RGD Reference Report - The FTO variant is associated with chronic complications of diabetes mellitus in Czech population. - Rat Genome Database

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The FTO variant is associated with chronic complications of diabetes mellitus in Czech population.

Authors: Hubacek, Jaroslav A  Dlouha, Dana  Klementova, Marta  Lanska, Vera  Neskudla, Tomas  Pelikanova, Terezie 
Citation: Hubacek JA, etal., Gene. 2018 Feb 5;642:220-224. doi: 10.1016/j.gene.2017.11.040. Epub 2017 Nov 14.
RGD ID: 329813082
Pubmed: PMID:29154870   (View Abstract at PubMed)
DOI: DOI:10.1016/j.gene.2017.11.040   (Journal Full-text)


BACKGROUND: Genome-wide association studies have resulted in the identification of the FTO gene as an important genetic determinant of diabetes mellitus. The aim of this study was to confirm the role of this gene in the development of DM in the Czech-Slavonic population and to analyse whether this gene is associated with common DM complications.
METHODS: Two groups of patients (814 with T1DM and 848 with T2DM) and a group of healthy controls (2339 individuals) - both of Czech origin - were genotyped for the FTO rs17817449 SNP. ANOVA and logistic regression were used for the statistical evaluations.
RESULTS: The frequency of the GG genotype was significantly higher in T2DM (25.4% vs. 16.7%, P<0.0005) but not in T1DM patients (19.3% vs. 16.7%, P=0.20) than in controls. The increased risk of development of diabetic nephropathy was observed both for T1DM patients (GG vs. TT homozygotes, P<0.01) and T2DM patients (G carriers vs. TT homozygotes, P<0.05). FTO genotype predicted the development of diabetic neuropathy (GG vs. TT comparison; P<0.01) in the T2DM patients only. No association between FTO genotype and development of retinopathy was detected. All presented values are after adjustment for age, sex, BMI and duration of diabetes.
CONCLUSIONS: We confirm the association between the FTO rs17817449 SNP and susceptibility to T2DM in the Czech-Slavonic population. The same variant is associated with a spectrum of chronic complications in both types of diabetes.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Diabetic Nephropathies susceptibilityIAGP 329813082associated with diabetes mellitus and DNA:SNP: :rs17817449 (human)RGD 
Diabetic Nephropathies susceptibilityISOFTO (Homo sapiens)329813082; 329813082associated with diabetes mellitus and DNA:SNP: :rs17817449 (human)RGD 
diabetic neuropathy susceptibilityIAGP 329813082associated with type 2 diabetes mellitus and DNA:SNP: :rs17817449 (human)RGD 
diabetic neuropathy susceptibilityISOFTO (Homo sapiens)329813082; 329813082associated with type 2 diabetes mellitus and DNA:SNP: :rs17817449 (human)RGD 
type 2 diabetes mellitus susceptibilityIAGP 329813082DNA:SNP: :rs17817449 (human)RGD 
type 2 diabetes mellitus susceptibilityISOFTO (Homo sapiens)329813082; 329813082DNA:SNP: :rs17817449 (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fto  (FTO, alpha-ketoglutarate dependent dioxygenase)

Genes (Mus musculus)
Fto  (FTO alpha-ketoglutarate dependent dioxygenase)

Genes (Homo sapiens)
FTO  (FTO alpha-ketoglutarate dependent dioxygenase)


Additional Information