained from the Gene Expression Omnibus database: GSE15197, GSE113439, GSE53408, and GSE67597. The comparative analysis of mRNA and miRNA expression data and the modular analysis of a transcriptome-based weighted gene coexpression network unraveled disease-specific gene and miRNA signatures. DEAD-box helicase 52 (DDx52), ESF1 nucleolar pre-RNA processing protein (ESF1), heterogeneous nuclear ribonuclearprotein A3 (MNRNPA3), Myosin VA (MYO5A), replication factor C subunit 1 (RFC1), and arginine and serine rich coiled coil 1 (RSRC1) were detected as the salient genes for IPAH. In addition, the salient gene-based drug repositioning analysis identified alvespimycin, tanespimycin, geldanamycin, LY294002, cephaeline, digoxigenin, lanatoside C, helveticoside, trichostatin A, phenoxybenzamine, genistein, pioglitazone, and rosiglitazone as potential drug candidates for IPAH. In conclusion, this study provides new molecular signatures in relation to IPAH and attendant potential drug candidates for further experimental and translational clinical research for patients with IPAH.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
primary pulmonary hypertension  HEP 401940160mRNA:increased expression:lung (human)RGD 
primary pulmonary hypertension  ISORFC1 (Homo sapiens)401940160; 401940160mRNA:increased expression:lung (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Rfc1  (replication factor C subunit 1)

Genes (Mus musculus)
Rfc1  (replication factor C (activator 1) 1)

Genes (Homo sapiens)
RFC1  (replication factor C subunit 1)


Additional Information