RGD Reference Report - Growth pattern switch of renal cells and expression of cell cycle related proteins at the early stage of diabetic nephropathy. - Rat Genome Database

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Growth pattern switch of renal cells and expression of cell cycle related proteins at the early stage of diabetic nephropathy.

Authors: Zhang, Y  Shi, Y  Liu, Y  Dong, H  Liu, M  Li, Y  Duan, H 
Citation: Zhang Y, etal., Biochem Biophys Res Commun. 2007 Nov 9;363(1):159-64. Epub 2007 Aug 31.
RGD ID: 2289273
Pubmed: PMID:17825795   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2007.08.139   (Journal Full-text)

Renal hypertrophy, partly due to cell proliferation and hypertrophy, has been found correlated to renal function deterioration in diabetes mellitus. We screened the up-regulated cell cycle related genes to investigate cell growth and the expression of cell cycle regulating proteins at the early stage of diabetic nephropathy using STZ-induced diabetic rats. Cyclin E, CDK(2) and P(27) were found significantly up-regulated in diabetic kidney. Increased cell proliferation in the kidney was seen at day 3, peaked at day 5, and returned to normal level at day 30. Cyclin E and CDK(2) expression also peeked at day 5 and P(27) activity peaked at day 14. These findings indicate that a hyperplastic growth period of renal cells is followed by a hypertrophic growth period at the early stage of diabetes. The growth pattern switch may be regulated by cell cycle regulating proteins, Cyclin E, CDK(2), and P(27).

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Diabetic Nephropathies  ISOCcne1 (Rattus norvegicus)2289273; 2289273protein:increased expression:kidneyRGD 
Diabetic Nephropathies  IEP 2289273protein:increased expression:kidneyRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccne1  (cyclin E1)

Genes (Mus musculus)
Ccne1  (cyclin E1)

Genes (Homo sapiens)
CCNE1  (cyclin E1)


Additional Information