Nell2 (neural EGFL like 2) - Rat Genome Database

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Gene: Nell2 (neural EGFL like 2) Rattus norvegicus
Analyze
Symbol: Nell2
Name: neural EGFL like 2
RGD ID: 620999
Description: Enables heparin binding activity; identical protein binding activity; and protein kinase C binding activity. Involved in several processes, including development of secondary female sexual characteristics; neuron cellular homeostasis; and positive regulation of hormone secretion. Located in several cellular components, including dendrite; extracellular space; and perikaryon. Orthologous to human NELL2 (neural EGFL like 2); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC681834; NEL-like 2; NEL-like 2 (chicken); nel-like 2 homolog (chicken); NEL-like protein 2; protein kinase C-binding protein NELL2; rCG50753-like; similar to protein kinase C-binding protein NELL2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87128,222,333 - 128,542,127 (-)NCBIGRCr8
mRatBN7.27126,343,089 - 126,662,903 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7126,198,851 - 126,733,503 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7128,140,978 - 128,460,541 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07130,366,500 - 130,686,074 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07130,268,233 - 130,594,773 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07136,526,497 - 136,853,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7136,526,496 - 136,853,957 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07136,173,239 - 136,494,641 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47133,758,271 - 134,080,104 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17133,835,295 - 134,156,541 (-)NCBI
Celera7122,721,504 - 123,171,087 (-)NCBICelera
Cytogenetic Map7q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
atrazine  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
calcitriol  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
cytarabine  (ISO)
dexamethasone  (EXP)
Diallyl sulfide  (ISO)
dichlorine  (EXP)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenylmercury acetate  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A neuron-specific EGF family protein, NELL2, promotes survival of neurons through mitogen-activated protein kinases. Aihara K, etal., Brain Res Mol Brain Res. 2003 Aug 19;116(1-2):86-93.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. NELL2, a neuron-specific EGF-like protein, is selectively expressed in glutamatergic neurons and contributes to the glutamatergic control of GnRH neurons at puberty. Ha CM, etal., Neuroendocrinology. 2008;88(3):199-211. doi: 10.1159/000139579. Epub 2008 Jun 12.
5. Alternative splicing generates a novel non-secretable cytosolic isoform of NELL2. Hwang EM, etal., Biochem Biophys Res Commun. 2007 Feb 16;353(3):805-11. doi: 10.1016/j.bbrc.2006.12.115. Epub 2006 Dec 22.
6. Ontogeny and the possible function of a novel epidermal growth factor-like repeat domain-containing protein, NELL2, in the rat brain. Kim H, etal., J Neurochem 2002 Dec;83(6):1389-400.
7. NELL2 Function in Axon Development of Hippocampal Neurons. Kim HR, etal., Mol Cells. 2020 Jun 30;43(6):581-589. doi: 10.14348/molcells.2020.0032.
8. Involvement of epidermal growth factor-like domain of NELL proteins in the novel protein-protein interaction with protein kinase C. Kuroda S and Tanizawa K, Biochem Biophys Res Commun 1999 Nov 30;265(3):752-7.
9. Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2. Kuroda S, etal., Biochem Biophys Res Commun 1999 Nov;265(1):79-86.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9480764   PMID:12477932   PMID:18513367   PMID:18677093   PMID:19931511   PMID:21643849   PMID:22496866   PMID:24352699   PMID:25177948   PMID:28301916   PMID:35950455  


Genomics

Comparative Map Data
Nell2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87128,222,333 - 128,542,127 (-)NCBIGRCr8
mRatBN7.27126,343,089 - 126,662,903 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7126,198,851 - 126,733,503 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7128,140,978 - 128,460,541 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07130,366,500 - 130,686,074 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07130,268,233 - 130,594,773 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07136,526,497 - 136,853,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7136,526,496 - 136,853,957 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07136,173,239 - 136,494,641 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47133,758,271 - 134,080,104 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17133,835,295 - 134,156,541 (-)NCBI
Celera7122,721,504 - 123,171,087 (-)NCBICelera
Cytogenetic Map7q35NCBI
NELL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381244,508,275 - 44,921,848 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1244,508,275 - 44,921,848 (-)EnsemblGRCh38hg38GRCh38
GRCh371244,902,058 - 45,307,772 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361243,188,332 - 43,556,405 (-)NCBINCBI36Build 36hg18NCBI36
Build 341243,188,331 - 43,556,405NCBI
Celera1243,705,353 - 44,111,067 (-)NCBICelera
Cytogenetic Map12q12NCBI
HuRef1241,929,510 - 42,335,961 (-)NCBIHuRef
CHM1_11244,867,040 - 45,272,689 (-)NCBICHM1_1
T2T-CHM13v2.01244,466,949 - 44,872,599 (-)NCBIT2T-CHM13v2.0
Nell2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391595,117,321 - 95,426,677 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1594,973,111 - 95,426,440 (-)EnsemblGRCm39 Ensembl
GRCm381595,219,440 - 95,528,796 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1595,075,230 - 95,528,559 (-)EnsemblGRCm38mm10GRCm38
MGSCv371595,049,881 - 95,359,137 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361595,048,113 - 95,356,432 (-)NCBIMGSCv36mm8
Celera1597,364,534 - 97,674,925 (-)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1549.39NCBI
Nell2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555003,669,837 - 4,080,443 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555003,669,893 - 4,049,765 (-)NCBIChiLan1.0ChiLan1.0
NELL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21049,258,879 - 49,665,010 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11249,255,637 - 49,661,768 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01243,820,215 - 44,226,249 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11244,680,223 - 45,094,070 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1244,688,209 - 45,094,070 (+)Ensemblpanpan1.1panPan2
NELL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1279,300,001 - 9,680,974 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl279,299,893 - 9,680,363 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2736,632,740 - 37,013,748 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0279,488,781 - 9,870,311 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl279,551,037 - 9,870,309 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1279,358,260 - 9,676,754 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0279,396,929 - 9,716,175 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02736,867,127 - 37,248,415 (-)NCBIUU_Cfam_GSD_1.0
Nell2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494569,939,345 - 70,302,004 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365122,863,485 - 3,224,941 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365122,862,823 - 3,225,350 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NELL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl575,505,099 - 75,893,454 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1575,505,092 - 75,837,324 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2578,515,865 - 78,687,458 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NELL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11140,701,718 - 41,057,489 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1140,701,723 - 41,057,349 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037205,411,968 - 205,768,291 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nell2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248167,503,067 - 8,007,081 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248167,502,615 - 8,006,241 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nell2
2053 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:41
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000008985
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)7116677189127103496Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat

Markers in Region
D7Got112  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27126,483,674 - 126,483,890 (+)MAPPERmRatBN7.2
Rnor_6.07136,667,635 - 136,667,850NCBIRnor6.0
Rnor_5.07136,313,943 - 136,314,158UniSTSRnor5.0
RGSC_v3.47133,898,569 - 133,898,785RGDRGSC3.4
RGSC_v3.47133,898,570 - 133,898,785UniSTSRGSC3.4
RGSC_v3.47133,897,726 - 133,898,785UniSTSRGSC3.4
RGSC_v3.17133,975,007 - 133,975,222RGD
Celera7122,993,100 - 122,993,319UniSTS
RH 3.4 Map71041.7UniSTS
RH 3.4 Map71041.7RGD
RH 2.0 Map7752.8RGD
Cytogenetic Map7q35UniSTS
BF420438  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27126,464,799 - 126,464,906 (+)MAPPERmRatBN7.2
Rnor_6.07136,648,763 - 136,648,869NCBIRnor6.0
Rnor_5.07136,295,071 - 136,295,177UniSTSRnor5.0
RGSC_v3.47133,878,834 - 133,878,940UniSTSRGSC3.4
Celera7122,974,223 - 122,974,329UniSTS
RH 3.4 Map71040.3UniSTS
Cytogenetic Map7q35UniSTS
RH130208  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27126,343,118 - 126,343,338 (+)MAPPERmRatBN7.2
Rnor_6.07136,526,527 - 136,526,746NCBIRnor6.0
Rnor_5.07136,173,269 - 136,173,488UniSTSRnor5.0
RGSC_v3.47133,758,301 - 133,758,520UniSTSRGSC3.4
Celera7122,721,534 - 122,721,753UniSTS
RH 3.4 Map71036.7UniSTS
Cytogenetic Map7q35UniSTS
RH130209  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27126,343,192 - 126,343,344 (+)MAPPERmRatBN7.2
Rnor_6.07136,526,601 - 136,526,752NCBIRnor6.0
Rnor_5.07136,173,343 - 136,173,494UniSTSRnor5.0
RGSC_v3.47133,758,375 - 133,758,526UniSTSRGSC3.4
Celera7122,721,608 - 122,721,759UniSTS
RH 3.4 Map71037.4UniSTS
Cytogenetic Map7q35UniSTS
BI277674  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27126,559,900 - 126,560,050 (+)MAPPERmRatBN7.2
Rnor_6.07136,743,493 - 136,743,642NCBIRnor6.0
Rnor_5.07136,388,008 - 136,388,157UniSTSRnor5.0
RGSC_v3.47133,975,104 - 133,975,253UniSTSRGSC3.4
Celera7123,069,314 - 123,069,463UniSTS
RH 3.4 Map71038.2UniSTS
Cytogenetic Map7q35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 74 10
Low 3 22 22 7 8 7 5 5 16 31 8 5
Below cutoff 19 28 27 7 27 3 6 14 2 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008985   ⟹   ENSRNOP00000008985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7126,343,090 - 126,662,694 (-)Ensembl
Rnor_6.0 Ensembl7136,526,496 - 136,853,957 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087376   ⟹   ENSRNOP00000073082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7126,352,591 - 126,595,056 (-)Ensembl
Rnor_6.0 Ensembl7136,527,135 - 136,853,154 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099152   ⟹   ENSRNOP00000088740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7126,343,090 - 126,662,028 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099586   ⟹   ENSRNOP00000093001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7126,343,090 - 126,733,503 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115194   ⟹   ENSRNOP00000094642
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7126,198,851 - 126,662,694 (-)Ensembl
RefSeq Acc Id: NM_031070   ⟹   NP_112332
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87128,222,333 - 128,542,127 (-)NCBI
mRatBN7.27126,343,089 - 126,662,903 (-)NCBI
Rnor_6.07136,526,497 - 136,853,820 (-)NCBI
Rnor_5.07136,173,239 - 136,494,641 (-)NCBI
RGSC_v3.47133,758,271 - 134,080,104 (-)RGD
Celera7122,721,504 - 123,171,087 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765798   ⟹   XP_008764020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87128,222,333 - 128,541,810 (-)NCBI
mRatBN7.27126,343,089 - 126,662,586 (-)NCBI
Rnor_6.07136,526,497 - 136,853,712 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_112332   ⟸   NM_031070
- Peptide Label: precursor
- UniProtKB: Q62918 (UniProtKB/Swiss-Prot),   C8CB44 (UniProtKB/Swiss-Prot),   A1E5S7 (UniProtKB/Swiss-Prot),   Q561K2 (UniProtKB/TrEMBL),   Q8R417 (UniProtKB/TrEMBL),   A0A8I6AS19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764020   ⟸   XM_008765798
- Peptide Label: isoform X1
- UniProtKB: Q62918 (UniProtKB/Swiss-Prot),   C8CB44 (UniProtKB/Swiss-Prot),   A1E5S7 (UniProtKB/Swiss-Prot),   Q561K2 (UniProtKB/TrEMBL),   A0A8I6AS19 (UniProtKB/TrEMBL),   Q8R417 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008985   ⟸   ENSRNOT00000008985
RefSeq Acc Id: ENSRNOP00000073082   ⟸   ENSRNOT00000087376
RefSeq Acc Id: ENSRNOP00000088740   ⟸   ENSRNOT00000099152
RefSeq Acc Id: ENSRNOP00000094642   ⟸   ENSRNOT00000115194
RefSeq Acc Id: ENSRNOP00000093001   ⟸   ENSRNOT00000099586
Protein Domains
EGF-like   Laminin G-like   VWFC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62918-F1-model_v2 AlphaFold Q62918 1-816 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620999 AgrOrtholog
BioCyc Gene G2FUF-32288 BioCyc
Ensembl Genes ENSRNOG00000006235 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00065017359 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008985 ENTREZGENE
  ENSRNOT00000008985.8 UniProtKB/Swiss-Prot
  ENSRNOT00000087376.2 UniProtKB/TrEMBL
  ENSRNOT00000099152 ENTREZGENE
  ENSRNOT00000099586.1 UniProtKB/TrEMBL
  ENSRNOT00000115194.1 UniProtKB/TrEMBL
  ENSRNOT00065028985 UniProtKB/Swiss-Prot
  ENSRNOT00065028999 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.20.200.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7312010 IMAGE-MGC_LOAD
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSPN-like_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81734 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105410 IMAGE-MGC_LOAD
NCBI Gene 81734 ENTREZGENE
PANTHER NEL HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN KINASE C-BINDING PROTEIN NELL2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nell2 PhenoGen
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFC_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006235 RatGTEx
  ENSRNOG00065017359 RatGTEx
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LamG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSPN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWC_out UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FnI-like domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K4K9_RAT UniProtKB/TrEMBL
  A0A8I6AH61_RAT UniProtKB/TrEMBL
  A0A8I6AS19 ENTREZGENE, UniProtKB/TrEMBL
  A1E5S7 ENTREZGENE
  C8CB44 ENTREZGENE
  NELL2_RAT UniProtKB/Swiss-Prot
  Q561K2 ENTREZGENE
  Q62918 ENTREZGENE
  Q8R417 ENTREZGENE
UniProt Secondary A1E5S7 UniProtKB/Swiss-Prot
  C8CB44 UniProtKB/Swiss-Prot
  Q561K2 UniProtKB/Swiss-Prot
  Q8R417 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-06-26 Nell2  neural EGFL like 2  Nell2  NEL-like 2 (chicken)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-17 Nell2  NEL-like 2 (chicken)  LOC681834  similar to protein kinase C-binding protein NELL2  Data merged from RGD:1590527 737654 PROVISIONAL
2008-02-22 Nell2  NEL-like 2 (chicken)  Nell2  nel-like 2 homolog (chicken)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC681834  similar to protein kinase C-binding protein NELL2      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Nell2  nel-like 2 homolog (chicken)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Nell2  nel-like 2 homolog (chicken)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains an NH2-terminal thrombospondin-1 (TSP-1)-like module, five von Willebrand factor C domains, and six epidermal growth factor-like domains 633407
gene_expression expressed in embryos (from day 10); predominant in CNS in prenatal stages in ventricular zone of psinal cord, medulla and pons; expression decreases after birth; in adults found in tenia tecta, piriform cortex, hippocampus, dentate gyrus, cerebellar corte 628415
gene_process may have a role in neurogeneiss in CNS, maintenance of neural functions; may regulate intracellular machinery involving calcium mediated signaling as well as synaptic transport 628415
gene_process neural tissue-specific epidermal growth factor (EGF)-like repeat domain-containing protein 628415