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Gene: Adam2 (ADAM metallopeptidase domain 2) Rattus norvegicus

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Symbol:

Adam2

Name:

ADAM metallopeptidase domain 2

RGD ID:

69299

Description:

Predicted to enable metalloendopeptidase activity. Involved in male gonad development and spermatogenesis. Located in acrosomal vesicle. Orthologous to human ADAM2 (ADAM metallopeptidase domain 2); INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

a disintegrin and metallopeptidase domain 2; a disintegrin and metalloprotease domain (ADAM) 2; a disintegrin and metalloprotease domain 2; A disintegrin and metalloprotease domain 2 (Fertilin beta); ADAM 2; beta; disintegrin and metalloproteinase domain-containing protein 2; fertilin beta; fertilin subunit beta; Ftnb; PH-30; PH30; PH30-beta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	44,418,191 - 44,459,570 (-)	NCBI		GRCr8
mRatBN7.2	15	40,242,651 - 40,284,025 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	40,242,783 - 40,283,952 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	42,107,929 - 42,148,828 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	43,258,129 - 43,299,026 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	41,703,086 - 41,744,269 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	42,708,536 - 42,751,281 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	42,708,387 - 42,751,330 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	48,842,808 - 48,883,837 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	45,449,574 - 45,491,663 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	45,465,353 - 45,507,443 (-)	NCBI
Celera	15	39,914,632 - 39,955,090 (-)	NCBI		Celera
Cytogenetic Map	15	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Adam2	Rat	Alzheimer's disease		ISO	ADAM2 (Homo sapiens)	10047127	protein:increased expression:brain	RGD
Adam2	Rat	Kidney Reperfusion Injury		IEP		10047130		RGD

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Adam2	Rat	1,2-dimethylhydrazine	decreases expression	ISO	Adam2 (Mus musculus)	6480464	1 and 2-Dimethylhydrazine results in decreased expression of ADAM2 mRNA	CTD	PMID:22206623
Adam2	Rat	17alpha-ethynylestradiol	increases expression	ISO	Adam2 (Mus musculus)	6480464	Ethinyl Estradiol results in increased expression of ADAM2 mRNA	CTD	PMID:17942748
Adam2	Rat	17alpha-ethynylestradiol	multiple interactions	ISO	Adam2 (Mus musculus)	6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADAM2 mRNA	CTD	PMID:17942748
Adam2	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	Adam2 (Mus musculus)	6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADAM2 mRNA	CTD	PMID:17942748
Adam2	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	Adam2 (Mus musculus)	6480464	Tetrachlorodibenzodioxin results in increased expression of ADAM2 mRNA	CTD	PMID:15328365 more ...
Adam2	Rat	3,3',4,4',5-pentachlorobiphenyl	increases expression	ISO	Adam2 (Mus musculus)	6480464	3 more ...	CTD	PMID:23994337
Adam2	Rat	4,4'-diaminodiphenylmethane	decreases expression	ISO	Adam2 (Mus musculus)	6480464	4 and 4'-diaminodiphenylmethane results in decreased expression of ADAM2 mRNA	CTD	PMID:18648102
Adam2	Rat	6-propyl-2-thiouracil	increases expression	EXP		6480464	Propylthiouracil results in increased expression of ADAM2 mRNA	CTD	PMID:24780913
Adam2	Rat	aflatoxin B1	decreases methylation	ISO	ADAM2 (Homo sapiens)	6480464	Aflatoxin B1 results in decreased methylation of ADAM2 gene	CTD	PMID:27153756
Adam2	Rat	aflatoxin B1	increases methylation	ISO	ADAM2 (Homo sapiens)	6480464	Aflatoxin B1 results in increased methylation of ADAM2 intron	CTD	PMID:30157460
Adam2	Rat	ammonium chloride	affects expression	EXP		6480464	Ammonium Chloride affects the expression of ADAM2 mRNA	CTD	PMID:16483693
Adam2	Rat	arsane	affects methylation	ISO	ADAM2 (Homo sapiens)	6480464	Arsenic affects the methylation of ADAM2 gene	CTD	PMID:25304211
Adam2	Rat	arsenic atom	affects methylation	ISO	ADAM2 (Homo sapiens)	6480464	Arsenic affects the methylation of ADAM2 gene	CTD	PMID:25304211
Adam2	Rat	benzo[a]pyrene	affects expression	ISO	Adam2 (Mus musculus)	6480464	Benzo(a)pyrene affects the expression of ADAM2 mRNA	CTD	PMID:22641617
Adam2	Rat	benzo[a]pyrene	affects methylation	ISO	ADAM2 (Homo sapiens)	6480464	Benzo(a)pyrene affects the methylation of ADAM2 promoter	CTD	PMID:27901495
Adam2	Rat	beta-naphthoflavone	increases expression	ISO	Adam2 (Mus musculus)	6480464	beta-Naphthoflavone results in increased expression of ADAM2 mRNA	CTD	PMID:23994337
Adam2	Rat	bis(2-ethylhexyl) phthalate	decreases expression	ISO	Adam2 (Mus musculus)	6480464	Diethylhexyl Phthalate results in decreased expression of ADAM2 mRNA	CTD	PMID:33162236
Adam2	Rat	bis(2-ethylhexyl) phthalate	increases expression	ISO	Adam2 (Mus musculus)	6480464	Diethylhexyl Phthalate results in increased expression of ADAM2 mRNA	CTD	PMID:34319233
Adam2	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of ADAM2 mRNA	CTD	PMID:25181051
Adam2	Rat	bisphenol A	increases methylation	EXP		6480464	bisphenol A results in increased methylation of ADAM2 gene	CTD	PMID:28505145
Adam2	Rat	calcitriol	decreases expression	ISO	ADAM2 (Homo sapiens)	6480464	Calcitriol results in decreased expression of ADAM2 mRNA	CTD	PMID:21592394
Adam2	Rat	calcitriol	multiple interactions	ISO	ADAM2 (Homo sapiens)	6480464	[Testosterone co-treated with Calcitriol] results in decreased expression of ADAM2 mRNA	CTD	PMID:21592394
Adam2	Rat	copper(II) sulfate	decreases expression	ISO	ADAM2 (Homo sapiens)	6480464	Copper Sulfate results in decreased expression of ADAM2 mRNA	CTD	PMID:19549813
Adam2	Rat	epoxiconazole	affects expression	ISO	Adam2 (Mus musculus)	6480464	epoxiconazole affects the expression of ADAM2 mRNA	CTD	PMID:35436446
Adam2	Rat	fenvalerate	increases expression	EXP		6480464	fenvalerate results in increased expression of ADAM2 mRNA	CTD	PMID:30307764
Adam2	Rat	folic acid	decreases expression	ISO	ADAM2 (Homo sapiens)	6480464	Folic Acid results in decreased expression of ADAM2 mRNA	CTD	PMID:21867686
Adam2	Rat	lead diacetate	increases methylation	EXP		6480464	lead acetate results in increased methylation of ADAM2 gene	CTD	PMID:29571894
Adam2	Rat	ozone	multiple interactions	ISO	Adam2 (Mus musculus)	6480464	[Air Pollutants results in increased abundance of Ozone] which results in decreased expression of ADAM2 mRNA	CTD	PMID:27106289
Adam2	Rat	paracetamol	affects expression	ISO	Adam2 (Mus musculus)	6480464	Acetaminophen affects the expression of ADAM2 mRNA	CTD	PMID:17562736
Adam2	Rat	pirinixic acid	decreases expression	ISO	Adam2 (Mus musculus)	6480464	pirinixic acid results in decreased expression of ADAM2 mRNA	CTD	PMID:17950772
Adam2	Rat	Ptaquiloside	decreases expression	ISO	Adam2 (Mus musculus)	6480464	ptaquiloside results in decreased expression of ADAM2 mRNA	CTD	PMID:23274088
Adam2	Rat	sodium arsenite	increases expression	ISO	Adam2 (Mus musculus)	6480464	sodium arsenite results in increased expression of ADAM2 mRNA	CTD	PMID:16014739
Adam2	Rat	testosterone	decreases expression	ISO	ADAM2 (Homo sapiens)	6480464	Testosterone results in decreased expression of ADAM2 mRNA	CTD	PMID:21592394
Adam2	Rat	testosterone	multiple interactions	ISO	ADAM2 (Homo sapiens)	6480464	[Testosterone co-treated with Calcitriol] results in decreased expression of ADAM2 mRNA	CTD	PMID:21592394
Adam2	Rat	titanium dioxide	decreases expression	ISO	Adam2 (Mus musculus)	6480464	titanium dioxide results in decreased expression of ADAM2 mRNA	CTD	PMID:35295148
Adam2	Rat	trichloroethene	decreases expression	EXP		6480464	Trichloroethylene results in decreased expression of ADAM2 mRNA	CTD	PMID:33387578
Adam2	Rat	Triptolide	increases expression	ISO	Adam2 (Mus musculus)	6480464	triptolide results in increased expression of ADAM2 mRNA	CTD	PMID:32835833
Adam2	Rat	valproic acid	affects expression	ISO	Adam2 (Mus musculus)	6480464	Valproic Acid affects the expression of ADAM2 mRNA	CTD	PMID:17292431
Adam2	Rat	zinc atom	decreases expression	ISO	ADAM2 (Homo sapiens)	6480464	Zinc results in decreased expression of ADAM2 mRNA	CTD	PMID:16870260
Adam2	Rat	zinc dichloride	decreases expression	ISO	ADAM2 (Homo sapiens)	6480464	zinc chloride results in decreased expression of ADAM2 mRNA	CTD	PMID:16870260
Adam2	Rat	zinc(0)	decreases expression	ISO	ADAM2 (Homo sapiens)	6480464	Zinc results in decreased expression of ADAM2 mRNA	CTD	PMID:16870260

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Adam2	Rat	adult behavior	acts_upstream_of_or_within	ISO	Adam2 (Mus musculus)	1624291	MGI:3625523 PMID:16504143	RGD	PMID:16504143
Adam2	Rat	adult behavior	acts_upstream_of_or_within	IEA	UniProtKB:Q60718 and ensembl:ENSMUSP00000022618	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adam2	Rat	binding of sperm to zona pellucida	involved_in	IBA	MGI:102518 and PANTHER:PTN000224851	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Adam2	Rat	cell adhesion	involved_in	IEA	UniProtKB-KW:KW-0130	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Adam2	Rat	cell adhesion	acts_upstream_of_or_within	IEA	UniProtKB:Q60718 and ensembl:ENSMUSP00000022618	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adam2	Rat	cell adhesion	acts_upstream_of_or_within	ISO	Adam2 (Mus musculus)	1624291	UniProtKB:Q13797 and PMID:21060781	RGD	PMID:21060781
Adam2	Rat	cell adhesion	involved_in	IBA	MGI:1340894 and PANTHER:PTN000224851	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Adam2	Rat	gene expression	acts_upstream_of_or_within	IEA	UniProtKB:Q60718 and ensembl:ENSMUSP00000022618	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adam2	Rat	gene expression	acts_upstream_of_or_within	ISO	Adam2 (Mus musculus)	1624291	PMID:16407499	RGD	PMID:16407499
Adam2	Rat	male gonad development		IEP		10047128		RGD
Adam2	Rat	male gonad development	involved_in	IBA	PANTHER:PTN000224851 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Adam2	Rat	positive regulation of gene expression	acts_upstream_of_or_within	ISO	Adam2 (Mus musculus)	1624291	MGI:1857764 PMID:19129510	RGD	PMID:19129510
Adam2	Rat	positive regulation of gene expression	acts_upstream_of_or_within	IEA	UniProtKB:Q60718 and ensembl:ENSMUSP00000022618	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adam2	Rat	proteolysis	involved_in	IEA	InterPro:IPR001590	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Adam2	Rat	proteolysis	involved_in	IBA	FB:FBgn0034903 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Adam2	Rat	spermatogenesis		IEP		68863		RGD
Adam2	Rat	visual learning	acts_upstream_of_or_within	ISO	Adam2 (Mus musculus)	1624291	MGI:3625523 PMID:16504143	RGD	PMID:16504143
Adam2	Rat	visual learning	acts_upstream_of_or_within	IEA	UniProtKB:Q60718 and ensembl:ENSMUSP00000022618	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Adam2	Rat	acrosomal vesicle		IDA		68863		RGD
Adam2	Rat	cell surface	located_in	IEA	UniProtKB:Q60718 and ensembl:ENSMUSP00000022618	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adam2	Rat	cell surface	is_active_in	ISO	Adam2 (Mus musculus)	1624291	PMID:16407499	RGD	PMID:16407499
Adam2	Rat	cell surface	located_in	ISO	Adam2 (Mus musculus)	1624291	PMID:21273369	RGD	PMID:21273369
Adam2	Rat	membrane	located_in	IEA	UniProtKB-SubCell:SL-0162	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Adam2	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Adam2	Rat	plasma membrane	is_active_in	IBA	MGI:102518 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Adam2	Rat	protein-containing complex	part_of	IEA	UniProtKB:Q60718 and ensembl:ENSMUSP00000022618	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Adam2	Rat	protein-containing complex	part_of	ISO	Adam2 (Mus musculus)	1624291	PMID:19129510	RGD	PMID:19129510

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Adam2	Rat	metalloendopeptidase activity	enables	IEA	InterPro:IPR001590	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Adam2	Rat	metalloendopeptidase activity	enables	IBA	FB:FBgn0034903 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Adam2	Rat	metallopeptidase activity	enables	IEA	InterPro:IPR024079	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Adam2	Rat	protein binding	enables	ISO	Adam2 (Mus musculus)	1624291	PR:Q60813 more ...	RGD	PMID:15194697

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Altered cell-matrix associated ADAM proteins in Alzheimer disease.	Gerst JL, etal., J Neurosci Res. 2000 Mar 1;59(5):680-4.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Cloning and sequence analysis of rat fertilin alpha and beta--developmental expression, processing and immunolocalization.	McLaughlin EA, etal., Mol Hum Reprod 1997 Sep;3(9):801-9.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation
11.	Chronological gene expression of ADAMs during testicular development: prespermatogonia (gonocytes) express fertilin beta (ADAM2).	Rosselot C, etal., Dev Dyn. 2003 Jul;227(3):458-67.
12.	Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat.	Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
13.	Monitoring changes in gene expression in renal ischemia-reperfusion in the rat.	Yoshida T, etal., Kidney Int. 2002 May;61(5):1646-54.

PMID:16504143	PMID:19129510	PMID:21060781	PMID:21273369	PMID:30396079

Adam2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	44,418,191 - 44,459,570 (-)	NCBI		GRCr8
mRatBN7.2	15	40,242,651 - 40,284,025 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	40,242,783 - 40,283,952 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	42,107,929 - 42,148,828 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	43,258,129 - 43,299,026 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	41,703,086 - 41,744,269 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	42,708,536 - 42,751,281 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	42,708,387 - 42,751,330 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	48,842,808 - 48,883,837 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	45,449,574 - 45,491,663 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	45,465,353 - 45,507,443 (-)	NCBI
Celera	15	39,914,632 - 39,955,090 (-)	NCBI		Celera
Cytogenetic Map	15	p12	NCBI

ADAM2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	39,743,735 - 39,838,227 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	39,743,735 - 39,838,227 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	39,601,254 - 39,695,746 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	39,720,411 - 39,814,936 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	39,720,413 - 39,814,936	NCBI
Celera	8	38,553,126 - 38,647,899 (-)	NCBI		Celera
Cytogenetic Map	8	p11.22	NCBI
HuRef	8	38,134,819 - 38,229,371 (-)	NCBI		HuRef
CHM1_1	8	39,648,176 - 39,742,718 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	40,020,946 - 40,115,447 (-)	NCBI		T2T-CHM13v2.0

Adam2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	66,264,778 - 66,315,300 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	66,264,778 - 66,315,182 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	66,027,322 - 66,077,851 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	66,027,329 - 66,077,733 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	66,646,166 - 66,696,570 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	64,981,442 - 65,039,019 (-)	NCBI		MGSCv36	mm8
Celera	14	63,775,697 - 63,826,131 (-)	NCBI		Celera
Cytogenetic Map	14	D1	NCBI
cM Map	14	34.36	NCBI

Adam2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	50,046,004 - 50,117,201 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	50,046,262 - 50,115,004 (+)	NCBI	ChiLan1.0	ChiLan1.0

ADAM2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	58,199,433 - 58,295,832 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	33,916,514 - 34,012,905 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	38,939,413 - 39,034,142 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	36,448,201 - 36,542,784 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	36,448,201 - 36,542,784 (-)	Ensembl	panpan1.1		panPan2

ADAM2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	25,781,508 - 25,912,988 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	25,782,267 - 25,912,891 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	26,296,840 - 26,434,482 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	27,604,238 - 27,740,761 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	27,605,309 - 27,722,734 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	25,906,520 - 26,037,639 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	26,466,004 - 26,599,845 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	26,520,781 - 26,651,970 (-)	NCBI		UU_Cfam_GSD_1.0

Adam2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	8,134,275 - 8,190,300 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936675	397,161 - 451,153 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936675	393,160 - 451,851 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADAM2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	47,207,722 - 47,278,315 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	47,207,727 - 47,278,315 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	54,055,205 - 54,124,179 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADAM2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	37,758,276 - 37,884,459 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666052	4,067,374 - 4,172,869 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Adam2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	22,317,961 - 22,383,736 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624758	22,318,565 - 22,384,360 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Adam2
347 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	21
Count of miRNA genes:	20
Interacting mature miRNAs:	21
Transcripts:	ENSRNOT00000066478
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331729	Rf42	Renal function QTL 42	3.071		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	15	17362897	73690657	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	42356671	Rat
1582227	Gluco30	Glucose level QTL 30	3.6	0.0003	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	15	28030665	82262678	Rat
1582228	Epfw3	Epididymal fat weight QTL 3	4.1	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	22806240	98288169	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	22806240	98288169	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	306329	45306329	Rat
2293686	Bmd36	Bone mineral density QTL 36	7.4	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	15	33611058	71477291	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	12496141	65205939	Rat
2298549	Neuinf12	Neuroinflammation QTL 12	3.5		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	15	1	55302115	Rat
2293691	Bmd37	Bone mineral density QTL 37	6.6	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	15	33611058	71477291	Rat
2293688	Bss29	Bone structure and strength QTL 29	5.31	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	15	11111142	56111142	Rat
1582214	Stl21	Serum triglyceride level QTL 21	3.1	0.022	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	15	28030665	82262678	Rat
631273	Lecl2	Lens clarity QTL 2		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	15	10596089	55596089	Rat
2300167	Bmd63	Bone mineral density QTL 63	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
731170	Pur3	Proteinuria QTL 3	2.3	0.0005	urine protein amount (VT:0005160)	urine protein excretion rate (CMO:0000759)	15	1	41686771	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2266368	46921453	Rat
152025253	Hrtrt24	Heart rate QTL 24	3.82		heart pumping trait (VT:2000009)		15	27885774	86257085	Rat
10054130	Srcrt8	Stress Responsive Cort QTL 8	2.18	0.0085	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	22117933	67117933	Rat
2300173	Bmd62	Bone mineral density QTL 62	12.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2324620	Coatc3	Coat color QTL 3			coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	15	19856566	46187442	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	16725528	80672115	Rat
1582251	Gluco24	Glucose level QTL 24	3.2	0.0008	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	5530756	50530756	Rat
1598828	Glom14	Glomerulus QTL 14	2.5		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	15	34054139	79054139	Rat
1582242	Gluco28	Glucose level QTL 28	3.3	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	15	28030665	82262678	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	22806240	98288169	Rat
1582244	Bw79	Body weight QTL 79	4	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat

Adam2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	40,242,712 - 40,242,898 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	42,708,466 - 42,708,651	NCBI	Rnor6.0
Rnor_5.0	15	48,883,722 - 48,883,907	UniSTS	Rnor5.0
RGSC_v3.4	15	45,449,504 - 45,449,689	UniSTS	RGSC3.4
Celera	15	39,914,562 - 39,914,747	UniSTS
Cytogenetic Map	15	p12	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
4	7	5	52	61	60	44	10	44	3	85	26	43	6	49	16


RefSeq Transcripts	NM_020077	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093615	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093616	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093617	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063274593	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X99794	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000066478 ⟹ ENSRNOP00000061122

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	40,242,783 - 40,283,952 (-)	Ensembl
Rnor_6.0 Ensembl	15	42,708,387 - 42,751,330 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000118188 ⟹ ENSRNOP00000084478

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	40,244,203 - 40,283,952 (-)	Ensembl

RefSeq Acc Id:

NM_020077 ⟹ NP_064462

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	44,418,199 - 44,459,516 (-)	NCBI
mRatBN7.2	15	40,242,651 - 40,283,970 (-)	NCBI
Rnor_6.0	15	42,708,536 - 42,751,281 (-)	NCBI
Rnor_5.0	15	48,842,808 - 48,883,837 (+)	NCBI
RGSC_v3.4	15	45,449,574 - 45,491,663 (-)	RGD
Celera	15	39,914,632 - 39,955,090 (-)	RGD

Sequence:

show sequence

CCCGGGGAATGGCCATGTGGCTCCTCTTGCTTCTGCTGAGTGGGCTGAGTAGACTTGGAGGGCTTAGCGAGCCCCAAACAGAAGGCACTCGTGAGAAATTACACGTGCAAGTCACGGTGCCAGAGAAA
ATCCGGTCCATCACAAGTGAAGGCTACGAAACACAGGTGACCTACAGTCTCAAAATCGAAGGGAAAACATACATCCTGAACCTAATGCAAAAAGCGTTCTTGCCTCCCAACTTTAGAGTCTACAGCTA
TGACAGCACAGGGATCATGAGGCCTCTTGAGCAGAAGTTTCAGAATATCTGCTACTTCCAAGGATACATTGAAGGTTATCCAAATTCTATGGTGATTGTTAGCACATGTACTGGACTCAGGGGAGTAC
TTCAGTTTGGAAACGTTAGCTACGGAATTGAACCCCTGGAATCTTCCAGTGGTTTTGAACATGTAATCTACCAAGTGGAACCTAAGAAAGGAGACACATTACTCTATGCCGAGAAGGATATGGATTTA
AGAGACCCGCAGTATAAGATACGAAGTATCAAGCCTCAGCGAACCGTCTCGCACTATCTGGAAATACACATTGTAGTTGAAAAGCAGATGTTTGAGCATATTGGGGCTGATACAGCTGTTGTCACTCA
AAAGATTTTCCAGTTGATTGGACTGACAAATGCTATCTTTGCCCCCTTTAATCTTACAGTAATTCTGTCTTCCCTGGAATTTTGGATGGACGAAAACAAAATCTCGACCACGGGTGATGCTAACAAGT
TGCTGTACAGGTTCCTGAAGTGGAAACAGTCGTACCTCGTTCTGCGACCACATGACATGGCGTTTTTACTCGTCTACAGGGACACCACTGATTATGTTGGCGCCACCTATCAAGGGAAGATGTGTGAC
AAGAACTATGCAGGAGGCGTTGCTCTGCACCCCAAAGCCGTAACTCTGGAATCACTTGCAATTATTTTAGTTCAGCTGCTGAGCCTCAGCATGGGGGTCGCATATGACGATGTGAACACGTGCCAGTG
CGGAGTACCCATCTGCGTGATGAACCCCGAAGCACTTCATTCCAGCGGTGTGAGGTCCTTCAGTAACTGCAGCATGGAGGACTTCTCCAAGTTTATCGTAAGTCAAAGCTCCCACTGTCTTCAGAACC
AGCCACACCTACAGCCGTCGTACAAGATGGCAGTCTGTGGGAATGGAGAGTTGGAAGAAGGAGAAGTTTGCGACTGTGGACAGGAGGGCTGTGACGATAAGCCTCCTCCATGCTGTAATCCCACCACC
TGTCAGCTGTCAGAGGGCTCCACTTGCTCCACCGGAAGTTGCTGCGACGCTTCGTGCAATCTGAAGGCAAAAGGGGAACTTTGCAGGCCTGCCAATCAGGAATGTGACGTCACAGAGTACTGCAACGG
CACTTCCGAAGTGTGTGAAGAAGACTTCTTTGTTCAAGACGGTCACCCATGTGCAGAACAGAAGTGGATCTGTATTAATGGCACCTGTCAGAGTGGAGCACAGCAGTGCCGGGATCTGTTTGGCACTG
ATGCAGACTATGGTACAAAAGAATGTTACTCGGAGCTGAATTCCAAAAGTGACATATCTGGGAGCTGCGGTATCACTCCTACGGGGTACAAGGACTGCGCACCTAATGACCGGATGTGTGGAAAACTA
ATATGTATATACCAAAGTGAAGACATACTTAAAATGAGGTCTGCCATTGTTATCTATGCCAATATAAGCGGGCAAATCTGCATCTCCCTGGAATACCCCCCAGGTCACAAAGAGAGCAAGAAGATGTG
TGTGAGAGATGGAACTGTCTGCGGGTCAGGGAAGGTTTGCTTGAATCAAGAGTGTGTAGAAGATACTTTCTTGAACTATGATTGCACCCCAGAAAAATGCAACCACCATGGGGTATGTAATAACAAGA
AGCATTGCCACTGTGAGCCCACATACTTACCTCCGGATTGTAAAAATACGGAGGATACATGGCCTGGTGGGAGCGTTGACAGTGGCAACCAGCAACGGGCTGAATCCATCCCTGCACGGTCCTATGTT
GCAAGTGCCTACCGCTCCAAGTCTGCAAGGTGGCCATTTTTCCTGATCATCCCTTTCTACGTGGTGATCCTTGTCCTGATCGGCATGCTGGTAAAAGTCTATTCCCAAAGAAAAAAATGGAGAATGGA
TGACTTCTCAAGTGAAGAACAATTTGAAAGTGAAAGTGAATCCAAAGACTAGTCTGGACAGCAAAGATTCCAGTGTCATGTAATTCTCTTCAGTGGACAGAAAAAAAAGTGGAAAAGAAAAACCTATG
CATCATCTGTTTGCCTGAAAGTCAAGCCTGCATGTTGTGGTTTCCATCTGGCCAGAAATCATATCTCTCCATACACATGTGTGATACATATATGTGTATATAATTCCATAAATGATTTACTTGTAAG

hide sequence

RefSeq Acc Id:

XM_039093614 ⟹ XP_038949542

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	44,418,191 - 44,459,570 (-)	NCBI
mRatBN7.2	15	40,242,784 - 40,284,025 (-)	NCBI

RefSeq Acc Id:

XM_039093615 ⟹ XP_038949543

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	44,418,191 - 44,455,137 (-)	NCBI
mRatBN7.2	15	40,242,784 - 40,279,592 (-)	NCBI

RefSeq Acc Id:

XM_039093616 ⟹ XP_038949544

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	44,418,191 - 44,445,557 (-)	NCBI
mRatBN7.2	15	40,242,784 - 40,269,999 (-)	NCBI

RefSeq Acc Id:

XM_039093617 ⟹ XP_038949545

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	44,418,191 - 44,443,240 (-)	NCBI
mRatBN7.2	15	40,242,784 - 40,267,719 (-)	NCBI

RefSeq Acc Id:

XM_063274593 ⟹ XP_063130663

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	44,418,191 - 44,455,133 (-)	NCBI


Protein RefSeqs	NP_064462	(Get FASTA)	NCBI Sequence Viewer
	XP_038949542	(Get FASTA)	NCBI Sequence Viewer
	XP_038949543	(Get FASTA)	NCBI Sequence Viewer
	XP_038949544	(Get FASTA)	NCBI Sequence Viewer
	XP_038949545	(Get FASTA)	NCBI Sequence Viewer
	XP_063130663	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAA68127	(Get FASTA)	NCBI Sequence Viewer
	EDL85375	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000061122
GenBank Protein	Q63202	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_064462 ⟸ NM_020077
- Peptide Label:	precursor
- UniProtKB:	A6K6L5 (UniProtKB/TrEMBL), F1M6W4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAMWLLLLLLSGLSRLGGLSEPQTEGTREKLHVQVTVPEKIRSITSEGYETQVTYSLKIEGKTYILNLMQKAFLPPNFRVYSYDSTGIMRPLEQKFQNICYFQGYIEGYPNSMVIVSTCTGLRGVLQF GNVSYGIEPLESSSGFEHVIYQVEPKKGDTLLYAEKDMDLRDPQYKIRSIKPQRTVSHYLEIHIVVEKQMFEHIGADTAVVTQKIFQLIGLTNAIFAPFNLTVILSSLEFWMDENKISTTGDANKLLY RFLKWKQSYLVLRPHDMAFLLVYRDTTDYVGATYQGKMCDKNYAGGVALHPKAVTLESLAIILVQLLSLSMGVAYDDVNTCQCGVPICVMNPEALHSSGVRSFSNCSMEDFSKFIVSQSSHCLQNQPH LQPSYKMAVCGNGELEEGEVCDCGQEGCDDKPPPCCNPTTCQLSEGSTCSTGSCCDASCNLKAKGELCRPANQECDVTEYCNGTSEVCEEDFFVQDGHPCAEQKWICINGTCQSGAQQCRDLFGTDAD YGTKECYSELNSKSDISGSCGITPTGYKDCAPNDRMCGKLICIYQSEDILKMRSAIVIYANISGQICISLEYPPGHKESKKMCVRDGTVCGSGKVCLNQECVEDTFLNYDCTPEKCNHHGVCNNKKHC HCEPTYLPPDCKNTEDTWPGGSVDSGNQQRAESIPARSYVASAYRSKSARWPFFLIIPFYVVILVLIGMLVKVYSQRKKWRMDDFSSEEQFESESESKD hide sequence

Ensembl Acc Id:

ENSRNOP00000061122 ⟸ ENSRNOT00000066478

RefSeq Acc Id:	XP_038949542 ⟸ XM_039093614
- Peptide Label:	isoform X1
- UniProtKB:	F1M6W4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038949543 ⟸ XM_039093615
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038949544 ⟸ XM_039093616
- Peptide Label:	isoform X3

Protein Domains

Disintegrin EGF-like Peptidase M12B

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q63202-F1-model_v2	AlphaFold	Q63202	1-737	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

RGD ID:

13699754

Promoter ID:

EPDNEW_R10277

Type:

multiple initiation site

Name:

Adam2_1

Description:

ADAM metallopeptidase domain 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	15	42,751,310 - 42,751,370	EPDNEW

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-13333	BioCyc
Ensembl Genes	ENSRNOG00000017027	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000066478	ENTREZGENE
Gene3D-CATH	3.40.390.10	UniProtKB/Swiss-Prot
	4.10.70.10	UniProtKB/Swiss-Prot
InterPro	ADAM_Cys-rich	UniProtKB/Swiss-Prot
	Disintegrin_CS	UniProtKB/Swiss-Prot
	Disintegrin_dom	UniProtKB/Swiss-Prot
	Disintegrin_dom_sf	UniProtKB/Swiss-Prot
	EGF-like_dom	UniProtKB/Swiss-Prot
	MetalloPept_cat_dom_sf	UniProtKB/Swiss-Prot
	Peptidase_M12B	UniProtKB/Swiss-Prot
	Peptidase_M12B_N	UniProtKB/Swiss-Prot
	Reprolysin_adamalysin	UniProtKB/Swiss-Prot
KEGG Report	rno:56806	UniProtKB/Swiss-Prot
NCBI Gene	56806	ENTREZGENE
PANTHER	ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN	UniProtKB/Swiss-Prot
	PTHR11905:SF108	UniProtKB/Swiss-Prot
Pfam	ADAM_CR	UniProtKB/Swiss-Prot
	Disintegrin	UniProtKB/Swiss-Prot
	Pep_M12B_propep	UniProtKB/Swiss-Prot
	Reprolysin	UniProtKB/Swiss-Prot
PhenoGen	Adam2	PhenoGen
PROSITE	ADAM_MEPRO	UniProtKB/Swiss-Prot
	DISINTEGRIN_1	UniProtKB/Swiss-Prot
	DISINTEGRIN_2	UniProtKB/Swiss-Prot
	EGF_3	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000017027	RatGTEx
SMART	ACR	UniProtKB/Swiss-Prot
	DISIN	UniProtKB/Swiss-Prot
Superfamily-SCOP	Metalloproteases ('zincins'), catalytic domain	UniProtKB/Swiss-Prot
	SSF57552	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZZF4_RAT	UniProtKB/TrEMBL
	A6K6L5	ENTREZGENE, UniProtKB/TrEMBL
	ADAM2_RAT	UniProtKB/Swiss-Prot
	F1M6W4	ENTREZGENE, UniProtKB/TrEMBL
	Q63202	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-18	Adam2	ADAM metallopeptidase domain 2	Adam2	a disintegrin and metallopeptidase domain 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-18	Adam2	a disintegrin and metallopeptidase domain 2	Adam2	a disintegrin and metalloprotease domain 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Adam2	a disintegrin and metalloprotease domain 2			Name updated	70584	APPROVED

Note Type	Note	Reference
gene_cellular_localization	localized to the acrosomal cap of spermatozoa and elongating spermatids	68863
gene_process	sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization; may have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct	724707
gene_product	member of the MDC (metalloproteinase-like, disintegrin-like, cysteine-rich) protein family; non catalytic	724707
gene_regulation	interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg	68863

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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