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Gene: RFC1 (replication factor C subunit 1) Homo sapiens
Symbol: RFC1
Name: replication factor C subunit 1
RGD ID: 1353491
Description: Exhibits DNA clamp unloader activity. Involved in DNA clamp unloading. Localizes to DNA replication factor C complex; Elg1 RFC-like complex; and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A1; A1 140 kDa subunit; activator 1 140 kDa subunit; activator 1 large subunit; activator 1 subunit 1; CANVAS; DNA-binding protein PO-GA; MGC51786; MHC binding factor, beta; MHCBFB; PO-GA; RECC1; replication factor C (activator 1) 1, 145kDa; replication factor C 140 kDa subunit; replication factor C large subunit; replication factor C1; RF-C 140 kDa subunit; RFC; RFC140
Mus musculus (house mouse) : Rfc1 (replication factor C (activator 1) 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rfc1 (replication factor C subunit 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rfc1 (replication factor C subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : RFC1 (replication factor C subunit 1)
Canis lupus familiaris (dog) : RFC1 (replication factor C subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rfc1 (replication factor C subunit 1)
Sus scrofa (pig) : RFC1 (replication factor C subunit 1)
Chlorocebus sabaeus (African green monkey) : RFC1 (replication factor C subunit 1)
Heterocephalus glaber (naked mole-rat) : Rfc1 (replication factor C subunit 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: RFC1 (GeneID: 5981) and SLC19A1 (GeneID: 6573) share the RFC1 symbol/alias in common. RFC1 is the official symbol for the gene name 'replication factor C subunit 1' and is an alias for 'reduced folate carrier 1' on the 'solute carrier family 19 member 1' gene. [18 May 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl439,287,456 - 39,366,375 (-)EnsemblGRCh38hg38GRCh38
GRCh38439,287,456 - 39,366,381 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37439,289,069 - 39,368,001 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36438,965,471 - 39,044,390 (-)NCBINCBI36hg18NCBI36
Build 34439,111,641 - 39,190,561NCBI
Celera439,726,898 - 39,805,822 (-)NCBI
Cytogenetic Map4p14NCBI
HuRef438,614,348 - 38,693,267 (-)NCBIHuRef
CHM1_1439,288,683 - 39,367,619 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RFC1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1353491
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.