Rgs21 (regulator of G-protein signaling 21) - Rat Genome Database

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Gene: Rgs21 (regulator of G-protein signaling 21) Rattus norvegicus
Analyze
Symbol: Rgs21
Name: regulator of G-protein signaling 21
RGD ID: 2320695
Description: Predicted to be involved in sensory perception of taste and transmission of nerve impulse. Orthologous to human RGS21 (regulator of G protein signaling 21); INTERACTS WITH 3-chloropropane-1,2-diol; 1-chloro-2,4-dinitrobenzene (ortholog); aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100361166; LOC102551739; regulator of G-protein signaling 2-like; regulator of G-protein signaling 21-like; regulator of G-protein signalling 21
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81358,789,739 - 58,839,579 (-)NCBIGRCr8
mRatBN7.21356,239,448 - 56,289,290 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1356,240,735 - 56,266,573 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1358,812,305 - 58,836,431 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01360,060,587 - 60,084,698 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01357,344,131 - 57,368,217 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01361,286,425 - 61,310,742 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1361,286,425 - 61,306,939 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01366,383,680 - 66,410,571 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41358,350,188 - 58,374,682 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1356,310,505 - 56,334,954 (-)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
Additional References at PubMed
PMID:15066150  


Genomics

Comparative Map Data
Rgs21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81358,789,739 - 58,839,579 (-)NCBIGRCr8
mRatBN7.21356,239,448 - 56,289,290 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1356,240,735 - 56,266,573 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1358,812,305 - 58,836,431 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01360,060,587 - 60,084,698 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01357,344,131 - 57,368,217 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01361,286,425 - 61,310,742 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1361,286,425 - 61,306,939 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01366,383,680 - 66,410,571 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41358,350,188 - 58,374,682 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1356,310,505 - 56,334,954 (-)NCBICelera
Cytogenetic Map13q21NCBI
RGS21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381192,316,992 - 192,367,285 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1192,316,992 - 192,367,285 (+)EnsemblGRCh38hg38GRCh38
GRCh371192,286,122 - 192,336,415 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361190,552,745 - 190,603,038 (+)NCBINCBI36Build 36hg18NCBI36
Celera1165,395,907 - 165,446,198 (+)NCBICelera
Cytogenetic Map1q31.2NCBI
HuRef1163,522,586 - 163,572,879 (+)NCBIHuRef
CHM1_11193,707,847 - 193,758,121 (+)NCBICHM1_1
T2T-CHM13v2.01191,663,986 - 191,714,313 (+)NCBIT2T-CHM13v2.0
Rgs21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391144,392,388 - 144,443,185 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1144,392,386 - 144,443,405 (-)EnsemblGRCm39 Ensembl
GRCm381144,519,690 - 144,567,667 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1144,516,648 - 144,567,667 (-)EnsemblGRCm38mm10GRCm38
MGSCv371146,366,820 - 146,392,450 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361146,281,908 - 146,321,232 (-)NCBIMGSCv36mm8
Celera1147,075,900 - 147,101,511 (-)NCBICelera
Cytogenetic Map1FNCBI
cM Map162.66NCBI
Rgs21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540629,778,745 - 29,800,009 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540629,778,745 - 29,800,009 (+)NCBIChiLan1.0ChiLan1.0
RGS21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2157,417,062 - 57,467,247 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1157,081,040 - 57,131,224 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01167,785,840 - 167,836,026 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11172,080,852 - 172,130,971 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1172,080,852 - 172,130,971 (+)Ensemblpanpan1.1panPan2
RGS21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1386,562,392 - 6,585,898 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl386,562,409 - 6,585,898 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha386,659,502 - 6,682,991 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0386,579,770 - 6,603,229 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl386,579,770 - 6,603,229 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1386,578,785 - 6,602,234 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0386,944,076 - 6,967,530 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0387,180,476 - 7,203,948 (-)NCBIUU_Cfam_GSD_1.0
Rgs21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934481,434,134 - 81,478,379 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936638692,013 - 709,883 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936638688,157 - 709,883 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl101,340,758 - 1,394,203 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1101,341,821 - 1,396,191 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2102,929,142 - 2,955,021 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RGS21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12537,053,888 - 37,084,551 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2537,060,252 - 37,078,574 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605538,034,992 - 38,053,732 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgs21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248141,291,766 - 1,313,828 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248141,291,766 - 1,313,828 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rgs21
217 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat

Markers in Region
D13Got232  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21356,281,826 - 56,282,028 (+)MAPPERmRatBN7.2
Rnor_6.01361,325,560 - 61,325,761NCBIRnor6.0
Rnor_5.01366,312,462 - 66,312,663UniSTSRnor5.0
RGSC_v3.41358,390,305 - 58,390,506UniSTSRGSC3.4
Celera1356,350,344 - 56,350,545UniSTS
Cytogenetic Map13 RGD


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system nervous system renal system reproductive system respiratory system
High
Medium
Low 2 2
Below cutoff 1 7 3 4 2 6 7 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000086610   ⟹   ENSRNOP00000071119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1356,240,735 - 56,266,573 (-)Ensembl
Rnor_6.0 Ensembl1361,286,425 - 61,306,939 (-)Ensembl
RefSeq Acc Id: NM_001287022   ⟹   NP_001273951
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,789,739 - 58,839,579 (-)NCBI
mRatBN7.21356,239,448 - 56,289,290 (-)NCBI
Rnor_6.01361,286,425 - 61,310,742 (-)NCBI
Celera1356,310,505 - 56,334,954 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063271944   ⟹   XP_063128014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,792,824 - 58,836,399 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001273951 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128014 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071119
  ENSRNOP00000071119.2
Reference Protein Sequences
RefSeq Acc Id: NP_001273951   ⟸   NM_001287022
- UniProtKB: A0A0G2JZN6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071119   ⟸   ENSRNOT00000086610
RefSeq Acc Id: XP_063128014   ⟸   XM_063271944
- Peptide Label: isoform X1
Protein Domains
RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JZN6-F1-model_v2 AlphaFold A0A0G2JZN6 1-152 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2320695 AgrOrtholog
BioCyc Gene G2FUF-17999 BioCyc
Ensembl Genes ENSRNOG00000056369 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000086610 ENTREZGENE
  ENSRNOT00000086610.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.167.10 UniProtKB/TrEMBL
  1.10.196.10 UniProtKB/TrEMBL
InterPro RGS UniProtKB/TrEMBL
  RGS_sf UniProtKB/TrEMBL
  RGS_subdom1 UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/TrEMBL
KEGG Report rno:100361166 UniProtKB/TrEMBL
NCBI Gene 100361166 ENTREZGENE
PANTHER REGULATOR OF G PROTEIN SIGNALING UniProtKB/TrEMBL
  REGULATOR OF G-PROTEIN SIGNALING 21 UniProtKB/TrEMBL
Pfam RGS UniProtKB/TrEMBL
PhenoGen Rgs21 PhenoGen
PRINTS RGSPROTEIN UniProtKB/TrEMBL
PROSITE RGS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056369 RatGTEx
SMART RGS UniProtKB/TrEMBL
Superfamily-SCOP SSF48097 UniProtKB/TrEMBL
UniProt A0A0G2JZN6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Rgs21  regulator of G-protein signaling 21  LOC102551739  regulator of G-protein signaling 21-like  Data merged from RGD:7555782 737654 PROVISIONAL
2013-12-17 LOC102551739  regulator of G-protein signaling 21-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-08-10 Rgs21  regulator of G-protein signaling 21  LOC100361166  regulator of G-protein signaling 2-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100361166  regulator of G-protein signaling 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL