RGD Reference Report - The adenovirus-mediated transfer of PTEN inhibits the growth of esophageal cancer cells in vitro and in vivo. - Rat Genome Database

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The adenovirus-mediated transfer of PTEN inhibits the growth of esophageal cancer cells in vitro and in vivo.

Authors: Zhou, Yong-An  Zhang, Tao  Zhao, Jin-Bo  Wang, Xiao-Ping  Jiang, Tao  Gu, Zhong-Ping  Wang, Xian-Ni  Li, Xiao-Fei 
Citation: Zhou YA, etal., Biosci Biotechnol Biochem. 2010;74(4):736-40. doi: 10.1271/bbb.90787. Epub 2010 Apr 7.
RGD ID: 127285592
Pubmed: PMID:20378992   (View Abstract at PubMed)
DOI: DOI:10.1271/bbb.90787   (Journal Full-text)

The development and progression of esophageal cancer is associated with multiple alterations in the genome, including loss of the tumor suppressor phosphatase and tensin homolog deleted from the chromosome 10 (PTEN) gene. The purpose of this study was to determine the effects of adenovirus-mediated MMAC/PTEN expression on the growth and survival of human esophageal cancer cells in vitro and in vivo. We found that compared to control cells, overexpression of PTEN significantly suppressed growth and induced apoptosis in esophageal cancer cell lines Eca-109 and TE-1 via downregulation of Bcl-2 expression and changes in cell-cycle progression. Adenovirus PTEN also inhibited the growth of subcutaneous tumor xenografts by significantly reducing tumor size in vivo. Thus our results confirm the proposed functional role of MMAC/PTEN as a regulator of esophageal cancer progression in vivo and in vitro. PTEN might be an important biological marker and potential therapeutic target in the treatment of human esophageal cancer.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
esophageal cancer treatmentIMP 127285592human gene and cells in a mouse modelRGD 
esophageal cancer treatmentISOPTEN (Homo sapiens)127285592; 127285592human gene and cells in a mouse modelRGD 

Objects Annotated

Genes (Rattus norvegicus)
Pten  (phosphatase and tensin homolog)

Genes (Mus musculus)
Pten  (phosphatase and tensin homolog)

Genes (Homo sapiens)
PTEN  (phosphatase and tensin homolog)


Additional Information